JPWO2013125064A1 - Semi-solidified nutrient - Google Patents

Abstract

A semi-solidified nutrient in which the occurrence of water separation is suppressed is provided. A semi-solid nutrient containing a nutrient containing a carbohydrate and a protein source, moisture, agar and modified starch, wherein the content of the agar is 0.05 to The semi-solidified nutrient, which is 1.5% by mass and the content of the modified starch is 0.5 to 10% by mass based on the total amount of the nutrient.

Description

  The present invention relates to a semi-solidified nutrient.

  2. Description of the Related Art In recent years, nutritional supplements that can easily consume necessary nutrients have attracted attention as nutritional supplements that replace food. As such nutrients, solid, semi-solid, liquid, etc. are known, and among these, semi-solid nutrients are useful as nutritional supplements in the medical field and food field, and are widely used. Progressing.

  The above-mentioned semi-solidified nutrient in the medical field is mainly applied to patients, infants, elderly people, etc., and the administration method is roughly divided into oral administration and tube administration.

  Oral administration is mainly applied to those who have difficulty swallowing with difficulty in chewing or swallowing due to aging or cerebrovascular disorders. People who have difficulty swallowing have difficulty eating a normal meal. In particular, when ingesting water, low-viscosity juice, or the like, the ability to swallow is reduced, and therefore sufficient consideration must be given to backflow and dusk. Generally, hospitals have devised methods such as mixing commercially available thickeners with liquid nutrients, tea, water, etc., and giving them after giving appropriate viscosity. However, if too much thickener is added, the pharyngeal residue may occur due to partial lumps, and the viscosity increases after the thickener is added to the food (stable viscosity). There is a problem that preparation takes time because it takes a little time to prepare.

  In recent years, various semi-solid nutrients have been developed for those with difficulty in swallowing. Properties required for the semi-solidified nutrient include moderate viscosity, moderate shape retention, difficulty in adhering to the oral cavity and pharynx, difficulty in water separation, and the like. In addition, from the viewpoint of improving nutritional status and improving QOL (Quality of Life), it is desired to have properties such as high nutritional value and excellent texture and flavor.

  Tube administration is mainly applied to elderly people, patients, etc. who cannot be administered orally, and semi-solid nutrients are administered using enteral nutrition.

  In general, enteral nutrition is a nutritional method aimed at meeting the demand for calories and nutrients (protein sources, minerals, vitamins, etc.) required by the living body, and is the physiological method following oral intake. Is. For this reason, enteral nutrition is usually selected over high calorie infusion therapy (TPN), which is intravenous nutritional supplementation, for patients with intestinal function that cannot be ingested. In the enteral nutrition method, examples of the administration method of the nutrient include administration using an oral gastric tube, administration using a nasogastric tube, administration using a gastrostoma, and the like. When used, administration using gastrostomy is primarily selected. In this case, the required properties include moderate viscosity, and it is difficult for the nutrients to remain in the tube when it is administered from the gastrostomy through the tube, and it is difficult to contaminate the tube. In particular, regarding viscosity, it is important to maintain a high viscosity. When a nutrient with low viscosity is administered from the gastrostomy, depending on the condition of the patient, the nutrient may flow back from the stomach to the esophagus, causing problems such as esophagitis and pneumonia.

  On the other hand, the above-mentioned semi-solidified nutrient in the food field has a unique texture and can easily and quickly ingest nutrients, and thus is mainly applied to portable foods, diet foods, and the like. At this time, due to the recent increase in health consciousness, there is a tendency to lack specific health foods that contain specific health functional ingredients that are involved in the physiological functions and biological activities of the body as well as the nutrients that are required on a daily basis. Some are sold as nutritional functional foods that further contain nutritional components.

  Various kinds of the above-mentioned semi-solidified nutrient have been reported so far. For example, Patent Document 1 discloses a semi-solid nutrient obtained by adding agar or whole egg as a semi-solid agent to the enteral nutrient as a semi-solid nutrient applied to the enteral nutrition method. . Patent Document 2 discloses a gel enteral nutrient characterized by containing agar and alginic acid and / or a salt thereof. Furthermore, Patent Document 3 discloses a semi-solidifying agent for enteral nutrition for gastrostomy patients, which contains agar and LM pectin.

Japanese Patent No. 3516673 JP 2008-69090 A JP 2010-229073 A

  However, as in Patent Document 1, since the semi-solidified nutrient prepared by blending a lot of agar tends to be in a jelly shape, once it is crushed by transportation during transportation or stimulation of falling, Water separation may occur. Ingestion of a nutrient that causes water separation changes the viscosity and shape retention of the nutrient that is suitably set according to the application, and may cause gastroesophageal reflux, vomiting, diarrhea, and the like. In addition, in elderly people who are difficult to chew and swallow, patients who cannot be ingested, etc., water that has been removed from the water may cause a rash or aspiration pneumonia. Furthermore, the occurrence of water separation may cause problems such as deterioration over time in stability and handleability.

  Further, as in Patent Document 2, the semi-solidified nutrient prepared by using alginic acid together with agar has a non-uniform semi-solidified nutrient because sodium alginate itself reacts with calcium ions to form aggregates. It is easy to become an agent.

  As in Patent Document 3, a semi-solidified nutrient prepared by using LM pectin together with agar has a certain shape-retaining property, but water separation may occur slightly. When the amount of LM pectin was increased to suppress the water separation, there was a problem that adhesion to the tube increased and workability during administration could be reduced.

  Then, an object of this invention is to provide the semi-solidification nutrient with which generation | occurrence | production of water separation was suppressed.

  As a result of intensive studies, the present inventors have found that the above-mentioned problems can be solved by adding a predetermined amount of agar and a predetermined amount of modified starch to a semi-solidified nutrient, thereby completing the present invention. It came to. That is, this invention relates to the semi-solidified nutrient containing a nutrient containing a saccharide | sugar and a protein source, a water | moisture content, agar, and modified starch. At this time, the content of the agar is 0.05 to 1.5% by mass with respect to the total amount of the nutrient, and the content of the modified starch is 0.5 to 10% by mass with respect to the total amount of the nutrient. It is characterized by being.

  According to the present invention, a semi-solidified nutrient in which the occurrence of water separation is suppressed is provided.

[Semi-solidified nutrient]
The semi-solidified nutrient according to the present invention includes nutrients, moisture, agar, and modified starch.

[Nutrient]
Nutrients essentially include carbohydrate and protein sources. The nutrient may further contain at least one selected from the group consisting of lipids, vitamins, minerals, and dietary fiber as an optional component.

  The total amount of nutrients in the semi-solidified nutrient is preferably 8 to 65% by mass, and more preferably 12 to 54% by mass.

(Sugar)
Carbohydrates are also called carbohydrates and serve as energy sources.

  The carbohydrate that can be used is not particularly limited as long as it is absorbed into a living body and becomes an energy source, and examples thereof include monosaccharides, disaccharides, and polysaccharides. Specific examples of monosaccharides include glucose (glucose), fructose (fructose), galactose and the like. Specific examples of the disaccharide include sucrose (sucrose), lactose (lactose), maltose (malt sugar), isomaltose, trehalose and the like. Specific examples of the polysaccharide include starch (amylose, amylopectin), dextrin and the like. Of these, dextrin is preferably used.

  Dextrin is a general term for substances in which several α-glucoses are polymerized by glycosidic bonds, and can be obtained by hydrolysis of starch. Since dextrin has a slow degradation rate in the small intestine and is slowly absorbed, it can prevent a rapid increase in blood sugar. Moreover, by using dextrin, the osmotic pressure of the semi-solidified nutrient can be reduced, and osmotic diarrhea can be prevented. As the dextrin, either a high molecular dextrin having a high degree of polymerization of α-glucose or a low molecular dextrin having a low degree of polymerization of α-glucose may be used, but a high molecular dextrin capable of reducing the osmotic pressure should be used. Is preferred. The low molecular weight dextrin is also called maltodextrin, and usually 3 to 5 α-glucose is polymerized.

  The dextrin may be prepared by itself or a commercially available product may be used. When preparing dextrin, known starches such as corn, waxy corn, wheat, rice, waxy rice, waxy miro, beans (broad beans, mung beans, red beans, etc.), potatoes, sweet potatoes, tapioca, etc. It can be prepared by hydrolysis by a known method. On the other hand, examples of commercially available dextrin include TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.) and the like, which can be suitably used.

  The above carbohydrates may be used alone or in combination of two or more.

  Although content of the saccharide | sugar in a semi-solidified nutrient can be suitably adjusted with the subject to apply, it is preferable that it is 5-30 mass% with respect to the total amount of a semi-solidified nutrient.

(Protein source)
The protein source is not particularly limited, and known proteins can be used. For example, amino acids, peptides, plant proteins, animal proteins and the like can be mentioned.

Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine; and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc. Of the non-essential amino acids. These other, 4-hydroxyproline, 5-hydroxylysine, .gamma.-carboxyglutamic acid, O- phosphoserine, O- phosphotyrosine, N- acetylserine, N ^omega - methyl arginine, pyroglutamic acid, modified amino acid, such as M- formylmethionine; Special amino acids such as ornithine, citrulline, γ-aminobutyric acid (GABA), thyroxine, S-adenylmethionine can also be included. The amino acids may be stereoisomers (enantiomers, diastereomers), positional isomers, or a mixture thereof. Furthermore, the amino acid may be in the form of an inorganic acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) that can be hydrolyzed in vivo.

  As the peptide, one obtained by polymerizing two or more of the above amino acids via a peptide bond (amide bond) can be used. The peptide may be a dipeptide, a tripeptide, an oligopeptide (having about 10 amino acids), or a polypeptide (having several tens to several hundred amino acids). Some oligopeptides such as lactotripeptides, casein decapeptides, valyltyrosine-containing sadden peptides and the like may have health functions such as antihypertensive action.

  Examples of plant proteins include proteins contained in grains such as rice and beans such as soybeans and tofu. In addition, about soy protein, it can have health functions, such as combining with a bile acid and promoting the excretion of cholesterol.

  Examples of animal proteins include proteins contained in eggs, meats, seafood, milk and the like.

  Of these, whey protein made from milk (whey) as a raw material, casein protein contained in milk, and soy protein are preferably used, and whey protein is more preferably used. Examples of the whey protein include whey protein concentrate (WPC), whey protein isolate (WPI), hydrolyzed whey peptide (WPH) and the like. Commercially available products such as WPC, WPI, and soy protein may be used. As commercially available products, WPI18855 (manufactured by Fontera), WPI18822 (manufactured by Fontera), WPI1895 (manufactured by Fontera), WPC392 (manufactured by Fontera) ), WPC80 (manufactured by Fontera), WPC7009 (manufactured by Fontera), WPC164 (manufactured by Fontera), WPC162 (manufactured by Fontera), WPC132 (manufactured by Fontera), WPC472 (manufactured by Fontera), Prolina 900 (Fuji Oil) New Fuji Pro 3000 (Fuji Oil Co., Ltd.), New Fuji Pro 1700N (Fuji Oil Co., Ltd.) and the like.

  The above protein sources may be used alone or in admixture of two or more.

  The content of the protein source in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 1 to 18% by mass, and 3 to 12% by mass with respect to the total amount of the semi-solidified nutrient. It is more preferable that

(Lipid)
Lipids can be a source of energy, biomembrane constituents, steroid hormones and bile acids.

  The lipid that can be used is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats and oils, and fish oils.

  Examples of saturated fatty acids include caprylic acid, capric acid, lauric acid, palmitic acid, stearic acid and the like.

  Examples of the unsaturated fatty acid include oleic acid, palmitoleic acid, linoleic acid, arachidonic acid, α-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like. In addition, about EPA and DHA, it can have health functions, such as a blood cholesterol raise inhibitory effect and a neutral fat rise inhibitory effect.

  Vegetable oils include coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, cashew oil, hazelnut Oil, macadamia nut oil, mongolian oil, pecan oil, pine nut oil, pistachio oil, walnut oil, gourd seed oil, buffalo pumpkin oil, pumpkin seed oil, watermelon seed oil, amaranth oil, apricot oil, apple oil, argan oil , Avocado oil, babas oil, moringa oil, borneo oil, cape chestnut oil, cocoa butter, carob oil, kofne palm oil, coriander seed oil, dica oil, flaxseed oil, grape seed oil, hemp oil, kapok seed oil, lale mantia oil , Marula oil, Meadow foam oil, mustard oil, Na Meg butter, okra oil, papaya oil, perilla oil, pequi oil, pine nut oil, poppy oil, pruned oil, quinoa oil, niger seed oil, rice bran oil, Royle oil, Thatcha inchi oil, camellia oil, thistle oil, tomato oil , Wheat oil, sesame oil, sunflower oil, germ oil, coconut oil, peanut oil and the like.

  Examples of animal fats include lard (pig fat), head (tallow), milk fat, and the like.

  Examples of fish oil include fish oil such as mackerel, salmon, yellowtail, sardine, saury.

  Among these, it is preferable to use linoleic acid and α-linolenic acid that cannot be synthesized in vivo by humans, or lipids containing these.

  The above lipids may be used alone or in combination of two or more.

  The lipid content in the semi-solidified nutrient can be appropriately adjusted by the subject to be applied, but is preferably 0 to 10% by mass, and 1 to 6% by mass with respect to the total amount of the semi-solidified nutrient. More preferably.

(vitamin)
Vitamins are a general term for organic compounds other than carbohydrates, protein sources, and lipids that are necessary to maintain the nutritional state of living organisms.

  Vitamin A (retinol), vitamin D (ergocalciferol, cholecalciferol), vitamin E (tocopherol, tocotrienol) vitamin K (phylloquinone, menaquinone) and other fat-soluble vitamins: vitamin B1 (thiamine), vitamin B2 (Riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxal, pyridoxamine, pyridoxine), vitamin B7 (biotin), vitamin B9 (folic acid), vitamin B12 (cyanocobalamin, hydroxocobalamin), vitamin C And water-soluble vitamins such as (ascorbic acid). These vitamins may be used alone or in combination of two or more.

  The content of vitamins in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied. Normally, fat-soluble vitamins are added in an amount that does not cause excess disease, and water-soluble vitamins are not limited in the amount added. The preferable content of each vitamin per 100 g of the semi-solidified nutrient is as follows.

Fat-soluble vitamins;
Vitamin A: preferably 0 to 3000 μg, more preferably 20 to 200 μg
Vitamin D: preferably 0.1-50 μg, more preferably 0.1-5.0 μg
Vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg
Vitamin K: preferably 0.5 to 1000 μg, more preferably 2 to 50 μg
Water-soluble vitamins;
Vitamin B1: preferably 0.01-40 mg, more preferably 0.1-5 mg
Vitamin B2: preferably 0.01-20 mg, more preferably 0.05-5 mg
Niacin: preferably 0.1 to 300 mg NE, more preferably 0.5 to 30 mg NE
Pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 10 mg
Vitamin B6: preferably 0.01-60 mg, more preferably 0.1-10 mg
Biotin: preferably 0.1 to 1000 μg, more preferably 1 to 100 μg
Folic acid: preferably 1-1000 μg, more preferably 10-200 μg
Vitamin B12: preferably 0.01-100 μg, more preferably 0.2-60 μg
Vitamin C: preferably 1-2000 mg, more preferably 5-1000 mg.

(mineral)
Minerals are elements other than organic compounds that are necessary for maintaining the nutritional state of living organisms.

  Examples of the mineral include quasi-major elements such as sodium, potassium, calcium, phosphorus and magnesium; essential trace elements such as iron, zinc, copper, iodine, manganese, selenium, chromium and molybdenum. These minerals may be used alone or in combination of two or more.

  The mineral content in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied. The preferable content of each mineral per 100 g of the semi-solidified nutrient is as follows.

Quasi-major elements;
Sodium: preferably 5 to 6000 mg, more preferably 10 to 3500 mg
Potassium: preferably 1 to 3500 mg, more preferably 25 to 1800 mg
Calcium: preferably 10 to 2300 mg, more preferably 30 to 300 mg
Phosphorus: preferably 1 to 3500 mg, more preferably 25 to 1500 mg
Magnesium: preferably 1 to 740 mg, more preferably 10 to 150 mg
Essential trace elements;
Iron: preferably 0.1-55 mg, more preferably 1-10 mg
Zinc: preferably 0.1-30 mg, more preferably 1-15 mg
Copper: preferably 0.01 to 10 mg, more preferably 0.06 to 6 mg
Iodine: preferably 0.1 to 3000 μg, more preferably 1 to 150 μg
Manganese: preferably 0.01-11 mg, more preferably 0.1-4 mg
Selenium: preferably 0.1 to 450 μg, more preferably 1 to 35 μg
Chromium: preferably 0.1 to 40 μg, more preferably 1 to 35 μg
Molybdenum: preferably 0.1 to 320 μg, more preferably 1 to 25 μg.

(Dietary fiber)
Dietary fiber can have functions such as reduced nutrient utilization, reduced plasma cholesterol, improved blood glucose response, improved colon function, and prevention of colon cancer. In addition, dietary fiber may be fermented by intestinal bacteria and converted to short chain fatty acids, carbon dioxide gas, hydrogen gas, methane gas, and the like. Among these, since short chain fatty acids are absorbed in the large intestine, dietary fiber may be an energy source.

  The dietary fiber is not particularly limited, but is insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, psyllium seed, low molecular weight sodium alginate; water-soluble pectin, guar gum, konjac mannan, glucomannan, alginic acid , Agar, chemically modified polysaccharide, polydextrose, indigestible oligosaccharide, maltitol, inulin, carrageenan, wheat bran, indigestible dextrin (eg, Pine Fiber C (manufactured by Matsutani Chemical Co., Ltd.), polydextrose, guar gum decomposition And water-soluble dietary fibers such as foods, etc. These dietary fibers may be used alone or in admixture of two or more.

  The content of dietary fiber in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.

[moisture]
The semi-solidified nutrient according to the present invention contains moisture.

  The water content in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied, the desired viscosity, and the like, but is preferably 46 to 88 mass% with respect to the total amount of the semi-solidified nutrient.

[Agar]
The semi-solidified nutrient according to this embodiment contains 0.05 to 1.5% by mass, preferably 0.5 to 1% by mass of agar, based on the total amount of the semi-solidified nutrient. Generation | occurrence | production of water separation can be suppressed when a semi-solidification nutrient contains agar with the said content with predetermined amount modified starch.

  Agar is a product obtained by freezing and drying mucus of red algae such as plover and gonori, and contains polysaccharides such as agarose and agaropectin as a main component. The agarose and agaropectin have a structure in which galactose and 3,6-andehydrogalactose are alternately polymerized. Agar may have different properties depending on the degree of polymerization and molecular weight of agarose and agaropectin, the content of sulfate groups and pyruvate groups in the agar, etc., but it is not particularly limited in the semi-solidified nutrient according to this embodiment. Any of these may be used. In addition, when agar with high elasticity is used, the semi-solidified nutrient tends to be in a jelly shape close to a solid. On the other hand, when agar with low elasticity is used, the semi-solidified nutrient tends to be a paste that is close to a liquid. Examples of commercially available products include Ultra Agar UX30 (manufactured by Ina Food Industry Co., Ltd.), Ultra Agar UX100 (manufactured by Ina Food Industry Co., Ltd.), Ultra Agar AX-30 (manufactured by Ina Food Industry Co., Ltd.), and Ultra Agar AX-100 ( Ina Food Industry Co., Ltd.), Ultra Agar BX-30 (Ina Food Industry Co., Ltd.), Ultra Agar BX-100 (Ina Food Industry Co., Ltd.) and the like can be used.

[Modified starch]
The semi-solidified nutrient according to this embodiment contains 0.5 to 10% by mass, preferably 0.7 to 5% by mass of modified starch, based on the total amount of the semi-solidified nutrient. Generation | occurrence | production of water separation can be suppressed by a semi-solidified nutrient containing modified starch with the said content with a predetermined amount of agar.

  Modified starch is obtained by subjecting starch to physical, enzymatic or chemical treatment. By performing the treatment, physical properties such as solubility in water, gelatinization temperature, viscosity stability at the time of heat dissolution, and physical property stability are changed.

  Examples of the physical treatment include wet heat treatment, high frequency treatment, radiation treatment, bleaching treatment, acid treatment, and base treatment. Examples of the enzymatic treatment include treatment with enzymes such as α-amylase, β-amylase, glucoamylase 7, isoamylase, and pullulanase. Examples of the chemical treatment include oxidation treatment, esterification treatment, acetylation treatment, etherification treatment, and crosslinking treatment.

  The modified starch obtained by the above treatment is not particularly limited, but roasted dextrin, acid-treated starch, alkali-treated starch, bleached starch, enzyme-treated starch, starch glycolate sodium, starch phosphate sodium, acetylated adipic acid Cross-linked starch, acetylated oxidized starch, acetylated phosphate cross-linked starch, starch sodium octenyl succinate, starch acetate, oxidized starch, hydroxypropylated phosphate cross-linked starch, hydroxypropyl starch, phosphate cross-linked starch, phosphorylated starch, monophosphate Examples include esterified phosphoric acid crosslinked starch. Of these, acetylated phosphate-crosslinked starch, hydroxypropylated phosphate-crosslinked starch, hydroxypropyl starch, and phosphate-crosslinked starch are preferably used, and acetylated phosphate-crosslinked starch, hydroxypropylated phosphate-crosslinked starch, hydroxy More preferably, propyl starch is used.

  The modified starch may be prepared by itself or a commercially available product may be used. In the case of self-preparation, a modified starch can be prepared by subjecting a known starch, for example, the above-mentioned starch, to at least one or more of the above physical treatment, enzymatic treatment, and chemical treatment. Commercially available products include, for example, WMS (acetylated phosphoric acid crosslinked starch: Matsutani Chemical Industry Co., Ltd.), Matsutani Suisen (acetylated phosphoric acid crosslinked starch: Matsutani Chemical Industry Co., Ltd.), Farinex VA70WM (hydroxypropylated phosphorus) Acid-crosslinked starch: manufactured by Matsutani Chemical Co., Ltd.), Farinex VA70X (hydroxypropylated phosphoric acid-crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.), Farinex VA70C (hydroxypropylated phosphoric acid-crosslinked starch: manufactured by Matsutani Chemical Industry Co., Ltd.) ), Select Amir XF (hydroxypropylated phosphate cross-linked starch: made by Matsutani Chemical Co., Ltd.), Food Starch HR-7 (hydroxypropylated phosphate cross-linked starch: made by Matsutani Chemical Co., Ltd.), Pine Ace # 1 (hydroxy) Propylated phosphate bridging den : Matsutani Chemical Industry Co., Ltd.), Matsutani Yugao (Hydroxypropylated phosphate cross-linked starch: Made by Matsutani Chemical Industry Co., Ltd.), Matsutani Asagao (Hydroxypropylated phosphate cross-linked starch: Made by Matsutani Chemical Industry Co., Ltd.), Farinex AG100 (hydroxypropyl starch: made by Matsutani Chemical Co., Ltd.), Yuri Matsutani (hydroxypropyl starch: made by Matsutani Chemical Co., Ltd.), etc. can be used.

  The above-mentioned modified starch may be used alone or in combination of two or more.

[Other ingredients]
The semi-solidified nutrient according to this embodiment may further contain other known components such as health functional ingredients, food additives, thickeners and the like.

(Health functional ingredient)
A health function component is a component that exhibits a certain function for a living body when ingested. Examples of the health function component include indigestible oligosaccharide, sugar alcohol, calcium citrate malate (CCM) and casein phosphopeptide (CPP), chitosan, L-arabinose, guava leaf polyphenol, wheat albumin, beans Examples include drum extract, diacylglycerol, diacylglycerol plant sterol, soy isoflavone, and milk basic protein.

Indigestible oligosaccharides Indigestible oligosaccharides are saccharides that are not as large in molecular weight (about 300 to 3000) as polysaccharides among compounds in which monosaccharides are linked by glycosidic bonds. The indigestible oligosaccharides are not degraded by human digestive enzymes, but those digested by human digestive enzymes can be included in the aforementioned carbohydrates. Ingestion of indigestible oligosaccharides can provide a bowel regulation effect.

  The indigestible oligosaccharide is not particularly limited, and examples thereof include xylooligosaccharide, fructooligosaccharide, soybean oligosaccharide, isomaltoligosaccharide, dairy oligosaccharide, lactulose, and galactooligosaccharide. These indigestible oligosaccharides may be used alone or in combination of two or more.

  The content of the indigestible oligosaccharide in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.

  Sugar alcohol Sugar alcohol is a kind of sugar produced by reduction of the carbonyl group of aldose or ketose, and it is not easily absorbed from the small intestine into the body and does not easily become calories. Sugar alcohol is difficult to be metabolized to acid by oral bacteria and can prevent plaque formation. The sugar alcohol can be used as a low calorie sweetener.

  Examples of the sugar alcohol include erythritol, maltitol, palatinose and the like. These sugar alcohols may be used alone or in admixture of two or more.

  The content of the sugar alcohol in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.

Calcium citrate malate (CCM) and casein phosphopeptide (CPP)
CCM and CPP can promote calcium absorption and promote bone formation. The CCM and CPP may be used alone or in combination. CCM and CPP are preferably used in combination with calcium.

  The contents of CCM and CPP in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.

(Food additive)
The food additive is used for the purpose of processing or storing the food by adding, mixing, moistening or other methods to the food. As food additives, in addition to the purpose of fortification, for example, zinc gluconate and copper gluconate, ascorbic acid 2-glucoside, cyclodextrin, antioxidant, colorant, sweetener, pH adjuster, acidulant, An emulsifier, a fragrance | flavor, etc. are mentioned.

Zinc gluconate and copper gluconate Zinc gluconate and copper gluconate are gluconates utilizing high chelating ability of gluconate with heavy metal ions. Since it becomes easy to be absorbed when it is made into the form of gluconate, zinc and copper can be absorbed effectively. The zinc gluconate and copper gluconate may be used alone or in combination.

  The contents of zinc gluconate and copper gluconate in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.

Ascorbic acid 2-glucoside Ascorbic acid 2-glucoside is a compound in which glucose is α-coordinated to the hydroxyl group at the 2-position of vitamin C (ascorbic acid), and is not subject to oxygen attack. It is a vitamin C derivative with high stability. Vitamin C can be efficiently absorbed by ascorbic acid 2-glucoside.

  The content of ascorbic acid 2-glucoside in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.

Cyclodextrin Cyclodextrin is a cyclic oligosaccharide having a cyclic structure in which glucose is bound by a glucoside bond. Those consisting of 6 glucoses are called α-cyclodextrin, those consisting of 7 glucoses are called β-cyclodextrin, and those consisting of 8 glucoses are called γ-cyclodextrin. Cyclodextrins can have functions such as an allergy suppressing effect, a blood sugar level increase suppressing effect, and an emulsifying action. The said cyclodextrin may be used independently or may be used in mixture of 2 or more types.

  The content of cyclodextrin in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.

Antioxidant Antioxidant has the function of preventing alteration of semi-solidified nutrient due to oxidation.

  Although it does not restrict | limit especially as antioxidant, Ascorbic acid and its sodium salt, erythorbic acid, its sodium salt, etc. may be used. These antioxidants may be used alone or in combination of two or more.

  Colorant The colorant has a function of beautifying the semi-solidified nutrient.

  Although it does not restrict | limit especially as a coloring agent, Edible tar pigment | dye (Edible red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105, and No. 106, Edible blue No. 1 and No. 2, Edible yellow No. 4 And No. 5, Edible Green No. 3, etc.), β-carotene, water-soluble anato, chlorophyll derivatives (chlorophyll a, chlorphyll b, copper chlorophyll, copper chlorophyllin sodium, iron chlorophyllin sodium, etc.), riboflavin, iron sesquioxide, titanium dioxide Safflower yellow pigment, cochineal pigment, gardenia yellow pigment, turmeric pigment, red cabbage pigment, beet red, grape skin pigment, paprika pigment, caramel and the like can be used. These colorants may be used alone or in admixture of two or more.

Sweetener The sweetener has a function of imparting sweetness to the semi-solidified nutrient.

  The sweetener is not particularly limited, but saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract Stevia processed sweeteners, thaumatin, curculin, disodium glycyrrhizinate and the like can be used. These sweeteners may be used alone or in combination of two or more.

pH adjuster The pH adjuster has a function of adjusting the pH of the semi-solidified nutrient.

  The pH adjuster is not particularly limited, and citric acid, gluconic acid, succinic acid, potassium carbonate, sodium hydrogen carbonate, carbon dioxide, lactic acid, sodium lactate, sodium citrate, adipic acid and the like can be used. These pH adjusters may be used alone or in combination of two or more.

Acidulant The acidulant has functions such as imparting acidity to the nutrient, preventing oxidation of the food, and adjusting the pH.

  The acidulant is not particularly limited, and acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid, phosphoric acid and the like can be used. These acidulants may be used alone or in combination of two or more.

Emulsifier The emulsifier has functions such as improving the solubility of oil-soluble components such as lipids in water.

  Although it does not restrict | limit especially as an emulsifier, Synthetic emulsifiers, such as natural emulsifiers, such as a lecithin, saponin, and casein sodium; glycerol fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, etc. are mentioned. These emulsifiers may be used alone or in combination of two or more.

Fragrance The fragrance has a function of flavoring and smelling the semi-solidified nutrient.

  The fragrance is not particularly limited, but acetophenone, α-amylcinnamaldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, decanal, decanol, ethyl acetoacetate, silica Ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geraniol, isoamyl acetate, isoamyl butyrate, isoamyl phenyl acetate, dl-menthol, l-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-borneol, etc. Can be mentioned. These fragrances may be used alone or in combination of two or more.

Others Enzymes such as α-amylase, β-amylase, glucoamylase, glucose isomerase, trehalose producing enzyme, trehalose releasing enzyme, glutaminase, yeast, and the like can be used.

  Content of the said food additive in a semi-solidification nutrient can be suitably adjusted with the subject etc. to apply.

(Thickener)
The thickener has a function of imparting viscosity to the semi-solidified nutrient. The thickener is other than agar and modified starch, and can be appropriately blended in a semi-solidified nutrient in combination with agar and modified starch.

  The thickener is not particularly limited, but gelatin, pectin, guar gum, locust bean gum, konjac mannan, xanthan gum, tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose gellan gum, tara gum, tamarind seed gum, psyllium seed gum, gum arabic gum Curdlan, pullulan, sodium alginate, tragacanth gum, karaya gum, veegum and the like can be used. These thickeners may be used alone or in admixture of two or more.

  The content of the thickener in the semi-solidified nutrient can be appropriately adjusted in consideration of the viscosity and the like.

  The semi-solidified nutrient according to this embodiment can suppress the occurrence of water separation by containing a predetermined amount of agar and a predetermined amount of modified starch. The water separation rate of the semi-solidified nutrient is preferably 1% or less, and more preferably 0.5% or less. A water separation rate of 1% or less is preferable because the viscosity and shape retention of a semi-solidified nutrient that is suitably set according to the application can be maintained. In addition, in this specification, the value measured by the method described in the Example shall be employ | adopted for "water separation rate".

  Moreover, the viscosity of the semi-solidified nutrient according to this embodiment is preferably 10,000 to 50,000 mPa · s, more preferably 15,000 to 30,000 mPa · s at 25 ° C. It is preferable that the semi-solidified nutrient has a viscosity of 10,000 mPa · s or more because gastroesophageal reflux, aspiration pneumonia, and the like can hardly occur. On the other hand, it is preferable that the viscosity of the semi-solidified nutrient is 50000 mPa · s or less because digestion can be facilitated. The viscosity can be adjusted mainly by appropriately setting the contents of agar, modified starch, and other thickeners in the semi-solidified nutrient. In this specification, “viscosity” is a value measured by the method described in the examples.

  Although the calorie | heat amount of the semi-solidified nutrient which concerns on this form changes also with uses of a semi-solidified nutrient, it is preferable that it is 0.5-2.5 kcal / g, and it is 0 from the viewpoint of the safety | security of moisture management. More preferably, it is 0.5 to 1.0 kcal / g, but more preferably 1.0 to 2.5 kcal / g when administered to a patient with water limitation, a burn patient, or the like. The amount of heat can be adjusted by appropriately setting the amount of sugar, lipid, protein source, dietary fiber, and the like. In the present specification, the value calculated by the method described in the examples is adopted as the “heat amount”.

  The pH of the semi-solidified nutrient according to this embodiment is preferably 3.0 to 4.5, and more preferably 3.5 to 3.9. If pH is in the said range, since the proliferation of bacteria can be suppressed and a refreshing feeling can be obtained, it is preferable. The said pH can be adjusted by setting suitably addition amount, such as a pH adjuster and a sour agent. In the present specification, “pH” is a value measured by the method described in the examples.

[Usage]
The semi-solidified nutrient described above can be applied to fields such as medicine and food.

(Medical field)
In the medical field, semi-solidified nutrients are used, for example, as enteral nutrients and can be applied to enteral nutrition. The administration method of the semi-solidified nutrient in enteral nutrition is not particularly limited, but is usually oral administration or administration using gastrostomy. Oral administration can be applied to elderly people and patients who have difficulty in chewing and swallowing and whose intestines are functioning. In addition, administration using a gastrostoma can be targeted to elderly people or patients who have difficulty in oral intake and have a functioning intestine.

  The semi-solidified nutrient according to the present embodiment includes nutrients, moisture, a predetermined amount of agar, and a predetermined amount of modified starch. It is preferable that the content of the nutrients is contained in an amount capable of satisfying demands such as calories and nitrogen sources required by the living body intended for enteral nutrition. Moreover, it is preferable to set the water content of the semi-solidified nutrient in consideration of the conditions of elderly people and patients to be administered, water management, and the like.

  The components that can be added in addition to the components essential to the semi-solidified nutrient according to the present embodiment are not particularly limited, and are appropriately set according to the administration method, the state of the elderly or patient to which the semi-solidified nutrient is applied, etc. Can be done. For example, in the case of oral administration, a sweetener, a sour agent, a fragrance, etc. may be added from the viewpoint of improving the taste at the time of ingestion, and in the case of administration using a gastric fistula from the viewpoint of preventing discomfort at the time of getp. preferable. Moreover, it is preferable that the patient who needs whole body management contains the vitamin and mineral required in order to maintain a nutritional state. In order to improve constipation due to the administration of a semi-solidified nutrient, it is preferable to add dietary fiber to elderly people with reduced digestive function.

  According to the semi-solidified nutrient according to this embodiment, since the occurrence of water separation is suppressed, the semi-solidified nutrient is absorbed with desired kinetics, and it is difficult to cause gastroesophageal reflux and aspiration pneumonia. sell. Furthermore, preservability and handleability at the time of injection of a gastrostomy tube in administration using a gastrostoma can be improved.

  Moreover, since the semi-solidified nutrient according to the present embodiment can adjust the viscosity, calorie, pH and the like while suppressing the occurrence of water separation, for example, administration using a gastrostoma by adjusting the viscosity Can improve the adhesion to the gastrostomy tube and the digestibility of the semi-solidified nutrient. In addition, by adjusting the amount of heat, nutrition management of elderly people and patients to which the semi-solidified nutrient is applied can be facilitated. Furthermore, preservability and a refreshing feeling can be improved by adjusting pH. The viscosity, heat amount, pH and the like can be controlled by appropriately adjusting the components in the semi-solidified nutrient and the content thereof.

(Food field)
In the food field, the semi-solidified nutrient can be applied to a favorite food, for example.

  The semi-solidified nutrient according to the present embodiment includes nutrients, moisture, a predetermined amount of agar, and a predetermined amount of modified starch. The content of the nutrient is preferably selected as appropriate according to the intended consumer. That is, the nutrient content can be set low when sold as diet food, and the nutrient content can be set high when sold as a nutritionally-adjusted food to replace meals. In addition, the water content of the semi-solidified nutrient can be selected as appropriate in consideration of the texture and whereabouts of the food to be produced.

  Components that can be added in addition to the components essential to the semi-solidified nutrient according to the present embodiment are not particularly limited, and may be appropriately selected according to the food to be produced. For example, when imparting a refreshing feeling to a semi-solid nutritional food, it is preferable to add a pH adjuster to make the pH acidic.

  According to the semi-solidified nutrient according to the present embodiment, since the occurrence of water separation can be suppressed, energy and the like can be suitably supplied, and the food can be excellent in palatability.

  Moreover, since the semi-solidified nutrient according to the present embodiment can adjust the viscosity, the amount of heat, the pH and the like while suppressing the occurrence of water separation, various product developments can be performed depending on the purpose. For example, by adjusting the viscosity, a semi-solidified nutrient having a different texture can be produced. Moreover, the semi-solidification nutrient according to a request can be manufactured by adjusting calorie | heat amount. Furthermore, the semi-solidification nutrient which provided the desired refreshing feeling can be manufactured by adjusting pH. The viscosity, heat amount, pH and the like can be controlled by appropriately adjusting the components in the semi-solidified nutrient and the content thereof.

[Method for producing semi-solidified nutrient]
The semi-solidified nutrient according to this embodiment can be produced by a known method. For example, it can be produced by adding nutrients, agar, modified starch, and other desired components to warm water and stirring. Also, prepare a solution in which agar is dissolved in warm water and a solution in which modified starch is dissolved in water, add nutrients and other desired ingredients to one, and mix and stir the two solutions Can be manufactured.

  The obtained semi-solidified nutrient can be made into a product by, for example, filling the container after continuous sterilization. Although it does not restrict | limit especially as the method of the said continuous sterilization, Ultra high temperature short time (UHT) sterilization, hot water sterilization, batch type sterilization, and these combination are mentioned. The sterilization is preferably performed in a short time. By performing sterilization in a short time, deterioration of components contained in the semi-solidified nutrient can be suppressed.

  It does not specifically limit as a container filled with a semi-solidification nutrient, A well-known container may be used. Examples of the container include a tetrapack, a cart can, a glass container, a metal can, an aluminum pouch, and a plastic container. Of these, it is preferable to use a plastic container.

  As a raw material of the plastic container, polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyvinyl acetate (PVAc), polycarbonate (PC), polybutylene terephthalate (PBT), polyethylene terephthalate (PET), Polyethylene naphthalate (PEN), ethylene-vinyl acetate copolymer (EVA), ethylene-α-olefin copolymer, polyfluorocarbon, polyimide and the like are preferably used.

  The plastic container further includes polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, and the like. Gas barrier resin layer: Gas barrier inorganic layers such as an aluminum foil, an aluminum vapor deposition film, a silicon oxide film, and an aluminum oxide film may be used in appropriate combination. By providing the gas barrier layer, deterioration of the semi-solidified nutrient due to oxygen, water vapor, or the like can be prevented.

  The container may be further shielded from light. By the light shielding, for example, deterioration due to light such as vitamin A, vitamin B2, vitamin C, and vitamin K that can be contained in the semi-solidified nutrient can be suppressed.

  The above-mentioned container may use what is marketed, for example, a soft pouch (made by Fuji Seal Co., Ltd.), a bottled pouch (made by Toppan Printing Co., Ltd.), a spouch (made by Dai Nippon Printing Co., Ltd.), a cheer pack (Co., Ltd.) Hosokawa Yoko) etc. can be used.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto. In addition, although the display of "part" or "%" is used in an Example, unless otherwise indicated, "mass part" or "mass%" is represented.

Example 1
1200 parts of the prepared water was put in a 5 L stainless steel bucket and heated to 80 ° C. or higher in a hot water bath. Subsequently, 22 parts of Ultra Agar UX30 (manufactured by Ina Food Industry Co., Ltd.), which is agar, was added and dissolved. The obtained solution was cooled to 50 to 60 ° C., 140 parts of WPI895 (whey protein isolate: manufactured by Fonterra) as a protein source, and TK-16 (dextrin: manufactured by Matsutani Chemical Co., Ltd.) 395 as a carbohydrate. Parts were added. To this solution, 60 parts of vegetable oil as lipid, 10 parts of glycerin fatty acid ester as emulsifier, and 40 parts of WMS (acetylated phosphoric acid cross-linked starch: made by Matsutani Chemical Industry Co., Ltd.) as modified starch are mixed at 50 to 55 ° C. The dispersion was mixed. Furthermore, as vitamins, water-soluble vitamin mix 0.3 parts, fat-soluble vitamin mix 1.5 parts; minerals as calcium gluconate 20 parts, magnesium chloride 10 parts, potassium chloride 3.2 parts, sodium chloride 0.2 parts , 10 parts of sodium dihydrogen phosphate, and 6 parts of tripotassium citrate; 25 parts of sun fiber HG (Guar gum hydrolyzate: Taiyo Kagaku Co., Ltd.) as dietary fiber; 0.5 part of yeast mix; 24 parts of acid, 8 parts of malic acid, and 27.3 parts of lactic acid; 0.6 parts of ascorbic acid diglucoside; 0.3 parts of zinc gluconate; 0.03 parts of copper gluconate; And stirred. Water was added until the obtained mixed solution was 4000 parts, and the mixture was dissolved and dispersed until a uniform state was obtained.

  The obtained solution was subjected to continuous sterilization, filled in an aluminum pouch with a stopper so that the amount was 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, a semi-solidified nutrient containing a pouch was produced by cooling.

(Example 2)
A semi-solid nutrient was produced in the same manner as in Example 1 except that the protein source was changed to 150 parts of WPC392 (whey protein concentrate: manufactured by Fonterra).

(Example 3)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the protein source was changed to 140 parts of Lacprodan DI-3065 (hydrolyzed whey peptide: manufactured by AlaFoods).

Example 4
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the protein source was changed to 140 parts of Prolina 900 (soy protein: manufactured by Fuji Oil Co., Ltd.).

(Example 5)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the amount of agar added was changed to 32 parts.

(Example 6)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the amount of sugar TK-16 added was changed to 270 parts and the amount of modified starch WMS added was changed to 165 parts. .

(Example 7)
Semi-solidified nutrient in the same manner as in Example 1 except that WMS, which is a modified starch, was changed to 40 parts of Farinex VA70WM (hydroxypropylated phosphate-crosslinked starch: Matsutani Chemical Industry Co., Ltd.). Manufactured.

(Example 8)
The same method as in Example 1 except that the amount of sugar TK-16 added was changed to 410 parts, the amount of agar added was changed to 40 parts, and the amount of processed starch WMS added was changed to 25 parts. Semi-solidified nutrient was produced.

Example 9
The same method as in Example 1 except that the amount of sugar TK-16 added was changed to 155 parts, the amount of agar added was changed to 4 parts, and the amount of WMS added to modified starch was changed to 280 parts. Semi-solidified nutrient was produced.

(Example 10)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the addition amount of each component was changed. Specifically, 255 parts of carbohydrate TK-16; 90 parts of WPI 1895 as protein source; 35 parts of vegetable oil as lipid; 30 parts of agar; 180 parts of WMS as modified starch; vitamin 0.2 parts of water-soluble vitamin mix, 1 part of fat-soluble vitamin mix; minerals, 13 parts of calcium gluconate, 7 parts of magnesium chloride, 2 parts of potassium chloride, 0.1 part of sodium chloride, diphosphoric acid phosphate 7 parts of sodium hydride and 4 parts of tripotassium citrate; 15 parts of guar gum hydrolyzate which is dietary fiber; 7 parts of glycerin fatty acid ester as emulsifier; 0.3 part of yeast mix; 20 parts citric acid, 5 parts malic acid, and 18 parts lactic acid; 0.4 part ascorbic acid diglucoside; 0.2 part zinc gluconate; copper gluconate 0.02 parts; was changed perfume in one part.

(Example 11)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the addition amount of each component was changed. Specifically, 800 parts of carbohydrate TK-16; 300 parts of WPI 1895 as protein source; 120 parts of vegetable oil as lipid; 8 parts of agar; 80 parts of WMS as modified starch; vitamin , 0.6 parts water-soluble vitamin mix, 3 parts fat-soluble vitamin mix; minerals, 40 parts calcium gluconate, 20 parts magnesium chloride, 6 parts potassium chloride, 0.4 parts sodium chloride, phosphoric acid 20 parts of sodium dihydrogen and 12 parts of tripotassium citrate; 50 parts of guar gum hydrolyzate which is dietary fiber; 20 parts of glycerin fatty acid ester as emulsifier; 1 part of yeast mix; 30 parts acid, 16 parts malic acid and 40 parts lactic acid; 1.2 parts ascorbic acid diglucoside; 0.6 parts zinc gluconate; 0.06 parts of emissions copper; was changed to 3 parts of perfume.

(Example 12)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the addition amount of each component was changed. Specifically, 900 parts of carbohydrate TK-16; 600 parts of WPI1895 as protein source; 350 parts of vegetable oil as lipids; 8 parts of agar; 133 parts of WMS as modified starch; 1 part water-soluble vitamin mix, 5 parts fat-soluble vitamin mix; minerals, 67 parts calcium gluconate, 33 parts magnesium chloride, 11 parts potassium chloride, 0.7 parts sodium chloride, dihydrogen phosphate 33 parts of sodium and 20 parts of tripotassium citrate; 83 parts of guar gum hydrolyzate which is a dietary fiber; 33 parts of glycerin fatty acid ester which is an emulsifier; 2 parts of yeast mix; citric acid which is a sour agent 30 parts, 27 parts malic acid, and 50 parts lactic acid; 2 parts ascorbic acid diglucoside; 1.0 part zinc gluconate; 0.1 parts of copper; changed the perfume to 5 parts.

(Example 13)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that ascorbic acid diglucoside was changed to 1 part ascorbic acid.

(Example 14)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the guar gum hydrolyzate that was dietary fiber was changed to 28 parts of pine fiber C.

(Comparative Example 1)
A semi-solid nutrient was produced in the same manner as in Example 1 except that the amount of TK-16, which was a sugar, was changed to 435 parts, and WMS, which was a modified starch, was not added.

(Comparative Example 2)
A semi-solidified nutrient was produced in the same manner as in Example 1 except that the amount of sugar TK-16 added was changed to 425 parts; the amount of modified starch WMS added was changed to 10 parts. .

(Comparative Example 3)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 2 except that WMS, which was a modified starch, was changed to 10 parts of Farinex VA70WM.

(Comparative Example 4)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 2 except that the amount of agar added was changed to 80 parts.

(Comparative Example 5)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 1 except that the amount of agar added was changed to 8 parts and 8 parts of pectin was added.

(Comparative Example 6)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 1 except that 16 parts of pectin was added and no agar was added.

(Comparative Example 7)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 1 except that the amount of agar added was changed to 8 parts and 8 parts of guar gum was added.

(Comparative Example 8)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 1 except that 16 parts of guar gum was added and no agar was added.

(Comparative Example 9)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 1 except that the amount of agar added was changed to 8 parts and 8 parts of locust bean gum was added.

(Comparative Example 10)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 1 except that 16 parts of locust bean gum was added and no agar was added.

(Comparative Example 11)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 1 except that the amount of agar added was changed to 8 parts and 8 parts of konjac mannan was added.

(Comparative Example 12)
A semi-solidified nutrient was produced in the same manner as in Comparative Example 1 except that 16 parts of konjac mannan was added and no agar was added.

  The compositions of the semi-solidified nutrients produced in Examples 1 to 14 and Comparative Examples 1 to 12 are shown in Table 1 and Table 2, respectively.

[Evaluation of semi-solidified nutrients]
The following evaluation was performed about each semi-solidified nutrient obtained in the Example and the comparative example.

<Water separation rate>
200 g of the semi-solidified nutrient was left on a sieve of 60 mesh (300 μm opening: TEST-SIEVE for JIS standard) and left at room temperature (25 ° C.). After 30 minutes, the weight of the liquid amount (water separation amount) that passed through the sieve was measured, and the ratio of the water separation amount to 200 g of the semi-solidified nutrient was calculated according to the following formula.

  The evaluation of the water separation rate is based on a semi-solidified nutrient that was allowed to stand for 24 hours at 25 ° C and a semi-solidified nutrient that was subjected to an accelerated test (stable for 4 weeks at 40 ° C) that assumed storage for 7 months and a half. I went for both.

<Viscosity>
The viscosity of the semi-solidified nutrient was measured using a B-type viscometer DV-II + Pro (manufactured by Brookfield). The measurement was performed for 1 minute under conditions of room temperature (25 ° C.) and a rotation speed of 6 rpm.

<Amount of heat>
Based on the general energy conversion factor, namely 4 kcal / g for carbohydrates, 4 kcal / g for protein source, 9 kcal / g for lipids, and 2 kcal / g for dietary fiber, Calculated.

  In the above formula, a value containing modified starch is used as the saccharide.

<PH>
The pH of the semi-solidified nutrient was measured using a pH meter METTLER TOLEDO MP220 (METTTLER TOLEDO).

<Properties>
The property of the semi-solidified nutrient was visually determined.

<Shape retention>
A 50 mL catheter tip syringe filled with a semi-solidified nutrient was connected to a tube with an inner diameter of 4 mm, and the shape after extrusion of the semi-solidified nutrient from the syringe was visually confirmed to determine shape retention. The shape retention was judged according to the following evaluation criteria.

◎: Nutrient discharged from the syringe does not deform by its own weight until about 10 minutes after discharge ○: Nutrient discharged from the syringe does not deform by its own weight until about 5 minutes after discharge △: Nutrient discharged from the syringe However, it deform | transforms a little immediately after discharge x: The nutrient which was discharged from the syringe deform | transforms greatly immediately after discharge.

<Coagulation unevenness>
About the semi-solidified nutrient, the unevenness of aggregation was visually evaluated according to the following evaluation criteria.

○: The surface of the nutrient solution discharged from the container in a straight line of about 20 cm has a smooth appearance. ×: The appearance of the nutrient solution discharged from the container in a straight line of about 20 cm has a rough appearance.

<Stickiness>
A 50 mL catheter tip syringe filled with a semi-solid nutrient is connected to a tube with an inner diameter of 4 mm, and the entire amount of the semi-solid nutrient is extruded from the syringe. Stickiness was evaluated according to the degree. The stickiness was evaluated according to the following criteria.

◎: Cleaning of the tube is completed with 10 mL of water ○: Cleaning of the tube is completed with 20 mL of water △: Cleaning of the tube is completed with 40 mL of water ×: Even if the tube is cleaned with 40 mL of water Semi-solidified nutrient remains in the inside.

  The said evaluation result about the semi-solidified nutrient of Examples 1-14 and Comparative Examples 1-12 is shown in Table 3 with agar content and modified starch content.

  As is clear from the results in Table 3, it can be seen that the semi-solidified nutrients of the examples contain a predetermined amount of agar and a predetermined amount of modified starch, thereby suppressing the occurrence of water separation.

  On the other hand, the semi-solidified nutrients of Comparative Examples 1 to 4 did not contain the predetermined amount of agar and the predetermined amount of modified starch, and exhibited a high water separation rate. In particular, since the semi-solidified nutrient of Comparative Example 4 contained 2.0% by mass of agar, it was in a jelly shape close to a solid and also showed a high water separation rate. Therefore, the semi-solidified nutrient of Comparative Example 4, for example, in administration using a gastrostoma, when injected into a gastrostomy tube, the jelly-like form collapsed and became a small jelly fragment, It is understood that esophageal reflux can occur.

  Moreover, although the semi-solidified nutrient of Comparative Examples 5-12 is what used a well-known thickener individually or together with agar, all were not able to fully suppress generation | occurrence | production of water separation.

  In addition, from the results of Examples 1 to 14, the semi-solidified nutrient according to the present invention requires a desired component while suppressing the occurrence of water separation by appropriately changing the type and components of components that can be contained. It was found that it can be contained in such an amount that the viscosity, heat quantity, pH and the like can be controlled.

Claims (4)

Nutrients including carbohydrate and protein sources;
Moisture,
Agar and modified starch;
A semi-solidified nutrient containing
The content of the agar is 0.05 to 1.5 mass% with respect to the total amount of the nutrient,
The semi-solidified nutrient in which the content of the modified starch is 0.5 to 10% by mass based on the total amount of the nutrient.   The semi-solidified nutrient of Claim 1 whose viscosity in 25 degreeC is 10,000-50000 mPa * s.   The semi-solidified nutrient according to claim 1 or 2, wherein the calorific value is 0.5 to 2.5 kcal / g.   The semi-solidified nutrient according to any one of claims 1 to 3, wherein the pH is 3.0 to 4.5.