JPWO2012063876A1 - Press-through pack package - Google Patents

Abstract

The press-through pack package according to the present invention includes a styrene-acrylic acid copolymer resin, a styrene-methacrylic acid copolymer resin, a styrene-maleic anhydride copolymer resin, and any one of the three copolymer resins. And at least a layer containing a thermoplastic resin containing at least one selected from the group consisting of ternary copolymer resins containing an ester component, and less than 5 parts by weight of an inorganic filler with respect to 100 parts by weight of the thermoplastic resin. It has a lid made of a stretched film having one layer.

Description

  The present invention relates to a press-through pack package having a lid material film that can be suitably used mainly for packaging pharmaceutical products such as tablets and capsules or foods such as candy and chocolate.

  2. Description of the Related Art A press-through pack (hereinafter referred to as “PTP”) package including a bottom material and a lid material is known as one of packaging forms for drugs, foods, and the like. The PTP package is formed by forming a plastic sheet made of polyvinyl chloride resin or polypropylene resin as a bottom material having pocket-shaped recesses by vacuum forming or pressure forming, and filling the recesses with contents. The flange portion other than the concave portion is formed by sealing with a heat-sealable lid material.

  The PTP package is configured to take out the contents by breaking the lid material by applying a force in the direction of the lid material from the outside of the bottom material to the stored contents. For this reason, the lid | cover material of a PTP package body is requested | required of the property (press through property) of being easily torn by extruding the contents. At present, an aluminum foil excellent in press-through property is widely used as a cover material.

However, the PTP package using an aluminum foil lid has the following problems. In other words, when the package is discarded after the contents are taken out, it is desirable to separate and collect the plastic bottom material and the aluminum foil lid material from the viewpoint of the recent recycling of resources. There is a problem that it requires labor and is physically difficult. In addition, in the case of incineration treatment, there is a problem that the incinerator is damaged due to a large amount of heat generated from the aluminum foil, or the incineration efficiency is lowered by melting and integrating. In addition, the production of aluminum requires a great deal of electrical energy, and has problems in terms of cost and environmental aspects such as CO ₂ emission. In addition, at the PTP packaging site, the aluminum foil lid roll is actually attached to and removed from the packaging machine by hand, increasing the burden on workers due to handling heavy objects, and risk of injury due to falling etc. There is.

  Under such circumstances, various plastic lid material films have been proposed as PTP lid materials that do not use aluminum foil (see Patent Documents 1 to 4).

  In Patent Document 1, in order to reduce the burst strength of the resin film and to develop good press-through properties, 5 to 250 masses with respect to 100 mass parts of a resin such as polyolefin, polyester, polyvinyl chloride, polystyrene, or styrene copolymer. A cover sheet for PTP in which part of the inorganic filler is blended is described.

  Patent Document 2 describes a PTP lid material in which a resin film layer is formed on one side of a polypropylene sheet containing an inorganic powder.

  Patent Document 3 is provided with a cover film for PTP imparted with press-through properties by providing countless scratches that do not penetrate the surface of the plastic film, and a protective layer by a resin coating for protecting the scratches. PTP cover material films and PTPs using these films are described.

  Patent Document 4 describes a PTP package formed by laminating a film obtained by uniaxially stretching a general-purpose resin such as polystyrene and the uniaxially stretched direction and the major axis direction of the opening.

Japanese Patent Laid-Open No. 10-101133 JP 09-57920 A Japanese Patent Laid-Open No. 06-39015 Japanese Utility Model Publication No.54-11258

  By the way, in recent years, in the case of PTP packaging for pharmaceutical products, in addition to the conventional product name logo and designs that show how to use, product codes, expiration dates, serial numbers, quantities for the purpose of preventing medical accidents and ensuring traceability There is a growing need to print various information such as these, or to print barcodes including such information. PTP packaging for pharmaceuticals is generally small, and it is necessary to print this information in a limited narrow space on the lid film. Therefore, as the amount of information to be printed increases, the readability of printing is required more. Become.

  Since the lid material sheet for PTP described in Patent Document 1 contains a large amount of inorganic filler in the resin, the surface becomes rough, and when printing is performed on this lid material sheet, printing is unclear. turn into. For this reason, if the printing of the cover material sheet is unclear, the print information is difficult to read or misread. Further, since a large amount of the inorganic filler is added, there is always a possibility that the filler may fall off from the lid sheet, and there is a risk of contamination of the contents of the medicine and food.

  In the sheet described in Patent Document 2, a resin film is provided on the surface of a polypropylene-based sheet containing an inorganic powder to improve printing clarity. However, by laminating the resin film layer, the strength of the lid member increases and the press-through property tends to decrease. Further, if the resin film layer is made thin in order to minimize this, the reduction in surface roughness is insufficient and the printing legibility cannot be improved sufficiently. For this reason, it is difficult to achieve both press-through properties and printability. Moreover, since it is necessary to laminate | stack a resin film layer, manufacturing cost becomes high.

  The film described in Patent Document 3 is formed by laminating a protective layer in order to prevent pinholes due to scratches provided for imparting press-through properties, but, as in Patent Document 2, depending on the thickness of the protective layer. The press-through property is insufficient. In addition, there is room for improvement in that the print legibility becomes insufficient due to the rough surface of the scratches, and the manufacturing cost increases.

  On the other hand, the PTP cover material film is required to have excellent press-through properties in view of the ease of taking out the contents, but is required to have a strength that can withstand various loads received during the manufacturing process of the PTP package. That is, the PTP lid material film undergoes many processing steps such as a film forming process, a slitting process, a printing process, a sealing agent application process, and a sealing process to the bottom material before being sealed to the bottom material. It is necessary to have a tensile strength that can withstand a load such as a tension received in the process. It is recognized that the films described in Patent Documents 1 to 3 are easily broken by the addition of an inorganic filler, inorganic powder, or imparting scratches and exhibit press-through properties, but at the same time the tensile strength is reduced, Troubles such as film breakage are likely to occur in the processing step.

  The film described in Patent Document 4 is a film obtained by stretching a resin such as general-purpose polystyrene in a uniaxial direction. However, there is no special device for imparting press-through property, the press-through property is inferior, and in a direction parallel to the stretching direction. Since it is easy to tear and the directionality is easy to appear in the tearing of the film, it is necessary to limit the shape of the contents and the direction in which the lid film and the bottom material are laminated.

  The present invention has been made in view of the above circumstances, and is extremely light compared to a conventional aluminum foil lid, and is easy to dispose of after use, and contaminates the contents. Another object of the present invention is to provide a PTP package having a plastic lid material film which is excellent in press-through property and print legibility, and further excellent in processability, tablet extrusion sound, and heat seal stability.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have solved the above-mentioned problems by using, as a lid for PTP, a film obtained by stretching a thermoplastic resin with or without a small amount of inorganic particles. As a result, the present invention has been completed.

That is, the present invention provides the following PTP lid material film and PTP package.
(1) A styrene-acrylic acid copolymer resin, a styrene-methacrylic acid copolymer resin, a styrene-maleic anhydride copolymer resin, and a ternary further containing an ester component in any one of the three copolymer resins. A lid comprising a stretched film having at least one layer containing a thermoplastic resin containing at least one selected from the group consisting of copolymer resins and less than 5 parts by weight of an inorganic filler with respect to 100 parts by weight of the thermoplastic resin A press-through pack package having a material.
(2) The stretched film is a peak value of orientation relaxation stress measured at a temperature 20 ° C. higher than the Vicat softening point of the thermoplastic resin, and one of the values of MD and TD of the film is 0.2 to 4.0 MPa, the press-through pack package according to (1).
(3) The stretched film is a peak value of orientation relaxation stress (ORS) measured at a temperature 20 ° C. higher than the Vicat softening point of the thermoplastic resin, and both the MD and TD values of the film are The press-through pack package according to (1), which has a pressure of 0.2 to 4.0 MPa.
(4) The press-through pack package according to any one of (1) to (3), wherein the inorganic filler has an average particle size of 1 to 10 μm.
(5) The press-through pack package according to any one of (1) to (4), wherein the inorganic filler is an amorphous aluminosilicate.
(6) The stretched film has a puncture strength of 1 to 5 N, and is a press-through pack package according to any one of (1) to (5).
(7) The press-through pack package according to any one of (1) to (6), wherein the stretched film has a thickness of 5 to 30 μm.
(8) The stretched film is a press-through pack package according to any one of (1) to (7), wherein an aluminum vapor deposition layer is laminated on at least one surface.

  Since the lid material used for the PTP package of the present invention is made of a plastic film with little or no inorganic content, there is almost no risk of the contents being contaminated by the removal of the inorganic filler, and the plastic PTP bottom When used together with the material, the separation process at the time of disposal after use becomes easy, and even when incinerated, there is no fear of damaging the incinerator, there are few incineration residues, and it is environmentally friendly. Moreover, since this cover material is excellent in press-through property, PTP which can take out the content easily by using this can be manufactured. Furthermore, since the surface of the lid can be reduced in roughness, clear printing with excellent legibility can be achieved.

  Furthermore, the lid material is easy to produce a clear and loud sound when the tablet (contents) is pushed out (hereinafter referred to as tablet extrusion sound), so it can be opened as a PTP package. It is easy to confirm what has been done by hearing as well as visual and tactile sense, and there is a sense of security that it is opened for the first time. In addition, there are advantages such as that you can enjoy the opening itself and can also prevent the dementia of the elderly.

  Furthermore, the lid material can be stably heat-sealed without causing deformation such as wrinkles in the lid material film when heat-sealing with the bottom material, and an aesthetic packaging body can be obtained.

It is sectional drawing which shows embodiment of the PTP package body provided with the cover material film which concerns on this invention. It is sectional drawing which shows embodiment of the PTP package provided with the multilayer cover material film which concerns on this invention. It is sectional drawing which shows embodiment of the PTP package provided with the cover material film with a vapor deposition layer which concerns on this invention.

  DESCRIPTION OF EXEMPLARY EMBODIMENTS Hereinafter, preferred embodiments of the invention will be described in detail with reference to the drawings. The package of the present invention is mainly used for filling pharmaceuticals such as tablets and capsules or foods such as candy and chocolate as the contents. Here, the case of filling tablets is exemplified. Note that the present invention is not limited to the following embodiments.

  A PTP package 10 shown in FIG. 1 includes a bottom material 1 and a lid material film 4 </ b> A, and a tablet 2 is filled in a pocket-shaped recess 1 a formed in the bottom material 1. A seal layer 3 made of a heat sealant is formed between the bottom material 1 and the lid material film 4A. The seal layer 3 bonds the flange portion 1b of the bottom material 1 and the surface F1 of the lid material film 4A. ing. A printed portion 5 such as a product name logo is formed on the surface F2 opposite to the bottom material 1 of the lid film 4A, and an OP (Over Print) varnish layer 6 for protecting the printed portion 5 is formed on the surface F2. It is formed so as to cover the entire surface.

  The lid material film 4A includes a styrene-acrylic acid copolymer resin, a styrene-methacrylic acid copolymer resin, a styrene-maleic anhydride copolymer resin, and an ester component added to any one of these three copolymer resins. It consists of a stretched film containing a thermoplastic resin containing at least one selected from the group consisting of ternary copolymer resins.

  Examples of the ester component of the terpolymer resin include methyl acrylate, ethyl acrylate, propyl acrylate, butyl acrylate, hexyl acrylate, cyclohexyl acrylate, methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, hexyl methacrylate, and cyclohexyl methacrylate. It is done. These ester components are effective in improving the thermal stability of the resin when heat is continuously applied, for example, during melt processing in an extruder.

  Each styrene component in the styrene copolymer resin is preferably 70 to 97 wt% (mass%), more preferably 75 to 95 wt%, based on the total of the resin components constituting the styrene copolymer resin. When the styrene component is 97 wt% or less, not only the press-through property is improved but also the heat resistance of the resin is improved, and the lid film is stable without being deformed when heat-sealing with the bottom material in the manufacturing process of the PTP package. Manufacturing becomes possible. Further, when the styrene component is 70 wt% or more, it is easy to stretch and form a film when forming a lid material film, and both rigidity and press-through property can be achieved. Of these, styrene-methacrylic acid copolymer resins and ternary copolymer resins containing an ester component are more preferred in terms of ease of extrusion stretch film formation. Here, “styrene copolymer resin” refers to a copolymer resin in which the styrene component exceeds 50 wt% regardless of the number of types of components of the copolymer resin.

  Moreover, in the ternary copolymer resin, the content of the ester component is preferably 2 to 20 wt%, based on the total of the ternary components including other copolymer resin components, and preferably 2 to 10 wt%. More preferably. When the ester component is 20 wt% or less, the balance between heat resistance and rigidity is improved, and it becomes possible to stabilize processability in the production process of the PTP package. Further, when the ester component is 2 wt% or more, the thermal stability at the time of melt processing is improved, there is no outflow of gel, and it becomes possible to perform extrusion stretching film formation stably for a long time.

  Stability at the time of film formation for the styrenic resin suitably used in this embodiment (there is no necking, the stretching start position is stable, and the thickness variation is small enough to cause no practical problems (general When R is 10 μm or less))), and after that, in various processes leading to PTP packaging, impact resistance against impacts such as restarting after a temporary stop or punching of the packaging process is required. There is. In order to improve these characteristics, 0.5-80 wt% of at least one selected from high impact polystyrene (HIPS), a styrene-conjugated diene copolymer, and a hydrogenated styrene-conjugated diene copolymer is used. % Is preferable. A more preferable blending amount is 1.0 to 45 wt%, and a still more preferable blending amount is 1.0 to 30 wt%. When blended in an amount of 0.5 wt% or more, stretching stability and impact resistance are improved, and when it is 80 wt% or less, press-through property and film stiffness are maintained.

  The resin composition forming the lid film 4A may be a thermoplastic resin blended with an inorganic filler. Although it is possible to develop good press-through properties without blending inorganic fillers, the users of PTP packages are not always healthy people, and the elderly and children with weak power are also targeted. In consideration of this, it is possible to reduce the piercing strength and adjust the press-through property by blending an inorganic filler according to the preference of the feeling of use when extruding the contents. The blending ratio is less than 5 parts by mass of the inorganic filler with respect to 100 parts by mass of the thermoplastic resin. When the blending amount of the inorganic filler is 5 parts by mass or more, the roughness of the film surface increases and the print sharpness deteriorates. The blending amount of the inorganic filler is preferably less than 3 parts by mass and more preferably 2 parts by mass or less with respect to 100 parts by mass of the thermoplastic resin from the viewpoint of press-through property and risk of falling off.

  As the inorganic filler, amorphous alumina silicate, silica, alumina, talc, kaolin, mica, wollastonite, clay, calcium carbonate, asbestos, glass fiber, aluminum sulfate and the like can be used. In particular, amorphous aluminosilicate is preferred because it has low hygroscopicity, and can suppress thickness fluctuations due to pressure fluctuations during film extrusion and poor foaming of the film.

  1-10 micrometers is suitable for the average particle diameter of an inorganic filler, and 3-7 micrometers is more suitable. If the average particle size is 10 μm or less, the roughness of the film surface is small, clearer printing is possible when printing on the film, and if it is 1 μm or more, it is easy to adjust the press-through property with a small amount. . Here, the “average particle size” means a value measured by a Coulter counter method.

  The lid material film 4A needs to be a stretched film. As described above, the cover film 4A is required to have a tensile strength capable of withstanding each processing because a strong tension is applied to the film in each processing step until it is used. While the thermoplastic resin film is stretched and oriented, the tensile strength in the stretching direction is greatly improved, while the improvement in piercing strength tends to be relatively small. For this reason, even if it reduces a piercing strength by making a thermoplastic resin film thin or adding an inorganic filler, it can give the tensile strength which can endure processing by setting it as a stretched film. That is, in the case of a PTP cover film using an unstretched film, it is necessary to add a large amount of inorganic filler and scratches in order to achieve piercing strength that achieves good press-through properties. As a result, the tensile strength decreases and the processability becomes insufficient. In order to improve this, when the film is thickened, the press-through property is lowered. On the other hand, with the stretched film of this embodiment, it becomes possible to obtain a thinner PTP lid material film having good press-through properties and tensile strength that can withstand processing.

  In the case of a uniaxially stretched film, it is easy to tear in a direction parallel to the stretching direction, and the direction of the film is likely to be broken. Therefore, it is necessary to consider the shape of the contents and the stretching direction of the lid material film. For example, the contents can be taken out more easily when the long side direction of the contents is parallel to the extending direction of the lid material film. On the other hand, since the biaxially stretched film is less likely to be broken, the biaxially stretched film is more preferably used in this embodiment.

  Each orientation relaxation stress peak value (hereinafter referred to as ORS) at a temperature 20 ° C. higher than the Vicat softening point of the thermoplastic resin used for the film of the present embodiment is MD (Machine Direction) and TD (Transverse Direction). Any one value is preferably 0.2 to 4.0 MPa, both MD and TD values are more preferably 0.2 to 4.0 MPa, and 0.3 to 3.0 MPa. It is more preferable, and it is still more preferable that it is 0.3-2.0 MPa.

  The orientation relaxation stress peak value (ORS) is an index representing the strength of the stretching orientation of the film, and is a characteristic value determined by the stretching ratio and temperature after film extrusion. In general, when the draw ratio is increased (lower) under the condition of a constant stretching temperature, ORS increases (decreases), and the tensile strength in that direction tends to be higher (lower). When the stretching temperature is increased (decreased) under certain conditions, the ORS decreases (increases), and the tensile strength in that direction tends to be low (high). Based on such characteristics, the ORS is set in a preferable range so that a necessary tensile strength film can be obtained. When each ORS is 0.2 MPa or more, there is no trouble such as tearing or tearing in the PTP packaging process, and high-speed packaging is possible. When each ORS is 4.0 MPa or less, the bottom material during PTP packaging The punching cutability after heat sealing is good, the occurrence of whiskers and thread-like waste at the cut end face can be suppressed, and the press-through property is also good.

  In addition, the ratio of MD to TD ORS is preferably 0.1 to 40, more preferably 0.2 to 15 from the viewpoint of tearing and tearing troubles in the PTP packaging process, press-through property, and tablet extrusion sound. Yes, more preferably 0.5 to 2.0.

  The Vicat softening point here means a value measured according to JIS K7206. The test load is 50 N, and the heating rate is 50 ° C./h. Moreover, when using the mixed resin by a some thermoplastic resin for the film of this embodiment, the Vicat softening point of the mixed resin composition is said. Furthermore, when the lid material film of the present embodiment is a multilayer stretched film, only the resin layer containing the thermoplastic resin used in the film of the present embodiment is the target, and the total thickness of the target layer is 1, The sum of values obtained by multiplying the thickness ratio of each target layer by each Vicat softening point is defined as the Vicat softening point.

  The Vicat softening point of the resin composition of the present embodiment is preferably 80 ° C. or higher from the viewpoint of enabling stable heat sealing that does not cause deformation such as wrinkles in the lid material film during heat sealing with the bottom material. More preferably, it is 95 ° C. or higher, and most preferably 110 ° C. or higher.

  The PTP lid material film of the present embodiment preferably has a puncture strength of 1 to 5 N measured in accordance with the puncture strength test of JIS Z1707. When the piercing strength is 1 N or more, the strength is moderate and the lid material is rarely torn unintentionally when used as a PTP package. When the puncture strength is 5 N or less, the film is easily broken and appropriate press-through properties are exhibited. Considering the case where the user of the PTP package is an elderly person or a child with weak power, the piercing strength is more preferably 1 to 3N.

  The thickness of the film of this embodiment is preferably 5 to 30 μm. When the thickness is 5 μm or more, the strength of the film is moderate within the range of the stress relaxation peak value, and the tensile strength that can withstand the processing step is easily expressed, and when it is 30 μm or less, the press-through property is moderate within the range of the inorganic filler. Is easy to develop.

  As a typical example of the method for producing the stretched film of the present embodiment, a thermoplastic resin (a resin in which an inorganic filler is blended at a predetermined ratio if necessary) is melt-kneaded with a screw extruder or the like, and a T-die. Examples thereof include a method of uniaxial stretching by roll stretching or tenter stretching, a method of biaxial stretching by tenter stretching following roll stretching, or a method of stretching by an inflation method. The draw ratio at this time is preferably 5 to 10 times in each drawing direction.

  In this embodiment, an additive usually used in the technical field as desired, for example, a metal soap that assists the dispersion of inorganic particles, a colorant, a plasticizer, an antioxidant, a heat stabilizer, an ultraviolet absorber, a lubricant, a charge It is possible to mix | blend an inhibitor etc. in the range which does not impair the characteristic of this invention.

  The PTP package of the present embodiment has the above-described configuration, so that it is extremely light with respect to a conventional aluminum foil lid, and is easy to dispose of after use, and presses without contaminating the contents. Excellent through and print legibility.

  In addition, the package has an advantage that, when a tablet is extruded, it is easy to make a tapping sound (tablet extrusion sound) so that it can be easily confirmed not only visually and by touch but also by hearing.

  Furthermore, the PTP package of the present invention is capable of stable heat sealing that does not cause deformation such as wrinkles in the lid material film during the heat sealing of the lid material and the bottom material, and an aesthetic packaging body is obtained.

  The preferred embodiment of the present invention has been described above, but the present invention is not limited to the above embodiment. For example, in the above-described embodiment, the lid material film 4A made of a single-layer stretched film is exemplified, but the lid material film may be a multilayer stretched film having two or more layers.

  The PTP package 20 shown in FIG. 2 is different from the PTP package 10 in that the lid material film 4B is a multilayer stretched film. The lid material film 4B is a three-layer film including a center layer 42 and surface layers 41 provided on both sides thereof. The multilayer stretched film can be produced in the same manner as the above-mentioned single layer stretched film by a T-die method or an inflation method using an apparatus including a plurality of screw extruders and a multilayer die.

  For example, when it is desired to reduce the puncture strength as much as possible and to maintain the smoothness of the film surface, a stretched film having a three-layer structure of thermoplastic resin single layer / inorganic filler-containing thermoplastic resin layer / thermoplastic resin single layer And Also, by changing the stacking order to make a stretched film with a three-layer structure of inorganic filler-containing thermoplastic resin layer / thermoplastic resin single layer / inorganic filler-containing thermoplastic resin layer, the tensile strength is maintained in the center layer. On the other hand, it is possible to impart press-through property with the inorganic filler on the surface layer. Furthermore, it can also be set as the lid | cover material film for PTP from which the color differs in the front and back in consideration of the designability by making it into a multilayer stretched film using colored resins with different colors. In either case, it can be appropriately carried out within the scope of the object of the present invention.

  Moreover, in the said embodiment, although the case where the sealing layer 3 was directly provided on the surface F1 of the lid | cover material film 4A was illustrated, you may interpose another layer between a lid | cover material film and a sealing layer. In the PTP package 30 shown in FIG. 3, the vapor deposition layer 7 and the seal layer 3 are laminated in this order on the surface F1 of the lid material film 4C. Moreover, the vapor deposition layer 7 and the sealing layer 3 may be arrange | positioned facing each surface of the cover material film 4C. In addition to printing on these lid material films, it is preferable to perform known surface treatments such as corona treatment, plasma treatment, flame treatment, and solvent treatment on the surface of the lid material film in advance when laminating a seal layer, a vapor deposition layer, and the like. .

  The PTP lid material film is required to have a barrier property that suppresses the permeation of water vapor when the contents have a hygroscopic property. In that case, it is preferable to laminate | stack the vapor deposition layer (barrier layer) which has barrier property on the surface of a cover material film. Examples of the material for the barrier layer include aluminum and metal oxides (aluminum oxide, silicon oxide, etc.).

In recent years, in the field of pharmaceutical PTP packaging, a method has been adopted in which near-infrared rays are irradiated on the PTP packaging after the contents are packaged, and the inspection of foreign matter is performed using reflection by an aluminum foil lid. There is a case. In this case, since an aluminum layer that reflects near-infrared rays is essential, it is preferable to provide an aluminum vapor deposition layer on the PTP cover material film in order to satisfy both the barrier property requirement and the foreign matter inspection.
In recent years, double-sided printing may be used from the viewpoint of medical errors. In this case, it is important to conceal (to prevent the characters and patterns on the opposite side from seeping through). Is preferred.

  The thickness of the aluminum vapor-deposited layer is appropriately adjusted according to the required barrier property (especially water vapor permeability) or near-infrared reflection property, or concealment property during double-sided printing, but preferably 10 nm from the viewpoint of barrier property. It is -500 nm, More preferably, it is 20 nm-100 nm. Even if the thickness exceeds 500 nm, the gas barrier property equivalent effect cannot be obtained. Moreover, from a viewpoint of the reflection characteristic of near infrared rays and the concealability at the time of double-sided printing, it is preferably 10 nm to 200 nm, and more preferably 20 nm to 100 nm. Moreover, when performing a semi-transparent half vapor deposition process from a designable viewpoint, it is preferably 1 nm to 50 nm, and more preferably 3 nm to 20 nm. As for the problem at the time of disposal, which is the object of the present invention, it is physically difficult to separate the aluminum vapor deposition layer. However, in the incineration process, the aluminum layer is compared with the conventional aluminum foil lid material having a thickness of about 20 μm. Is greatly reduced (over 97%) and there is little risk of damaging the incinerator.

  Hereinafter, the contents of the present invention will be described more specifically with reference to examples and comparative examples. The present invention is not limited to these examples.

[Evaluation item]
About the lid | cover material film produced by the Example and the comparative example, and the PTP package using this, the following items were evaluated.

<Puncture strength>
In accordance with JIS Z1707, a semicircular needle having a diameter of 1 mm and a tip shape radius of 0.5 mm was pierced at a speed of 50 mm per minute, and the maximum stress until the needle penetrated was measured.

<Orientation relaxation stress (ORS)>
In an oil bath adjusted to a temperature 20 ° C. higher than the Vicat softening point of the thermoplastic resin used in the lid material film (or a composition in the case of using a plurality of thermoplastic resins) in accordance with ASTM D-1504 The orientation relaxation stress (peak) value was measured. The measurement direction was measured in the vertical direction (MD) and the horizontal direction (TD).

<Press-through property>
Sensory evaluation was conducted on the ease of tearing of the lid film when extruding tablets from the PTP package. Judgment criteria are as follows.
A: The touch is equivalent to that of a conventional aluminum foil cover material and is practical.
B: Although there is a little resistance during extrusion, there is no practical problem.
C: The film is not easily broken and is difficult to extrude. It is somewhat inferior to practical aptitude.
D: The film is very difficult to tear and very difficult to extrude. Judged as unsuitable for practical use.

<Print sharpness>
About the ease of legibility by printing black Gothic alphabet letters with a character size = 7 points on a cover film on a gravure printing machine using a plate with a number of lines = 175 lines / inch and a plate depth = 24 μm. Evaluation was performed. Judgment criteria are as follows.
A: It is printed clearly and is fully legible.
B: Although some characters are faint or loose, they are legible and have no practical problem.
C: Characters are faint or loose, but somehow readable and somewhat inferior in practical aptitude.
D: The blurring of characters is severely illegible or misread, and is judged unsuitable for practical use.

<Tablet extrusion sound, tablet extrusion volume>
In a quiet room with a noise level of 40 dB or less, with the distance from the measurer's ear to the PTP package set to 60 cm, push the bottom material side of the PTP package with your thumb and push out the tablet. The sound when pushing and opening was performed by sensory evaluation by hearing.
A: A loud and loud sound is clear and very good.
B: Good sound and good sound.
C: There is only a dull sound that is not much different from the conventional aluminum foil lid.

  In addition, with the distance from the sound collection microphone of the custom-made digital sound level meter SL-1320 to the PTP package set to 5 cm, the maximum value of the noise level measured when the tablet is extruded in the same manner as described above Volume was set. The measurement conditions of the sound level meter were mode: FAST, characteristic: A characteristic, and range: auto. Each measurement was carried out 10 times, and the average value was used.

  The pocket size of the bottom material sheet of the PTP molded body is a circle having a diameter of 10 mm and a height of 5 mm, and the tablet size is a circle having a diameter of 8.6 mm and a height of 3.8 mm (the space occupation ratio of the tablet in the pocket is 56). %).

[Production of PTP package]
The materials used in Examples and Comparative Examples are as follows.
(1) Styrene resin (i) Styrene / methacrylic acid copolymer: SMAA-1 (methacrylic acid content 13 wt%, Vicat softening point = 128 ° C.)
(Ii) Styrene / methyl methacrylate / methacrylic acid copolymer: SMAA-2 (methyl methacrylate content 5 wt%, methacrylic acid content 10 wt%, Vicat softening point = 123 ° C.)
(Iii) High impact polystyrene: HIPS-1 (PS Japan, high impact polystyrene HT478, Vicat softening point = 96 ° C)
(Iv) High impact polystyrene: HIPS-2 (impact polystyrene SX100 manufactured by PS Japan, Vicat softening point = 85 ° C.)
(V) High impact polystyrene: HIPS-3 (impact polystyrene GH8300-5 manufactured by DIC, Vicat softening point = 95 ° C.)
(Vi) Styrene acrylic acid copolymer: SAA-1 (Vicat softening point = 126 ° C.)
(Vii) Styrene maleic anhydride copolymer: SMA-1 (Vicat softening point = 83 ° C.)
(Viii) Polystyrene: GPPS-1 (Polystyrene # 685 manufactured by PS Japan, Vicat softening point = 103 ° C.))
(Ix) High impact polystyrene: HIPS-4 (PS Japan, high impact polystyrene 492, Vicat softening point = 91 ° C.)
(2) Amorphous sodium aluminosilicate / calcium (trade name: Shilton JC, manufactured by Mizusawa Chemical)
(3) Silica (Tokai Chemical Industries, Microid)

Example 1
As the styrenic resin, SMAA-1, HIPS-1, and HIPS-2 were blended in the proportions shown in Example 1 in Table 1, and a biaxially stretched film was formed by an inflation method. Next, after the corona treatment of 50 mN / m was performed on the obtained film, the above-mentioned alphabet letters were printed using a gravure printing machine, and OP varnish was applied thereon. Furthermore, after the corona treatment of 50 mN / m was similarly performed on the surface opposite to the printing surface, an ethylene vinyl acetate emulsion heat sealant was applied at a thickness of about 7 g / m ^{2 in} terms of dry film, A lid material film for PTP was used. Subsequently, using a polyvinyl chloride (PVC) having a thickness of 200 μm for the bottom material sheet, the PTP molding machine (FBP-M1 manufactured by CKD) was used to fill the tablet into the bottom material formed with the dents, and each of the above PTPs The lid material film was adhered to obtain a PTP package. At this time, the pocket size of the bottom material sheet is a circle having a diameter of 10 mm and a height of 5 mm, and the tablet size is a circle having a tablet diameter of 8.6 mm and a tablet height of 3.8 mm (the space occupation ratio of the tablets in the pocket is 56). %)Met.

(Example 2)
A biaxially stretched film was prepared in the same manner as in Example 1 except that SMAA-2 and HIPS-3 were used in the blending ratios described in Example 2 of Table 1 as the styrenic resin. A lid material film was prepared to obtain a PTP package.

<Evaluation of Examples 1 and 2>
The PTP package according to Examples 1 and 2 was prepared using a lid material film that does not contain an inorganic filler. However, the lid film does not undergo deformation such as wrinkles during heat sealing with the bottom material. Heat sealing was possible, and the packaging suitability was excellent. Further, the produced PTP package was very good in both press-through property and print sharpness.

  In addition, the tablet extrusion sound was very good with a clear and loud sound. The tablet extrusion volume was 61.7 dB in Example 1 and 61.5 dB in Example 2.

  On the other hand, the tablet extrusion sound of the widely used aluminum foil lid (film thickness 20 μm) is a dull sound, the tablet extrusion sound volume is as low as 57.8 dB, and it is opened by hearing compared to Examples 1 and 2. The confirmation effect was inferior.

(Example 3)
Silica is contained as an inorganic filler, and a biaxially stretched film is produced by increasing the area stretch ratio by about 30% (thickness: 15 μm), and PTP packaging is performed in the same manner as in Example 1 except that this is used as a lid. The body was made.

Example 4
A biaxially stretched film containing amorphous aluminosilicate as an inorganic filler was prepared (thickness: 20 μm), and a PTP package was prepared in the same manner as in Example 2 except that this was used as a lid.

<Evaluation of Examples 3 and 4>
In Example 3, a small amount of silica was added as an inorganic filler, and a slight roughness was observed on the surface, but the press-through property was good and the print sharpness was satisfactory without any practical problem. In Example 4, similarly, a small amount of amorphous aluminosilicate was added as an inorganic filler. However, compared to Example 2, press-through was performed more smoothly and printing sharpness was good.

(Comparative Example 1)
A cast film (non-stretched film) having a thickness of 20 μm was produced by the T-die method using the same composition as in Example 2, and thereafter, production of a PTP package was attempted in the same manner as in Example 1. In the process, the film was frequently torn and could not proceed to the subsequent processes.

(Example 5)
Using a multi-layer die of 2 types and 3 layers, the blended composition of Example 2 (Vicat softening point; 120 ° C.) was placed in the core layer, and 90 parts by mass of GPPS (polystyrene made by PS Japan; 685) in both outer layers A resin composition of 10 parts by mass of high impact polystyrene (PS Japan, high impact polystyrene 492; the above HIPS-4) is arranged so that the thickness ratio of each layer (outer layer / core layer / outer layer) is 10/80/10. Similarly to Example 1, a biaxially stretched film having a thickness of 14 μm was obtained by an inflation method. The ORS (MD / TD) at 140 ° C. of the obtained film was 0.29 / 0.28 (MPa). Moreover, the piercing strength was 2.0N. Using this film, a PTP package was produced in the same manner as in Example 1.

<Evaluation of Example 5>
As in Examples 1 and 2, the PTP package according to Example 5 uses a lid material film that does not contain an inorganic filler. In addition to being excellent in stability in the PTP packaging process, the printing clarity is remarkably high. In addition, the press-through property was almost uncomfortable as compared with the conventional aluminum lid material, and was extremely excellent in workability and practicality as a PTP package.

(Examples 6-14, 18, 19)
Except having used the extending | stretching method of Table 2 and Table 3, the stretched film was produced similarly to Example 2, and the lid | cover material film for PTP was produced similarly in the following, and the PTP package body was obtained.
(Example 20)
A stretched film was produced in the same manner as in Example 18 except that the blending ratio of the resins shown in Table 3 was used, and a PTP lid film was produced in the same manner as described above to obtain a PTP package.

<Evaluation of Examples 6 to 14 and 18 to 20>
The PTP packaging bodies according to Examples 6 to 14 and 18 to 20 are produced by various stretching methods shown in Tables 2 and 3 using a lid material film that does not contain an inorganic filler. During the heat sealing, a stable heat sealing that does not cause deformation such as wrinkles in the lid material film is possible, and the packaging property is excellent. Moreover, the produced PTP package was good in both press-through property and print sharpness. The results are shown in Tables 2 and 3. In particular, from the viewpoint of press-through property, the ORS is preferably 0.2 to 4.0 MPa for both MD and TD, more preferably 0.3 to 3.0 MPa, and 0.3 to 2.0 MPa. It turns out that it is still more preferable. Moreover, from the viewpoint of both press-through property and tablet extrusion sound, the ratio of the MD and TD ORS is preferably 0.2 to 15, and 0.5 to 2.0.

(Examples 15 to 17)
A stretched film was produced in the same manner as in Example 2 except that the blending ratio of the resins shown in Table 3 and the stretching method were used, and then a PTP lid film was produced in the same manner to obtain a PTP package. .

<Evaluation of Example 15>
The PTP package according to Example 15 uses a lid material film that does not contain HIPS as a resin composition, but it was also observed that the stability during stretching was slightly unstable. Good results were obtained for both through-through and print sharpness. The results are shown in Table 3.

<Evaluation of Example 16>
In Example 16, SAA was used as the styrenic resin, but the surface was slightly rough, but the press-through property was good and the print sharpness was satisfactory without any practical problem. .

<Evaluation of Example 17>
In Example 17, SMA was used as the styrenic resin, but the surface was slightly wrinkled during heat sealing with the bottom material in the PTP molding machine, and the surface was rough, but the press-through property was Good results with good print sharpness and no practical problems were obtained.

(Comparative Example 2)
A stretched film was produced in the same manner as in Example 2 except that the blending ratio of the resins shown in Table 3 and the stretching method were used, and then a PTP lid film was produced in the same manner to obtain a PTP package. .

<Evaluation of Comparative Example 2>
The PTP package according to Comparative Example 2 uses general-purpose polystyrene as a lid material film as a resin composition, but the tablet was very difficult to extrude and the press-through property was very poor. Also, since the press-through property is very poor and it is necessary to put a strong force on the fingers when extruding, the bottom material is greatly deformed or the heat seal layer between the bottom material and the lid material film peels off. As a result, it was not possible to correctly evaluate the tablet extrusion sound and tablet extrusion volume. The results are shown in Table 3.

  The PTP package of the present invention can be suitably used for packaging pharmaceutical products such as tablets and capsules and foods such as candy and chocolate.

  DESCRIPTION OF SYMBOLS 1 ... Bottom material, 1a ... Concave part of bottom material, 1b ... Flange part of bottom material, 2 ... Tablet, 3 ... Seal layer, 4A, 4B, 4C ... Cover material film, 41 ... Surface layer of multilayer cover material film, 42 ... Center layer of multilayer cover material film, 5 ... printed portion, 6 ... OP varnish layer, 7 ... vapor deposition layer, 10, 20, 30 ... package.

Claims (8)

  Styrene-acrylic acid copolymer resin, styrene-methacrylic acid copolymer resin, styrene-maleic anhydride copolymer resin, and ternary copolymer resin further containing an ester component in any one of the three kinds of copolymer resins A cover material comprising a stretched film having at least one layer containing a thermoplastic resin containing at least one selected from the group consisting of and an inorganic filler of less than 5 parts by mass with respect to 100 parts by mass of the thermoplastic resin. Press-through pack package.   The stretched film has a peak value of orientation relaxation stress measured at a temperature 20 ° C. higher than the Vicat softening point of the thermoplastic resin, and one of MD and TD of the film has a value of 0.00. The press-through pack package according to claim 1, wherein the press-through pack package has a pressure of 2 to 4.0 MPa.   The stretched film has a peak value of orientation relaxation stress measured at a temperature 20 ° C. higher than the Vicat softening point of the thermoplastic resin, and both the MD and TD values of the film are 0.2-4. The press-through pack package according to claim 1, wherein the pressure-through pack package is 0 MPa.   The average particle diameter of this inorganic filler is 1-10 micrometers, The press through pack packaging body as described in any one of Claims 1-3 characterized by the above-mentioned.   The press-through pack package according to any one of claims 1 to 4, wherein the inorganic filler is an amorphous aluminosilicate.   The press-through pack package according to any one of claims 1 to 5, wherein the stretched film has a puncture strength of 1 to 5N.   The press-through pack package according to any one of claims 1 to 6, wherein the stretched film has a thickness of 5 to 30 µm.   The press-through pack package according to any one of claims 1 to 7, wherein the stretched film has an aluminum vapor deposition layer laminated on at least one surface.

Images