JPWO2009031455A1 - Automatic analyzer - Google Patents

Abstract

The automatic analyzer (1) performs a blank analysis process before the start of the analysis process or at a predetermined timing during the analysis process. Then, the blank value for the reaction vessel on the reaction table (19) is acquired as information relating to the reaction vessel, and stored in the storage unit (47) in association with the serial number assigned to the reaction vessel. In addition, the serial number of the reaction vessel placed at each placement position of the reaction table (19) by the reader / writer device (25) at the timing of starting the analysis process or when the analysis is once suspended and resumed. And check the arrangement of the reaction vessels on the reaction table (19). In the sample analysis process, the analysis unit (41) corrects the measurement result of the measurement optical system (23) using the blank value for the reaction container to be measured, and analyzes the sample.

Description

  The present invention relates to an automatic analyzer equipped with a measuring means for measuring the absorbance of a liquid in a reaction vessel.

  2. Description of the Related Art Conventionally, there is known an automatic analyzer that analyzes a sample by dispensing a sample and a reagent in a reaction vessel and reacting them, and measuring the absorbance of a reaction solution in the reaction vessel. This automatic analyzer is equipped with a reaction table in which a plurality of reaction containers can be arranged and stored, and on this reaction table, a sample or reagent is dispensed into each reaction container, and the reaction in each reaction container is performed. The solution is measured and analyzed. Each reaction container on the reaction table is detachable as disclosed in, for example, Patent Document 1, and is appropriately removed from the reaction table for maintenance such as cleaning and replacement of the reaction container.

  In addition, automatic analyzers conventionally perform a blank analysis process that measures absorbance before the analysis process, when a reagent is replaced, or when a blank sample is supplied into the reaction container or when the reaction container is empty. The absorbance of the reaction solution is corrected using the acquired blank value.

JP 2006-90992 A

  By the way, in the conventional apparatus configuration, the reaction container on the reaction table cannot be discriminated / recognized on the apparatus side. For this reason, when the reaction container is replaced or a new reaction container is placed and the arrangement of the reaction containers on the reaction table is changed, there is a problem that information relating to the reaction containers used in the apparatus cannot be managed. It was happening. For example, since the characteristics of the blank value acquired by the blank analysis process are different for each reaction container, it is desirable to acquire a blank value for each reaction container on the reaction table in order to improve analysis accuracy. However, even if a blank value is acquired for each reaction container, if the arrangement of the reaction containers on the reaction table changes, it becomes impossible to determine which reaction container each blank value has been acquired. For this reason, there was a problem that the measurement result could not be corrected using an appropriate blank value, and the analysis accuracy was lowered.

  This invention is made | formed in view of the above, Comprising: It aims at providing the automatic analyzer which can manage appropriately the information regarding the reaction container currently used.

  In order to solve the above-described problems and achieve the object, an automatic analyzer according to the present invention is an automatic analyzer having a measuring means for measuring the absorbance of a liquid in a reaction container, and the reaction container includes: An identification medium uniquely assigned to the reaction container is written, and a non-contact type information medium configured to be able to read the identification information is mounted, and the information medium of the reaction container to be measured by the measuring means From the identification information reading means for reading the identification information in a non-contact state, the reaction container information storage means for storing information relating to the reaction container in association with the identification information read by the identification information reading means, It is characterized by providing.

  In the automatic analyzer according to the present invention, in the above invention, the information related to the reaction container stored in the reaction container information storage unit includes a blank value for the reaction container, and at a predetermined timing, A blank value acquisition means for performing a blank analysis process for measuring absorbance by the measurement means in a state where a blank sample is supplied into the reaction container or in an empty state of the reaction container, and acquiring a blank value for the reaction container; Based on the blank value acquired by the blank value acquisition unit, the blank value update unit that updates the blank value stored in the reaction vessel information storage unit in association with the identification information of the reaction vessel, and the identification The measurement measured by the measuring means using a blank value corresponding to the identification information read by the information reading means By correcting the absorbance of the liquid in the reaction vessel of an elephant, characterized in that it and a analysis means for analyzing a liquid in the reaction vessel of the measurement target.

  In the automatic analyzer according to the present invention, in the above invention, a blank value corresponding to the identification information read from the information medium of the reaction vessel to be measured by the identification information reading unit is stored in the reaction vessel information storage unit. A blank value determination unit that determines whether or not the value is stored is stored, and the blank value acquisition unit performs a blank analysis process when the blank value determination unit determines that the value is not stored, and the reaction of the measurement target A blank value for the container is obtained.

  In the automatic analyzer according to the present invention, in the above invention, a blank value corresponding to the identification information read from the information medium of the reaction vessel to be measured by the identification information reading unit is stored in the reaction vessel information storage unit. A blank value determination means for determining whether or not the value is stored, and a notification for notifying that there is no blank value for the reaction container to be measured when it is determined that the blank value determination means is not stored. And means.

  In the automatic analyzer according to the present invention as set forth in the invention described above, the reaction container information storage means stores a history of blank values for the reaction container acquired by the blank value acquisition means, and stores the reaction container information. A blank value history display control means for performing control to display a history of blank values for the reaction vessel stored in the means on the display unit is provided.

  In the automatic analyzer according to the present invention as set forth in the invention described above, the reaction container is mounted on a reaction container mounting table in which a plurality of reaction containers can be arranged and stored. Reaction container position storage for storing an initial arrangement of the reaction containers on the reaction container mounting table in which each mounting position is associated with identification information assigned to the reaction container mounted at each mounting position. And a blank for each position that stores a blank value of the reaction container placed at each placement position of the reaction container placement table stored in the reaction container information storage means in association with each placement position Based on the value storage means, the identification information read by the identification information reading means, and the initial arrangement of the reaction vessels stored in the reaction vessel position storage means, the change in the arrangement of the reaction vessels is detected. Sequence change detection And when the sequence change is detected by the sequence change detecting means, the identification information stored in the reaction container position storage means in association with the placement position of the reaction container in which the sequence change is detected. To the read identification information, and the blank value stored in the position-specific blank value storage means in association with the placement position of the reaction container in which the array change is detected is stored in the reaction container. Data updating means for rewriting the blank value stored in association with the read identification information in the information storage means, and the analysis means analyzes the liquid in the reaction container to be measured, The measurement is performed using a blank value stored in the position-specific blank value storage unit in association with the mounting position of the reaction container to be measured.

  The automatic analyzer according to the present invention is characterized in that, in the above invention, the information related to the reaction container stored in the reaction container information storage means includes a use start date or the number of times of use of the reaction container. To do.

  According to the present invention, an information medium storing identification information uniquely assigned to the reaction container is attached to the reaction container, and the information is read from the information medium attached to the reaction container to be measured by the measuring means. Information related to the reaction container can be stored in association with the identification information. According to this, there exists an effect that the information regarding the reaction container currently used with the automatic analyzer can be managed appropriately.

  In addition, the blank value acquired for the reaction container can be stored in association with the identification information uniquely assigned to the reaction container. On the other hand, an information medium in which the identification information is stored is attached to the reaction container, and the absorbance of the liquid in the reaction container to be measured, which is measured by the measuring means, is measured on the information medium attached to the reaction container to be measured. It can correct | amend using the blank value corresponding to the identification information read from. According to this, the light absorbency of the reaction liquid measured by the measuring means can be appropriately corrected for each reaction container, and the analysis accuracy can be improved.

FIG. 1 is a schematic perspective view showing an example of the internal configuration of the automatic analyzer. FIG. 2 is a block diagram illustrating an example of a functional configuration of the automatic analyzer. FIG. 3 is a partial longitudinal sectional view in the radial direction of the reaction table. FIG. 4 is a partial cross-sectional view of the reaction table. FIG. 5 is a perspective view showing the reaction vessel. FIG. 6 is a diagram showing a transport path of the reaction container on the reaction table. FIG. 7 is a diagram illustrating a data configuration example of the position / reaction vessel correspondence table. FIG. 8 is a diagram illustrating a data configuration example of the latest blank value table. FIG. 9 is a diagram illustrating a data configuration example of the blank value DB. FIG. 10 is a flowchart illustrating a processing procedure of the control unit. FIG. 11 is a diagram illustrating an example of the position screen. FIG. 12 is a diagram illustrating an example of a position-specific water blank value list screen. FIG. 13 is a diagram showing an example of the position-serial number screen. FIG. 14 is a diagram showing an example of a serial number-specific water blank value list screen. FIG. 15 is a partial longitudinal sectional view in the radial direction of a reaction table according to a modification. FIG. 16 is a partial cross-sectional view of a reaction table according to a modification. FIG. 17 is a flowchart illustrating a processing procedure of the control unit according to the modification. FIG. 18A is a side view of a reaction container set according to a modified example. FIG. 18-2 is a plan view of a reaction container set according to a modification.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Automatic analyzer 11 Sample table 13 Sample dispensing mechanism 15 (15-1, 2) Reagent table 17 (17-1, 2) Reagent dispensing mechanism 19 Reaction table 23 Measurement optical system 25 Reader / writer apparatus 27 (27-1) , 2, 3) Stirring device 29 Cleaning device 4 Control unit 41 Analysis unit 43 Input unit 45 Display unit 47 Storage unit 471 Position / reaction vessel correspondence table 473 Latest blank value table 475 Blank value DB
111, 111b Sample reaction container 151 Reagent reaction container 22 Reaction container 223 IC tag 223a Serial number

  DESCRIPTION OF EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. The automatic analyzer according to the present embodiment is an apparatus that automatically performs biochemical analysis of a plurality of specimens, and dispenses specimens and reagents to be analyzed into reaction containers, respectively. The reaction is measured optically. FIG. 1 is a schematic perspective view showing an example of the internal configuration of the automatic analyzer 1 according to the present embodiment, and FIG. 2 is a block diagram showing an example of the functional configuration of the automatic analyzer 1. FIG. 3 is a partial longitudinal sectional view in the radial direction of the reaction table 19 as a reaction vessel mounting table constituting the automatic analyzer 1, and FIG. 4 is a partial transverse sectional view of the reaction table 19. The automatic analyzer 1 includes a sample table 11, a sample dispensing mechanism 13, two reagent tables 15 (15-1, 15-2), two reagent dispensing mechanisms 17 (17-1, 17-2), and a reaction table. 19, measurement optical system 23, reader / writer device 25, three stirring devices 27 (27-1, 27-2, 27-3), cleaning device 29, and the like. In addition, as shown in FIG. 2, the automatic analyzer 1 controls each part of the apparatus, and controls the operation of the entire apparatus by giving an operation timing instruction and data transfer to each part. Part 4 is provided.

  As shown in FIG. 1, a plurality of sample reaction containers 111 are stored in the sample table 11 at regular intervals along the circumferential direction. The sample reaction container 111 accommodates a sample such as blood or urine. The sample table 11 is configured to be capable of intermittent rotation about the rotation axis of the center by a drive mechanism (not shown) under the control of the control unit 4. Transport to position. Then, the sample in the sample reaction container 111 transported to the predetermined position is dispensed by the sample dispensing mechanism 13 into the reaction container 22 that is transported while being arranged on the reaction table 19. In addition, on the sample table 11, a sample reaction vessel 111b containing a blank sample such as ion exchange water for obtaining a blank value, which is an example of information related to the reaction vessel, is appropriately placed. Then, the blank sample is dispensed by the sample dispensing mechanism 13 into the reaction container 22 to be blanked on the reaction table 19.

  The specimen dispensing mechanism 13 includes an arm 131 that freely moves up and down in the vertical direction and rotates around a vertical line passing through its base end as a central axis. The arm 131 includes a liquid such as a specimen or a blank sample. A probe for performing suction and discharge is attached. Under the control of the control unit 4, the sample dispensing mechanism 13 aspirates a sample or a blank sample from the sample reaction container 111 transported to a predetermined position on the sample table 11 with a probe. Then, the arm 131 is rotated, and the sample or blank sample is discharged into the reaction container 22 transported to the sample dispensing position on the reaction table 19 to perform dispensing. The probe of the specimen dispensing mechanism 13 is flushed and washed in a washing tank (not shown) disposed on the movement path after the dispensing is completed.

  The reagent table 15 (15-1, 15-2) is configured to be capable of intermittent rotation about the rotation axis thereof by a drive mechanism (not shown) under the control of the control unit 4, A desired reagent reaction container 151 is transported to a predetermined position. Each reagent reaction container 151 contains a predetermined reagent corresponding to the analysis item. For example, one reagent table 15-1 contains a reagent reaction container 151 containing a first reagent, and the other reagent. The table 15-2 stores a reagent reaction container 151 containing a second reagent. In addition, a thermostat bath (not shown) is provided below each reagent table 15, and the reagents stored in each reagent reaction container 151 are kept cool and kept in a constant temperature state. Thereby, evaporation and denaturation of the reagent can be suppressed.

  The reagent dispensing mechanism 17 (17-1, 17-2), like the sample dispensing mechanism 13, can freely move up and down in the vertical direction and rotate around the vertical line passing through its proximal end as the central axis. The arm 171 is provided, and the arm 171 is configured with a probe for aspirating and discharging the reagent, respectively. One reagent dispensing mechanism 17-1 sucks the first reagent from the reagent reaction container 151 transported to a predetermined position on the reagent table 15-1 by the probe under the control of the control unit 4. Then, the arm 171 is rotated, and dispensing is performed by discharging the first reagent into the reaction container 22 transported to the first reagent dispensing position on the reaction table 19. Similarly, the other reagent dispensing mechanism 17-2 sucks the second reagent with the probe from the reagent reaction container 151 transported to a predetermined position on the reagent table 15-2 under the control of the control unit 4. . Then, the arm 171 is rotated, and the second reagent is discharged into the reaction container 22 transported to the second reagent dispensing position on the reaction table 19 to perform dispensing. The probe of each reagent dispensing mechanism 17 is flushed and washed in a washing tank (not shown) disposed on the movement path after the dispensing is completed.

  A plurality of storage chambers 21 are formed on the reaction table 19 at equal intervals along the circumferential direction, and reaction containers 22 are detachably mounted in the storage chambers 21. FIG. 5 is a perspective view showing the reaction vessel 22. As shown in FIG. 5, the reaction vessel 22 is a rectangular tube-like reaction vessel that holds a liquid therein, and an IC that is an information medium in which a non-contact type IC chip such as an RFID tag is built in the outer surface 221. A tag 223 is attached and attached, for example. The IC tag 223 includes a memory, an antenna, a control circuit, and the like, and is configured to be able to read, write, and rewrite data in the memory by the reader / writer device 25, and responds to radio waves from the reader / writer device 25. Then, the data written in the memory is transmitted to the reader / writer device 25. Alternatively, the IC tag 223 writes the data received from the reader / writer device 25 into the memory. The reaction vessel 22 is formed of an optically transparent material. Specifically, a material that transmits 80% or more of the light contained in the analysis light (340 to 800 nm) emitted from the measurement optical system 23, for example, glass including heat-resistant glass, synthetic resin such as cyclic olefin, polystyrene, or the like. used.

  The reaction container 22 is placed on the reaction table 19 with the IC tag 223 facing outward. Specifically, as shown in FIGS. 3 and 4, the reaction table 19 divides the reaction table 19 into storage chambers 21 (see FIG. 1) and holds the reaction vessel 22 to hold the reaction vessel 191. The reaction vessel 22 is held by the reaction vessel holding member 191 and placed on the reaction table 19. The reaction vessel holding member 191 is configured to be rotatable about the center of the reaction table 19 as a rotation axis by a drive mechanism (not shown) under the control of the control unit 4, and rotates by ¼ turn in one cycle. Rotate one reaction vessel in four cycles. By the rotation of the reaction container holding member 191, the reaction container 22 is moved from the specimen dispensing position on the reaction table 19, the first reagent dispensing position, the second reagent dispensing position, the stirring position, the measurement position, and the cleaning device 29. It is transported to various positions such as a waste liquid discharge position, a cleaning position, and a suction drying position (tag reading position). A constant temperature bath 193 such as a water bath is provided below the reaction container holding member 191 to keep the internal temperature at a temperature about the body temperature.

  Further, as shown in FIG. 3, the reaction vessel holding member 191 is formed with a photometric hole 195 for transmitting the analysis light from the measurement optical system 23 in the radial direction of the reaction table 19 with the reaction vessel 22 interposed therebetween. ing. On the other hand, although not shown, the thermostat 193 communicates with the photometric hole 195 of the reaction container holding member 191 that holds the reaction container 22 at the measurement position, and the analysis light from the measurement optical system 23 is transmitted in the radial direction of the reaction table 19. An opening for guiding from the inside to the outside is formed.

  The measurement optical system 23 corresponds to a measurement unit, and under the control of the control unit 4, the reaction vessel 22 transported to the measurement position is irradiated with analysis light, and the reaction solution or blank sample in the reaction vessel 22 is irradiated. Absorbance measurement is performed by receiving light that has passed through the liquid. For example, as shown in FIG. 1, a light source 231 that emits analysis light (340 to 800 nm) for analyzing a reaction solution or a blank sample in a reaction vessel 22, and a reaction in the reaction vessel 22 that is emitted from the light source 231. A photometric sensor 233 that measures the amount of light transmitted through the liquid or the blank sample. A measurement result by the measurement optical system 23 is output to the control unit 4 and analyzed by an analysis unit 41 connected to the control unit 4.

  A reader / writer device 25 is disposed on the outer peripheral side of the reaction table 19. The reader / writer device 25 corresponds to identification information reading means, and performs short-range wireless communication with the IC tag 223 attached to the reaction container 22 under the control of the control unit 4 to transmit data. Reading is performed without contact. Specifically, as shown in FIG. 3, short-range wireless communication is performed for the reaction container 22 conveyed to the position opposed to the reader / writer device 25 as the reaction container holding member 191 rotates. In the present embodiment, as shown in FIG. 2, a serial number 223a, which is identification information uniquely assigned to the reaction container 22, is stored in the memory of the IC tag 223 attached to the reaction container 22. The reader / writer device 25 reads the serial number 223a and outputs it to the control unit 4. At this time, the reaction container holding member 191 that holds each reaction container 22 partitions the reaction containers 22 and prevents interference between the IC tags 223 attached to the adjacent reaction containers 22. The communication distance between the IC tag 223 and the reader / writer device 25, the communication method, and the like can be selected as appropriate. In order to prevent interference between the IC tags 223, a reader / writer device 25 having a narrow directional antenna can be used.

  The stirrer 27 (27-1, 27-2, 27-3) stirs the sample and the reagent dispensed into the reaction vessel 22 transported to the stir position by a stirrer (not shown) and performs a reaction. Promote. After the stirring is completed, the stirring rod is washed and washed with a cleaning tank (not shown) to which cleaning water is supplied.

  The cleaning device 29 cleans and dries the reaction container 22 that is sequentially transported to the waste liquid discharge position, the cleaning position, and the suction drying position after the measurement by the measurement optical system 23 is completed.

  Specifically, a waste liquid suction nozzle is provided above the waste liquid discharge position, and is connected to a tank or a suction pump for storing the waste liquid. Under the control of the control unit 4, the waste liquid suction nozzle moves up and down with respect to the inside of the reaction container 22 at the waste liquid discharge position by the drive mechanism, and sucks the reaction liquid (waste liquid) in the reaction container 22. Discharge.

  Above the cleaning position, a cleaning nozzle that combines a cleaning liquid discharge nozzle for supplying a cleaning liquid into the reaction container 22 and a cleaning liquid suction nozzle for discharging the cleaning liquid supplied into the reaction container 22 by the cleaning liquid discharge nozzle The cleaning liquid discharge nozzle is connected to a tank or pump that stores cleaning liquid such as pure water, for example, and the cleaning liquid suction nozzle is connected to a tank or pump that stores cleaning waste liquid. In the present embodiment, the cleaning device 29 includes two sets of cleaning nozzles, which are provided above the first and second cleaning positions, respectively. Under the control of the control unit 4, each cleaning nozzle moves up and down with respect to the inside of the reaction container 22 at the cleaning position by its drive mechanism, and discharges the cleaning liquid into the reaction container 22 by the cleaning liquid discharge nozzle and supplies it. At the same time, the cleaning liquid in the reaction vessel 22 is sucked and discharged by the cleaning liquid suction nozzle.

  A suction drying nozzle is provided above the suction drying position, and is connected to a tank for storing waste liquid and a suction pump. Under the control of the control unit 4, the suction drying nozzle moves up and down with respect to the inside of the reaction vessel 22 at the suction drying position by the drive mechanism, and sucks and dries the cleaning liquid remaining in the reaction vessel 22. The reader / writer device 25 described above is provided, for example, in the vicinity of the suction drying position, and the IC tag 223 mounted on the reaction container 22 transported to the suction drying position with the rotation of the reaction container holding member 191 and the short-range wireless communication. Communicate. Hereinafter, the suction drying position is appropriately referred to as a tag reading position.

  FIG. 6 is a diagram showing a transport path of the reaction container 22 on the reaction table 19, and the reaction container 22 is sequentially transported to each position P1 to P12, and an analysis process is executed. That is, in the automatic analyzer 1 configured as described above, the reaction container 22 is first transported to the first reagent dispensing position P1, and the reagent dispensing mechanism 17-1 is placed in the reaction container 22 in the first reagent in the reagent reaction container 151. To dispense. Next, the reaction vessel 22 is transported to the first stirring position P2, and the stirring device 27-1 stirs the first reagent in the reaction vessel 22. Next, the reaction container 22 is transported to the sample dispensing position P3, and the sample dispensing mechanism 13 dispenses the sample in the sample reaction container 111 into the reaction container 22. Next, the reaction container 22 is transported to the second stirring position P4, and the stirring device 27-2 stirs the first reagent and the sample in the reaction container 22. This promotes the reaction. Then, the reaction container 22 is transported to the measurement position P5, and the measurement optical system 23 measures the absorbance of the reaction solution in the reaction container 22. The measurement result is output to the analysis unit 41 via the control unit 4 and analyzed. Thereby, the component analysis of the specimen is automatically performed. Subsequently, the reaction container 22 is transported to the second reagent dispensing position P6, and the reagent dispensing mechanism 17-2 dispenses the second reagent in the reagent reaction container 151 into the reaction container 22. Next, the reaction container 22 is transported to the third stirring position P7, and the stirring device 27-3 stirs the first reagent, the sample, and the second reagent in the reaction container 22. This promotes the reaction. Then, the reaction container 22 is transported to the measurement position P8, and the measurement optical system 23 measures the absorbance of the reaction solution in the reaction container 22. The measurement result is output to the analysis unit 41 and analyzed.

  Subsequently, the reaction container 22 is transported to the waste liquid discharge position P9, and the cleaning device 29 discharges the waste liquid in the reaction container 22. Next, the reaction vessel 22 is sequentially transported to the first cleaning position P10 and the second cleaning position P11. At each of the cleaning positions P10 and P11, the cleaning device 29 discharges and sucks cleaning water into the reaction vessel 22 to perform water cleaning inside. Next, the reaction container 22 is conveyed to the suction drying position P12, and the cleaning device 29 sucks the cleaning water in the reaction container 22 and dries it. The reaction container 22 sucked and dried at the suction drying position P12 is again transported to the first reagent dispensing position P1, and a series of analysis operations are continuously repeated. Further, the IC tag 223 of the reaction container 22 transported to the suction drying position (tag reading position) P12 is read by the reader / writer device 25 at a timing such as when the analysis process is started or when the analysis is once interrupted and restarted. The short-range wireless communication is performed to read the serial number 223a, and the reaction container 22 placed at each placement position (placement position) of the reaction table 19 is determined and recognized.

  Moreover, in the automatic analyzer 1 of this Embodiment, the blank analysis process about the reaction container 22 on the reaction table 19 is performed at predetermined timing, and the blank value about this reaction container 22 is newly acquired. In this blank analysis process, a blank sample is dispensed in the reaction vessel 22 to be blanked instead of the specimen and the reagent, and a blank value is obtained. That is, the reaction container 22 is first transported to the sample dispensing position (P3), and the sample dispensing mechanism 13 dispenses the blank sample in the sample reaction container 111b into the reaction container 22. Then, the reaction container 22 is transported to the measurement positions (P5, P8), and the measurement optical system 23 measures the absorbance of the blank sample in the reaction container 22. The measurement result is output to the analysis unit 41 and analyzed. Thereby, a blank value for the reaction container 22 to be blanked is obtained.

  The control unit 4 is composed of a microcomputer or the like, and is stored in a proper place in the apparatus. The control unit 4 corresponds to a blank value acquisition unit, a blank value update unit, a blank value determination unit, an array change detection unit, a data update unit, and a blank value history display control unit. Control blank analysis processing. As shown in FIG. 2, the control unit 4 is connected to an analysis unit 41 so that a measurement result by the measurement optical system 23 is appropriately output.

  The analysis unit 41 corresponds to an analysis unit, analyzes the concentration of the analysis target component in the sample based on the measurement result by the measurement optical system 23, and outputs the analysis result to the control unit 4. Specifically, the analysis unit 41 calculates the absorbance based on the light amount related to the reaction liquid in the reaction container 22 to be measured, which is measured by the measurement optical system 23. And the analysis part 41 correct | amends the light absorbency computed using the blank value about the reaction container 22 of this measuring object, and converts it into the density | concentration of an analysis object component. In addition, the analysis unit 41 analyzes the blank value of the blank sample based on the measurement result by the measurement optical system 23 and outputs the analysis result to the control unit 4. Specifically, the analysis unit 41 calculates the absorbance based on the amount of light relating to the blank sample in the blank acquisition target reaction container 22 measured by the measurement optical system 23, and acquires it as a blank value for the reaction container 22. To do.

  The control unit 4 also includes an input unit 43 including an input device such as a keyboard and a mouse for inputting information necessary for analysis such as the number of samples and analysis items, an analysis result screen, a warning display screen, and various settings. It is connected to a display unit 45 and a storage unit 47 configured by a display device such as an LCD or an ELD for displaying an input screen for input.

  The storage unit 47 is realized by various IC memories such as ROM and RAM such as flash memory that can be updated and stored, a hard disk connected with a built-in or data communication terminal, an information storage medium such as a CD-ROM, and a reading device thereof. In addition to the analysis results, various programs necessary for the operation of the automatic analyzer 1, data related to the execution of these programs, and the like are stored. Further, the storage unit 47 includes a position / reaction container correspondence table 471 as a reaction container position storage means, a latest blank value table 473 as a position-specific blank value storage means, and a blank value DB 475 as a reaction container information storage means. Is stored.

  The position / reaction container correspondence table 471 is a data table in which the serial number of the reaction container 22 placed at each placement position is set in association with the position number for identifying each placement position of the reaction table 19. is there. FIG. 7 is a diagram showing a data configuration example of the position / reaction container correspondence table 471. As shown in FIG. Here, the position number is, for example, a serial number assigned to each placement position in the clockwise direction with reference to a predetermined placement position on the reaction table 19. The control unit 4 controls the reader / writer device 25 at a timing before starting the analysis process or when the analysis is temporarily stopped and then restarted, for example, to place each placement position of the reaction table 19 (that is, each reaction table 19). The IC tags 223 of the reaction vessels 22 placed in the storage chamber 21) are sequentially read, and each reaction vessel 22 is discriminated and recognized to generate or update the position / reaction vessel correspondence table 471.

  The latest blank value table 473 is a data table in which the latest blank value for the reaction vessel 22 placed at the placement position is set in association with each position number. FIG. 8 is a diagram illustrating a data configuration example of the latest blank value table 473. In this latest blank value table 473, blank values for the respective wavelengths of 350 nm to 800 nm emitted from the light source 231 of the measurement optical system 23 are set. This blank value corresponds to the latest blank value set in the blank value characteristic history 476a of the blank value information 476 in which the corresponding serial number is set in the blank value DB 475. When the control unit 4 performs a blank analysis process before starting the analysis process or at a predetermined timing during the analysis process and newly acquires a blank value for the reaction vessel 22, the control unit 4 sets a blank value corresponding to the position number. Rewrite with the latest data acquired.

  The blank value DB 475 manages blank value history information for each reaction vessel 22. FIG. 9 is a diagram illustrating a data configuration example of the blank value DB 475. This blank value DB 475 stores, for each serial number, blank value information 476 in which a blank value characteristic history 476a for the reaction vessel 22 to which this serial number is assigned is set. In this blank value characteristic history 476a, a history of blank values acquired in the past is set in association with the acquisition date and position number at the time of acquisition. The control unit 4 performs a blank analysis process before the start of the analysis process or at a predetermined timing during the analysis process, and records a record in which the acquired blank value is associated with the acquisition date together with the position number of the reaction container 22 to be acquired. Generate. And it adds to the blank value characteristic log | history 476a with which the serial number of the reaction container 22 of blank acquisition object was matched. Thus, the blank value DB 475 manages the history of blank values in association with the serial number of the reaction vessel 22. For this reason, for example, when the user takes out the reaction container 22 from the reaction table 19 for maintenance or the like and performs the work of placing it again, the reaction container 22 is replaced on the reaction table 19 or on the reaction table 19. Even when the reaction vessel 22 on the reaction table 19 is changed due to the placement of a reaction vessel 22 having a new serial number, the history of blank values acquired for each reaction vessel 22 is properly managed. can do.

  Next, the processing procedure of the control unit 4 will be described with reference to the flowchart shown in FIG. As shown in FIG. 10, when starting the analysis (step S11: Yes), the control unit 4 first checks the arrangement of the reaction containers 22 on the reaction table 19 as a preparation process (step S13). Specifically, the control unit 4 controls the reader / writer device 25 to read the IC tag 223 of the reaction container 22 at the tag reading position and acquire the serial number by the reaction container holding member 191 of the reaction table 19 once. This is repeated until the reaction container 22 placed at each placement position of the reaction table 19 is identified and recognized. When the first analysis is started (step S15: Yes), the control unit 4 associates the serial number acquired from the reaction container 22 with the position number of the placement position, and matches the position / reaction container correspondence table 471. Is generated and stored in the storage unit 47 (step S17). Subsequently, the control unit 4 performs a blank analysis process to acquire a blank value for each reaction container 22, and associates the acquired blank value with the acquisition date together with the position number of the reaction container 22 to be blank acquired. A record is generated as a blank value characteristic history 476a, and blank value information 476 associated with the serial number acquired from the reaction container 22 is generated and set in the blank value DB 475 (step S19). Furthermore, the control part 4 produces | generates the newest blank value table 473 which matched the acquired blank value with the position number (step S21).

  On the other hand, at the start of the second and subsequent analyzes (step S15: No), the control unit 4 sets the correspondence between the position number of each mounting position and the acquired serial number in the position / reaction container correspondence table 471. The change in the arrangement of the reaction vessels 22 on the reaction table 19 is detected by comparison with the corresponding relationship between the position number and the serial number (step S23). Here, the acquired serial number is the same as one of the serial numbers set in the position / reaction container correspondence table 471. However, when the combination with the position number is different, that is, the reaction container 22 is displayed on the reaction table 19. If the position number is changed (step S25: Yes), the serial number of the corresponding position number is changed to update the position / reaction container correspondence table 471, and the blank value corresponding to this position number is changed to update the latest blank value table. 473 is updated, and the data is updated (step S27).

  When a new serial number not set in the position / reaction container correspondence table 471 is acquired, that is, when a new reaction container 22 is placed on the reaction table 19 (step S29: Yes), the control unit 4 First, it is determined whether or not the blank value information 476 in which the new serial number is set is stored in the blank value DB 475. Then, if stored (step S31: Yes), the control unit 4 reads the latest blank value of the blank value characteristic history 476a and corresponds to the position number of the newly placed reaction vessel 22. The serial number is rewritten to update the position / reaction container correspondence table 471, and the blank value corresponding to this position number is rewritten with the read blank value to update the latest blank value table 473 and update the data (step S33). Moreover, when not memorize | stored (step S31: No), the control part 4 performs a blank analysis process and acquires the blank value about this reaction container 22 (step S35). And the control part 4 produces | generates the record which matched the acquired blank value with the acquisition date with the position number of the reaction container 22 of the blank acquisition object, and adds it to the blank value characteristic log | history 476a matched with the serial number. The blank value DB 475 is updated, the serial number corresponding to the position number is rewritten, the position / reaction vessel correspondence table 471 is updated, and the blank value corresponding to this position number is rewritten with the acquired blank value to obtain the latest blank value. The table 473 is updated and the data is updated (step S37).

  Then, the control unit 4 moves to a sample analysis process (step S39). In this analysis process, the control unit 4 outputs the measurement result by the measurement optical system 23 to the analysis unit 41 together with the blank value associated with the position number of the reaction container 22 to be measured in the latest blank value table 473. In response to this, the analysis unit 41 calculates the absorbance from the measurement result input from the control unit 4, corrects the calculated absorbance using the blank value input from the control unit 4, and determines the concentration of the analysis target component. Convert to. Moreover, the control part 4 performs a blank analysis process regularly, and acquires the blank value about each reaction container 22. FIG. At this time, the control unit 4 updates the blank value DB 475 by adding the acquired blank value to the blank value characteristic history 476a associated with the serial number of the reaction container 22 to be blanked, and sets the position number. The latest blank value table 473 is updated by rewriting the corresponding blank value.

  Moreover, the control part 4 performs control which displays the historical information of the blank value about each reaction container 22 managed as blank value DB475 on the display part 45 according to user operation. Specifically, the control unit 4 performs control to display a position screen or a position-serial number screen when a blank value browsing instruction is input from the input unit 43.

  FIG. 11 is a diagram illustrating an example of the position screen W10. As shown in FIG. 11, a position selection button B11 with a position number assigned thereto is arranged on the position screen W10. Further, a screen transition button B13 for transitioning to the position-serial number screen is arranged, and when the screen transition button B13 is pressed, a position-serial number screen (see FIG. 13) is displayed. When the user wants to view the history information of the blank value for each position number, this position screen W10 is displayed, and by pressing the position selection button B11 to which the desired position number is assigned, the blank value at the placement position is displayed. Display history information for.

  For example, when the position selection button B11-1 is pressed to select the position number “11”, a position-specific water blank value list screen is displayed. FIG. 12 is a diagram illustrating an example of the position-specific water blank value list screen W20. In this position-specific water blank value list screen W20, blank value history information at the placement position “11” in the reaction table 19, that is, reactions that have been placed at the placement position “11” so far. The blank value history information about the container 22 is displayed. At this time, the control unit 4 refers to the blank value DB 475 and extracts a record in which “11” is associated with the position number from the blank value characteristic history 476 a of each blank value information 476. And the control part 4 makes the blank value of two wavelengths (340 nm, 380 nm) by the side of a short wavelength the water blank value list L20 by making into a display object the predetermined number of records with a new acquisition date among the extracted records, for example. Control the display. Further, the control unit 4 performs control to create and display a water blank value graph G20 with the acquisition date on the horizontal axis and the absorbance on the vertical axis according to the contents of the water blank value list L20. According to the water blank value list screen W20 by position, the reaction container 22 at the mounting position of “11” was replaced on November 26, 2006, but at each wavelength of 340 nm and 380 nm before and after the replacement. It can be confirmed that the characteristics of the blank value have not changed.

  The position-specific water blank value list screen W20 includes a button B21 for moving to the previous wavelength and a button B23 for moving to the next wavelength, and a position screen for displaying the water blank value list and the water blank value graph for other wavelengths. And a screen transition button B27 for transitioning to the position-serial number screen are arranged, and the screen display is updated according to a user operation.

  FIG. 13 is a diagram showing an example of the position-serial number screen W30. As shown in FIG. 13, the position-serial number screen W30 includes a serial number selection button B31 to which the serial number of the reaction vessel 22 currently placed at the placement position is attached in correspondence with the position number. Has been placed. If the next button B33 is pressed, the serial number of the reaction vessel 22 placed at the placement position “31” or later can be selected. Further, if the screen transition button B35 is pressed, the screen can transition to the position screen (see FIG. 11). When the user wants to view the history information of the blank value for each serial number, the position-serial number screen W30 is displayed and the desired serial number selection button B31 is pressed, whereby the history of the blank value of the reaction container 22 is displayed. Display information.

  For example, when the serial number selection button B31-1 is pressed to select the serial number “008844”, a water blank value list screen for each serial number is displayed. FIG. 14 is a diagram illustrating an example of the serial number-specific water blank value list screen W40. This serial number water blank value list screen W40 displays blank value history information for the reaction vessel 22 with the serial number “008844”. At this time, the control unit 4 refers to the blank value DB 475 and, for example, a predetermined number of records with a new acquisition date from the blank value characteristic history 476a of the blank value information 476 in which “008844” is set as the serial number. As a display target, control is performed to display blank values of two wavelengths (340 nm, 380 nm) on the short wavelength side as a water blank value list L40. Furthermore, according to the content of the water blank value list L40, the control unit 4 performs control to create and display a water blank value graph G40 with the acquisition date on the horizontal axis and the absorbance on the vertical axis. According to this serial number water blank value list screen W40, the placement position of the reaction vessel 22 with the serial number “008844” was changed on November 26, 2006, but before and after the change, each of 340 nm and 380 nm was changed. It can be confirmed that the characteristic of the blank value at the wavelength is not changed.

  In addition, on the serial number-specific water blank value list screen W40, a button B41 to the previous wavelength, a button B43 to the next wavelength, and screen transition buttons B45, B47 are arranged in the same manner as the water blank value list screen W20 by position. The screen display is updated according to the user operation.

  In this way, the user can check the characteristic change of the blank value for each position number or each serial number on the water blank value list screen for each position or the water blank value list screen for each serial number. For example, it is possible to grasp deterioration due to dirt, scratches, or the like accompanying the use of 22, and to determine the timing of maintenance such as cleaning or replacement of the reaction vessel 22.

  As described above, according to the present embodiment, the blank value acquired for each reaction vessel 22 on the reaction table 19 can be managed in association with the identification information uniquely assigned to the reaction vessel 22. . In addition, the arrangement of the reaction vessels 22 on the reaction table 19 is checked before starting the analysis process or when the analysis is temporarily stopped and then restarted, and each position number and the reaction placed at the placement position are checked. The latest blank value for the container 22 can be associated. Then, the absorbance of the reaction liquid in the reaction container 22 to be measured by the measurement optical system 23 can be corrected using the latest blank value acquired for the reaction container 22 to be measured. According to this, a measurement result can be correct | amended appropriately for every reaction container 22, and an analysis precision can be improved. Further, since the reaction vessel 22 placed on the reaction table 19 can be discriminated and recognized, it is possible to prevent a situation in which it is impossible to determine which reaction vessel 22 each blank value is acquired. For this reason, at the timing before the start of the analysis process or the like, the blank analysis process may be performed only for the reaction vessel 22 for which the blank value has not been acquired, and it is not necessary to acquire blank values for all the reaction vessels 22 again. Therefore, the time required for the blank analysis process can be reduced, and the analysis process can be made more efficient.

  In the above-described embodiment, the IC tag 223 is mounted on the outer surface 221 of the reaction container 22 and the IC tag 223 is read by the reader / writer device 25 installed on the outer peripheral side of the reaction table 19. An IC tag may be attached to the bottom of the container, and a reader / writer device may be installed on the bottom of the reaction table to read the IC tag.

  FIG. 15 is a partial vertical sectional view in the radial direction of the reaction table 19b constituting the automatic analyzer 1, and FIG. 16 is a partial horizontal sectional view of the reaction table 19b. In this modification, a reader / writer device 25b is installed at the bottom of the reaction table 19b below the thermostat 193b and is connected to the control unit. Specifically, the reader / writer device 25b is close to the IC tag 223b mounted on the bottom surface of the reaction container 22b that is sequentially transported to the tag reading position near the tag reading position of the reaction table 19b. Installed in a possible position. Then, short-range wireless communication is performed for the reaction vessel 22b transported to the tag reading position, and the serial number stored in the memory of the IC tag 223b is read in a non-contact manner and output to the control unit. At this time, the reaction container holding member 191b that holds each reaction container 22b partitions the reaction containers 22b and prevents interference between the IC tags 223b attached to the adjacent reaction containers 22b.

  Further, the installation position of the reader / writer device 25 is not limited to the vicinity of the suction drying position, and may be installed, for example, in the vicinity of the waste liquid discharge position or in the vicinity of the first or second cleaning position. It may be installed at any position on the transport path.

  In the embodiment described above, the serial number of the reaction vessel 22b placed at each placement position of the reaction table 19b is set at a timing such as when the analysis process is started or when the analysis is once suspended and resumed. Although the case of collecting in a lump has been described, the IC tag of the reaction container conveyed to the tag reading position during the analysis process may be read as needed. For example, the reader / writer device is installed at any position on the reaction table where the reaction container stops until the sample is dispensed after being transported to the first reagent dispensing position, and the first reagent is dispensed. Until then, the reaction vessel is configured to be discriminated / recognized, and a reaction vessel having no blank value is not used for analysis. Or while continuing analysis using other reaction containers, you may make it acquire the blank value of the reaction container which has not acquired the blank value.

  In the above-described embodiment, when a new reaction container 22 is placed on the reaction table 19 and a blank value for the reaction container 22 has already been acquired, When the reaction vessel 22 is replaced, the analysis is performed using the acquired blank value. However, when the arrangement of the reaction vessel 22 on the reaction table 19 is changed, a new blank value is always set. You may comprise so that it may acquire. Or it is good also as a structure which determines whether a blank value is newly acquired based on the acquisition date of the newest blank value. In this case, since a blank value for the reaction vessel 22 can be newly acquired based on the elapsed time from the latest acquisition date, it is possible to prevent a situation in which the measured absorbance of the reaction solution is corrected with old data. Analysis accuracy can be further improved.

  In the blank analysis process, the absorbance was measured in a state where a blank sample was supplied to the blank acquisition target reaction vessel 22 and the blank value was acquired, but the blank acquisition target reaction vessel 22 was empty. It is good also as measuring a light absorbency and acquiring a blank value.

  In addition, when a new reaction container 22 in which no blank value is stored in the blank value DB 475 is placed, a blank analysis process is performed, and a blank value for the reaction container 22 is automatically acquired. It is good also as a structure which alert | reports that a blank value does not exist, without performing a blank analysis process.

  FIG. 17 is a flowchart illustrating a processing procedure of the control unit according to the present modification. In addition, the same code | symbol is attached | subjected about the process same as the process demonstrated in FIG. As shown in FIG. 17, in this modification, the control unit functions as a notification unit, and at the start of the second and subsequent analysis, a new serial number that is not set in the position / reaction container correspondence table 471 is entered. When acquired, that is, when a new reaction vessel 22 is placed on the reaction table 19 (step S29: Yes), blank value information 476 in which this new serial number is set is stored in the blank value DB 475. If there is no blank (step S31: No), notification is made that there is no blank value for the reaction vessel 22 (step S45). For example, the control unit controls the display unit 45 to display a message indicating that there is no blank value for the reaction vessel 22. And a control part makes this reaction container 22 a use prohibition reaction container (step S47), and transfers to step S39. Thereby, in the analysis process of step S39, this blank value does not exist, and the reaction vessel 22 which is a use-prohibited reaction vessel is not used. In step S45, the control unit may perform control to display a message that prompts the user to acquire a blank value for the reaction vessel 22. And a control part performs a blank analysis process according to user operation, for example, and acquires the blank value about this reaction container 22. FIG. If a blank value is obtained, this reaction vessel 22 is used in the analysis step.

  Further, the present invention is not limited to the configuration in which the reaction containers are individually placed on the reaction table, and can be similarly applied to the case where a reaction container set including a plurality of reaction containers is placed on the reaction table. 18A is a side view of the reaction container set 30, and FIG. 18B is a plan view of the reaction container set 30. The reaction container set 30 is configured by holding a plurality of reaction containers 31 (seven 31 a to 31 g in FIGS. 18A and 18B) on a holder 33, and an IC tag 35 on the upper surface of the holder 33. Is installed. The IC tag 35 stores an identification number uniquely assigned to the reaction container set 30. In this case, on the apparatus side, a blank value for each reaction container 31 constituting the reaction container set 30 is managed in association with the identification number of the reaction container set 30. Specifically, among the reaction vessels 31 of the reaction vessel set 30, for example, the reaction vessel 31a on the side where the IC tag 35 is attached is set to “1”, and the reaction vessels 31a to 31g are assigned “1” to “7”. Allocate an array number. Then, a blank value for each array number is stored in association with the identification number. Further, the arrangement of the reaction containers 31 is determined according to the combination of the reaction container sets 30 placed on the reaction table, and the reaction containers 31 at the respective placement positions are discriminated and recognized.

  Moreover, although the case where a blank value is managed as an example of information related to a reaction container has been described, the information related to a reaction container is not limited to the blank value, for example, to manage the use start date and the number of times of use of the reaction container. Also good. In this case, for example, as in the above-described embodiment, the serial number of the reaction container placed at each placement position is associated with the position number for identifying each placement position of the reaction table. The set position / reaction container correspondence table is stored in the storage unit and managed. Further, the latest reaction container information table in which the use start date of the reaction container placed at the placement position and the latest use count are set in association with each position number is stored in the storage unit and managed. Further, the reaction container information in which the use start date and the latest use count are set in association with the identification information read in the past is stored and managed in the storage unit.

  Specifically, the control unit changes the arrangement of the reaction vessels by replacing the reaction vessels on the reaction table based on the correspondence between the position numbers and serial numbers set in the position / reaction vessel correspondence table. If it is determined, the position / reaction container correspondence table is updated by replacing the serial number of the corresponding position number, and the latest reaction container information table is updated by replacing the use start date and the number of times of use corresponding to this position number. . In addition, when a new serial number not set in the position / reaction container correspondence table is acquired, that is, when a new reaction container is placed on the reaction table, the controller first places the new placement number. The position / reaction container correspondence table is updated by rewriting the serial number corresponding to the position number of the reaction container. Subsequently, the control unit generates a record associated with the read new serial number with the current time as the use start date or the use count as the initial value “1”, and adds it to the reaction container information. Subsequently, the control unit rewrites the use start date and the number of uses corresponding to this position number and updates the latest blank value table. When managing the number of times of use, each time the identification information is read, the control unit counts up the number of times of use corresponding to the position number to update the latest reaction vessel information table and corresponds to the read identification information. The reaction container information is updated by rewriting the use count value with the updated use count value.

  It is desirable to replace the reaction vessel after the lapse of a predetermined period from the start date of use or when the number of uses exceeds the predetermined number. However, conventionally, there has been a problem that the reaction container on the reaction table cannot be discriminated / recognized on the apparatus side, and if the reaction container is replaced on the reaction table, the use start date and the number of times of use cannot be managed correctly. On the other hand, in this modified example, when the reaction container is changed on the reaction table, such as when the reaction container is replaced on the reaction table or a reaction container with a new serial number is placed on the reaction table. Even so, the use start date and the number of times of use of each reaction vessel can be appropriately managed. Therefore, for example, the degree of consumption of the reaction container is determined using the use start date and the number of use, and when a predetermined period has elapsed from the use start date or when the use number exceeds the predetermined number, It is possible to present a message prompting replacement to the user by displaying it on the display unit 45 or the like.

  In each of the above-described embodiments, the case where two reagent tables are provided in the automatic analyzer 1 has been described. However, the number of reagent tables may be one.

  As described above, the automatic analyzer of the present invention is useful for appropriately managing information related to the reaction vessel being used.

Claims (7)

An automatic analyzer equipped with a measuring means for measuring the absorbance of the liquid in the reaction vessel,
In the reaction container, identification information uniquely assigned to the reaction container is written, and a non-contact type information medium configured to be able to read the identification information is mounted,
Identification information reading means for reading out the identification information in a non-contact state from the information medium of the reaction vessel to be measured by the measurement means;
Reaction container information storage means for storing information relating to the reaction container in association with the identification information read by the identification information reading means;
An automatic analyzer characterized by comprising. Information relating to the reaction vessel stored in the reaction vessel information storage means includes a blank value for the reaction vessel,
At a predetermined timing, a blank analysis process is performed in which the absorbance is measured by the measurement means in a state where a blank sample is supplied into the reaction container or in the reaction container is empty, and a blank value for the reaction container is obtained. Blank value acquisition means;
Based on the blank value acquired by the blank value acquisition means, the blank value update means for updating the blank value stored in the reaction container information storage means in association with the identification information of the reaction container;
Using the blank value corresponding to the identification information read by the identification information reading means to correct the absorbance of the liquid in the measurement target reaction container measured by the measurement means, An analysis means for analyzing the liquid of
The automatic analyzer according to claim 1, further comprising: A blank value determining means for determining whether or not a blank value corresponding to the identification information read from the information medium of the reaction container to be measured by the identification information reading means is stored in the reaction container information storage means;
The blank value acquisition unit performs blank analysis processing when it is determined that the blank value determination unit does not store the blank value, and acquires a blank value for the reaction vessel to be measured. Automatic analyzer described in 1. A blank value determination means for determining whether or not a blank value corresponding to the identification information read from the information medium of the reaction container to be measured by the identification information reading means is stored in the reaction container information storage means;
Informing means for notifying that there is no blank value for the reaction container to be measured, when it is determined by the blank value determining means that it is not stored;
The automatic analyzer according to claim 2, further comprising: The reaction container information storage means stores a history of blank values for the reaction container acquired by the blank value acquisition means,
5. A blank value history display control means for performing control to display a history of blank values for the reaction container stored in the reaction container information storage means on a display unit. Automatic analyzer described in 1. The reaction vessel is mounted on a reaction vessel mounting table that can accommodate and accommodate a plurality of reaction vessels,
Initial arrangement of the reaction containers on the reaction container mounting table in which each mounting position of the reaction container mounting table is associated with identification information assigned to the reaction container mounted at each mounting position in advance. Reaction container position storage means for storing
Blank value storage means for each position for storing blank values for the reaction containers placed at the placement positions of the reaction container placement table stored in the reaction container information storage means in association with the placement positions. When,
An array change detecting means for detecting an array change of the reaction container based on the identification information read by the identification information reading means and the initial array of the reaction container stored in the reaction container position storage means; ,
When a sequence change is detected by the sequence change detection means, the identification information stored in the reaction container position storage means in association with the placement position of the reaction container in which the sequence change is detected is read. While rewriting the issued identification information, the blank value stored in the position-specific blank value storage means in association with the placement position of the reaction container in which the sequence change is detected is stored in the reaction container information storage means. Data updating means for rewriting the blank value stored in association with the read identification information,
With
The analysis means analyzes the liquid in the measurement target reaction container using a blank value stored in the position-specific blank value storage means in association with the mounting position of the measurement target reaction container. The automatic analyzer according to any one of claims 2 to 5.   The automatic analysis according to any one of claims 1 to 6, wherein the information related to the reaction vessel stored in the reaction vessel information storage means includes a use start date or a use frequency of the reaction vessel. apparatus.

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