JPS6479167A - Novel synthesis of 6-acyl-7-deacetylforskolin derivative - Google Patents
Novel synthesis of 6-acyl-7-deacetylforskolin derivativeInfo
- Publication number
- JPS6479167A JPS6479167A JP63159381A JP15938188A JPS6479167A JP S6479167 A JPS6479167 A JP S6479167A JP 63159381 A JP63159381 A JP 63159381A JP 15938188 A JP15938188 A JP 15938188A JP S6479167 A JPS6479167 A JP S6479167A
- Authority
- JP
- Japan
- Prior art keywords
- acyl
- solvent
- compound
- formula
- novel synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyrane Compounds (AREA)
Abstract
PURPOSE:To obtain the title substance of high purity in high yield, which can be expected to be used as a medicine, by acyl rearrangement of 7-acyl-7- deacetylforskolin derivative only with heat. CONSTITUTION:The compound of formula I (R<1> is hydroxyl which may be esterified; R<2> is acyl; R<3> is 2-3C hydrocarbon group) is heated at 150-250 deg.C in case of no solvent for 15-60min or at 70 deg.C to the boiling point of the solvent for 3-8hr to give the compound of formula II. Direct heating is preferably conducted under fusing, any solvents whether they dissolve the compound of formula I or not can be used, when a solvent is employed, and the solvent is preferably anhydrous, in order to avoid hydrolysis of the acyl group. The solvent is for example DMF, DMSO or acetonitrile. When R<2> is dimethylaminopropionyl, the treatment of the reaction mixture with the amine corresponding the amine component inhabits the formation of by-products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63159381A JPH0739408B2 (en) | 1987-06-29 | 1988-06-29 | Novel method for producing 6-acyl-7-deacetylforskolin derivative |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-159639 | 1987-06-29 | ||
| JP15963987 | 1987-06-29 | ||
| JP63159381A JPH0739408B2 (en) | 1987-06-29 | 1988-06-29 | Novel method for producing 6-acyl-7-deacetylforskolin derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6479167A true JPS6479167A (en) | 1989-03-24 |
| JPH0739408B2 JPH0739408B2 (en) | 1995-05-01 |
Family
ID=26486200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63159381A Expired - Fee Related JPH0739408B2 (en) | 1987-06-29 | 1988-06-29 | Novel method for producing 6-acyl-7-deacetylforskolin derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0739408B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3043332U (en) * | 1997-05-12 | 1997-11-18 | 本 小竹 | Pet animal droppings |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5371077A (en) * | 1976-12-03 | 1978-06-24 | Hoechst Ag | Polyoxidize labdane derivative and process for preparing same |
-
1988
- 1988-06-29 JP JP63159381A patent/JPH0739408B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5371077A (en) * | 1976-12-03 | 1978-06-24 | Hoechst Ag | Polyoxidize labdane derivative and process for preparing same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0739408B2 (en) | 1995-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |