JPS6479158A - 2-nitroimidazole derivative - Google Patents
2-nitroimidazole derivativeInfo
- Publication number
- JPS6479158A JPS6479158A JP23700587A JP23700587A JPS6479158A JP S6479158 A JPS6479158 A JP S6479158A JP 23700587 A JP23700587 A JP 23700587A JP 23700587 A JP23700587 A JP 23700587A JP S6479158 A JPS6479158 A JP S6479158A
- Authority
- JP
- Japan
- Prior art keywords
- nitroimidazole
- derivative
- hydroxylamine
- formula
- methyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The 2-nitroimidazole derivative of formula (R is H or acetyl) and its salt. EXAMPLE:2-Nitroimidazole-1-acetohydroxamic acid. USE:Useful as a radiation sensitizer. It has low toxicity. PREPARATION:The compound of formula can be produced e.g. by reacting 2-nitroimidazole-1-acetic acid methyl ester with hydroxylamine or its derivative in a solvent (e.g., methanol) at 10-25 deg.C for 1-24hr. The amount of hydroxylamine, etc., is preferably 4-5mol. per 1mol. of the methyl ester.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23700587A JP2598649B2 (en) | 1987-09-21 | 1987-09-21 | 2-nitroimidazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23700587A JP2598649B2 (en) | 1987-09-21 | 1987-09-21 | 2-nitroimidazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6479158A true JPS6479158A (en) | 1989-03-24 |
JP2598649B2 JP2598649B2 (en) | 1997-04-09 |
Family
ID=17008974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP23700587A Expired - Lifetime JP2598649B2 (en) | 1987-09-21 | 1987-09-21 | 2-nitroimidazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2598649B2 (en) |
-
1987
- 1987-09-21 JP JP23700587A patent/JP2598649B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2598649B2 (en) | 1997-04-09 |
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