JPS6470482A - Physiologically active substance pi6621 - Google Patents
Physiologically active substance pi6621Info
- Publication number
- JPS6470482A JPS6470482A JP62227243A JP22724387A JPS6470482A JP S6470482 A JPS6470482 A JP S6470482A JP 62227243 A JP62227243 A JP 62227243A JP 22724387 A JP22724387 A JP 22724387A JP S6470482 A JPS6470482 A JP S6470482A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- organic solvent
- water
- insoluble
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013543 active substance Substances 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 230000004520 agglutination Effects 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
- 238000009630 liquid culture Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by the formula. Appearance; reddish orange crystal. Melting point; 190.5-193 deg.C. Elementary analysis value (%); C, 62.98; H, 6.51. Molecular weight; 1,071. Molecular formula; C55H68O20. Specific rotatory power; [alpha]D<22>+21.0 deg.C (C=0.5, chloroform). Solubility; insoluble in water and soluble in methanol, ethyl acetate, benzene, etc. Color reaction; negative to the ninhydrin reaction and positive to the vanillin-sulfuric acid and iodine reaction. Neutral substance. USE:With powerful inhibitory action on blood platelet agglutination and carcinostatic action. PREPARATION:For example, Streptomyces.matensis A-6621 (FERM BP-1422) is cultivated in a liquid culture medium at pH 6-7 and 28-30 deg.C under aerobic condition for 4 days and the culture is filtered to extract microbial cells with an organic solvent. The resultant extract solution is then transferred and dissolved in a water-insoluble organic solvent, concentrated, isolated and purified by subjecting to column chromatography and high-speed liquid chromatography.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62227243A JPS6470482A (en) | 1987-09-10 | 1987-09-10 | Physiologically active substance pi6621 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62227243A JPS6470482A (en) | 1987-09-10 | 1987-09-10 | Physiologically active substance pi6621 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6470482A true JPS6470482A (en) | 1989-03-15 |
Family
ID=16857762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62227243A Pending JPS6470482A (en) | 1987-09-10 | 1987-09-10 | Physiologically active substance pi6621 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6470482A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2013061919A1 (en) * | 2011-10-25 | 2015-04-02 | 学校法人立命館 | Novel compound and process for producing the same |
-
1987
- 1987-09-10 JP JP62227243A patent/JPS6470482A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2013061919A1 (en) * | 2011-10-25 | 2015-04-02 | 学校法人立命館 | Novel compound and process for producing the same |
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