JPS646293A - N-(nalpha-(1(s)-carboxy-3-cyclohexylpropyl)-l-lysyl)-n-cyclopent ylglycine - Google Patents

N-(nalpha-(1(s)-carboxy-3-cyclohexylpropyl)-l-lysyl)-n-cyclopent ylglycine

Info

Publication number
JPS646293A
JPS646293A JP63070631A JP7063188A JPS646293A JP S646293 A JPS646293 A JP S646293A JP 63070631 A JP63070631 A JP 63070631A JP 7063188 A JP7063188 A JP 7063188A JP S646293 A JPS646293 A JP S646293A
Authority
JP
Japan
Prior art keywords
cyclohexylpropyl
lysyl
carboxy
ylglycine
nalpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63070631A
Other languages
Japanese (ja)
Inventor
Shizuo Saito
Hajime Watanabe
Shuji Fukushima
Shinichi Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Breweries Ltd
Original Assignee
Asahi Breweries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Breweries Ltd filed Critical Asahi Breweries Ltd
Priority to JP63070631A priority Critical patent/JPS646293A/en
Publication of JPS646293A publication Critical patent/JPS646293A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:N-[N<alpha>-( 1-(S)-carboxy-3-cyclohexylpropyl )-L-lysyl]-N-cyclopentyl glycine and its salt. USE:A transferase-inhibitor and a hypotensor. PREPARATION:A ketone of formula I (R1 is OH, lower alkoxy, lower aralkoxy or cycloalkoxy) is made to react with a protected peptide of formula II (R2 is OH, lower alkoxy, lower aralkoxy or cycloalkoxy; R3 is protecting group other than H) in the presence of a reducing agent and, as necessary, the protect ing group is removed from the product and the compound is optionally converted to a salt. The product is purified by chromatography or fractional recrystallization and, as necessary, the protecting group is removed to properly separate an isomer having higher biological activity.
JP63070631A 1987-03-24 1988-03-24 N-(nalpha-(1(s)-carboxy-3-cyclohexylpropyl)-l-lysyl)-n-cyclopent ylglycine Pending JPS646293A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63070631A JPS646293A (en) 1987-03-24 1988-03-24 N-(nalpha-(1(s)-carboxy-3-cyclohexylpropyl)-l-lysyl)-n-cyclopent ylglycine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6777087 1987-03-24
JP63070631A JPS646293A (en) 1987-03-24 1988-03-24 N-(nalpha-(1(s)-carboxy-3-cyclohexylpropyl)-l-lysyl)-n-cyclopent ylglycine

Publications (1)

Publication Number Publication Date
JPS646293A true JPS646293A (en) 1989-01-10

Family

ID=26408983

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63070631A Pending JPS646293A (en) 1987-03-24 1988-03-24 N-(nalpha-(1(s)-carboxy-3-cyclohexylpropyl)-l-lysyl)-n-cyclopent ylglycine

Country Status (1)

Country Link
JP (1) JPS646293A (en)

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