JPS646265A - Production of thiazepine derivative - Google Patents

Production of thiazepine derivative

Info

Publication number
JPS646265A
JPS646265A JP63032381A JP3238188A JPS646265A JP S646265 A JPS646265 A JP S646265A JP 63032381 A JP63032381 A JP 63032381A JP 3238188 A JP3238188 A JP 3238188A JP S646265 A JPS646265 A JP S646265A
Authority
JP
Japan
Prior art keywords
compound
group
formula
protective group
formula iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63032381A
Other languages
Japanese (ja)
Other versions
JP2628876B2 (en
Inventor
Hiroaki Yanagisawa
Sadao Ishihara
Akiko Ando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP63032381A priority Critical patent/JP2628876B2/en
Publication of JPS646265A publication Critical patent/JPS646265A/en
Application granted granted Critical
Publication of JP2628876B2 publication Critical patent/JP2628876B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE:To obtain a perhydro compound, by reducing alpha-[5-oxo-4,5,6,7- tetrahydro-2-(2-thienyl)-6(R)-triphenylme-thylamino-1,4-thiazepin-4-yl ]acetic acid t-butyl ester, etc. CONSTITUTION:The objective compound can be produced by reacting a compound of formula I (R<1> is aryl or heterocyclic group; R<2> is protective group for carboxyl group; R<4> is protective group for amino group) with an oxidizing agent (e.g. t-butyl hypochlorite) in a proper solvent at -80-+100 deg.C for 30min-a whole day and night, reducing the obtained compound of formula II with Mg preferably in methanol at 20-30 deg.C and, as necessary, eliminating the protective group of the amino group from the resultant compound of formula III. The objective compound such as the compound of formula III is useful as an intermediate for hypotensive agent.
JP63032381A 1987-02-17 1988-02-15 Method for producing thiazepine derivatives Expired - Lifetime JP2628876B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63032381A JP2628876B2 (en) 1987-02-17 1988-02-15 Method for producing thiazepine derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-34196 1987-02-17
JP3419687 1987-02-17
JP63032381A JP2628876B2 (en) 1987-02-17 1988-02-15 Method for producing thiazepine derivatives

Publications (2)

Publication Number Publication Date
JPS646265A true JPS646265A (en) 1989-01-10
JP2628876B2 JP2628876B2 (en) 1997-07-09

Family

ID=26370943

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63032381A Expired - Lifetime JP2628876B2 (en) 1987-02-17 1988-02-15 Method for producing thiazepine derivatives

Country Status (1)

Country Link
JP (1) JP2628876B2 (en)

Also Published As

Publication number Publication date
JP2628876B2 (en) 1997-07-09

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