JPS646168B2 - - Google Patents

Info

Publication number

JPS646168B2

JPS646168B2 JP54111966A JP11196679A JPS646168B2 JP S646168 B2 JPS646168 B2 JP S646168B2 JP 54111966 A JP54111966 A JP 54111966A JP 11196679 A JP11196679 A JP 11196679A JP S646168 B2 JPS646168 B2 JP S646168B2

Authority

JP

Japan

Prior art keywords

parts

substance

present

aminobenzoic acid

nervous system

Prior art date

1979-08-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
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• ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical group NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 11
• 150000003839 salts Chemical class 0.000 claims description 9
• 229960004050 aminobenzoic acid Drugs 0.000 claims description 7
• 210000003169 central nervous system Anatomy 0.000 claims description 7
• 239000004480 active ingredient Substances 0.000 claims description 5
• 239000003907 antipyretic analgesic agent Substances 0.000 claims description 4
• 159000000000 sodium salts Chemical group 0.000 claims 1
• 239000000126 substance Substances 0.000 description 19
• 239000003814 drug Substances 0.000 description 10
• 238000000034 method Methods 0.000 description 8
• 229940079593 drug Drugs 0.000 description 7
• 239000008187 granular material Substances 0.000 description 6
• 239000000243 solution Substances 0.000 description 6
• 241001465754 Metazoa Species 0.000 description 5
• 241000699670 Mus sp. Species 0.000 description 5
• 239000000523 sample Substances 0.000 description 5
• XETSAYZRDCRPJY-UHFFFAOYSA-M sodium;4-aminobenzoate Chemical compound [Na+].NC1=CC=C(C([O-])=O)C=C1 XETSAYZRDCRPJY-UHFFFAOYSA-M 0.000 description 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• 241000700159 Rattus Species 0.000 description 4
• 230000000202 analgesic effect Effects 0.000 description 4
• 230000001754 anti-pyretic effect Effects 0.000 description 4
• 230000036760 body temperature Effects 0.000 description 4
• 239000000203 mixture Substances 0.000 description 4
• 230000007886 mutagenicity Effects 0.000 description 4
• 231100000299 mutagenicity Toxicity 0.000 description 4
• 230000000638 stimulation Effects 0.000 description 4
• 239000003826 tablet Substances 0.000 description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 206010037660 Pyrexia Diseases 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 239000002221 antipyretic Substances 0.000 description 3
• 230000037396 body weight Effects 0.000 description 3
• 239000002775 capsule Substances 0.000 description 3
• 238000009472 formulation Methods 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 238000002347 injection Methods 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 229920001817 Agar Polymers 0.000 description 2
• 244000063299 Bacillus subtilis Species 0.000 description 2
• 235000014469 Bacillus subtilis Nutrition 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 241000699666 Mus <mouse, genus> Species 0.000 description 2
• 239000004372 Polyvinyl alcohol Substances 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 238000000862 absorption spectrum Methods 0.000 description 2
• 230000007059 acute toxicity Effects 0.000 description 2
• 231100000403 acute toxicity Toxicity 0.000 description 2
• 239000008272 agar Substances 0.000 description 2
• RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 239000001913 cellulose Substances 0.000 description 2
• 229920002678 cellulose Polymers 0.000 description 2
• 239000012153 distilled water Substances 0.000 description 2
• 239000008298 dragée Substances 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 239000002504 physiological saline solution Substances 0.000 description 2
• 229920002451 polyvinyl alcohol Polymers 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• XFDUHJPVQKIXHO-UHFFFAOYSA-N 3-aminobenzoic acid Chemical compound NC1=CC=CC(C(O)=O)=C1 XFDUHJPVQKIXHO-UHFFFAOYSA-N 0.000 description 1
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
• 229930192392 Mitomycin Natural products 0.000 description 1
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
• VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical group O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
• 208000000114 Pain Threshold Diseases 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
• 150000001342 alkaline earth metals Chemical class 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• 150000005415 aminobenzoic acids Chemical class 0.000 description 1
• 239000000730 antalgic agent Substances 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 238000011888 autopsy Methods 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
• 235000013539 calcium stearate Nutrition 0.000 description 1
• 239000008116 calcium stearate Substances 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• 230000000711 cancerogenic effect Effects 0.000 description 1
• 231100000315 carcinogenic Toxicity 0.000 description 1
• 239000003874 central nervous system depressant Substances 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 229910052802 copper Inorganic materials 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 239000000839 emulsion Substances 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 230000009036 growth inhibition Effects 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 229910017053 inorganic salt Inorganic materials 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 229930027917 kanamycin Natural products 0.000 description 1
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
• 229960000318 kanamycin Drugs 0.000 description 1
• 229930182823 kanamycin A Natural products 0.000 description 1
• 231100000053 low toxicity Toxicity 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 235000013372 meat Nutrition 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 229960004857 mitomycin Drugs 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 230000037040 pain threshold Effects 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000008223 sterile water Substances 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 239000007940 sugar coated tablet Substances 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 230000002110 toxicologic effect Effects 0.000 description 1
• 231100000027 toxicology Toxicity 0.000 description 1