JPS6445354A - Optical active n-carbamoyl-2-(r)-amino-4-phenylbutyric acid - Google Patents
Optical active n-carbamoyl-2-(r)-amino-4-phenylbutyric acidInfo
- Publication number
- JPS6445354A JPS6445354A JP20086287A JP20086287A JPS6445354A JP S6445354 A JPS6445354 A JP S6445354A JP 20086287 A JP20086287 A JP 20086287A JP 20086287 A JP20086287 A JP 20086287A JP S6445354 A JPS6445354 A JP S6445354A
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- amino
- formula
- carbamoyl
- microbial cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:Optically active N-carbamoyl-2-(R)-amino-4-phenylbutyric acid of formula. USE:A production precursor for angiotensinase inhibitor. PREPARATION:The objective compound of formula can be produced by using D,L-5-phenetylhydantoin as a substrate and hydrolyzing the substrate with a hydantoinase (EC, 3.5.2.2) or microbial cell capable of producing said enzyme. The enzyme is purified enzyme or microbial cell producing said enzyme and the use of microbial cell is convenient because of simplified reaction operation. The compound of formula can be converted into an N-substituted-L-amino acid derivative having a prescribed steric configuration by treating with a diazotizing agent and a halogenation agent under acidic condition and condensing the product with an L-amino acid derivative.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20086287A JPS6445354A (en) | 1987-08-13 | 1987-08-13 | Optical active n-carbamoyl-2-(r)-amino-4-phenylbutyric acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20086287A JPS6445354A (en) | 1987-08-13 | 1987-08-13 | Optical active n-carbamoyl-2-(r)-amino-4-phenylbutyric acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6445354A true JPS6445354A (en) | 1989-02-17 |
Family
ID=16431460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20086287A Pending JPS6445354A (en) | 1987-08-13 | 1987-08-13 | Optical active n-carbamoyl-2-(r)-amino-4-phenylbutyric acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6445354A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11670327B2 (en) | 2018-03-19 | 2023-06-06 | Kabushiki Kaisha Toshiba | Disk device with grease splash prevention |
-
1987
- 1987-08-13 JP JP20086287A patent/JPS6445354A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11670327B2 (en) | 2018-03-19 | 2023-06-06 | Kabushiki Kaisha Toshiba | Disk device with grease splash prevention |
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