JPS6426547A - Carbamate of 4-hydroxyanisole as prodrug for treating melanoma - Google Patents

Carbamate of 4-hydroxyanisole as prodrug for treating melanoma

Info

Publication number
JPS6426547A
JPS6426547A JP63156052A JP15605288A JPS6426547A JP S6426547 A JPS6426547 A JP S6426547A JP 63156052 A JP63156052 A JP 63156052A JP 15605288 A JP15605288 A JP 15605288A JP S6426547 A JPS6426547 A JP S6426547A
Authority
JP
Japan
Prior art keywords
hydroxyanisole
prodrug
carbamate
treating melanoma
melanoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63156052A
Other languages
English (en)
Inventor
Esu Saari Uorufuretsudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS6426547A publication Critical patent/JPS6426547A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP63156052A 1987-06-25 1988-06-25 Carbamate of 4-hydroxyanisole as prodrug for treating melanoma Pending JPS6426547A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/066,153 US4812590A (en) 1987-06-25 1987-06-25 Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma

Publications (1)

Publication Number Publication Date
JPS6426547A true JPS6426547A (en) 1989-01-27

Family

ID=22067589

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63156052A Pending JPS6426547A (en) 1987-06-25 1988-06-25 Carbamate of 4-hydroxyanisole as prodrug for treating melanoma

Country Status (3)

Country Link
US (1) US4812590A (ja)
EP (1) EP0296811A3 (ja)
JP (1) JPS6426547A (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017536416A (ja) * 2014-11-25 2017-12-07 コンセントリック アナルジジックス，インク． フェノール酸ｔｒｐｖ１アゴニストのプロドラッグ

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US5639737A (en) * 1991-11-04 1997-06-17 Co Enzyme Technology Ltd. Method and compositions for treating malignant tumors and inhibiting growth and metastases of malignant tumors
MX9206309A (es) * 1991-11-04 1994-05-31 David Rubin Metodo y composicion para tratar tumores que tienen alta actividad de tirosinasa.
US5760008A (en) * 1991-11-04 1998-06-02 Co Enzyme Technology Ltd. Method and compositions for treating malignant tumors and inhibiting metastases of malignant tumors
US5476842A (en) * 1991-11-04 1995-12-19 Co Enzyme Technology Ltd. Method and compositions for treating tumors having high tyrosinase activity
GB9625895D0 (en) * 1996-12-13 1997-01-29 Riley Patrick A Novel compound useful as therapeutic agents and assay reagents
DE60005017T2 (de) 1999-06-25 2004-06-09 Vertex Pharmaceuticals Inc., Cambridge Prodrugs von impdh-inhibierenden carbamaten
AU2002341792B2 (en) 2001-09-21 2007-09-06 The Administrators Of The Tulane Educational Fund Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
JP4477881B2 (ja) * 2002-03-01 2010-06-09 ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド 治療剤または細胞毒性剤と生物活性ペプチドとの抱合体
RS20050810A (en) 2003-04-29 2007-08-03 Pfizer Inc., 5,7-diaminopyrazolo(4,3-d)pyrimidines useful in the treatment of hypertension
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
WO2005097799A1 (en) 2004-04-07 2005-10-20 Pfizer Limited Pyrazolo`4,3-d! pyrimidines
WO2010082050A1 (en) 2009-01-16 2010-07-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
KR20150000464A (ko) 2011-11-03 2015-01-02 바이엘 인텔렉쳐 프로퍼티 게엠베하 펩티드의 방출가능한 연결을 위한 티로신 기재의 링커
JOP20190001B1 (ar) 2011-11-03 2022-03-14 Bayer Pharma AG عقار أولي معتمد على جليكول عديد إثيلين من أدرينومدالين واستخدامه
AP2017009826A0 (en) 2014-09-26 2017-03-31 Bayer Pharma AG Stabilized adrenomedullin derivatives and use thereof
US11634384B2 (en) 2014-11-25 2023-04-25 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
WO2017205534A1 (en) 2016-05-25 2017-11-30 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
AU2019310118A1 (en) 2018-07-27 2021-03-11 Concentric Analgesics, Inc. Pegylated prodrugs of phenolic TRPV1 agonists
CN114174326A (zh) 2019-06-18 2022-03-11 拜耳公司 长期稳定的肾上腺髓质素类似物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3131213A (en) * 1957-05-21 1964-04-28 Sterling Drug Inc 2, 6-dimethyl and 2, 6-diethylphenyl n-(aminoalkyl) carbamates and acid addition salts thereof
DE1154269B (de) * 1962-06-19 1963-09-12 Bayer Ag Verfahren zur Herstellung von Urethangruppen enthaltenden Schaumstoffen
CH441861A (de) * 1964-01-25 1967-08-15 Bayer Ag Schädlingsbekämpfungsmittel
US3647859A (en) * 1967-04-29 1972-03-07 Haruo Ogura Aminoalcohol derivatives
BE757496A (fr) * 1969-10-14 1971-03-16 Ono Pharmaceutical Co Nouveaux esters phenyles de l'acide guanidinocaproique et leur production
US4387058A (en) * 1981-10-02 1983-06-07 The Dow Chemical Company Carbamic acid derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017536416A (ja) * 2014-11-25 2017-12-07 コンセントリック アナルジジックス，インク． フェノール酸ｔｒｐｖ１アゴニストのプロドラッグ
JP2020114813A (ja) * 2014-11-25 2020-07-30 コンセントリック アナルジジックス，インク． フェノール性ｔｒｐｖ１アゴニストのプロドラッグ

Also Published As

Publication number Publication date
US4812590A (en) 1989-03-14
EP0296811A3 (en) 1990-03-21
EP0296811A2 (en) 1988-12-28

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