JPS6417649A - Preparation of antithrombogenic cellulose - Google Patents

Preparation of antithrombogenic cellulose

Info

Publication number
JPS6417649A
JPS6417649A JP62173892A JP17389287A JPS6417649A JP S6417649 A JPS6417649 A JP S6417649A JP 62173892 A JP62173892 A JP 62173892A JP 17389287 A JP17389287 A JP 17389287A JP S6417649 A JPS6417649 A JP S6417649A
Authority
JP
Japan
Prior art keywords
cellulose
heparin
water
org
base material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62173892A
Other languages
Japanese (ja)
Other versions
JP2644756B2 (en
Inventor
Masanori Sakakibara
Masatomi Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP62173892A priority Critical patent/JP2644756B2/en
Publication of JPS6417649A publication Critical patent/JPS6417649A/en
Application granted granted Critical
Publication of JP2644756B2 publication Critical patent/JP2644756B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

PURPOSE:To impart an antithrombogenic property stable for a long period of time, by activating base material composed of regenerated cellulose or a cellulose derivative with alkali and subsequently bringing the same into contact with heparin dissolved in a water-org. solvent mixture. CONSTITUTION:Alkali activation is performed by immersing a base material composed of regenerated cellulose or a cellulose in an sodium hydroxide or potassium hydroxide solution with a concn. of 1X10<-6>-50wt.% at 0-200 deg.C for 5sec-120min. A water-org. solvent mixture dissolving heparin is a water- tetrahydrofuran mixture and the concn. of heparin in this mixture is 0.01-20wt.% and the contact with heparin dissolved in the water-org. solvent mixture is performed at 0-125 deg.C for 1-2X10<4>min. By this method, cellulose is swollen on the surface region of the base material as alkali cellulose and, further, the hydrogen bond of cellulose is cut to enhance the mobility of a molecule and said cellulose becomes a state easy to take-in heparin. Therefore, antithrombogenic cellulose shows heparin gradual release property even in blood.
JP62173892A 1987-07-14 1987-07-14 Method for producing anticoagulable cellulose Expired - Fee Related JP2644756B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62173892A JP2644756B2 (en) 1987-07-14 1987-07-14 Method for producing anticoagulable cellulose

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62173892A JP2644756B2 (en) 1987-07-14 1987-07-14 Method for producing anticoagulable cellulose

Publications (2)

Publication Number Publication Date
JPS6417649A true JPS6417649A (en) 1989-01-20
JP2644756B2 JP2644756B2 (en) 1997-08-25

Family

ID=15969035

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62173892A Expired - Fee Related JP2644756B2 (en) 1987-07-14 1987-07-14 Method for producing anticoagulable cellulose

Country Status (1)

Country Link
JP (1) JP2644756B2 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526673A (en) * 2003-03-21 2006-11-24 ザ ユニバーシティ オブ アラバマ Cellulose matrix encapsulation and method
US7888412B2 (en) 2004-03-26 2011-02-15 Board Of Trustees Of The University Of Alabama Polymer dissolution and blend formation in ionic liquids
US8668807B2 (en) 2008-02-19 2014-03-11 Board Of Trustees Of The University Of Alabama Ionic liquid systems for the processing of biomass, their components and/or derivatives, and mixtures thereof
US8784691B2 (en) 2009-07-24 2014-07-22 Board Of Trustees Of The University Of Alabama Conductive composites prepared using ionic liquids
US8883193B2 (en) 2005-06-29 2014-11-11 The University Of Alabama Cellulosic biocomposites as molecular scaffolds for nano-architectures
US9096743B2 (en) 2009-06-01 2015-08-04 The Board Of Trustees Of The University Of Alabama Process for forming films, fibers, and beads from chitinous biomass
US9278134B2 (en) 2008-12-29 2016-03-08 The Board Of Trustees Of The University Of Alabama Dual functioning ionic liquids and salts thereof
US9394375B2 (en) 2011-03-25 2016-07-19 Board Of Trustees Of The University Of Alabama Compositions containing recyclable ionic liquids for use in biomass processing
US10100131B2 (en) 2014-08-27 2018-10-16 The Board Of Trustees Of The University Of Alabama Chemical pulping of chitinous biomass for chitin
US10927191B2 (en) 2017-01-06 2021-02-23 The Board Of Trustees Of The University Of Alabama Coagulation of chitin from ionic liquid solutions using kosmotropic salts
US10941258B2 (en) 2017-03-24 2021-03-09 The Board Of Trustees Of The University Of Alabama Metal particle-chitin composite materials and methods of making thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53120883A (en) * 1977-03-29 1978-10-21 Unitika Ltd Antiithrombus cellulose material
JPS59225064A (en) * 1983-06-03 1984-12-18 ユニチカ株式会社 Carrier for immobilizing physiologically active substance
JPH0334739A (en) * 1989-06-30 1991-02-14 Nippon Telegr & Teleph Corp <Ntt> Packet communication system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53120883A (en) * 1977-03-29 1978-10-21 Unitika Ltd Antiithrombus cellulose material
JPS59225064A (en) * 1983-06-03 1984-12-18 ユニチカ株式会社 Carrier for immobilizing physiologically active substance
JPH0334739A (en) * 1989-06-30 1991-02-14 Nippon Telegr & Teleph Corp <Ntt> Packet communication system

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526673A (en) * 2003-03-21 2006-11-24 ザ ユニバーシティ オブ アラバマ Cellulose matrix encapsulation and method
EP1648692A4 (en) * 2003-03-21 2009-06-10 Univ Alabama Cellulose matrix encapsulation and method
JP2011125864A (en) * 2003-03-21 2011-06-30 Univ Of Alabama Cellulose matrix encapsulation and method
US7888412B2 (en) 2004-03-26 2011-02-15 Board Of Trustees Of The University Of Alabama Polymer dissolution and blend formation in ionic liquids
US8883193B2 (en) 2005-06-29 2014-11-11 The University Of Alabama Cellulosic biocomposites as molecular scaffolds for nano-architectures
US8668807B2 (en) 2008-02-19 2014-03-11 Board Of Trustees Of The University Of Alabama Ionic liquid systems for the processing of biomass, their components and/or derivatives, and mixtures thereof
US9278134B2 (en) 2008-12-29 2016-03-08 The Board Of Trustees Of The University Of Alabama Dual functioning ionic liquids and salts thereof
US9096743B2 (en) 2009-06-01 2015-08-04 The Board Of Trustees Of The University Of Alabama Process for forming films, fibers, and beads from chitinous biomass
US8784691B2 (en) 2009-07-24 2014-07-22 Board Of Trustees Of The University Of Alabama Conductive composites prepared using ionic liquids
US9394375B2 (en) 2011-03-25 2016-07-19 Board Of Trustees Of The University Of Alabama Compositions containing recyclable ionic liquids for use in biomass processing
US10100131B2 (en) 2014-08-27 2018-10-16 The Board Of Trustees Of The University Of Alabama Chemical pulping of chitinous biomass for chitin
US10927191B2 (en) 2017-01-06 2021-02-23 The Board Of Trustees Of The University Of Alabama Coagulation of chitin from ionic liquid solutions using kosmotropic salts
US10941258B2 (en) 2017-03-24 2021-03-09 The Board Of Trustees Of The University Of Alabama Metal particle-chitin composite materials and methods of making thereof

Also Published As

Publication number Publication date
JP2644756B2 (en) 1997-08-25

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees