JPS6416776A - Novel antibiotic substance - Google Patents

Novel antibiotic substance

Info

Publication number
JPS6416776A
JPS6416776A JP17367287A JP17367287A JPS6416776A JP S6416776 A JPS6416776 A JP S6416776A JP 17367287 A JP17367287 A JP 17367287A JP 17367287 A JP17367287 A JP 17367287A JP S6416776 A JPS6416776 A JP S6416776A
Authority
JP
Japan
Prior art keywords
formula
antibiotic substance
methylenolactomycin
ferm
penicillium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17367287A
Other languages
Japanese (ja)
Other versions
JP2524760B2 (en
Inventor
Mitsuru Nakayama
Shohei Nakagawa
Tomikichi Boku
Akira Hirota
Shoji Shima
Osamu Nakanishi
Yoshihiro Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teikoku Kako Co Ltd
Original Assignee
Teikoku Kako Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Kako Co Ltd filed Critical Teikoku Kako Co Ltd
Priority to JP17367287A priority Critical patent/JP2524760B2/en
Publication of JPS6416776A publication Critical patent/JPS6416776A/en
Application granted granted Critical
Publication of JP2524760B2 publication Critical patent/JP2524760B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

NEW MATERIAL:An antibiotic substance methylenolactomycin of formula having the following physical and chemical properties. Melting point, 82.5-83.5 deg.C; specific rotation, [alpha]D<26>=-2.37 deg. (C3.0 CH3OH); molecular formula, C11H16O4; molecular weight, 212; solubility, easily soluble in methanol, acetone, ethyl acetate, ethyl ether, chloroform and benzene, insoluble in n-hexane and water; etc. USE:A medicine. It has antibacterial activity against a certain kind of bacteria, exhibits life-prolonging effect to a mouse affected with Ehrlich ascites carcinoma and has anti-tumor activity. PREPARATION:Penicillium 24-4 strain (FERM P-9437) or Penicillium 43-3 strain (FERM P-9438) is cultured in a liquid medium under shaking or under aeration and agitation for 72-216hr and the objective antibiotic substance, methylenolactomycin of formula, is separated from the cultured product.
JP17367287A 1987-07-10 1987-07-10 New antibiotics Expired - Lifetime JP2524760B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17367287A JP2524760B2 (en) 1987-07-10 1987-07-10 New antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17367287A JP2524760B2 (en) 1987-07-10 1987-07-10 New antibiotics

Publications (2)

Publication Number Publication Date
JPS6416776A true JPS6416776A (en) 1989-01-20
JP2524760B2 JP2524760B2 (en) 1996-08-14

Family

ID=15964960

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17367287A Expired - Lifetime JP2524760B2 (en) 1987-07-10 1987-07-10 New antibiotics

Country Status (1)

Country Link
JP (1) JP2524760B2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006506409A (en) * 2002-11-05 2006-02-23 マグナケム インターナショナル ラボラトリーズ， インコーポレイテッド Synthetic lactone formulations and methods and uses
US8188145B2 (en) 2002-06-12 2012-05-29 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
US8501431B2 (en) 2008-10-24 2013-08-06 Magnachem International Laboratories, Inc. Method for screening for compounds selectively interacting with RAD9
US8536348B2 (en) 2001-06-13 2013-09-17 Magnachem International Laboratories, Inc. Lactone formulations and method of use

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003248810B2 (en) * 2002-07-01 2009-08-20 Fasgen, Llc. Novel compounds, pharmaceutical compositions containing same, and methods of use for same

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8536348B2 (en) 2001-06-13 2013-09-17 Magnachem International Laboratories, Inc. Lactone formulations and method of use
US8188145B2 (en) 2002-06-12 2012-05-29 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
JP2006506409A (en) * 2002-11-05 2006-02-23 マグナケム インターナショナル ラボラトリーズ， インコーポレイテッド Synthetic lactone formulations and methods and uses
US7956088B2 (en) 2002-11-05 2011-06-07 Magnachem International Laboratories, Inc. Synthetic lactone formulations and methods of use
JP4869597B2 (en) * 2002-11-05 2012-02-08 マグナケム インターナショナル ラボラトリーズ， インコーポレイテッド Synthetic lactone formulations and methods of use
US8546444B2 (en) 2004-04-23 2013-10-01 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
US8501431B2 (en) 2008-10-24 2013-08-06 Magnachem International Laboratories, Inc. Method for screening for compounds selectively interacting with RAD9

Also Published As

Publication number Publication date
JP2524760B2 (en) 1996-08-14

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