JPS638323A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:A composition for oral cavity preventing reduction in flavor resulting from permeation or release of spice through a plastic container in preservation, obtained by blending a spice-containing composition for oral cavity packed in a plastic contain with a specific aliphatic alcohol. CONSTITUTION:A spice-containing composition for oral cavity packed in a container made of a plastic especially having >=1ml/100inch<2>.24hr.atm coefficient of oxygen permeability measured by film with 1 mil thickness at room temperature is blended with 0.1-10wt% based on the total amount of the composition of 18-28C higher aliphatic alcohol liquid at normal temperature, especially containing a branched structure or at least one unsaturated bond to prevent the spice from permeating the container, to keep the spice of the composition stably for a long period, to enlarge the width of spice selection and to provide the composition with desired spice.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to an oral composition filled in a plastic container. The present invention relates to an oral cavity composition filled in a plastic container that is prevented from permeating through the plastic container and escaping during storage, and thus retaining its flavor well over a long period of time.

In recent years, containers for oral compositions have diversified due to marketing demands, and oral compositions filled in plastic pump containers and blow tubes have become commercially available. has been made into

However, such plastic containers, especially those with an oxygen permeability coefficient of 1 mN/100 inch2・24 hr・
Containers made of plastic with a thickness of atm or higher (1 mil (thickness), room temperature) have a lower cost than containers made of metal such as aluminum, or containers made from a laminate film made by laminating a metal foil such as aluminum onto a plastic film. 1. Flavoring agents blended into oral compositions tend to permeate and escape, and as a result, oral compositions filled in plastic containers tend to lose their flavor upon storage.

To address this problem, conventionally, fragrances with low volatility such as cinnamic aldehyde, cineole,
Oral compositions are flavored mainly with methyl salicylate, but the flavor stability is still insufficient, and it is not possible to stably use highly volatile flavoring materials, so it is difficult to create perfumes. The disadvantage is that the degree of freedom is reduced and the flavor becomes monotonous. On the other hand, the technology to improve plastic containers to prevent fragrance from permeating them is rarely put to practical use because it is technically unsound, increases the cost of the container, and is not sufficiently effective. has not been standardized. For example, plastics with low oxygen permeability (fragrance permeation) include hydrophilic liver fat such as Poval and its copolymers (
, it easily deteriorates due to moisture and cannot be used in a single layer. There are multilayer blow tubes that use polyethylene on both sides of these hydrophilic resins, but they have not been put to practical use in pump containers because they are extremely expensive.

Therefore, there has been a demand for the development of a technique that more reliably retains the flavor of oral compositions filled in plastic containers over a long period of time.

The present invention has been made in view of the above circumstances, and is a method of filling plastic containers that reliably prevents fragrance from permeating and escaping even when the plastic container is filled for a long period of time, thereby stably retaining the flavor. The object is to provide an oral composition.

In order to achieve the above object, the present inventors conducted various studies from the viewpoint of the composition to improve the stability of the flavor of an oral composition filled in a plastic container. As a result, when a higher aliphatic alcohol with a carbon number of 16 to 28 and liquid at room temperature (20°C) is blended into an oral composition, it is relatively easy to permeate through a plastic container as a fragrance blended into the oral composition. The oxygen permeability coefficient is 1 ml/1001nch2 when measured at room temperature using a mint fragrance and a film thickness of 1 mil (ml) that allows these fragrances to easily pass through.
・Even if a container made of plastic with a rating of 24 hr-atm or more is used and an oral composition flavored with this fragrance is filled into the plastic container and stored at high temperature for a long period of time, the plastic with mint fragrance will not be present. It was discovered that permeation through the manufactured container was suppressed and the flavor was stably maintained.

That is, it has been known to incorporate lauryl alcohol, myristyl alcohol, stearyl alcohol, etc., which are solid at room temperature, into oral compositions as higher aliphatic alcohols (Japanese Unexamined Patent Publication No. 101418/1983).

Although these alcohols do not have the effect of suppressing the permeation of fragrances through plastic containers,
It was discovered that a higher aliphatic alcohol of No. 28, which is liquid at room temperature, surprisingly has an excellent effect of suppressing the permeation of fragrances through plastics. Furthermore, this higher aliphatic alcohol, which is liquid at room temperature, has the effect of preventing fragrance from permeating through the plastic container and stably retaining the flavor, and this type of higher aliphatic alcohol is tasteless and odorless. For this reason, when incorporated into oral compositions, it does not impair flavor and does not cause any problems in terms of usability, and when incorporated into oral compositions such as toothpaste, it is difficult to be hydrolyzed and is stable. Furthermore, it does not affect other ingredients, and fluoride and other active ingredients can be incorporated without any problem, and therefore, the higher aliphatic alcohol is highly effective as an ingredient of oral compositions. This is the heading that led to the present invention.

Therefore, the present invention provides a composition for oral cavity, characterized in that a higher aliphatic alcohol having a carbon number of 16 to 28 and which is liquid at room temperature is blended into an oral composition containing a fragrance filled in a plastic container. A composition is provided.

The present applicant has previously proposed a fragrance-containing composition characterized by containing a higher aliphatic alcohol having 16 to 28 carbon atoms and which is liquid at room temperature as a fragrance retention agent (Japanese Patent Application No. It is a new finding of the present inventors that the higher aliphatic alcohol (No. 276,632) prevents perfume from permeating through a plastic container.

The present invention will be explained in more detail below.

The oral composition of the present invention can be prepared as a dentifrice composition such as a toothpaste, a mouthwash, a cream-like oral medicine, etc.
It contains a higher aliphatic alcohol that is liquid at 20°C.

Here, the above-mentioned alcohols include oleyl alcohol, eicosenol, tocosenol, octadecenol,
Tetracosenol, 2-hexyldecanol, 2-octyldodecanol, 5,7゜7-drimethyl-2-(
1,3,3-trimethylbutyl)-1-octatool,
Examples of instearyl alcohol and mixtures thereof include jojoba alcohol, and those having at least one unsaturated bond and/or having a branched structure are preferably used.

Note that these alcohols may be used alone or in combination of two or more.

The amount of the higher aliphatic alcohol blended above is not particularly limited, but it is preferably 0.1 to 10% (by weight, the same hereinafter), particularly 0.5 to 5% of the total composition. . If the amount of alcohol used is too small, the effect of suppressing the permeation of the fragrance into the plastic container will not be sufficiently exhibited, and if it is too large, the oral composition may not be fragrant or foamy, and may become oily. A situation may arise.

The oral composition of the present invention contains a fragrance, and according to the present invention, the above-mentioned higher aliphatic alcohol is blended to prevent the fragrance from permeating through the plastic container, so various fragrances can be used without any problem. Yes, there are no particular restrictions on the type of fragrance. For example, wintergreen type, which has low volatility and is relatively impermeable even when used in plastic containers,
Accent type fragrances such as cassia type may be used (
In addition, according to the present invention, in addition to more reliably suppressing the permeation of such fragrances through plastic containers, it is also possible to suppress mint-type fragrances such as peppermint and spearmint, which have high permeability through plastic containers and are easily susceptible to changes in flavor. It is effectively used because it reliably prevents permeation through the plastic container.

In addition, the amount of fragrance blended is 0.01 to 10% of the entire composition,
In particular, it is preferably 0.1 to 3%.

The oral composition of the present invention may contain commonly used components depending on the type thereof.

For example, in the case of toothpaste, dibasic calcium phosphate,
Calcium carbonate, calcium birophosphate.

Insoluble sodium metaphosphate, silicates (amorphous silicic anhydride, crystalline silicic anhydride, aluminosilicate, zirconosilicate, etc.), aluminum oxide, aluminum hydroxide, abrasives such as resins, sodium carboxymethyl cellulose, hydroxyethyl cellulose , alginate, carrageenan.

Gum arabic, polyvinyl alcohol, thickening silicone! Binder such as salt, polyethylene glycol, sorbitol,
Thickening agents such as glycerin and propylene glycol, sodium lauryl sulfate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate,
Surfactants such as sodium lauroyl sarcosinate, N-acyl glutamate, lauryl jetanolamide, sucrose fatty acid ester, saccharin sodium, stevioside, neohesberidyl dihydrochalcone, glycyrrhizin, perillartin.

Components such as sweeteners such as p-methoxycinnamic aldehyde, preservatives, and pigments can be blended. Also,
In oral-vaginal cleansing agents such as mouthwashes and other products, ingredients are appropriately blended according to the properties of the product. In addition, since the above-mentioned allure has the effect of improving the astringency and powderiness of silicates, silicates can be used effectively.

Additionally, for oral compositions, chlorhexidine salts.

Dextranase, mutanase, sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkyldiaminoethylglycine salt, allantoin, ε-aminocaproic acid, I-ranexamic acid, azulene, vitamin E, water-soluble primary or secondary Active ingredients such as diphosphates, quaternary ammonium compounds, and sodium chloride can also be blended. Further, fluorides such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride can also be blended without being affected by the blending of the higher aliphatic alcohols.

The oral composition of the present invention is filled into a plastic container, and in this case, there are no restrictions on the type of plastic that can be used to form the container, and various types of plastic can be used.
In particular, polyolefins such as polyethylene and polypropylene, which have relatively high perfume permeability, and rubbers can also be effectively used. That is, the following plastics can be used to form the container.

Oxygen permeability coefficient (+nQ/100inch2・24hr
tm) Polypropylene 120
~200 High density polyethylene 12
0-200 low density polyethylene 3
o○~500 polystyrene
400-450 polymethyl methacrylate
7bori1111:v vinyl
56~6゜Polyethylene terephthalate
3.5-5 poval (polyvinyl alcohol)
ku0.01 cellophane 0
．． 13 Polyvinylidene chloride 0.0
5~16-6 nylon 3.0
6-10 Nylon 5-5.5 Ethylene-vinyl acetate copolymer >1500 2 bar (ethylene-poval copolymer) <0.005 Vinyl chloride-vinyl acetate copolymer >20 Butyl rubber) 1500 Butadiene rubber 3000-4000 Silicone rubber 13000-150
00 natural rubber 450
0-5oOO Here, the oxygen permeability coefficient is a value measured at room temperature with a film thickness of 1 mil. Among these, those with an oxygen permeability coefficient of 1 or more are easily permeable to fragrances, but according to the present invention, those with an oxygen permeability coefficient of 1 or more can also be used effectively. be.

Note that the container may be constructed from a single layer of these plastics, or may be a multilayer structure made by suitably combining one or more of these plastics. In this case, the form of the plastic container is not limited, and examples thereof include blow tubes, pump type containers, and the like. More specifically, the plastic blow tube can be made of polyethylene, polypropylene, etc., and its thickness can usually be 300 to 400 μm. In addition, for plastic pump type containers, the body is made of polypropylene (thickness 1 to 1.5 mm +), the inner plate is made of polyethylene (thickness 0.5 to 1.5 mm), and the head is made of polypropylene or polyethylene if it is a piston type. , Polyethylene, ethylene-vinyl acetate copolymer in the case of a method in which the head is compressed and deformed to discharge.

Made of polyethylene terephthalate elastomer with a thickness of 0.
It can be formed to a length of 5 to 1.5 m.

Effects of the Invention According to the present invention, by incorporating a higher aliphatic alcohol having a carbon number of 16 to 28 and which is liquid at room temperature, the fragrance is prevented from permeating the plastic container, so that the composition for oral cavity can be improved. The flavor is stably maintained over a long period of time, and various flavoring agents can be used without any problems, so there is a wide range of flavoring agents to choose from, and the oral composition can be flavored with a desired flavor.

EXAMPLES Hereinafter, the present invention will be specifically explained by showing examples and comparative examples, but the present invention is not limited to the following examples.

[Examples 1 to 5. Comparative Examples 1 and 2] A toothpaste with the formulation shown in Table 1 was prepared and flavored with a sparemino 1-type fragrance whose flavor is relatively easy to change. ) or blow tube (polyethylene Z.

It was filled to a thickness of 300 μm).

After storing this at 40℃ for 1 month, its flavor was compared to the standard product (
(immediately after preparation), and its stability was determined according to the following evaluation criteria. The results are also listed in Table 1.

Review Ju group 5 points: No difference observed compared to standard product.

4 points: A slight difference is recognized.

3 points: A relatively significant difference is recognized.

2 points: There is a considerable difference.

1 point: A very significant difference is recognized.

From the results in Table 1, it is clear that the toothpaste that does not contain higher aliphatic alcohols that are liquid at room temperature and has 16 to 28 carbon atoms is 40
When stored for 1 month at ℃, spearmint flavor permeates the plastic container and the flavor deteriorates significantly, but by incorporating the higher aliphatic alcohol, the spearmint flavor permeates through the plastic container. It was observed that the flavor was suppressed and the flavor was retained well.

[Example 6] Toothpaste silicic anhydride 20.0%
Sodium carboxymethyl cellulose 1.2 Propylene glycol 3.0 Glycerin 20.0 Sodium saccharin 0.1 Sodium lauryl sulfate 1.2 Chlorhexidine hydrochloride 0.005 Paraben 0.05 Peppermint fragrance
0.9 oleyl alcohol
5.0100.0% [Example 7] Toothpaste zirconosilicate 25.0
%carboxymethylcellulose sodium 1.0
Polyethylene glycol 400 4.0 Sorbit 30.0 Saccharin sodium 0.1 Sodium lauryl sulfate 1.2 Sodium monofluorophosphate 0.76 Paraben 0.02 Spearmint fragrance 1.0 Jojoba alcohol
3.0 water
Remaining 100.0% [Example 8] Toothpaste aluminosilicate 20.0
%carboxymethylcellulose sodium 1.0
Polyethylene glycol 400 3.0 Sorbit 25.0 Titanium dioxide
1.0 Saccharanna 1 Helium
0.12 Sodium lauryl sulfate 1.5 Paraben
0.01 Wintergreen fragrance 1.0 Eicosenol 1.0 Jojoba alcohol 1.0 Water
100 left.
0% [Example 9] Toothpaste silicic anhydride 30.0% Sodium carboxymethyl cellulose 1.1 Propylene glycol 3.0 Sorbit
25.0 Sacchulin Sodium
0.1 Sodium lauryl sulfate
1.3 Lauric acid diethanolamide
0.4 monofluorophosphate
0.8 titanium dioxide
0.5 spearmint fragrance
0.9 stearyl alcohol 2
．． 0 water
~100.0% [Example 10] Toothpaste aluminum hydroxide 40.0%
Carboxymethyl cellulose sodium 0.8 Carrageenan 0.3 Propylene glycol 3.0 Glycerin 10.0 Sorbit
15.0 Saccharin Sodium
1.1 Sodium lauryl sulfate 1.3 Paraben 0.
02 Cassia fragrance 1.0 Tocosenol 0.5 Water 100.0% [Example 11] Toothpaste dicalcium phosphate 45.0
% carboxymethyl cellulose sodium 0.8
Carrageenan 0.2 Propylene glycol 3.0 Sorbit 20.0 Saccharin sodium 0.2 Sodium lauryl sulfate 1.6 Tranexamic acid
0.1 paraben
0.2 Peppermint fragrance 1.0 Jojoba alcohol 1.0 Oleyl alcohol 1.0 Water
100.0 remaining
% The toothpastes of Examples 6 to 9 were filled into polypropylene pump type containers (body thickness: 1.3 nwn). In addition, the toothpastes of Examples 7 to 11 were made of polyethylene (thickness: 300 μm)
filled into a blow tube.

The toothpastes of Examples 6 to 11 maintained good flavor even when stored at 40° C. for one month.

Claims (1)

[Claims] 1. A higher aliphatic alcohol having a carbon number of 16 to 28 and liquid at room temperature is blended into an oral composition containing a fragrance filled in a plastic container. Oral composition. 2. The composition according to claim 1, wherein the higher aliphatic alcohol has a branched structure. 3. The composition according to claim 1, wherein the higher aliphatic alcohol has at least one unsaturated bond. 4. The amount of higher aliphatic alcohol contained in the entire composition is 0.
A composition according to any one of claims 1 to 3, wherein the content is 1 to 10% by weight. 5. The plastic container has a film thickness of 1 mil and an oxygen permeability coefficient of 1 ml/100 in when measured at room temperature.
The composition according to any one of claims 1 to 4, which is made of a plastic having a capacity of 2.24 hr.atm or more.