JPS6377806A - Denture stabilizer - Google Patents

Abstract

PURPOSE:To obtain a denture stabilizer in a uniform ointment state, withstanding long-period preservation, by kneading sodium polyacrylate with soybean lecithin blended with edible fats and oils such as soybean oil, etc. CONSTITUTION:Sodium polyacrylate is kneaded with 35-60wt% based on the sodium polyacrylate of pasty soybean lecithin and packed into a proper tube to give a denture stabilizer in an ointment state. The pasty soybean lecithin is soybean lecithin which is mixed with 25-35wt% soybean oil into a pasty state and used for food processing. The denture stabilizer is yellow paste which is tasteless, has slightly a soybean-like smell, is hygienically harmless and shows no tendency of separation into dust and soybean lecithin as a base at all even if the denture stabilizer is subjected to a test wherein the stabilizer is exposed to low temperature and room temperature at intervals of 2hr ten times, respectively.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to ointments or denture adhesives for use in fixing dentures, and relates to the manufacture thereof.

Conventional dentures generally adhere closely to the mucous membranes of the palate, floor of the mouth, and alveolar arch (commonly known as the "dote") immediately after they are made, and are difficult to swallow when chewing food.
The purpose of use can be fulfilled without detachment. However, as the years pass, the palate, floor of the mouth,
As natural deformation of the alveolar arch occurs, a gap is created between the mucous membrane and the adhesive surface of the denture base, allowing food particles to enter, causing a foreign body sensation and pain. Such ill-fitting dentures can be restored by adjustment by the dentist, but in many cases patients neglect to request frequent adjustments, so the ill-fitting dentures gradually become unfit. The dentures become enlarged, and the dentures tend to fall off constantly, leading to problems with speech. Denture adhesives are used as a treatment to relieve such inconveniences.

(Alginic acid is used as a denture stabilizer) A method of mixing powdered adhesives such as IJum, carboxymethylcellulose, methylcellulose, gelatin, gum tragacanth, gum arabic, etc. and spraying it on the surface of the mucous membrane contact area of the denture, and powders of these adhesives. There is a method in which an ointment prepared by kneading the denture with a suitable ointment base is applied to the mucosal contact surface of the denture. In either case, the glue, which is the main ingredient, sticks to mucous membranes moistened with saliva, thereby fixing the denture in place.

In addition to the above-mentioned adhesives, sodium polyacrylate is known as a main component of denture fixatives (Japanese Unexamined Patent Publication No. 55-3
No. 8143). This substance has extremely strong adhesion to moist mucous membranes and remains sticky for a long time, so when this substance is used as a powder, it can serve as an excellent denture stabilizer.

Problems to be Solved by the Invention However, it has been extremely difficult to formulate sodium polyacrylate into an ointment and obtain a high quality ointment-like denture stabilizer. That is, powder of sodium polyacrylate is prepared by mixing it with vegetable oils, which are common ointment bases, mono- or di-esters of glycerin and fatty acids, which are synthetic oils, or glycols, such as glycerin and propylene glycol. When mixed together, it temporarily takes on a homogeneous ointment state, but the base and powder tend to separate over time. For this reason, if a kneaded preparation is filled into an ointment tube, the powder particles will aggregate, making it difficult to extrude from the tube, making it impossible to obtain a homogeneous denture stabilizer that can be stored for a long period of time. For example, when using synthetic oils and fats that are paste-like at room temperature such as glyceryl monooleate (Glyceryl Monooleate M G O manufactured by Nikko Chemical Co., Ltd.) and kneading it with sodium polyacrylate powder, the weight ratio will vary. After 24 hours of kneading, there is a clear tendency for the base material to separate from the powder, and extrusion from the tube becomes difficult due to agglomeration of the powder. This indicates that sodium polyacrylate has no interfacial affinity with this type of base. Therefore, even if a paste base prepared by adding beeswax having a relatively high melting point to liquid oil and fat is kneaded with sodium polyacrylate, the essential tendency of separation cannot be prevented for a long period of time. Said Japanese Unexamined Patent Publication No. 5
5-38143 Publication Example 5 (polyacrylic acid)
A method for producing an ointment containing IJum is described, and as described, 50 parts of a powdery substance consisting of 40 parts of sodium polyacrylate and 10 parts of sodium alginate are mixed into 4
It was impossible to obtain a product that was ointment-like at room temperature by kneading with 0 parts of beeswax and 10 parts of glycerin fatty acid ester. That is, in this product, 40 parts are honey plants, and the remaining 60 parts, most of which are 50 parts (83%), are powder, so this product is a hard spiral material at a moderate temperature.

Powder-like and ointment-like forms of denture adhesive each have their own characteristics, and it is not possible to definitively determine which is better. That is, in general, powdered denture stabilizers exhibit strong denture fixing power with a small amount, and can be used not only for complete denture bases but also for fixing partial dentures. For powdered fixatives containing gelatin powder, sufficient care must be taken to prevent moisture absorption. Ointment-like denture adhesives have slightly lower adhesive strength than the former, and their use is generally convenient only for complete dentures.

Powder-like and ointment-like denture adhesives are used depending on the structure of the denture, its fit, and the preference of the wearer. Recently, powdered denture stabilizers containing sodium polyacrylate as the main ingredient have come into practical use due to their excellent adhesive fixing power, but as ointments have the aforementioned drawbacks, ointment-like products have not yet been put into practical use. It has not yet been achieved. As a result of research into making an ointment from sodium polyacrylate, the present inventor discovered a method for producing a homogeneous ointment that can be stored for a long period of time.

Means for Solving the Problem The reason why powder particles of sodium polyacrylate tend to separate from the base material consisting of oils, fats, and glycols as described above was thought to be due to the interfacial properties unique to this material. It was necessary to search for substances that have a special affinity with powder particles of substances.

However, since denture adhesives are inevitably consumed along with saliva, food and drink, they need to be harmless to the human body, and it is clear that they are desirably non-irritating, odorless, and tasteless. It is. As a result of various studies under these severe constraints, the present inventors have found that soybean lecithin, a natural phospholipid, is most suitable for this purpose, and have completed the present invention. Natural phospholipids can also be obtained from egg yolks and animal organs, but soy lecithin extracted from soybeans is usually mixed with 25-35% soybean oil and supplied for industrial use (for food processing) in the form of candy. It has been found that this soybean lecithin is extremely well suited for the purposes of the present invention. When using solid lecithin that is not mixed with soybean oil, it is sufficient to add edible fats and oils such as soybean oil in advance and use it in the form of a candy or paste. Aspects of the present invention are as follows.

If you add 35 to 60% by weight of candy-like soy lecithin to the weight of sodium polyacrylate, which is usually commercially available as a food additive, and mix it, fill it into an appropriately sized tube, you can create a complete denture. A stabilizer is obtained that is compatible with fixation.

The thus obtained denture adhesive was heated to -5°C to -7°C every 2 hours.
Even when we conducted a test in which the powder was exposed to a cold temperature of 10°C and a room temperature of 23°C to 26°C 10 times each, there was no tendency for the powder to separate from the base soybean lecithin, indicating that a homogeneous mixed phase remained for a long time. It has been shown that they have the ability to maintain This denture adhesive is a tasteless yellow paste with a slight soybean oil-like odor, and is harmless from a sanitary standpoint. Next, embodiments of the present invention will be described.

Example 1 Sodium polyacrylate with a molecular weight of about 8 million 200
200g of mesh passing powder (Nippon Kayaku Co., Ltd.) and 240g of soybean lecithin (food additive compliant product mixed with soybean oil)
Add and mix evenly. This kneaded product was filled into a metal tube containing 20 g.

Push this out from the tip of the tube and attach a small amount to the mucosal adhesive surface of the alveolar arch of the complete denture base in several places. When you insert it into your mouth and bite down, the denture adhesive absorbs surrounding moisture and sticks to the mucosal surface. However, the dentures did not move during meals.

The liquid solution can be easily washed off with running water from the denture base surface if necessary. The amount of the present denture stabilizer to be used is not fixed depending on the degree of compatibility of the denture base with the oral mucosa, and denture wearers can easily find the appropriate amount through experience.

Effects of the Invention The previously known sodium polyacrylate is excellent in having strong adhesion to moist mucous membranes and long adhesion duration, and the soybean according to the present invention can be used as a suitable cartilage base for applying it to an ointment. Based on the heavy use of soybean lecithin mixed with lecithin or edible fats and oils (e.g. soybean oil), a sodium polyacrylate-containing denture stabilizer is commercialized in the form of an ointment, thus creating a denture stabilizer adhesive that is different from conventional powdered products. I developed the usage side and asked 1 question.

Procedural amendment 62, 2.25 Date: 1945 Hito, Commissioner of the Patent Office, Kuro 1) Mr. Akio-21, Indication of the case: Patent Application No. 220217, filed in 1988 2, Title of the invention: Denture stabilizer 3 , Relationship to the case of the person making the amendment Applicant name Showa Yakuhin Kako Co., Ltd. 4, Agent 7 Contents of amendment (1) The following sentence is added after line 20 on page 8 of the specification.

Example 2 4 parts of olive oil was added to 6 parts of light brown waxy soybean lecithin obtained as a by-product in the soybean oil refining process, and the mixture was stirred and kneaded uniformly while heating to 50-55°C under a nitrogen stream. After cooling, add 6 parts of sodium polyacrylate powder passed through a 150-mesh sieve with an average molecular weight of about 8 million to 4 parts of the olive oil-added cytin obtained and knead it uniformly. This product was used as a denture stabilizer in the same manner as in Example 1, and good results were obtained in the same manner as in Example 1.

Example 3 4 parts of peanut oil was added to 6 parts of waxy soybean lecithin, and the following procedure was carried out in the same manner as in Example 2 to prepare a cheese 5 made by filling 20 g of a mixture of peanut oil pre-lecithin and sodium polyacrylate. - Obtained a denture adhesive. A practical test was conducted on this product in the same manner as in Example 1, and as a result, usage results equivalent to those in Example 1 were obtained.

Example 4 3 parts of soybean oil was added to 7 parts of soybean lecithin with an iodine value of 950, and the mixture was mixed uniformly, and then hydrogenated by a known technology for hydrogenating fats and oils. In this way, a wax-like hydrogenated product having an iodine value of 41 and being soft at room temperature was obtained. Add an equal amount of soybean oil to this mixture and knead it uniformly, then add an equal amount of sodium polyacrylate (of the same quality as used in the previous example) to this total amount and knead until it becomes homogeneous. This kneaded product can be filled into a metal tube, and a practical test similar to that in Example 1 gave results that satisfied the purpose of the present invention. (2) "Metshu" on page 8, line 12 of the same book is corrected to "metsushu sieve."

Claims (2)

[Claims] (1) A denture stabilizer made by kneading sodium polyacrylate and soybean lecithin mixed with edible oil and fat. (2) Claim No. (1) in which the edible oil is soybean oil
Denture adhesive as described in Section 1.