JP2016179957A - Denture stabilizer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a denture stabilizer which can suppress reduction in adhesion even when receiving repeated load.SOLUTION: A denture stabilizer comprises liquid oil comprising triglyceride and biological wax.SELECTED DRAWING: None

Description

  The present invention relates to a denture stabilizer used by being filled between the oral mucosa and a denture base of a denture, for example.

  Conventionally, as this type of denture stabilizer, for example, a denture stabilizer containing liquid paraffin, white petrolatum, a cellulose derivative, and a methoxyethylene maleic anhydride copolymer salt is known (Patent Document 1). .

  The denture stabilizer described in Patent Document 1 adheres closely to the denture base and the oral mucosa so as to fill the gap between the denture base and the oral mucosa, for example, in order to stabilize the position of the denture mounted in the oral cavity. Used.

  However, the denture stabilizer described in Patent Document 1 has a problem that the adhesive strength tends to decrease when it is repeatedly loaded by mastication.

JP 2003-093412 A

  This invention makes it a subject to provide the denture stabilizer which can suppress that adhesive force falls even if it receives a repeated load.

  The denture stabilizer according to the present invention includes a liquid oil containing triglyceride and a biological wax. Such a denture stabilizer can sufficiently suppress a decrease in adhesive strength even when subjected to repeated loads.

  In the above denture stabilizer, the liquid oil is preferably olive oil. When the liquid oil is olive oil, there is an advantage that the safety of the denture stabilizer for the human body becomes better.

  In the above denture stabilizer, the biological wax is preferably beeswax. When the biological wax is beeswax, there is an advantage that the safety of the denture stabilizer for the human body becomes better.

  It is preferable that said denture stabilizer further contains a carboxymethylcellulose salt. When the denture stabilizer further contains a carboxymethylcellulose salt, there is an advantage that the feeling of use of the denture stabilizer to the oral mucosa becomes better.

  It is preferable that said denture stabilizer further contains at least one of water and a polyhydric alcohol. When the denture stabilizer further contains at least one of water and polyhydric alcohol, there is an advantage that the feeling of use of the denture stabilizer to the oral mucosa becomes better.

  The denture stabilizer of the present invention has an effect that it is possible to suppress a decrease in adhesive force even when subjected to repeated loads.

Schematic showing the test equipment for a repeated load test. The graph showing the adhesive force of each Example. The graph showing the adhesive force of each Example. The graph showing the adhesive force of a product and each Example. The graph showing the adhesive force after the repeated load of each Example. The graph showing the adhesive force after the repeated load of each Example. The graph showing the adhesive force after the repeated load of each Example. The graph showing the adhesive force of each Example. A graph showing the adhesive strength of a product. The graph showing the adhesive force after the repeated load of each Example. The graph showing the adhesive force after the repeated load of each Example. The graph showing the adhesive force after the repeated load of each Example. The graph showing the adhesive force of each Example. The graph showing the adhesive force of each Example.

  Below, one Embodiment of the denture stabilizer which concerns on this invention is described.

  The denture stabilizer of this embodiment contains at least a liquid oil containing triglycerides and a biological wax. It is preferable that the denture stabilizer of this embodiment further contains carboxymethylcellulose salt and at least one of water and a polyhydric alcohol.

  The denture stabilizer of this embodiment is usually a viscous body. The denture stabilizer of the present embodiment is configured to be deformed by applying an external force at room temperature, for example, and to keep its shape unless an external force is applied.

  The denture stabilizer becomes easier to deform as the temperature increases. The denture stabilizer is configured to adhere to both the oral mucosa and the denture base of the denture while maintaining its shape at 35 to 37 ° C. near the body temperature in the oral cavity.

  The liquid oil flows out of the beaker within 5 seconds when the beaker is tilted 90 degrees at 20 ° C. from a state where 50 mL is contained in a 100 mL beaker.

  Examples of the liquid oil include vegetable oil and synthetic oil.

Examples of the vegetable oil include olive oil, palm oil, soybean oil, rapeseed oil, sunflower oil, palm kernel oil, cottonseed oil, peanut oil, coconut oil, corn oil, sesame oil, castor oil, flaxseed oil, macadamia nut oil, jojoba seed oil, avocado Oil, apricot oil, kukui nut oil, grape seed oil, safflower oil, sweet almond oil, corn germ oil, hazelnut oil, meadowweed oil, rosehip oil, cranbear vicinica oil, and the like.
Examples of the synthetic oil include tri-2-ethylhexanoic acid glyceride.

  As the liquid oil, olive oil is preferable in that the safety of the denture stabilizer for the human body becomes better. Olive oil is a liquid oil obtained from olive fruit.

  The liquid oil preferably contains at least 80% by mass of triglyceride. The liquid oil contains, for example, fatty acid, glycerin and the like in addition to triglyceride.

  The triglyceride is a compound in which three fatty acids are ester-bonded to one glycerin.

  The fatty acid residue constituting the triglyceride is usually a carboxylic acid residue having 8 to 20 carbon atoms. Examples of fatty acid residues include saturated fatty acid residues and unsaturated fatty acid residues.

Examples of the saturated fatty acid residue include caprylic acid residue, capric acid residue, lauric acid residue, myristic acid residue, palmitic acid residue, stearic acid residue and the like.
Examples of the unsaturated fatty acid residue include oleic acid residue, linoleic acid residue, linolenic acid residue and the like.

  The triglyceride is preferably a triglyceride formed by binding at least one unsaturated fatty acid to glycerin, and more preferably a triglyceride formed by binding at least one oleic acid to glycerin. When the triglyceride is a triglyceride formed by binding at least one unsaturated fatty acid to glycerin, there is an advantage that the fluidity of the liquid oil can be more reliably maintained.

  As said liquid oil, what is marketed can be used, for example.

  The denture stabilizer of this embodiment preferably contains liquid oil in an amount of 25% by mass to 80% by mass, more preferably 30% by mass to 70% by mass, and more preferably 35% by mass to 50% by mass. Further preferred. By including 25 mass% or more of liquid oil, there exists an advantage that it becomes harder to feel pain when the denture stabilizer is peeled from the oral mucosa. By including 80 mass% or less of liquid oil, there is an advantage that the shape retention of the denture stabilizer and the adhesion to the oral mucosa become more sufficient.

  It is preferable that the denture stabilizer of this embodiment contains only olive oil as liquid oil. That is, the liquid oil is preferably only olive oil.

  The biological wax is a wax produced by a living organism. The biological wax is a solid that does not flow at 20 ° C. Examples of the organism include animals such as insects or plants.

  The biological wax contains at least an ester compound of a higher fatty acid and a monovalent or divalent higher alcohol. Examples of such an ester compound include myricyl palmitate, myricyl cellotate, and the like.

  Examples of the biological wax include animal waxes and vegetable waxes. Examples of the animal wax include beeswax. Examples of the vegetable wax include carnauba wax, candelilla wax, owl (owl), rice wax (rice bran wax), and the like.

  As the biological wax, beeswax is preferable in terms of improving the safety of the denture stabilizer for the human body, and white beeswax obtained by bleaching beeswax is more preferable. Beeswax is obtained from the wax component that is secreted from the bee's wax gland and attached to the beehive.

  As said biological origin wax, what is marketed can be used, for example.

  The denture stabilizer of this embodiment preferably contains 10% by mass or more and 50% by mass or less of biological wax, and more preferably contains 15% by mass or more and 30% by mass or less. By containing 10% by mass or more of the biological wax, there is an advantage that the denture stabilizer has sufficient shape retention and adhesion to the oral mucosa, and by containing 50% by mass or less of the biological wax, When the denture stabilizer is peeled off from the oral mucosa, there is an advantage that it is less likely to feel pain.

  The denture stabilizer of this embodiment preferably contains only beeswax as a biological wax. That is, the biological wax is preferably only beeswax.

  In the denture stabilizer of this embodiment, the mass ratio of liquid oil to biological wax is preferably liquid oil: biological wax = 1: 1 to 3: 1, and 1.5: 1 to 2.5. : 1 is more preferable. When the denture stabilizer is peeled from the oral mucosa, the liquid oil: biological wax = 1: 1 to 3: 1 makes it more difficult to feel pain, and the denture stabilizer retains its shape and the oral mucosa. There is an advantage that the adhesiveness to is more sufficient. In addition, there is an advantage that it is possible to more sufficiently suppress a decrease in adhesive strength even when a load is repeatedly applied by chewing or the like. In addition, in the denture stabilizer of this embodiment, the mass of liquid oil is usually larger than the mass of biological wax.

  The denture stabilizer of this embodiment can further improve the feeling of use of the denture stabilizer to the oral mucosa by further containing a carboxymethylcellulose salt.

  Examples of the carboxymethyl cellulose salt include sodium salt, potassium salt, ammonium salt and the like. As the carboxymethyl cellulose salt, carboxymethyl cellulose sodium salt is preferable. In addition, as carboxymethylcellulose salt, what is marketed can be used.

  The denture stabilizer of this embodiment preferably contains 1% by mass or more and 20% by mass or less of carboxymethyl cellulose salt, and more preferably contains 10% by mass or more and 20% by mass or less. By containing 1% by mass or more and 20% by mass or less of carboxymethyl cellulose salt, the feeling of use of the denture stabilizer to the oral mucosa can be improved.

  In the denture stabilizer of this embodiment, the mass ratio of liquid oil to carboxymethylcellulose salt is preferably liquid oil: carboxymethylcellulose salt = 1: 1 to 80: 1, and preferably 2: 1 to 3: 1. It is more preferable. When the denture stabilizer is peeled from the oral mucosa, the liquid oil: carboxymethyl cellulose salt is 1: 1 to 80: 1, and pain is less felt, and the shape retention of the denture stabilizer and the oral mucosa There is an advantage that the adhesiveness to is more sufficient.

  In the denture stabilizer of the present embodiment, the mass ratio of the biological wax to the carboxymethylcellulose salt is preferably biological wax: carboxymethylcellulose salt = 1: 1 to 40: 1, and 1.0: 1 to 1. More preferably, it is 5: 1. When the denture stabilizer is peeled from the oral mucosa, the biological wax: carboxymethyl cellulose salt = 1: 1 to 40: 1 makes it more difficult to feel pain, and the shape retention of the denture stabilizer and the oral cavity There is an advantage that adhesion to the mucous membrane becomes more sufficient.

  The denture stabilizer of this embodiment can further improve the feeling of use of the denture stabilizer to the oral mucosa by further including at least one of water and a polyhydric alcohol.

  The polyhydric alcohol is an organic compound having a plurality of hydroxy groups in a molecule and is mixed with water at any ratio at room temperature (20 ° C.).

  Examples of the polyhydric alcohol include glycerin, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, diglycerin, and dipropylene glycol.

  It is preferable that the denture stabilizer of this embodiment further contains glycerin as a polyhydric alcohol. By further containing glycerin, there is an advantage that pain is less felt when the denture stabilizer is peeled off from the oral mucosa.

  The denture stabilizer of this embodiment preferably contains 1% to 40% by mass of glycerin, and more preferably contains 15% to 30% by mass. By including 1% by mass or more and 40% by mass or less of glycerin, there is an advantage that the shape retention of the denture stabilizer and the adhesion to the oral mucosa become more sufficient.

  It is preferable that the denture stabilizer of this embodiment further contains water. By further containing water, there is an advantage that pain is less felt when the denture stabilizer is peeled off from the oral mucosa.

  It is preferable that the denture stabilizer of this embodiment contains 1 mass% or more and 10 mass% or less of water. By including 1 mass% or more and 10 mass% or less of water, there is an advantage that the shape retention of the denture stabilizer and the adhesion to the oral mucosa become more sufficient.

  It is preferable that the denture stabilizer of this embodiment further contains water and / or glycerin.

  The ratio of the mass of the liquid oil contained in the denture stabilizer of this embodiment and the total mass of glycerin and water may be the mass of the liquid oil: the total mass of glycerin and water = 1: 1 to 2: 1. preferable. Thereby, there exists an advantage that the shape retention property of a denture stabilizer and the adhesiveness to an oral mucosa will become more sufficient.

  The ratio of the mass of the biological wax contained in the denture stabilizer of this embodiment and the total mass of glycerin and water is the mass of biological wax: the total mass of glycerin and water = 0.5: 1 to 1.0. : 1 is preferred. Thereby, there exists an advantage that the shape retention property of a denture stabilizer and the adhesiveness to an oral mucosa will become more sufficient.

  The ratio of the mass of carboxymethylcellulose salt contained in the denture stabilizer of this embodiment and the total mass of glycerin and water is the mass of carboxymethylcellulose salt: total mass of glycerin and water = 0.1: 1 to 3: 1. And is more preferably 0.5: 1 to 1.0: 1. Thereby, there exists an advantage that the shape retention property of a denture stabilizer and the adhesiveness to an oral mucosa will become more sufficient.

  The denture stabilizer of this embodiment can contain a fragrance | flavor, a pH buffer agent, antiseptic | preservative, antioxidant, etc. other than said compounding component.

  The denture stabilizer is manufactured by a general method. Specifically, for example, liquid oil and biological wax are mixed while heating and stirring is continued. Thereafter, a carboxymethyl cellulose salt previously swelled in glycerin or water is put into the mixture, further stirred, and cooled after the mixture becomes uniform. In this way, a denture stabilizer can be produced.

  For example, the denture stabilizer is applied to the denture base of the denture, and then used in the oral cavity so as to come into contact with the oral mucosa.

  The denture stabilizer of the present embodiment can suppress a decrease in adhesive force even when a load is repeatedly applied by chewing or the like. In addition, when the denture stabilizer is peeled off from the oral mucosa, it becomes more difficult to feel pain. Moreover, since the denture stabilizer of this embodiment contains olive oil as liquid oil and beeswax as biologically-derived wax, the safety of the denture stabilizer with respect to a human body is favorable. Moreover, since the denture stabilizer of this embodiment contains carboxymethylcellulose salt, the usability | use_condition in the oral mucosa of a denture stabilizer is favorable. Moreover, since the denture stabilizer of this embodiment has sufficient shape retention property and adhesiveness to the oral mucosa, it is difficult to come off from the oral mucosa in the oral cavity.

  The denture stabilizer of this embodiment is as illustrated above, but the present invention is not limited to the above exemplified denture stabilizer. Moreover, in this invention, the various form employ | adopted in a general denture stabilizer can be employ | adopted in the range which does not impair the effect of this invention.

  Next, although an Example is given and this invention is demonstrated in more detail, this invention is not limited to these.

The denture stabilizer of each test example was manufactured with the composition shown in Table 1. Details of each raw material are as follows.
(A) [Liquid oil]
Olive oil (Japanese Pharmacopoeia)
・ Other liquid oils Liquid paraffin (B) [Biological wax]
(B-1) Beeswax (Product name “Code No. 03-0670-5” manufactured by Sigma-Aldrich Japan)
(B-2) White beeswax (Japan Pharmacopoeia Miki Chemical Industry Co., Ltd.)
(B-3) Carnauba wax (Raw materials for cosmetics, manufactured by Sankei Sangyo Co., Ltd.)
(B-4) Owl (Lot.1103080 Made by Matsuba Pharmaceutical Co., Ltd.)
・ Other waxes Paraffin (C) [Carboxymethylcellulose salt]
(C-1) Carboxymethylcellulose sodium salt (CMC-Na)
(Product name "Serogen PM-250L" manufactured by Daiichi Kogyo Seiyaku Co., Ltd.)
(D) [Polyhydric alcohol] Glycerin (E) [Water] Purified water

Example 1
In a beaker placed in hot water at 80 ° C. or higher, the liquid oil and wax shown in Table 1 were heated and stirred to dissolve until uniform. Thereafter, while stirring, the mixture was alternately placed in a room temperature environment and ice water together with a beaker, and stirring was continued until the mixture solidified. The solidified mixture was allowed to stand at room temperature for about 2 days. The mixture formed in the mixture after standing was pulverized by a roller. In this way, a viscous denture stabilizer was produced.

(Examples 2 to 11)
Denture stabilizers were produced in the same manner as in Example 1 except that the respective components were blended in the blending amounts shown in Table 1, respectively.

  The products shown below were used as denture stabilizers for each comparative example. The compounding component of each comparative example is shown below.

(Comparative Example 1)
Product AX Product Main ingredients: Methoxyethylene maleic anhydride copolymer salt, carboxymethylcellulose, light liquid paraffin, white petrolatum (Comparative Example 2)
Product BY Company product Main ingredients: Methoxyethylene maleic anhydride copolymer salt, carboxymethylcellulose, light liquid paraffin, white petrolatum (Comparative Example 3)
Product C Company Z Main components: Methoxyethylene maleic anhydride copolymer salt, carboxymethylcellulose, light liquid paraffin, white petrolatum

(Examples 12 to 18)
Denture stabilizers were produced in the same manner as in Example 1 except that the respective components were blended in the blending amounts shown in Table 2. In addition, when mix | blending water, water was added after the mixture solidified during manufacture, and the mixture after addition was knead | mixed with the roller.

(Examples 19 to 39)
Denture stabilizers were produced in the same manner as in Example 1 except that the respective components were blended in the blending amounts shown in Table 3, respectively. During production, a swollen product in which carboxymethylcellulose sodium salt (CMC-Na) is swollen in glycerin is prepared in advance, and the swollen product is added to the mixture solidified after cooling. Kneaded.
In Examples 24-39, the following were used as carboxymethylcellulose sodium salts.
Examples 24 and 25: Product name “Serogen F-BSH-12” manufactured by Daiichi Kogyo Seiyaku Co., Ltd. Examples 26 and 27: Product name “Serogen P-815C” manufactured by Daiichi Kogyo Seiyaku Co., Ltd. Examples 28 and 29: Product name “Serogen PM-250L” manufactured by Daiichi Kogyo Seiyaku Co., Ltd. Examples 30 and 31: Product name “Serogen HE1500F” manufactured by Daiichi Kogyo Seiyaku Co., Ltd. Examples 32 and 33: Product name “Serogen F-6HS9” manufactured by Daiichi Kogyo Seiyaku Co., Ltd. Examples 34 to 39: Product name “Serogen PM-250L” manufactured by Daiichi Kogyo Seiyaku Co., Ltd.

  Each manufactured denture stabilizer was used, and each evaluation was performed as follows. Details of each evaluation method are as follows.

<Evaluation 1: Evaluation of adhesive strength of denture stabilizer (no water immersion)>
Adhesive strength (adhesive strength) of denture stabilizer according to the method of measuring the adhesive strength of Japanese Industrial Standards JIS T6525-1: 2013 (denture base stabilization paste-Part 1: Adhesive denture base stabilization paste) Force) was measured. The measurement was performed without immersing the sample in water. The measurement conditions are as follows.
Sample holder-flat sample thickness-0.5 mm
Temperature -23 ° C
Measurement environment-in air

<Evaluation 2: Evaluation of adhesive strength of denture stabilizer (with water immersion)>
Adhesive strength of denture stabilizer in accordance with Japanese Industrial Standards JIS T6525-1: 2013 (denture base stabilization paste-Part 1: adhesive denture base stabilization paste cream type adhesive strength I and adhesive strength II) (Adhesive strength) was measured. The measurement conditions are as follows.
Equipment-Shimadzu Autograph "AGS-H"
Measurement environment-in air In addition, the above JIS standard describes that the adhesive strength of the denture base stabilizing paste material must be 5 kPa or more.

<Evaluation 3: Repeated load test>
In order to reproduce the change in tackiness during mastication in the oral cavity, the load change was measured by repeatedly bonding and peeling each denture stabilizer in water using the repeated load application device shown in FIG. The details of the measurement conditions are as follows.
Equipment-"Fudo Rheometer" manufactured by Fudo Kogyo Co., Ltd.
Sample thickness -0.5mm
Adhesion and peeling speed-20 mm / min Repeat frequency-6 times / min Temperature (water temperature)-23 ° C
Load -9.8N

The result of performing the above-described evaluation 1 for Examples 1 to 11 is shown in FIG.
The results of performing the above evaluation 1 for Examples 12 and 13 are shown in FIG.
FIG. 4 shows the results of performing the above-described evaluation 1 for Examples 12, 14 and the products A, B, and C of the comparative example.
FIG. 5 shows the results of the above-described evaluation 3 performed on the products C of Examples 12 and 13 and the comparative example.
FIG. 6 shows the results of the above-described evaluation 3 performed on the products A, B, and C of Examples 12 and 14 and the comparative example.
The results of performing the above evaluation 3 for Examples 12 and 15 to 18 are shown in FIG.

About Example 19-33, the result of having performed said evaluation 1 is shown in FIG.
FIG. 9 shows the result of the above evaluation 3 performed on the products A, B, and C of the comparative example.
About Example 19-23, the result of having performed said evaluation 3 is shown in FIG.
FIG. 11 shows the results of the above evaluation 3 for Examples 20, 24, 26, 28, 30, and 32.
FIG. 12 shows the results of the above evaluation 3 for Examples 22, 25, 27, 29, 31, and 33.
About Example 34-39, the result of having performed the adhesive strength I of said evaluation 2 is shown in FIG. FIG. 14 shows the result of the adhesion strength II of evaluation 2 described above.

  As can be seen from the above results, the denture stabilizers of the examples can suppress a decrease in adhesive strength even when subjected to repeated loads due to chewing or the like, compared to the denture stabilizers of the products of the comparative examples. .

  The denture stabilizer of this invention is used suitably, for example, in order to stabilize the position of the denture mounted in the oral cavity.

Claims (5)

  A denture stabilizer comprising a liquid oil containing triglycerides and a biological wax.   The denture stabilizer according to claim 1, wherein the liquid oil is olive oil.   The denture stabilizer according to claim 1 or 2, wherein the biological wax is beeswax.   The denture stabilizer according to any one of claims 1 to 3, further comprising a carboxymethylcellulose salt.   The denture stabilizer according to any one of claims 1 to 4, further comprising at least one of water and a polyhydric alcohol.