JPS6364983B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (A) Technical Field The present invention relates to a method and apparatus for mixing two or more types of liquid chemicals.

For example, an injection solution may be prepared by mixing two or more types of liquid drugs. In this case, it is necessary to collect a predetermined amount from a container containing the component chemicals, place them in a single container, and mix them.

(b) Summary A method and apparatus for preparing a mixture of drugs, such as an injection solution.

There are multiple component liquid containers containing a single liquid drug component. On the other hand, a mixed liquid container is provided in the vacuum chamber for containing the mixed liquid. A branch hose for discharging chemicals is attached to each component liquid container. A collection hose for introducing chemicals is attached to the mixed liquid container. The plurality of branch hoses and one collective hose are connected by a hose connector.

Each branch hose is provided with a sensor that can distinguish between a chemical solution and air, and a clamp mechanism that can tighten the hose and close the flow path.

When all the chemical liquid flows out from the component liquid container, air enters the branch hose. A sensor detects air inflow. Upon receiving the sensor signal, the clamp mechanism clamps the hose and blocks the flow path.

Such operations are performed for all component liquids. When the chemical solution has been discharged from all the component solution containers and all the hoses have been clamped, the collection hose is sealed at two locations and cut between.

(C) Prior art and its problems In the medical and pharmaceutical fields, it is often necessary to mix multiple different drugs.
If these different chemicals are mixed in advance, there is a risk that they may change in quality, deteriorate, or become contaminated.

For medical and practical reasons, it is still often preferred to mix multiple drugs on-site.

In such cases, a fixed amount of the drug is poured into a new container from the bottle containing the drug component. Physicians and pharmacists label the new container to indicate its ingredients and purpose.

If the mixed drug is to be used frequently, it is desirable that the mixed drug be storable.

However, mixed drugs such as injection solutions may penetrate into the sealed portion of the container and contaminate it. This is undesirable. The seal part consists of a push stopper or a threaded cap, but since these are opened and closed by the dispenser's hands, there is a risk of contamination.

First, when mixing drugs, it is important to avoid contamination of the drugs.

For this reason, it is desirable to avoid manual mixing. If it is done manually, different drugs are collected one after another into a measuring device, calculated, and put into a mixing container, so the drugs come into contact with hands and the air, and the measuring device is also contaminated.

Such manual operations may lead to contamination. To avoid this, there is a method in which the individual component drugs are pumped into sterilized containers. Since it is injected using a pump, there is no problem of manual contamination. The reciprocating volume of the pump defines the amount of individual drug delivered. Meter by pumping motion. This is possible because a pump with excellent quantitative performance is used. Furthermore, the weight of the mixed drug after all component drugs are mixed is also measured.

This method of mixing using a pump takes too long to prepare, and the possibility of contamination still exists because the hose connecting the pump to the mixing vessel is not sealed.

There is also the risk of chemical dripping from the pump hose.

Furthermore, since this method only measures the total weight of the mixture and only measures individual drugs by pump, the mixing ratio of the drugs is not necessarily correct.

In order to increase the accuracy of metering by the pump, the volume per pumping motion can be reduced, but this slows down the pumping operation and increases the time required for dispensing.

(d) Purpose This invention was made to achieve the following objects.

(1) Prepare a mixed solution from the component drugs as quickly as possible.

(2) Mixing the individual component drugs in precise amounts. The ratio of ingredients must be accurate.

(3) There is no risk of contamination.

(4) The mixing operation can be performed automatically. There is no need to touch the equipment or containers while the mixture is being prepared, so that pharmacists, rather than drug manufacturers, can mix drugs according to prescriptions and store them. .

(E) Configuration The device of the present invention includes a plurality of component liquid containers containing individual component drugs, a mixed liquid container for containing the mixed drugs, a branch hose connected to the component liquid containers, and a mixed liquid container. A collection hose connected to the container, a hose connector for connecting each branch hose to the collection hose, a sensor for determining whether the content of the branch hose is a drug or air, and a sensor for detecting a signal from the sensor. Therefore, there is a clamp mechanism that can clamp the branch hose, a seal mechanism that seals the collection hose at two locations, a cutting mechanism that is provided between the seal mechanisms and that can cut the collection hose, and a mixed liquid container. It is more similar to a vacuum chamber.

By drawing a vacuum inside the vacuum chamber, the mixed liquid container expands, and the drug is simultaneously released from the component liquid container.
It is absorbed into the mixed liquid container through the branch hose, hose connector, and collection hose. A sensor detects when all of the drug in the component liquid container has been expelled and air has entered the branch hose.
A clamp mechanism receives a signal from the sensor and operates to clamp the hose.

Since suction from the component liquid container to which the hose is clamped is stopped, air will not flow in from the branch hose.

Suction from other component liquid containers to the mixed liquid container continues.

A similar process is repeated for all other component liquids. In other words, the component liquid container is empty,
When air appears in the branch hose, it is detected by the sensor and the process is repeated by clamping the hose and cutting off the flow.

After all the sensors detect air and the branch hose is shut off, the sealing mechanism of the downstream collecting hose operates to seal the collecting hose at two locations. Subsequently, the middle of the sealed portion is cut by a cutting mechanism. Preferably, all mechanisms of the device are deactivated at the same time.

Air is introduced into the vacuum chamber, the vacuum chamber is opened, and the mixed liquid container filled with the mixed liquid is taken out.

The entire process is performed within 2 minutes. This is done more quickly than any prior art device.

As another example of the present invention, it is also possible to have two or more mixed liquid containers. In this case, since a collecting hose is provided for each mixed liquid container, a plurality of branches on the downstream side of the hose connector are also provided.

When filling a plurality of mixed liquid containers with mixed liquids, there are two methods regarding the order of filling.

One method is to house all mixed liquid containers in one vacuum chamber, simultaneously inflate the mixed liquid containers, and suck out the mixed liquid all at once.

The other case is when the vacuum chamber is small. A mixed liquid container is connected to the hose coupling by a collection hose. One by one, the mixed liquid containers are placed into a vacuum chamber, which is inflated and the mixed liquid is sucked out. The other mixed liquid container is outside the vacuum chamber. Of these, only the mixed liquid container inside the vacuum chamber can expand, and the one outside the vacuum chamber is not pressurized.
It is not possible to aspirate the mixture.

The filled mixed liquid container is removed from the vacuum chamber,
The next mixed liquid container is loaded into the vacuum chamber. The filled mixed liquid container is sealed. In this way, a plurality of mixed liquid containers are filled one after another.

It is undesirable for the sealing mechanism and the liquid mixture container in the vacuum chamber to be too far apart. After the collection hose is sealed and cut, it sticks to the mixed liquid container, but as it gets longer,
This is because it becomes a hindrance to later operations.

In such cases, a sealing mechanism may be provided within the vacuum chamber to cut the collection hose short.
In this way, the sealing mechanism and the mixed liquid container are brought very close to each other, so the uncut collection hose becomes short and does not interfere with the work. The sealing mechanism can be provided on the back side of the lid of the vacuum chamber or on the inner wall surface of the vacuum chamber.

In any case, it is desirable that the distance between the mixed liquid container and the sealing mechanism be minimized in the vacuum chamber.

In the invention described above, the proportion of each component liquid in the mixed liquid was determined by the volume of the component liquid container. This is because all the liquid in the component liquid container is drained and mixed into the mixed liquid. Measuring is performed when the component liquid is sealed in the component liquid container. There were no other measuring mechanisms.

In addition to this, it is also possible to measure the weight of the mixed liquid container to determine the mixed amount of the component liquids.

To do this, for example, a weight scale is installed in the vacuum chamber, and the mixed liquid container is suspended from the scale to measure the weight. Additionally, the weighing scale and sealing mechanism located within or outside the vacuum chamber may be coupled to a control device that is preprogrammed with the desired weights of the individual component liquids.

In an example of such an apparatus, each component liquid is sequentially introduced one by one into the mixed liquid container.

When a predetermined amount of the first component liquid is introduced into the mixed liquid container, the weighing scale generates a signal indicating completion of filling of the first component liquid. Upon receiving this signal, the first clamp mechanism clamps the first branch hose.

At the same time, open the second clamping mechanism. A second component liquid flows into the mixed liquid container.

The control device calculates the sum of the scheduled amount of the first component liquid and the scheduled amount of the second component liquid, and compares this with the weight of the liquid content in the mixed liquid container measured with a weighing scale, and determines whether these are the same. When the temperature reaches , the flow of the second component liquid is stopped. That is, the clamp mechanism of the second branch hose is closed.

Such operations are sequentially repeated until the last component liquid is reached. When the last component liquid is supplied, the last branch hose is also clamped.

Next, the collection hose is sealed in two places and cut in the middle.

Return the vacuum chamber to normal pressure, open the vacuum chamber, and take out the mixed liquid container filled with the predetermined amounts of all the component liquids.

By measuring the weight in this way, it is possible to accurately measure the amount of the component liquids to be mixed. Although this method can be used even when there is only one mixed liquid container, it is particularly effective when there are a plurality of mixed liquid containers as shown in FIG.

When one mixed liquid container is filled, the next mixed liquid container is placed in the vacuum chamber and the same operation is repeated. In this case, there is no need to newly connect or reconnect the hose, and there is no risk of drug contamination.

The sealing mechanism can be, for example, a mechanical seal as described below. Insert the two metal sleeves into the collection hose from the sides. The spacing should be equal to the spacing between the two sealing points of the sealing mechanism. Insert the sleeve section into the sealing mechanism. The sealing mechanism strongly presses the metal sleeve to plastically deform it. The sleeve deforms and presses down on the hose, closing off the hose flow path.

Alternatively, the hose may be held down and heat may be applied thereto to fuse and seal. Furthermore, it is also possible to press the hose and use ultrasonic waves to fuse and seal the hose pressing portion.

(F) Configuration of First Embodiment The present invention will be described below with reference to drawings showing embodiments.

FIG. 1 is a perspective view showing a first embodiment. FIG. 2 shows an enlarged view of the vicinity of the hose coupling. Third
The figure is a front view of a partial configuration of another embodiment, and FIG. 4 is a front view of a third embodiment. FIG. 5 is a front view of a partial configuration showing the fourth embodiment.

In FIG. 1, the stand 1 consists of a vertical rod and a horizontal rod perpendicular to the vertical rod. Holder 2 on the horizontal bar
is hanging down. The holder 2 supports three component liquid containers 3, 4, and 5 with their mouths facing down. That is, the sealing cap 6 is at the lowest point of the container.

A branch hose 7 is inserted from below into a sealing cap 6 of the respective component liquid container 3, 4, 5.
The branch hose 7 has a suitable cross-sectional area for passing the drug at a suitable rate, and is, for example, a plastic hose made of polyvinyl chloride. The plurality of branch hoses 7 are coupled to upstream branches of a hose coupling 8 having the same number of upstream branches. A sensor 9 is provided in the middle of the branch hose 7 to detect that air has flowed into the branch hose 7.

The sensor 9 distinguishes between air and the presence of a drug, for example, on the basis of optical principles.

Each branch hose 7 has a clamp mechanism 10.
is provided. The signal from sensor 9 is transmitted to clamp mechanism 1.
0, the clamp mechanism 10 operates to clamp down the corresponding branch hose and cut off the flow path.
The clamping mechanism can be constructed of, for example, a solenoid that is operated by the force of an electromagnet.

When the flow path of the branch hose 7 is cut off, the flow of the medicine from the corresponding component liquid container is stopped.

As shown in FIG. 2, the hose coupler 8 has the same number of upstream branch pipe sections 11 as the branch hoses 7. This holds the lower end of the branch hose 7 without leakage.

On the downstream side of the hose connector 8, in the embodiments shown in FIGS. 1 and 2, one integrated pipe section 12 is provided. Collection hose 1 continuous to mixed liquid container 14
3 is firmly inserted into the integrated pipe section 12. The other end 15 of the collection hose 13 is the mixed liquid container 14
It opens at the top of the container 14 so that liquid can be supplied into the container 14.

The mixed liquid container 14, the collection hose 13, the hose connector 8, the branch hose 7, and the insertion tube 16 are manufactured as one unit and packaged in a sterilized state. Immediately before use, the stand 1, seal mechanism 23, vacuum chamber 18 are removed from the packaging bag, and
is set for. The branch hoses 7 are passed through the clamp mechanism 10 and the sensor 9, respectively, and the collection hose 13 is set in the seal mechanism 23, and the mixed liquid container 1
4 is put into the vacuum chamber 18.

The vacuum chamber 18 used in this device has an opening at the top, which is covered by a lid 19 which can be opened and closed with a hinge.

The vacuum chamber 18 is connected to a vacuum generator 21 by an exhaust pipe 20. Cylindrical wall 22 of vacuum chamber 18
Above there is an airtight hole for passing the collection hose 13. The collection hose 13 enters the interior from the outside through this hole, reaches the upper end 15 of the mixed liquid container 14, and opens into the interior of the container 14.

In this example, a sealing mechanism 23 is placed on top of the vacuum generator 21. The two may need to work together, so it is convenient to combine them in this way. Collection hose 13 to seal mechanism 23
is passed through.

Two deformable metal sleeves 24, 24
are fitted into the collection hose 13 at regular intervals.
The sleeve 24 may be fitted into the collection hose 13 in advance. The sleeves 24, 24 are sealed by the sealing mechanism 2.
Insert into the holding device at the two sealing locations 25 in step 3. The holding device applies strong pressure to the metal sleeve 24 to plastically deform it. When the sleeve 24 is crimped in this manner, the internal flow path of the hose 13 is closed. In this way, the sealing mechanism uses not only mechanical sealing by caulking the sleeve, but also a heater-heat fusion method in which the hose is held down and heated with a heater to instantaneously melt the inner wall surface of the hose and join together. You can also use Alternatively, an ultrasonic fusion method may be used.

A cutting mechanism is provided between the two sealing locations 25, 25. This is to cut the collection hose 13 sealed at two places into two.

(g) Operation and operation of the first embodiment: Place the component solution containers 3, 4, and 5 containing the required amount of the drug on the horizontal bar of the stand 1 with the sealing cap 6 facing down. , suspended by holder 2. The liquid volumes in the component liquid containers 3, 4, and 5 may be equal or different.

Remove the integrated branch hose, collection hose, hose connector, and mixed liquid container from the bag.

The intermediate portion of the branch hose 7 is set in a mounting unit 27 consisting of a sensor 9 and a clamp mechanism 10. The mounting unit 27 can also be mounted on the stand 1 as shown. Insert the pointed insertion tube 16 at the tip of the branch hose 7 into the sealing cap 6.

A portion of the collection hose 13 is inserted into the sleeves 24, 24 of the seal mechanism 23. The mixed liquid container 14 at the end of the collection hose 13 is placed into the vacuum chamber 18 and hung from the lid 19 by the hanging tool 28.

Next, the vacuum generator 21 is activated. Vacuum chamber 1
The inside of 8 is evacuated and becomes negative pressure. All clamp mechanisms 10 that had closed the branch hoses 7 are opened.

The mixed liquid container 14 is, for example, a PVC bag and has a negative pressure on the outside, so it tends to expand due to the difference in pressure between the inside and outside.

Since the component liquid containers 3, 4, and 5 are at atmospheric pressure, the chemicals inside simultaneously flow into the mixed liquid container 14 via the branch hose 7, hose connector 8, and collection hose 13.

If the amounts of chemicals in the component liquid containers 3, 4, and 5 are equal, they will be emptied almost simultaneously, and air will enter the branch hose 7. Sensor 9 detects this and sends a signal to clamp mechanism 10. The clamp mechanism 10 holds down the branch hose 7 to stop the flow.

If the amounts of drugs in the component liquid containers 3, 4, and 5 are different, the component liquid container with the smallest amount of liquid will be emptied the fastest. Therefore, air enters the corresponding branch hose 7, and the sensor 9 detects this.
Sensor 9 sends a signal to clamping mechanism 10 . Clamp mechanism 10 closes branch hose 7. Such operations are repeated for each branch hose 7.

It is assumed that the last sensor 9 detects air inflow and all the clamp mechanisms 10 close the branch hoses 7. The sealing mechanism 23 works and the collection hose 13
are sealed at two sealing locations 25, 25.

Next, the cutting mechanism 26 cuts the intermediate portions of the sealed portions 25 , 25 .

At the same time, the vacuum generator 21 stops and the vacuum chamber 18
Air is introduced into the The vacuum chamber 18 is at atmospheric pressure. Open the lid 19. The mixed liquid container 14 filled with the mixed liquid and sealed is taken out. Label it and send it to the next processing step.

(H) Second Embodiment The embodiment shown in FIG. 3 differs from the first embodiment in that the hose connector 8' has a branch on the downstream side and there are a plurality of mixed liquid containers 14. It's on.

Three branching and integrating pipe sections 12 are shown here downstream of the hose coupling 8'. There are three separate collection hoses 13, . The other end of each collection hose 13 is a mixed liquid container 1 divided into three parts.
It is connected to 4.

A plurality of branch pipe sections 1 on the upstream side of the hose coupling 8'
1 is connected to a plurality of component liquid containers 3, 4, and 5, as in the previous example.

In this embodiment, one mixed liquid container 14
The chisel is placed in the vacuum chamber 18 and, as in the previous example, the mixture is sucked out by means of a vacuum. The other liquid mixture containers 14 are outside the vacuum chamber 18 .

Since atmospheric pressure is applied to the mixed liquid container 14 located outside, the mixed liquid does not enter the mixed liquid container 14. The mixed liquid is introduced only into the mixed liquid container 14 located inside the vacuum chamber 18 .

The container 14 filled with the mixed liquid is taken out from the vacuum chamber 18, and the next mixed liquid container 14 is placed into the vacuum chamber 18. Repeat this operation.

This embodiment is suitable when the liquid mixture container 14 is small, such as for pediatric medicine.

(k) Third Embodiment FIG. 4 shows a third embodiment. this is,
A weight scale 30 is provided within the vacuum chamber 18.
The weight scale 30 is provided inside the lid 19 of the vacuum chamber 18. A hanging tool 28 is installed horizontally from the weight scale 30. The mixed liquid container 14 is suspended from the hanging tool 28.

The weight scale 30 is connected to a control device 31.
The control device 31 inputs the filling amount of each component liquid in advance, and instructs the corresponding branch hose 7 to be clamped when the filling amount of each component liquid reaches a predetermined amount.

In this figure, meters and indicators showing the scheduled and actual filling amounts of component liquid containers 3, 4, and 5 are shown at A,
They are shown with labels B and C.

The control device 31 is coupled to a mounting unit 27 which includes a sensor 9 and a clamping mechanism 10.

In this example, the component ratio of the mixed liquid is determined by weight.

At the beginning of operation, all clamp mechanisms 10 are closed. Then, one by one, the clamp mechanism 1
0 is opened and a predetermined amount is filled from the component liquid solution container into the mixed liquid container 14.

As a certain component liquid flows into the mixed liquid container 14, its weight increases.The weight of the incoming liquid is measured by a weighing scale 30 and compared with a planned amount. When the inflow volume becomes equal to the predetermined volume, the controller 31 issues a stop signal for that component.
Clamp mechanism 10 for branch hose 7 through which the component passes
closes.

Next, branch hose 7 that connects to another component liquid container
The clamp mechanism 10 of is opened. Another component liquid flows into the mixed liquid container 14 through the hose. A weighing scale 30 measures the weight of this container.

The value obtained by adding the scheduled filling amount of the second component liquid to the scheduled filling amount of the first component liquid is determined by the controller 31.
is memorized.

The weight of the mixed liquid container 14 is determined by the weight scale 30, and when the weight becomes equal to the sum of the first and second scheduled amounts, the control device 31 clamps the second branch hose 7. A clamp command is issued to 10.

In this way, the planned phase weight amount, in which the planned weights of multiple component liquids are added in order, and the mixed liquid container 1
4 and when they are equal, the inflow of the mixed flow is stopped.

Such operations are repeated until all component liquids are filled into the mixed liquid container.

The above operations are performed using only the weight as a variable. However, when the amount of medicine in the component liquid containers 3, 4, and 5 is insufficient, the measured value on the weight scale will not increase, so there is a risk that the clamp mechanism will not work and air will enter the mixed liquid container 14. There is.

Therefore, as in the previous embodiment, the interlocking relationship between the sensor 9 and the clamp mechanism 10 is left as is, and the branch pipe 7
When air flows into the branch hose 7, the clamp mechanism is activated to close the branch hose 7.

Then, the clamp mechanism 10 of the branch hose 7 connected to the next component liquid container is opened, and the next drug is introduced into the mixed liquid container 14.

The mixing ratio of the component liquids that are emptied midway in the mixed liquid is lower than the appropriate value. The amount of shortage can be stored in the control device. When an empty component liquid container is replaced with a new one, only the insufficient amount is added from this container into the mixed liquid container 14.

(J) Fourth Embodiment FIG. 5 shows another embodiment. In this example, a sealing mechanism 23 is provided within the vacuum chamber 18.

There is no change in the fact that the sealing mechanism 23 seals the collection hose 13 at two places, and the cutting mechanism cuts the middle part.

The mixed liquid container 14, the sealing location, and the cutting location approach each other. After the hose is cut, only a very short hose tail 32 remains attached to the mixed liquid container 14.

Therefore, the hose tail portion 32 does not get in the way when handling the mixed liquid container in later processing.

[Brief explanation of drawings]

FIG. 1 is an overall perspective view of a compounding device for a mixture of chemicals according to a first embodiment of the present invention. FIG. 2 is an enlarged plan view of the vicinity of the hose connector. FIG. 3 is a partial front view showing another embodiment of the blending device of the present invention. FIG. 4 is a front view showing a third embodiment of the blending device of the present invention. FIG. 5 is a front view of a partial configuration of a fourth embodiment of the blending device of the present invention. DESCRIPTION OF SYMBOLS 1...stand, 2...holder, 3, 4, 5...component liquid container, 6...sealing cap, 7...branch hose, 8
... Hose connector, 9 ... Sensor, 10 ... Clamp mechanism, 11 ... Branch pipe section, 12 ... Integrated pipe section, 13 ... Collection hose, 14 ... Mixed liquid container, 15 ... Container side end of collection hose, 16 ... Difference Containing pipe, 18...Vacuum chamber, 1
9... Lid, 20... Exhaust pipe, 21... Vacuum generator, 22
...Cylindrical wall, 23...Seal mechanism, 24...Sleeve,
25... Sealing location, 26... Cutting location, 27... Mounting unit, 28... Hanging tool, 30... Weight scale, 31...
Control device.

Claims (1)

[Scope of Claims] 1. Two or more component liquid containers containing drugs as components, a mixed liquid container filled with the mixed drugs, a vacuum chamber containing the mixed liquid containers, and each component liquid container. The branch hose includes a connected branch hose, a collection hose connected to the mixed liquid container, and a hose connector that connects the branch hose and the collection hose, and the branch hose connects the component medicine from each component liquid container to the mixed liquid container. In a method of preparing a mixture of chemicals by suctioning through a collection hose, air flows into the branch hose 7 corresponding to each component to indicate that a predetermined amount of each component medicine has been introduced into the mixed liquid container. When it is detected that air has flowed into all the branch hoses 7, the collecting hose 13 is sealed at two places and the sealed middle is cut. A method of preparing a mixture of chemicals. 2. Two or more component liquid containers containing the component drugs, and a mixed liquid container filled with the mixed drugs,
A vacuum chamber containing a mixed liquid container, a branch hose connected to each component liquid container, a collection hose connected to the mixed liquid container, and a hose connector for connecting the branch hose and the collection hose, each In the method for preparing a mixture of chemicals in which the component drugs are sucked from the component liquid container into the mixed liquid container through a branch hose and a collection hose, the component liquids are sequentially sucked into the mixed liquid container 14, The weight of the mixed liquid container 14 is measured, and when the weight reaches a predetermined amount, the branch hose 7 corresponding to the component liquid is closed,
Next, open the branch hose 7 for the other component liquid, and suck this component liquid into the mixed liquid container 14.
When the weight of component 4 reaches the predetermined amount, this branch hose 7 is closed, and then suction of other component liquids is started, and after all the component liquids have been introduced into the mixed liquid container 14 in predetermined amounts. , a method for preparing a mixture of chemicals, characterized by sealing the collecting hose 13 and cutting the sealed middle of the collecting hose 13. 3. Two or more component liquid containers containing the component drugs, and a mixed liquid container filled with the mixed drugs;
A vacuum chamber containing a mixed liquid container, a branch hose connected to each component liquid container, a collection hose connected to the mixed liquid container, and a hose connector for connecting the branch hose and the collection hose, each In a compounding device for a drug mixture, in which component drugs are sucked from a component liquid container into a mixed liquid container through a branch hose and a collection hose, each branch hose 7 has a hose that can distinguish between the drug in the hose and the air. sensor 9 and sensor 9
A clamping mechanism 10 is provided which clamps the branch hose 7 in response to a signal, and the collecting hose 13 is provided with a clamping mechanism 10 that can seal the collecting hose 13 at two places.After all the clamp mechanisms have been activated, the collecting hose 13 is sealed. A compounding device for a mixture of chemicals, characterized in that it is provided with a sealing mechanism 23 which has a sealing mechanism 23, and a cutting mechanism 26 which cuts the collecting hose 13 at the middle of the sealing point. 4. Two or more component liquid containers containing the component drugs, a mixed liquid container filled with the mixed drug, a vacuum chamber containing the mixed liquid containers, and a branch hose connected to each component liquid container. , a collection hose connected to the mixed liquid container, and a hose connector that connects the branch hose and the collection hose, and the component medicine is sucked from each component container into the mixed liquid container through the branch hose and the collection hose. In the device for dispensing a mixture of chemicals, each branch hose 7 is provided with a clamp mechanism 10 that can clamp the branch hose 7, and a weighing scale 30 that measures the weight of the mixed liquid container 14 is provided.
It is connected to a weighing scale 30 and can store the required amount of component medicine in advance. When the weight of the mixed liquid container 14 reaches a predetermined value, the clamp mechanism 10 of the corresponding branch hose 7 is operated to close, and the next A compounding device for a mixture of chemicals, characterized in that it is comprised of a control device 31 for opening a branch hose clamp mechanism 10. 5 The hose connector 8 has a plurality of branches 1 on the downstream side.
2, 12,... and a plurality of mixed liquid containers 14, 1
A plurality of collection hoses 13, 1 connected to 4,...
3,... are coupled to the downstream branch 12,... 6. A compounding device for a mixture of chemicals according to any one of claims 3 to 5, wherein the sealing mechanism 23 is provided in the vacuum chamber 18. 7. The sealing mechanism 23 comprises two metal sleeves 24, 24 that are spaced apart from each other and match the shape of the collection hose 13.
A device for preparing a mixture of chemicals according to any of clause 6. 8. The drug mixture blending device according to any one of claims 3 to 7, wherein the clamp mechanism 10 is driven by magnetic force. 9. The chemical according to any one of claims 3 to 8, in which the mixed liquid container 14, the collection hose 13, the hose connector 8, the branch hose 7, and the insertion pipe 16 are integrated. Mixture blending device. 10 Claims 3 to 9 in which the seal mechanism 23 is driven by air pressure or oil pressure
A device for preparing a mixture of chemicals as described in any of paragraphs.