JPS6364403B2 - - Google Patents
Info
- Publication number
- JPS6364403B2 JPS6364403B2 JP9805180A JP9805180A JPS6364403B2 JP S6364403 B2 JPS6364403 B2 JP S6364403B2 JP 9805180 A JP9805180 A JP 9805180A JP 9805180 A JP9805180 A JP 9805180A JP S6364403 B2 JPS6364403 B2 JP S6364403B2
- Authority
- JP
- Japan
- Prior art keywords
- sharp
- strong
- trihydroxide
- medium
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 230000018044 dehydration Effects 0.000 claims description 4
- 238000006297 dehydration reaction Methods 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 150000002291 germanium compounds Chemical class 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 208000026278 immune system disease Diseases 0.000 claims description 2
- 238000012643 polycondensation polymerization Methods 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 239000007859 condensation product Substances 0.000 description 9
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 8
- 238000006116 polymerization reaction Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 230000016784 immunoglobulin production Effects 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000009386 Experimental Arthritis Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- -1 phenylgermanium trihydroxide Chemical compound 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- RQTSGHAKTDICKS-UHFFFAOYSA-N C(C)N(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCC(=O)OCC)=O Chemical compound C(C)N(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCC(=O)OCC)=O RQTSGHAKTDICKS-UHFFFAOYSA-N 0.000 description 1
- JLYUCMAHYTUPMO-UHFFFAOYSA-N C(CCC)N(C1=CC=C(C=C1)[Ge](O)(O)O)C(CC(=O)OCC)=O Chemical compound C(CCC)N(C1=CC=C(C=C1)[Ge](O)(O)O)C(CC(=O)OCC)=O JLYUCMAHYTUPMO-UHFFFAOYSA-N 0.000 description 1
- 238000011740 C57BL/6 mouse Methods 0.000 description 1
- NORBRJQIBBIIGS-UHFFFAOYSA-N CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CC(=O)OCC)=O Chemical compound CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CC(=O)OCC)=O NORBRJQIBBIIGS-UHFFFAOYSA-N 0.000 description 1
- UVVSOOQCNUVURC-UHFFFAOYSA-N CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCC(=O)O)=O Chemical compound CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCC(=O)O)=O UVVSOOQCNUVURC-UHFFFAOYSA-N 0.000 description 1
- WPIIWMMTAOQLEV-UHFFFAOYSA-N CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCC(=O)OCC)=O Chemical compound CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCC(=O)OCC)=O WPIIWMMTAOQLEV-UHFFFAOYSA-N 0.000 description 1
- VERAXMQFIZNFRQ-UHFFFAOYSA-N CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCCC(=O)O)=O Chemical compound CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCCC(=O)O)=O VERAXMQFIZNFRQ-UHFFFAOYSA-N 0.000 description 1
- YXYBHIIMTFIDDF-UHFFFAOYSA-N CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCCC(=O)OCC)=O Chemical compound CN(C1=CC=C(C=C1)[Ge](O)(O)O)C(CCCC(=O)OCC)=O YXYBHIIMTFIDDF-UHFFFAOYSA-N 0.000 description 1
- 208000027932 Collagen disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000011694 lewis rat Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9805180A JPS5699418A (en) | 1980-07-16 | 1980-07-16 | Remedy for immune disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9805180A JPS5699418A (en) | 1980-07-16 | 1980-07-16 | Remedy for immune disease |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP246180A Division JPS5699491A (en) | 1979-09-19 | 1980-01-11 | Organic germanium compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5699418A JPS5699418A (en) | 1981-08-10 |
| JPS6364403B2 true JPS6364403B2 (enExample) | 1988-12-12 |
Family
ID=14209413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9805180A Granted JPS5699418A (en) | 1980-07-16 | 1980-07-16 | Remedy for immune disease |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5699418A (enExample) |
-
1980
- 1980-07-16 JP JP9805180A patent/JPS5699418A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5699418A (en) | 1981-08-10 |
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