JPS6352700B2 - - Google Patents
Info
- Publication number
- JPS6352700B2 JPS6352700B2 JP55015917A JP1591780A JPS6352700B2 JP S6352700 B2 JPS6352700 B2 JP S6352700B2 JP 55015917 A JP55015917 A JP 55015917A JP 1591780 A JP1591780 A JP 1591780A JP S6352700 B2 JPS6352700 B2 JP S6352700B2
- Authority
- JP
- Japan
- Prior art keywords
- solution
- aqueous solution
- components
- immunoglobulin
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000243 solution Substances 0.000 claims description 47
- 108060003951 Immunoglobulin Proteins 0.000 claims description 25
- 102000018358 immunoglobulin Human genes 0.000 claims description 25
- 238000001962 electrophoresis Methods 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 21
- 239000007864 aqueous solution Substances 0.000 claims description 19
- 238000000926 separation method Methods 0.000 claims description 17
- 238000012546 transfer Methods 0.000 claims description 10
- 230000005684 electric field Effects 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 229940072221 immunoglobulins Drugs 0.000 description 8
- 238000005194 fractionation Methods 0.000 description 4
- 238000012869 ethanol precipitation Methods 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 201000005505 Measles Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000002096 anti-tetanic effect Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 230000037230 mobility Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 201000005404 rubella Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 239000004254 Ammonium phosphate Substances 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 description 1
- 235000019289 ammonium phosphates Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000538 anti-polioviral effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 238000000760 immunoelectrophoresis Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7905600 | 1979-02-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55110947A JPS55110947A (en) | 1980-08-27 |
| JPS6352700B2 true JPS6352700B2 (enrdf_load_stackoverflow) | 1988-10-19 |
Family
ID=10503254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1591780A Granted JPS55110947A (en) | 1979-02-16 | 1980-02-12 | Method of discriminating protein |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4246085A (enrdf_load_stackoverflow) |
| JP (1) | JPS55110947A (enrdf_load_stackoverflow) |
| DE (1) | DE3004138A1 (enrdf_load_stackoverflow) |
| SE (1) | SE450205B (enrdf_load_stackoverflow) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3279292D1 (en) * | 1981-04-08 | 1989-01-26 | Atomic Energy Authority Uk | Blood fractionation improvement |
| US5228960A (en) * | 1992-07-17 | 1993-07-20 | Beckman Instruments, Inc. | Analysis of samples by capillary electrophoretic immunosubtraction |
| US20070049732A1 (en) * | 2005-09-01 | 2007-03-01 | Zurlo Eugene J | Ultra-high yield intravenous immune globulin preparation |
| US7879332B2 (en) * | 2005-09-01 | 2011-02-01 | Plasma Technologies, Llc | Ultra-high yield intravenous immune globulin preparation |
| US8293242B2 (en) * | 2005-09-01 | 2012-10-23 | Plasma Technologies, Llc | Ultra-high yield of alpha-1-anti-trypsin |
| GB201413227D0 (en) | 2014-07-25 | 2014-09-10 | Bioproducts Lab Ltd | Process |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1186184A (en) * | 1966-03-23 | 1970-04-02 | Nat Res Dev | Improvements in or relating to Separation Apparatus. |
| US3870617A (en) * | 1971-03-30 | 1975-03-11 | Rhone Poulenc Sa | Apparatus for forced flow electrophoresis |
| GB1431888A (en) | 1972-09-06 | 1976-04-14 | Atomic Energy Authority Uk | Separation apparatus |
| US3989613A (en) * | 1973-05-16 | 1976-11-02 | The Dow Chemical Company | Continuous balanced flow fixed boundary electrophoresis |
| GB1578809A (en) * | 1977-08-17 | 1980-11-12 | Atomic Energy Authority Uk | Electrophoretic separation apparatus |
-
1980
- 1980-01-14 US US06/112,109 patent/US4246085A/en not_active Expired - Lifetime
- 1980-02-05 DE DE19803004138 patent/DE3004138A1/de active Granted
- 1980-02-12 JP JP1591780A patent/JPS55110947A/ja active Granted
- 1980-02-13 SE SE8001133A patent/SE450205B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3004138A1 (de) | 1980-08-28 |
| JPS55110947A (en) | 1980-08-27 |
| SE450205B (sv) | 1987-06-15 |
| SE8001133L (sv) | 1980-08-17 |
| DE3004138C2 (enrdf_load_stackoverflow) | 1989-01-19 |
| US4246085A (en) | 1981-01-20 |
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