JPS6341425A - Lubricant external ointment for combined purposes of lubrication in hyposecretion of bartholin's gland and mechanical troubles thereby - Google Patents

Abstract

PURPOSE:To prepare the title medical preparation by compounding lysozyme chloride. CONSTITUTION:Lysozyme chloride is added in 0.1-2.0%, preferably 0.3-0.7% concentration to give a medical preparation for external use which has lubricating action to relieve hyposecretion or retarded secretion of Bartholin's gland caused by aging or mental anxiety and troubles in coitus caused by mechanical frictions under such conditions. When the humectant agent is applied to female external sex organs, they become flexible to relax contraction or atrophy of the organs, reduce the friction by lubrication. The preparation can prevent bacterial disinfection and give psychical satisfaction, because it resembles Bartholin's juice.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a lubricating liquid for external use, and the ingredients blended into it are prepared using drugs listed in the Japan Pharmacopoeia's legal standards and items listed in the standards for cosmetic raw materials. Similar to this, it has excellent water absorption and moisturizing effects, and its gel-like structure reduces frictional resistance and protects tissues. At the same time, lysozyme chloride, which acts only when damage occurs, protects tissues. It attempts to treat local disorders. Therefore, the objective of the externally applied lubricating treatment liquid of the present invention is to eliminate all disorders caused by mechanical contact by applying it to the female genitals, and to treat people with abnormal conditions such as disorders. It is something. .

In the lining of the uterus, there is glandular secretion, and the cervical line secretes mucus that obstructs the cervical canal and does not slough off periodically, functioning as a barrier to bacterial infection and naturally providing protection against bacterial infection. It is being said.

In addition, the vaginal cavity has a filtration effect, so it is always kept moist, and the vaginal cavity has a self-cleaning effect due to vaginal discharge. The fluid derived from these is usually just enough to moisten the genital tract, and the fluctuations in secretion are small and constantly regulated.

In the vulva, there are Bartholin's lines and Skene's lines, which are subject to large fluctuations due to stimulation and psychological influences, and are secreted each time.
Moisten the vulva and vestibule.

These physiological phenomena become irregular during menopause.

After menopause, specific symptoms occur and genital degeneration is observed.

In women after menopause, ovarian function declines and its functional activity becomes impaired, genital atrophy occurs, fluid secreted decreases, and fat deposits in the vulvar tissue decrease throughout the body. Along with this, the activity of the sebaceous glands decreases, the subcutaneous fat of the entire vulva decreases, and the subcutaneous elastic fibers also decrease, which causes a parallel decline in the secretory function of Bartholin's and Skene's lines. As a result, the fibers lose their elasticity, become loose, dry, and brittle, and their resistance to external stimuli, trauma, and infection decreases.

In old age, atrophic and degenerative changes in the entire vulvar tissue progress further. The labia minora also shrink, become thinner, and become flatter.
The clitoris also shrinks, and the vagina and vestibule become narrower. As atrophy progresses, the skin loses its wettability and becomes dry, making it easily susceptible to injury from mechanical contact such as sexual intercourse. In the pupil area, after menopause.

The submucosal muscle layer atrophies and loses its elasticity, the wrinkles in the lta wall disappear, and the pillars atrophy, losing their elasticity and becoming smooth and slightly hard, and the vaginal cavity loses its mixed, 11A character and becomes narrow. go.

In this way, the water content of the vaginal mucosal epithelium decreases, the secretions from the vaginal wall decrease, the pH increases slightly, and the glycogen content in the mucosal epithelium decreases and the associated lactic acid production mechanism also decreases. The change to alkalinity caused by the thinning of the mucous membrane reduces or eliminates the Daederlein barrier that normally exists in the vagina, and the I111000 purifying action is lost, preventing the entry of pathogens from the outside. I will forgive you.

The pupil of the uterus is the area where the atrophy and regression caused by aging after menopause is most pronounced.

It appears parallel to the pupil and vulva, and this area gradually shrinks and becomes flat, and the external cervix no longer secretes mucus from the m-canal line and becomes narrower.

The mucosal epithelium also rapidly becomes thin, loses its wettability and becomes dry. For this reason, they are easily injured by external mechanical stimuli.

It also makes you more susceptible to bacterial infections.

On the other hand, in recent generations, an increasing number of people are suffering from mental overload due to overcrowding of mental labor, causing abnormalities in secretion due to mental illness, nervous anxiety, etc. This product has essential value for these people as well.

The present inventors have considered the changes in female genital organs from menopause to old age, and the state of abnormal secretion caused by modern mental and nervous anxiety. Similar in properties.

We succeeded in applying a coating solution with a mucus structure that has excellent water retention and wettability. The present invention has been completed by also providing treatment for other disorders that occur.

fA of the present invention! When Liquid 11 is applied to the vulvar female genitalia, the atrophied and narrowed area of the vulvar mucosa becomes flexible due to its water retention and wettability.

Alleviates atrophy and reduces frictional resistance due to its gel-like structure.

The goal is to eliminate obstacles to mechanical stimulation as much as possible, and to treat any problems that occur. By the way, this lubricant prevents bacterial infection, and it also gives a sense of mental satisfaction because its physical properties are similar to IJ's line separator liquid. This externally applied lubricating liquid is a conventionally known compound.

Antioxidants, preservatives, and chelating agents As thickeners, any of e-cellulose type, acrylic acid type, synthetic thickeners such as polyvinyl alcohol and polyvinylpyrrolidone, and natural thickeners such as xanthan gum can be used, and glycerin , 1.3 Butylene glycol, propine glycol, polyethylene glycol, or other moisturizing agent is mixed therein to form a jelly or paste, and the final product is acidified with lactic acid.

Initially 1m1 for 10 couples who have just remarried after the age of 55
One bottle was applied to the vulva, etc., and tested against mechanical contact such as sexual intercourse, and the purpose was achieved, with the exception of slight bleeding in 3 couples, such as severe vaginal opening atrophy and narrowing, and both husband and wife strongly recommend continuous use. I hoped. The three couples did not have any bacterial infections, and their disorders gradually healed with continuous use, and like the 94 people, they also improved and requested continued use. As we move toward an aging society, the externally applied lubricating liquid of the present invention is expected to become a daily necessity.

Next, the present invention will be explained by giving examples.

Example (1) (paste-like externally applied lubricant) A) 1)
Antioxidants 0.22) Preservatives 0.23) Humectants
2.0B) 4) Purified water
20.0C) 5) Purified water
20976) Glycerin
5.07) EDTA-2N,a
0.038>1% lactic acid
Appropriate amount D) 9) Hydroquine ethyl cellulose Appropriate amount 10) Purified water
4o, 0E) II) Lysozyme chloride
0.512) Purified water
10.0 Manufacturing method A) is dissolved in a humidified manner, and the humidified B) is added to C), which is lubricated and weighed, and homogenized by IJD. While stirring the boiled 10), gradually add 9) and stir until the mixture becomes transparent.After confirming complete dissolution, gradually add the solutions A) to C) and homogenize. Next, the completely dissolved E) is gradually oiled and leveled, and
H4.0 to 6.0, especially pH 5.51'+i, and then adjusted to a viscosity of 20 to 40 voices, especially about 30 poices, and used as a product.

However, it is also possible to commercialize products by adjusting the prescription amount of lysozyme chloride depending on whether the lubrication effect is emphasized or the treatment of disorders is emphasized.

However, in the case of using a ground-leveling agent, the same physical properties can be obtained by adjusting the properties according to item D).

Example (■) (Jelly-like externally applied lubricating liquid) Δ) I) Antioxidant 0.22) Preservative 0.23) Humectant
2,0B)4 f,
Y! Mu? water
20. DC>5) fη Kesui
20.976) Glycerin
5.07) EDTA-2Na
O,03D)8) Carboball 940
1.19) Purified water 26
゜5E) 10) Potassium carbonate
0.511) Glycerin 3,
012) lit ice making 1O
6OF) 13) 1% lactic acid
Appropriate amount G) 14) Lysozyme chloride
0.515>Purified water 10
．． 0 Production method A) was heated and dissolved, and then B) was added to C), which was oiled and weighed to make it uniform.I).

Next, gradually add 8) of D) to 9) which is being stirred with a homomixer to make a uniform suspension. Next, switch to propeller stirring (gradually add N to make it uniform.Next Gradually continue to lubricate the homogenized G), and then lubricate the homogenized E) evenly.
become For C', the pH is 4 to 6.0, especially <pH
5,5t) After maj, adjust in F) until the viscosity is 40-6
The product is adjusted to have 0 voices, especially around 50 points.

The suspension type is not limited to Examples (1) and (n).

patent applicant Tokyo Sanchu Chemical Co., Ltd.

Claims (1)

[Claims] a) characterized by containing lysozyme chloride (
1) is an externally applied lubricating liquid. b) characterized in that the concentration of lysozyme chloride is between 0.1% and 2.0%, in particular between 0.3% and 0.7%.