JPH10182435A - Coating lubricating liquid for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a physiologically harmless lubricating liquid for external use, comprising an acidic transparent paste or jelly-like lactic acid solution containing hyaluronic acid and hydroxyethylcellulose, excellent in water retainability and lubricity and useful as a lubricating liquid for coating female sexual organs. SOLUTION: This coating lubricating liquid for external use contains hyaluronic acid, which is a viscous substance always existing in the skins and joints of human bodies and gives viscoelasticity and moisture, and hydroxyethylcellulose as a thickening agent. The sodium hyaluronate and the hydroxyethylcellulose are preferably added in amount of 0.7-1.0%, 0.1-0.5% and 0.1-0.5%, respectively.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an externally applied lubricating liquid,
In particular, it relates to a lubricating liquid for application of female genitals.

[0002]

2. Description of the Related Art A lubricating liquid for external application, particularly a lubricating liquid for female genitals, is required to be physiologically similar to a secretion liquid, to protect tissues by a gel-like structure, and to be completely harmless. However, many jelly preparations conventionally marketed as lubricating liquids for application to female genitals are viscous liquids mainly composed of gelatin, sodium alginate, agaropectin, etc., and have a poor affinity for secretion fluid, so that they are uncomfortable even when applied. Therefore, it did not give the user satisfaction.

[0003]

BACKGROUND OF THE INVENTION The endometrium has glandular secretions, and the cervical line secretes mucus, plugging the cervix, and periodically exfoliating, acting as a barrier to bacterial infection. The secretion fluid is constantly adjusted to wet the genital tract, but if there is sexual arousal or irritation in the vulva, the secretion of the Bartholin line and Skein line will be affected and the wetness will fluctuate greatly I do.

[0004] During menopause in women, ovarian function declines and genital atrophy occurs, and the secretory function of the Bartholin and Skene lines decreases, loses elasticity and becomes dry and vulnerable.
Tissue resistance to external stimulation, trauma, and infection is diminished. In old age, the atrophy and regression of the entire vulvar tissue further increase, the water content of the vaginal mucosal epithelium and the secretion from the vaginal wall decrease, the mechanism of lactic acid production is inhibited, and the mucous membrane becomes thinner. The resulting change to alkalinity reduces or eliminates the vaginal resident Bacterial Dedellein bacilli, losing the natural self-cleansing action of the vagina and making it more susceptible to bacterial infection.

[0005] Such atrophy and decrease in wetness of the entire vulvar tissue from menopause to old age make it difficult for the elderly to engage in sexual activity, and there are many cases in which marital life is disrupted due to impotence or the like. For this reason, the demand for a coating solution capable of replenishing the female genitals with wettability and elasticity has increased, and a wide variety of jelly agents have already been marketed, but none of them has been satisfactory.

[0006]

SUMMARY OF THE INVENTION The present inventors have conducted various studies to obtain a jelly-like lubricating coating solution which is physiologically harmless and has excellent water retention and wettability. As a result, Japanese Patent No. 173475 (Japanese Patent Publication No. 3-72607) has been disclosed. The invention of (1) has been well received, but the present invention aims to provide a further improved externally applied lubricant.

[0007]

The object of the invention is achieved by the claims. That is, the gist of the present invention is an externally applied lubricating liquid for application to female genitals, comprising a transparent paste or jelly-like lactic acid acid solution containing hyaluronic acid and hydroxyethyl cellulose.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION In the following, this will be described in detail. Hyaluronic acid, which constitutes the externally applied lubricating liquid of the present invention, is a viscous substance which is always present in the skin and joints of the human body and gives moisture and viscoelasticity. Substance.

The external application lubricating liquid of the present invention is a mixture of hyaluronic acid as a main component and hydroxyethyl cellulose as a thickener, and the compounding ratio thereof is 0.7 to 1.0% of sodium hyaluronate. , Hydroxyethyl cellulose is in the range of 0.1 to 0.5%, and if it is outside this range, the wettability and lubricating effect cannot be obtained.

A jelly-like lubricant containing only hyaluronic acid as a main component has a feeling of exhilaration at the time of sexual intercourse, but undergoes enzymatic degradation by hyaluronidase which is present in a large amount in semen to form a smooth liquid oligosaccharide and flow out. And soiling the sheets, which can be eliminated by the addition of hydroxyethylcellulose. In the case of a solution containing only hyaluronic acid, the viscosity decreases by 3 to 5 poise after 6 months. However, the decrease in the viscosity can be suppressed by adding hydroxyethyl cellulose.

The secretion of female Bartholin's glands is mainly sialic acid, and the inside of the vagina is acidic at pH 4-5 due to the presence of lactic acid bacteria. Therefore, as a result of examining an acidic and stable thickener, it was found that hydroxyethyl cellulose is most suitable in terms of feeling without causing rash. In addition to this, other cellulosic compounds, PVP, Queen's sheet and the like can be blended to increase the feeling and prevent dirt.

The external lubricating liquid of the present invention includes conventionally known antioxidants, preservatives, collagen liquid, gelatin A liquid, Carboball 940, EDTA-2Na, potassium carbonate, sodium alginate, celtrol, glycerin, lactic acid, Glycyrrhizin K ₂ , urea, fragrance, etc. may be optionally added,
As a result, a transparent paste or jelly-like external lubricant is obtained.

When the jelly-like lubricating liquid of the present invention is applied to the vulva and other female genitalia, the mucous membrane of the vulva and the atrophied and narrowed area become softer due to water retention and wettability, and the jelly-like structure reduces frictional resistance. Obstacles to mechanical stimulation are eliminated. This lubricating fluid prevents bacterial infection and also provides mental well-being as it is similar to Bartholin's secretion fluid.
Such an effect is obtained when mucoprotein is contained in an extract or enzymatically-decomposed extract of umbilical cord, pig skin, chicken squirrel, animal eyeballs, etc. it is conceivable that.

[0014]

【Example】

Example 1 An external lubricant was prepared according to the following formulation. Sodium hyaluronate 0.7 g Hydroxyethylcellulose 0.1 g Glycerin 3.0 g Lactic acid 0.012 g Methyl parahydroxybenzoate 0.15 g Make up to 100.0 g with distilled water.

Example 2 1 g of jelly prepared according to the prescription of Example 1 was applied to the vagina of 20 sets of mature couples, and the condition after intercourse was examined. As a result, all sets were used continuously without any discomfort. I wished.

Example 3 An external lubricant was prepared according to the following formulation. Sodium hyaluronate 0.5 g Hydroxyethyl cellulose 0.1 g Glycerin 3.0 g Lactic acid 0.012 g Methyl paraoxybenzoate 0.15 g Make up to 100.0 g with distilled water. Men and women aged 65 and over who applied this topical lubricant locally
When asked about their names, 12 responded that they were better than the external lubricant of the patent.

[0017]

When the lubricating liquid of the present invention is applied, the water retention and wettability of the vulvar mucosa and the atrophied and narrowed part are improved,
Since the frictional resistance is reduced, it is possible to prevent bacterial infection due to a local frictional wound. Similar to physiological secretion, it has an affinity with the secretion of Bartholin wire and Skein wire, so it gives full satisfaction after use.

Claims (2)

[Claims] 1. An externally applied lubricating liquid for applying to female genitals, comprising a transparent paste or jelly-like lactic acid acid solution containing hyaluronic acid and hydroxyethyl cellulose. 2. The combination of sodium hyaluronate and hydroxyethylcellulose is sodium hyaluronate.
0.7-1.0%, hydroxyethyl cellulose 0.
The externally applied lubricating liquid according to claim 1, which is in the range of 1 to 0.5%.