JPS6333313A - External preparation - Google Patents
External preparationInfo
- Publication number
- JPS6333313A JPS6333313A JP17820386A JP17820386A JPS6333313A JP S6333313 A JPS6333313 A JP S6333313A JP 17820386 A JP17820386 A JP 17820386A JP 17820386 A JP17820386 A JP 17820386A JP S6333313 A JPS6333313 A JP S6333313A
- Authority
- JP
- Japan
- Prior art keywords
- tropolone
- external preparation
- solution
- active ingredient
- dissolved
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- MDYOLVRUBBJPFM-UHFFFAOYSA-N tropolone Chemical compound OC1=CC=CC=CC1=O MDYOLVRUBBJPFM-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000004480 active ingredient Substances 0.000 claims abstract description 7
- 230000000694 effects Effects 0.000 abstract description 11
- 239000006210 lotion Substances 0.000 abstract description 10
- 239000002537 cosmetic Substances 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 7
- 239000000839 emulsion Substances 0.000 abstract description 7
- -1 pack Substances 0.000 abstract description 7
- 239000000865 liniment Substances 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 239000002674 ointment Substances 0.000 abstract description 5
- 206010014970 Ephelides Diseases 0.000 abstract description 4
- 208000003351 Melanosis Diseases 0.000 abstract description 4
- 239000006071 cream Substances 0.000 abstract description 4
- 229940040145 liniment Drugs 0.000 abstract description 4
- 230000003405 preventing effect Effects 0.000 abstract description 4
- 208000010201 Exanthema Diseases 0.000 abstract description 3
- 102000003425 Tyrosinase Human genes 0.000 abstract description 3
- 108060008724 Tyrosinase Proteins 0.000 abstract description 3
- 201000005884 exanthem Diseases 0.000 abstract description 3
- 206010037844 rash Diseases 0.000 abstract description 3
- 231100000046 skin rash Toxicity 0.000 abstract description 3
- 230000002087 whitening effect Effects 0.000 abstract description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 206010040849 Skin fissures Diseases 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 8
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 239000008213 purified water Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 230000008099 melanin synthesis Effects 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 235000021355 Stearic acid Nutrition 0.000 description 4
- 229960000735 docosanol Drugs 0.000 description 4
- 229940075507 glyceryl monostearate Drugs 0.000 description 4
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 4
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 4
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 4
- 239000008117 stearic acid Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229940057995 liquid paraffin Drugs 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000007765 cera alba Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 235000019489 Almond oil Nutrition 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明はトロポロンを有効成分として含有してなる外用
剤に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an external preparation containing tropolone as an active ingredient.
本明細書にいう外用剤とは、化粧料のほかに外用に用い
られる医薬部外品（軟膏剤、ローション剤、リニメント
剤、乳剤など）を含む意味に用いられる。したがって、
本発明はさらに詳しくは、トロポロンを有効成分′とし
て含有してなる、色白効果のすぐれた化粧料およびシミ
、ソバカスなどの防止効果にすぐれた外用医薬部外品に
関するものである。As used herein, the term "external preparation" is used to include not only cosmetics but also quasi-drugs used for external use (ointments, lotions, liniments, emulsions, etc.). therefore,
More specifically, the present invention relates to cosmetics containing tropolone as an active ingredient, which have an excellent skin-whitening effect, and external quasi-drugs, which have an excellent effect on preventing spots, freckles, and the like.
［従来の技術および発明が解決しようとする問題点］
本発明の式：
であられされるトロポロンは従来より産業上で利用され
ていなかった。[Prior Art and Problems to be Solved by the Invention] Tropolone, which is represented by the formula of the present invention, has not been used industrially until now.
［問題点を解決するための手段］
しかるに本発明者は、トロポロンが意外にもチロシナー
ゼ活性抑制作用にもとづく顕著なメラニン生成抑制効果
を有し、色白効果やシミ、ソバカスなどの防止効果にす
ぐれていることを見出し、本発明を完成するにいたった
。[Means for Solving the Problems] However, the present inventor has discovered that tropolone surprisingly has a remarkable effect of inhibiting melanin production based on the inhibitory effect on tyrosinase activity, and is excellent in whitening the skin and preventing spots and freckles. This led to the completion of the present invention.
〔作用および実施例］
本発明のトロポロンのイン ビトロでのチロシナーゼ活
性抑制効果を調べた。試料液としてトロポロン（シグマ
社製）をエタノールに溶解し、１００＋ｎＭ 、１０ｍ
Ｍのエタノール溶液を調製した。[Effects and Examples] The in vitro inhibitory effect of tropolone on tyrosinase activity of the present invention was investigated. As a sample solution, Tropolone (manufactured by Sigma) was dissolved in ethanol, 100+nM, 10m
An ethanol solution of M was prepared.
酵素液（３１Ｂマウスメラノーマ細胞３０００Ｇ上清）
０．１ｍｌ、 １０ｍＭ ｄｏｐａ溶液１．０ｍｌおよ
び試料液１．９ｍｌを３７℃でインキュベートし、３０
秒ごとに４７５ｎｍの吸光値を測定した。結果を第１表
に示す。Enzyme solution (31B mouse melanoma cell 3000G supernatant)
0.1 ml, 1.0 ml of 10 mM dopa solution and 1.9 ml of sample solution were incubated at 37°C,
The absorbance value at 475 nm was measured every second. The results are shown in Table 1.
［以下余白］
つぎに本発明のトロポロンのメラニン生成抑制効果を培
養Ｂ１Ｂマウスメラノーマ細胞を用いて調べた。トロポ
ロン０．１５２７ ｇをｌＯ％ウシ胎児血清を含むイー
グルＭＥＭに加熱溶解し２５ｍ１とした。この溶液０
、１ ｍｌに同ＭＥＮ ４．９ ｍｌを加え、１．０ｍ
Ｍ溶液とした。本溶液を適宜量ＭＥＮで希釈し添加培地
を調製した。トロポロンの添加濃度を０．００１．０．
００２５．０．００５．０．０１および０．０２５ｍＭ
としてメラニン生成抑制効果を調べたところ、Ｏ，００
１ｍＭの濃度で肉眼的に明らかにメラニン生成の抑制を
認めた。０．００２５．０．００５．０、Ｏｌおよび０
．０２５ｉ＋Ｍでは濃度に比例して一層はっきりとメラ
ニン生成の抑制が認められた。[Margin below] Next, the melanin production inhibiting effect of tropolone of the present invention was investigated using cultured B1B mouse melanoma cells. 0.1527 g of tropolone was heated and dissolved in Eagle MEM containing 10% fetal bovine serum to make 25 ml. This solution 0
, add 4.9 ml of the same MEN to 1 ml, and make 1.0 m
This was used as M solution. This solution was diluted with an appropriate amount of MEN to prepare an added medium. The concentration of tropolone added was 0.001.0.
0025.0.005.0.01 and 0.025mM
When the melanin production suppressing effect was investigated as O,00
At a concentration of 1 mM, melanin production was visually clearly inhibited. 0.0025.0.005.0, Ol and 0
．． In 025i+M, suppression of melanin production was more clearly observed in proportion to the concentration.
本発明の外用剤は、ローション、パック、乳液、クリー
ムなどの一般の化粧料のかたちで用いられるほか、軟膏
剤、ローション剤、リニメント剤、乳剤などの外用の医
薬部外品のかたちでも用いられる。The external preparation of the present invention can be used in the form of general cosmetics such as lotions, packs, milky lotions, and creams, as well as in the form of external quasi-drugs such as ointments, lotions, liniments, and emulsions. .
本発明の外用剤は、有効成分であるトロポロンを化粧料
のばあい０．０００１〜０．１％、好ましくはｏ、ｏｏ
ｔ〜０．０５％、医薬部外品のばあいは０．０００５〜
０．５％、好ましくは０．００５〜０．１％含宵する。The external preparation of the present invention contains 0.0001 to 0.1% of the active ingredient tropolone in the case of cosmetics, preferably o, oo.
t~0.05%, 0.0005~ for quasi-drugs
It contains 0.5%, preferably 0.005 to 0.1%.
つぎに本発明を実施例および参考例を用いてさらに詳し
く説明するが、本発明はもとよりこれらに限られるもの
ではない。Next, the present invention will be explained in more detail using Examples and Reference Examples, but the present invention is not limited to these.
実施例１（ローション）
１ ポリオキシエチレン硬化ヒマシ油（６０Ｅ、０．）
１．０ｇ
２ 香 料
微量３ エタノール １０．
０ｇ４ パラオキシ安息香酸エステル Ｏ’、１ｇ５
グリチルリチン酸ジカリウム ０．１ｇ６ ソルビ
ット液（７０％） ３．０ｇ７ 濃グリセ
リン ３．０ｇ８ トロポロン
０．０３ｇ９ 精製水
全量１００ ｇ１〜９を均一に撹拌溶解してローシ
ョン１００ｇを調製した。Example 1 (Lotion) 1 Polyoxyethylene hydrogenated castor oil (60E, 0.)
1.0g 2 Flavoring
Trace amount 3 Ethanol 10.
0g4 Paraoxybenzoic acid ester O', 1g5
Dipotassium glycyrrhizinate 0.1g6 Sorbitol solution (70%) 3.0g7 Concentrated glycerin 3.0g8 Tropolone
0.03g9 Purified water
A total of 100 g of lotion 1 to 9 was uniformly stirred and dissolved to prepare 100 g of lotion.
実施例２（パック）
１ ポリビニルアルコール １２．０ｇ−２酸
化チタン ４．０ｇ３ プロピレン
グリコール ２，０ｇ４ ポリエチレングリ
コール１５００ ２．０ｇ−５エタノール
ｌＯ，０ｇ６ トロポロン
ｏ、ｏｉｇ７ 精製水 全ｆ
ｆ１ｌＯＯｓｒ１〜７を均一に撹拌混合してパック １
００ ｇを調製した。Example 2 (pack) 1 Polyvinyl alcohol 12.0g-Titanium dioxide 4.0g3 Propylene glycol 2.0g4 Polyethylene glycol 1500 2.0g-5 Ethanol
lO,0g6 Tropolone
o, oig7 purified water total f
Stir and mix f1lOOsr1~7 uniformly and pack 1
00 g was prepared.
実施例３（乳 液）
１ モノステアリン酸ポリオキシ
エチレンソルビタン（２０Ｅ、０．） １．０
ｇ２ テトラオレイン酸ポリオキシ
エチレンソルビット（８０Ｅ、０．） ０．５ｇ３
親油型モノステアリン酸グリセリン１．０ｇ
４ ステアリン酸 ０．５ｇ５ ベ
ヘニルアルコール ０．５ｇ６ アボカド
油 ４．０ｇ７ トリオクタン酸
グリセリル ４．０ｇ８ 天然ビタミンＥ
０．０２ｇ９ バラオキシ安息香酸エス
テル ０．２ｇ１０ キサンタンガム
０．１４ｇ１１ １．３−ブチレングリコール
５．０ｇ１２ エタノール
２．０．１３トロポロン ０
．００５ｇ１４ 香料
微量１５ 精製水 全量１００ｇ
−１〜９を加温溶解しくＡ液）、これとは別に１Ｏ１１
１および１５を加温溶解した（Ｂ液）。Ａ液にＢ液を加
え乳化撹拌し、冷却した（Ｃ液）。Example 3 (emulsion) 1 Polyoxyethylene sorbitan monostearate (20E, 0.) 1.0
g2 Polyoxyethylene sorbitol tetraoleate (80E, 0.) 0.5g3
Lipophilic glyceryl monostearate 1.0g 4 Stearic acid 0.5g5 Behenyl alcohol 0.5g6 Avocado oil 4.0g7 Glyceryl trioctanoate 4.0g8 Natural vitamin E
0.02g9 Roseoxybenzoic acid ester 0.2g10 Xanthan gum
0.14g11 1.3-butylene glycol
5.0g12 ethanol
2.0.13 Tropolone 0
．． 005g14 fragrance
Trace amount 15 Purified water Total amount 100g
-1 to 9 should be dissolved by heating (solution A), and separately 1O11
1 and 15 were dissolved by heating (solution B). Solution B was added to solution A, stirred to emulsify, and cooled (solution C).
Ｃ液に１２〜１４を加え、撹拌混合し、冷却して乳液１
００ ｇ−を調製した。Add 12 to 14 to liquid C, stir and mix, cool and make emulsion 1.
00 g- was prepared.
実施例４ （クリーム）
１ モノステアリン酸ポリオキシ
エチレンソルビタン（２０Ｅ、０．） １．０ｇ２
テトラオレイン酸ポリオキシ
エチレンソルビット（６０Ｅ、０．） １．５ ｇ
３ 親油型モノステアリン酸グリセリン１．５ｇ
４ サラシミツロウ ２．０ｇ５ パ
ラフィン ２．０ｇ６ ステアリン
酸 ３．０ｇ７ ベヘニルアルコー
ル ３．０ｇ８ 流動パラフィン
５．０ｇ９ アルモンド油
１２．０ｇｌ０ 天然ビタミンＥ
Ｏ，０２ｇ１１ メチルポリシロキサン
Ｏ，１ｇ１２ パラオキシ安息香酸エステル ０．
２ｇ１３ １．３−ブチレングリコール ゛ ５．
０ｇ１４ エタノール ２．０
ｇ１５トロポロン ０．０５ｇ−１
６香料 微量１７ 精製
水 全量１００ｇ１〜１２を加温溶
解しくＡ液）、これとは別に１３および１７を加温溶解
した（Ｂ液）。Ａ液にＢ液を加え乳化撹拌し、冷却した
（Ｃ液）。Ｃ液に１４〜１６を加え、撹拌混合し、冷却
してクリーム１００ｇを調製した。Example 4 (Cream) 1 Polyoxyethylene sorbitan monostearate (20E, 0.) 1.0g2
Polyoxyethylene sorbitol tetraoleate (60E, 0.) 1.5 g
3 Lipophilic glyceryl monostearate 1.5g 4 White beeswax 2.0g5 Paraffin 2.0g6 Stearic acid 3.0g7 Behenyl alcohol 3.0g8 Liquid paraffin
5.0g9 Almond oil
12.0gl0 natural vitamin E
O,02g11 Methylpolysiloxane
O, 1g12 paraoxybenzoic acid ester 0.
2g13 1.3-butylene glycol 5.
0g14 Ethanol 2.0
g15 Tropolone 0.05g-1
6 Fragrance Trace amount 17 Purified water Total amount 100g 1 to 12 were dissolved by heating (Liquid A), and separately, 13 and 17 were dissolved by heating (Liquid B). Solution B was added to solution A, stirred to emulsify, and cooled (solution C). 14 to 16 were added to Solution C, stirred and mixed, and cooled to prepare 100 g of cream.
実施例５（軟膏剤）
１ モノステアリン酸ポリオキシ
エチレンソルビタン（２０Ｅ、Ｏ，） １．０ｇ２
テトラオレイン酸ポリオキシ
エチレンソルビット（４０Ｅ、Ｏ，） １．５ｇ３
自己乳化型モノステアリン酸グリセリン１．５ｇ
４ サラシミツロウ ２．０ｆ５ パ
ラフィン ３．０ｇ６ ステアリン
酸 ３．０ｇ７ ベヘニルアルコー
ル ３，０ｇ８ 流動パラフィン
５．０ｇ９ トリオクタン酸グリセリル
２Ｑ、０ｇ１０ バラオキシ安息香酸エステル
０．２ｇ１１ グリセリン ５．
０．１２ 水酸化ナトリウム ０．０２
ｇ１３ エタノール ２．０
ｇ１４トロポロン ０．１ｇ１５
精製水 全量１００ｇ１〜１０
を加温溶解しくＡ液）、これとは別にＩＬ １２および
１５を加温溶解した（Ｂ液）。Ａ液にＢ液を加え乳化撹
拌し、冷却した（Ｃ液）。Example 5 (Ointment) 1 Polyoxyethylene sorbitan monostearate (20E, O,) 1.0g2
Polyoxyethylene sorbitol tetraoleate (40E, O,) 1.5g3
Self-emulsifying glyceryl monostearate 1.5g 4 White beeswax 2.0f5 Paraffin 3.0g6 Stearic acid 3.0g7 Behenyl alcohol 3.0g8 Liquid paraffin
5.0g9 Glyceryl trioctanoate
2Q, 0g10 roseoxybenzoic acid ester
0.2g11 Glycerin 5.
0.12 Sodium hydroxide 0.02
g13 ethanol 2.0
g14 Tropolone 0.1g15
Purified water total amount 100g1-10
was dissolved by heating (solution A), and separately, IL 12 and 15 were dissolved by heating (solution B). Solution B was added to solution A, stirred to emulsify, and cooled (solution C).
Ｃ液に１３および１４を加え、撹拌混合し、冷却して軟
膏剤１００ｇを調製した。13 and 14 were added to Solution C, stirred and mixed, and cooled to prepare 100 g of ointment.
実施例６（ローション剤）
１ ポリオキシエチレン硬化ヒマシ油（８０Ｅ、Ｏ，）
１．０ｇ
２ エタノール １５．０ｇ３
パラオキシ安息香酸エステル ０．１ｇ４ クエン酸
０．１ｇ５ クエン酸ナトリ
ウム ０．３ｇ６１．３−ブチレングリコ
ール ４．０ｇ７ トロポロン
０．０１ ｇ８ 精製水 全
量１００ ｇ１〜８を均一に撹拌溶解してローション剤
１００ｇを調製した。Example 6 (Lotion) 1 Polyoxyethylene hydrogenated castor oil (80E, O,)
1.0g 2 Ethanol 15.0g3
Paraoxybenzoic acid ester 0.1g4 Citric acid 0.1g5 Sodium citrate 0.3g6 1.3-Butylene glycol 4.0g7 Tropolone
0.01 g8 Purified water Total amount 100 g1 to 8 were uniformly stirred and dissolved to prepare 100 g of lotion.
実施例７（リニメント剤）
１ トラガント ５．０ｇ２ グ
リセリン ｌＯ，０ｇ３ エタノール
１０．０ｇ４ トロポロン
０．０５ｇ５ 精製水
全量１００ｇ１〜５を均一に撹拌混合してリニメ
ント剤１００ｇを調製した。Example 7 (Liniment agent) 1 Tragacanth 5.0g2 Glycerin 1O,0g3 Ethanol 10.0g4 Tropolone
0.05g5 Purified water
A total of 100 g of liniment agents 1 to 5 were uniformly stirred and mixed to prepare 100 g of liniment agent.
実施例８（乳 剤）
１ モノステアリン酸ポリオキシ
エチレンソルビタン（２０Ｅ、０．） １．０ｇ２
テトラオレイン酸ポリオ牛ジ
エチレンソルビット（４０Ｅ、０．） ０．５ｇ３
親油型モノステアリン酸グリセリン１．０ｇ
４ ステアリン酸 ０．５ｇ５ ベヘ
ニルアルコール ０．５ｇ６ 流動パラフィ
ン ４，０ｇ７ トリオクタン酸グリセ
リル ４．０ｇ８ オクタン酸セチル
２．０ｇ９ パラオキシ安息香酸エステル ０．
２ｇ１０ カルボキシビニルポリマー ０．０５
ｇ１１ １．３−ブチレングリコール ５．０
ｇ１２ 水酸化ナトリウム ０．０２５ｇ
１３ エタノール ２．０ｇ１
４トロポロン ０．０３ｇ１５
精製水 全量１００ｇ１〜９を加温
溶解しくＡ液）、これとは別に１０〜１２および１５を
加温溶解した（Ｂ液）。Ａ液にＢ液を加え乳化撹拌し、
冷却した（Ｃ液）。Example 8 (emulsion) 1 Polyoxyethylene sorbitan monostearate (20E, 0.) 1.0g2
Tetraoleic acid polio-bovine diethylene sorbitol (40E, 0.) 0.5g3
Lipophilic glyceryl monostearate 1.0g 4 Stearic acid 0.5g5 Behenyl alcohol 0.5g6 Liquid paraffin 4.0g7 Glyceryl trioctanoate 4.0g8 Cetyl octoate
2.0g9 Paraoxybenzoic acid ester 0.
2g10 carboxyvinyl polymer 0.05
g11 1.3-butylene glycol 5.0
g12 Sodium hydroxide 0.025g
13 Ethanol 2.0g1
4 Tropolone 0.03g15
A total of 100 g of purified water 1 to 9 was dissolved by heating (liquid A), and separately, 10 to 12 and 15 were dissolved by heating (liquid B). Add liquid B to liquid A and stir to emulsify.
It was cooled (liquid C).
Ｃ液に１３および１４を加え、撹拌混合し、冷却して乳
剤１００ｇを調製した。13 and 14 were added to Solution C, stirred and mixed, and cooled to prepare 100 g of emulsion.
実施例９
実施例１〜４でえられた化粧料それぞれについて、任意
に選んだ６０人の男女（男３０人、女３０人、年齢２０
〜５０歳のあいだでほぼ均一に抽出）に３力月間使用し
てもらい、安全性および効能についてのアンケートをと
った。結果を第２表に示す。Example 9 For each of the cosmetics obtained in Examples 1 to 4, 60 randomly selected men and women (30 men, 30 women, age 20
Participants (approximately uniformly distributed between the ages of 50 to 50) used the product for 3 months and completed a questionnaire regarding safety and efficacy. The results are shown in Table 2.
［以下余白］
実施例１０
実施例５〜８でえられた外用医薬部外品それぞれについ
て、任意に選んだ６０人の男女（男３０、人、女３０人
、年齢２０〜５０歳のあいだでほぼ均一に抽出）に３力
月間使用してもらい、安全性および効能についてのアン
ケートをとった。結果を第３表に示す。[Left below] Example 10 For each of the external quasi-drugs obtained in Examples 5 to 8, 60 randomly selected men and women (30 men, 30 women, between the ages of 20 and 50) were tested. (Extracted almost uniformly) used the product for three months, and completed a questionnaire regarding safety and efficacy. The results are shown in Table 3.
［以下余白コ
第２表および第３表の結果から、本発明の外用剤は肌ア
レ、皮膚のカブレなどを生じることがほとんどなく安全
に使用することができ、また色白結果、シミ、ソバカス
防止効果においてもすぐれていることがわかる。[From the results in Tables 2 and 3 in the margin below, it is clear that the external preparation of the present invention hardly causes skin irritation or skin rash, and can be used safely. It can be seen that the effect is also excellent.
参考例
本発明のトロポロンの貼布試験を、２０歳から５９歳に
わたる健康成人５０名（男２０名、女３０名）を対象と
し、つぎの条件で試みた。Reference Example A patch test of Tropolone of the present invention was conducted on 50 healthy adults (20 men, 30 women) aged 20 to 59 under the following conditions.
試験薬剤；
トロポロン ０．５％水溶液
コントロール（生理食塩水）
貼布時間：４８時間
貼布部位：上腕内側皮膚
貼布剤：パッチテスト用絆創膏
（大正製薬株式会社製）
貼布４８時間後の判定の結果、トロポロンはコントロー
ルと同様、陽性反応を示したものは全くなかった。Test drug: Tropolone 0.5% aqueous solution control (physiological saline) Application time: 48 hours Application site: Inner upper arm skin Patch: Patch test adhesive plaster (manufactured by Taisho Pharmaceutical Co., Ltd.) Judgment 48 hours after application As a result, tropolone showed no positive reaction, similar to the control.
［発明の効果］
本発明の外用剤は肌アレ、皮膚のカブレなどを生じるこ
となく安全に使用することができ、色白効果、シミ、ソ
バカス防止効果がすぐれているという効果を奏する。[Effects of the Invention] The external preparation of the present invention can be safely used without causing skin irritation or skin rash, and has excellent effects of whitening the skin and preventing spots and freckles.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17820386A JPS6333313A (en) | 1986-07-29 | 1986-07-29 | External preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17820386A JPS6333313A (en) | 1986-07-29 | 1986-07-29 | External preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6333313A true JPS6333313A (en) | 1988-02-13 |
Family
ID=16044377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17820386A Pending JPS6333313A (en) | 1986-07-29 | 1986-07-29 | External preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6333313A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09315960A (en) * | 1996-05-29 | 1997-12-09 | Nippon Flour Mills Co Ltd | Maillard reaction suppressor, cosmetic, food additive and food |
| JP2010006732A (en) * | 2008-06-26 | 2010-01-14 | Riron Soyaku Kenkyusho:Kk | Tyrosinase activity-inhibiting agent and skin-beautifying preparation for external use |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS568309A (en) * | 1979-06-29 | 1981-01-28 | Yasuaki Fukuda | White cosmetic |
| JPS56147705A (en) * | 1980-04-07 | 1981-11-16 | Rowaale Keshohin Kk | Dermatological composition |
| JPS56147704A (en) * | 1980-04-07 | 1981-11-16 | Rowaale Keshohin Kk | Dermatological composition |
-
1986
- 1986-07-29 JP JP17820386A patent/JPS6333313A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS568309A (en) * | 1979-06-29 | 1981-01-28 | Yasuaki Fukuda | White cosmetic |
| JPS56147705A (en) * | 1980-04-07 | 1981-11-16 | Rowaale Keshohin Kk | Dermatological composition |
| JPS56147704A (en) * | 1980-04-07 | 1981-11-16 | Rowaale Keshohin Kk | Dermatological composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09315960A (en) * | 1996-05-29 | 1997-12-09 | Nippon Flour Mills Co Ltd | Maillard reaction suppressor, cosmetic, food additive and food |
| JP2010006732A (en) * | 2008-06-26 | 2010-01-14 | Riron Soyaku Kenkyusho:Kk | Tyrosinase activity-inhibiting agent and skin-beautifying preparation for external use |
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