JPS63296770A - Subcutaneous embedding type reservoir - Google Patents

Abstract

PURPOSE:To prevent the leakage of an anti-cancer drug due to repeatedly performed puncture, by arranging a leakage preventing material constituted by alternately arranging a plate-shaped body and a soft elastomer having no flowability to a part where puncture is performed. CONSTITUTION:A reservoir main body 2 has depressed parts 3, 6 respectively provided to the upper and lower parts thereof by drilling and a leakage preventing material constituted by alternately arranging a plate-shaped body 4 and a soft elastomer 5 having no flowability is received in the depressed part 3 and a lid 1 is fixed to the upper part of the reservoir main body 2. A plate-shaped body 7 is received in the depressed part 6 to form an anti-cancer drug storing chamber and a bottom plate 8 is fixed to the lower part of the reservoir main body 2 and a hole 9 is pierced through one wall part of the depressed part 6 and a catheter 11 having a valve 10 is inserted in said hole 9. In the insertion of the catheter 11, operation such that the catheter 11 fixed to the reservoir main body is inserted in a blood vessel and the reservoir main body is embedded in the subcutaneous part of a patient is performed.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to improvements in subcutaneous implantable reservoirs used for intra-arterial injection of anticancer drugs in chemotherapy for advanced cancer patients.

(1) Conventional technology and its problems For the purpose of cancer treatment, when a catheter is inserted into the artery and left in place as a means for injecting an anticancer drug into the artery of a patient with advanced cancer, it is used as an anticancer drug inlet. When the distal end of the catheter is exposed outside the body, there are many medical problems in keeping the exposed portion clean. For example, problems arise such as it is extremely difficult to keep the exposed area clean when the patient takes a bath, and this poses a major hindrance to the patient's daily life. In addition, from a therapeutic perspective, this catheter placement method itself is troublesome, as it requires complicated procedures to operate aseptically, and there is a possibility of staining from the exposed area and bleeding due to damage. . These are major obstacles for patients with advanced cancer to return to society or receive outpatient treatment during their remaining years.

In order to solve this problem, a reservoir was implanted under the patient's skin that connected to the end of the catheter, without exposing the end of the catheter to the outside of the body, and an anticancer drug was injected percutaneously into this reservoir. A method has been proposed in which the anticancer drug is stored in an appropriate amount and flows out from the reservoir into the catheter.However, since anticancer drugs by their nature attack the tissues of the human body, leakage of the drug to the outside of the catheter is unlikely. Must be avoided at all costs. Conventional glue reservoirs lacked means to completely prevent leakage.

(2) Technical means to solve the problem The present invention provides a solution to the problem, in which the reservoir has a plate-like material and a non-fluid material in the part where the needle is penetrated, so that the drug will never leak out even if the needle is repeatedly penetrated. The present invention proposes a subcutaneously implantable reservoir in which a leakage prevention material made of alternating soft elastic bodies is provided.

In order to prevent leakage of the anticancer drug due to repeated punctures, the leakage prevention material must not only be made of a material that has resilience after the needle is removed, but also must be made of a material that has resilience after the needle is removed; the leakage prevention material itself must flow from the reservoir into the blood vessel via the catheter. Since this poses a serious threat to the patient's life, this must never occur. Therefore, the present invention solves the above problem by avoiding the use of a fluid material as the leakage prevention material.

(3) Embodiment An embodiment of the present invention will be explained with reference to the drawings. Fig. 1 is a sectional view taken along the line A-A' of Fig. 2 (plan view). A recessed portion 6 is formed in each recessed portion 3, and a plate-like member 4 and a non-flowable soft elastic member 5 are provided in each recessed portion 3.
11 is fixed to the upper part of the reservoir body 2 by inserting a leakage prevention material consisting of alternating layers, and a plate-like member 7 is fitted into the recessed part 6 to form a chamber for storing the anticancer drug. A bottom plate 8 is fixed to the lower part of the main body 2, and one of the recessed portions 6 is
A hole 9 is drilled through the wall, into which a valve 10 is inserted as shown in FIG.
The reservoir body 2, the bottom plate 8, and the catheter 11 are made of silicone rubber in order to be easily applied to living bodies, and the plate-like body 7 is made of silicone rubber so that a needle used for injecting anticancer drugs can easily penetrate it. The leakage prevention material should be made of a material that has a restoring force and does not leak out of the reservoir. That is, the non-flowable soft elastic body 5 includes 1) silicone putty, 2) a temperature-sensitive softening substance (for example, polyvinyl acetate, acrylic ester copolymer, methacrylic ester copolymer, etc.) 3 )
A water-containing softening material (for example, polyvinyl alcohol, etc.) is preferable, and the plate-shaped members 4 arranged alternately with this material are formed using Shore A silicone rubber of 50 to 70.

FIG. 4 shows a structure in which plate-like bodies 4 and soft elastic bodies 5 are arranged alternately.
This is an example.

Note that the valve 10 is a one-way valve that prevents backflow of the drug.

(4) How to use A catheter to be placed in an artery is inserted through, for example, the left thoracic artery, deep femoral artery, brachial artery, subclavian artery, etc., and the catheter 11 fixed to the catheter reservoir body 2 is A surgical procedure is performed in which the tube is inserted, ligated, and the reservoir is implanted under the worker's skin. The drug is injected by puncturing as shown in the figure.

(5) Effects of this invention This invention has the following special effects.

(a) When injecting anticancer drugs, reduce the need for aseptic protection, except for the puncture site.

(b) The drug can be easily injected and can be repeated repeatedly.

(1) It is possible to make the reservoir extremely small and lightweight, so it does not restrict the patient's daily life at all.

(1) The biocompatibility of the reservoir can be improved.

(E) Since the leakage of chemicals can be completely avoided, damage caused by this can be prevented, and the leakage prevention material itself can also be completely prevented from leaking into the human body, making it extremely safe.

(Force) It is safe because it does not cause problems such as damage to the catheter exposed part.

(g) The present invention can also be broadly applied to other therapies.

[Brief explanation of drawings]

Figure 1 is a sectional view taken along the line A-A in Figure 2, Figure 2 is a plan view, and Figure 3 is a sectional view taken along the line A-A in Figure 2.
The figure is a model diagram of the catheter 11, and FIG. 4 is an explanatory diagram showing an example of the arrangement of the leakage prevention material. 1. Lid 2. Reservoir main body 3. Concave portion 4. Plate body 5. Elastic body 6. Concave portion 7. Plate body 8. Bottom plate 9. Hole 10. Valve 11.・Catheter patent application agent Osamu Ogawa 4r! −1 or low ~ f0

Claims (1)

[Claims] 1 A leakage prevention material consisting of plate-shaped bodies 4 and non-flowable soft elastic bodies 5 arranged alternately is fitted into the recessed part 3 bored in the upper part of the reservoir body 2, and the lid 1 is fixed thereto. A plate-shaped body 7 is fitted into a recess 6 bored in the lower part of the reservoir body 2 to fix a bottom plate 8, and a hole 9 is bored through one wall of the recess 6, and a valve 10 is provided in the hole 9. A subcutaneous implantable reservoir characterized by a catheter 11 being inserted and fixed therein.