JPS63285458A - Liquid component measuring apparatus - Google Patents

Abstract

PURPOSE:To achieve a smaller size of the apparatus, by housing a measuring section, a mixer, a carrier liquid preheater and a defoamer into a sealed container. CONSTITUTION:A carrier liquid in a carrier liquid container 1 is sucked up with a pump 3 to be poured into a sealed container 14 through a check valve 18. The carrier liquid is heated with a heater 15 up to the optimum measuring temperature, while a gas dissolved in the carrier liquid is separated with an air reservoir 16 above the sealed container 14. Moreover, the carrier liquid is taken out of the sealed container 14 and a liquid to be measured is injected with an injecting section 6 for the liquid being measured. Thereafter, the carrier liquid is sent to a measuring section 8 incorporating an enzyme electrode 12 via a mixer 7 so set as to be immersed thereinto 17 in the sealed container 14 to determine the density of components in the liquid being measured.

Description

Detailed Description of the Invention (Industrial Field of Application) The present invention relates to a liquid component measuring device that measures a specific component in a liquid to be measured while flowing the liquid. It is used in measuring devices that use enzyme electrodes, such as for measuring components.

(Prior art) The importance of biochemical tests in medical care is increasing, and the development of automatic measuring devices is progressing.
No. 348 and other publications provide an apparatus that can quickly and accurately measure chemical components in various body fluids using enzyme reactions with relatively high accuracy.

FIG. 3 is a system diagram showing the concept of such a liquid component measuring device using conventional technology. As shown in FIG. 3, in the prior art, the parts constituting the flow line are separate parts for each function, which has the disadvantage of increasing the length of the apparatus.

(Problems to be Solved by the Invention) The present invention aims to invent a measurement unit that aggregates the functions of parts constituting a flow line, thereby reducing the size of the entire device and improving measurement accuracy.

(Means for Solving the Problem) In a liquid component measuring device configured by being connected by a line pipe as shown in FIG.
, a carrier liquid preheater 4 and a deaerator 5 are intended to be integrated as shown in FIGS. 1 and 2.

In other words, by storing the functions 4, 5, and 7 of the conventional technology in the sealed container 14, and using the measuring unit A which has the function 8, the functions of each part can be shared and the total number of parts can be reduced. This makes the entire 'AM smaller.

Fig. 2 is a system diagram showing the concept of a liquid component measuring device to which the present invention is applied, and Fig. 1 shows its main part, the measuring unit)A.
It is an explanatory diagram of the structure of the system, which consists of a measurement line from the carrier liquid container 1 to the three-way cock 10, a return line from 10 to 1, and a discharge line from IO to the waste liquid container 11, which are connected by a line pipe. There is.

The carrier liquid in the carrier liquid container 1 passes through the solution filter 2, is sucked up by the in-line pump 3, is supplied to the measurement line, passes through the check valve 18, and is transferred to the measurement unit A.
The carrier liquid enters the sealed container 14 and is heated to the optimum temperature for measurement (usually 37°C) by the heater 15 with an insulated tube, and is dissolved or dispersed in the carrier liquid in the air reservoir 16 on the right side of the sealed container L. The gas that had been present is separated.

The carrier liquid whose temperature has been raised and whose gas has been separated is taken out of the measuring unit A and reaches a liquid to be measured injection section 6, where the liquid to be measured is injected.

The carrier liquid injected with the liquid to be measured reaches the mixer 7 (spiral flow path mixer) installed so as to be submerged in the carrier liquid 17 in the sealed container 14, and the liquid to be measured and the carrier liquid are sufficiently mixed. Ru. At the same time, the temperature lowered in step 6 is raised to the optimum temperature and reaches the measuring section 8.

The measuring section 8 also serves as a lid for the sealed container 14,
It has a structure in which an enzyme electrode 12 is incorporated. The liquid mixture is brought into contact with the enzyme electrode 12 in a fluid state within the measuring section 8, and when the liquid mixture comes into contact with the enzyme electrode 12, the concentration of the target component in the liquid to be measured is determined by the action of the enzyme electrode.

Calculation and recording of concentration, control of optimum temperature, etc. are performed by the computer 13.

The mixed liquid that has been measured is transferred to the flow resistor 9 and the three-way cock 10.
is discharged through the

When the liquid to be measured disappears from the measurement line, the three-way cock switches to the return line and the carrier liquid returns to the line.

The shape of the sealed container 14 is not particularly limited, and may be any shape such as a cylinder, a box, or the shape of α. Further, the upper part of the sealed container is sealed by a lid incorporating the enzyme electrode 12, and although the lid may normally be made of plastic, it is preferably made of a material with high heat retention. FIGS. 1 and 2 show an embodiment in which the fluid carrier liquid injected with the liquid to be measured is introduced into the mixer 7 through a part of the measuring part 8 which also serves as the lid of the sealed container. However, it is not particularly necessary to adopt such an introduction method of penetrating a part of the measuring section 8.

(Function) The heater 15 with an insulated tube has the effect of heating the carrier liquid 17 introduced into the sealed container 14 to a suitable temperature for measurement and the effect of promoting separation of gas dissolved or dispersed in the carrier liquid 17 from the carrier liquid. The mixer 7, which is embedded in the carrier liquid 17 in a sealed container, has the function of uniformly mixing the carrier group and the liquid to be measured, and the function of reheating the mixed liquid to an appropriate temperature for measurement. The measuring section 8, which also serves as the lid of the container, has the functions of holding the enzyme electrode 12, keeping the carrier liquid 17 in the sealed container warm, and keeping the measured temperature in the measuring section 8 at a constant temperature optimal for measurement. ,
The measuring unit A has the function of compactly integrating the respective functional parts of the carrier liquid preheater 4, deaerator 5, mixer 7, and measuring section 8 in the prior art.

(Example) In FIG. 3, the measurement unit A shown in FIG. Figure 1.

The carrier liquid injected through the check valve 18 in FIG. The gas dissolved or dispersed in the liquid is separated into an air reservoir 16, and only the carrier liquid is sent from the joint 21 to the liquid to be measured injection section 6.

The carrier liquid and the liquid to be measured sent from the liquid to be measured injection part 6 are mixed in a mixer 7 installed in the carrier liquid 17.
・The temperature that dropped in the sample liquid injection part 6 as it was mixed was heated by 1M to the optimum temperature, and the enzyme electrode 12 was heated in the measurement part 8.
The concentration of the target component in the liquid to be measured is determined by the action of

The measured mixed liquid passes through the flow resistor 9 and is discharged.

Various types of gaskets are used for each part of the sealed container 14, and the structure is such that there is no leakage of liquid or air.

(Effects of the Invention) Since the present invention is constructed as described above, the number of components is small, the device is small, and a specific component in a liquid to be measured can be measured quickly and accurately, making it an extremely easy-to-use device.

4. ffi'i 11- Explanation of the Drawings Figure 1 is an explanatory diagram of the structure of the measuring device of the present invention, and Figure 2
The figure is a schematic system diagram of a liquid component measuring device using the same.

FIG. 3 is a schematic system diagram of a liquid component measuring device using a conventional technique.

Claims (1)

[Claims] A liquid to be measured injection part for injecting a liquid to be measured into a fluid carrier liquid, a mixing device for mixing the fluid carrier liquid and the liquid to be measured, and a measurement in which the mixed liquid thus obtained is brought into contact with an immobilized enzyme electrode in a fluid state. A discharge part that discharges the measured mixed liquid out of the system, a carrier liquid preheater, and a deaerator that discharges gas from the heated carrier liquid are connected by a line pipe. A liquid component measuring device, characterized in that the measuring section, the mixing device, the carrier liquid preheater, and the defoaming device are housed in a sealed container.