JPS63275518A - Semisolid composition - Google Patents

Abstract

PURPOSE:To obtain a semisolid composition suitably useful as base for dermatological ointment and cream of cosmetic, containing semisolid fats and oils, a low-molecular cyclic silicone and uniformly dispersed fine powder not absorbing the cyclic silicone. CONSTITUTION:A composition containing (A) semisolid fats and oils, preferably a mixture of fats and oils solid at normal temperature and fats and oils liquid at normal temperature, (B) a low-molecular cyclic silicone, preferably octamethylcyclotetrasiloxane or decamethylcyclopentasiloxane and further (C) uniformly dispersed fine powder (e.g. polyethylene, nylon or polystyrene) which does not substantially absorb the component C and preferably <=500mum, especially 10-50mum average particle diameter. When the composition is further mixed with a proper gelatinizing agent (e.g. dextrin fatty acid ester or cellulose derivative) into lipogel, precipitation of fat and oil components at low temperature is suppressed and a feeling in use of ointment or cream is much more improved.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to semi-solid compositions. The semisolid composition of the present invention is suitably used as a base for dermatological ointments and cosmetic creams.

[Prior Art] Mixtures of low-molecular-weight cyclic silicones such as octamethylcyclotetrasiloxane and oils and fats such as petrolatum are conventionally known as semi-solid compositions such as bases for ointments and creams (Japanese Unexamined Patent Application Publication No. 1983-1993). -145212 and JP-A-1980-
228405). Although these bases have improved the disadvantages of oils and fats, such as stickiness and high viscosity that cause them to be applied thickly, the low molecular weight cyclic silicone does not have sufficient volatility, so when applied to the skin, It takes several minutes to several hours to volatilize, and it has the drawback of leaving behind a slippery or slimy feel that is characteristic of silicone.

[Problems to be Solved by the Invention] An object of the present invention is to solve the above-mentioned problem of volatility of low-molecular-weight cyclic silicones, and to provide a semisolid composition useful as a base for ointments and creams that has an excellent feeling of use. Our goal is to provide the following.

[Means for Solving the Problems] The above objects of the present invention are achieved by the semi-solid composition of the present invention having the following configuration.

1) A semi-solid composition containing a semi-solid oil and fat and a low molecular weight cyclic silicone, further comprising a fine powder that does not substantially absorb the low molecular weight cyclic silicone and is uniformly dispersed therein.

2) 3f! where the low molecular weight cyclic silicone is octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane or a mixture thereof! The semi-solid composition according to item 1.

3) The semi-solid composition according to item 1 or 2, wherein the fine powder is a fine powder of polyethylene, polystyrene, crosslinked polystyrene, nylon or acrylic resin.

4) The semi-solid composition according to any one of items 1 to 3, which contains a gelling agent.

5) The gelling agent is one of dextrin fatty acid ester, sucrose fatty acid ester, cellulose derivative, and phospholipid.
5. The semi-solid composition according to item 4, comprising one or more species.

As described above, the present invention is a semi-solid composition containing a semi-solid fat and oil and a low-molecular cyclic silicone, in which fine powder that does not substantially absorb the low-molecular cyclic silicone is uniformly dispersed.

The fat used in the present invention is not particularly limited, but it is preferably a semi-solid fat that is a mixture of a fat that is solid at room temperature and a fat that is liquid.

Examples of fats and oils that are solid at room temperature include petrolatum, lanolin, lanolin derivatives, plastibase (trade name), waxes (e.g. microcrystalline wax, beeswax), solid paraffin, hydrogenated oils, and higher alcohols (
Examples include cetanol, stearyl alcohol), cholesterol, and cholesterol derivatives. Examples of oils that are liquid at room temperature per ml are liquid paraffin, higher fatty acid esters (e.g., isopropyl myristate, octyldodecyl myristate, isopropyl valmitate, etc.), and higher alcohols (e.g., otakunol, hexyldecanol, octyldodecanol, etc.) , vegetable oils (for example, camellia oil, olive oil, castor oil, etc.), squalane, and the like.

The fat content is 20 to 90% (weight percent) of the total composition.
(same below), solid fat 30-70%, liquid fat 7
0 to 80% is desirable.

The low-molecular-weight cyclic silicone used in the present invention is a solvent for semi-solid oil and fat, and is octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, or a mixture thereof (for example, manufactured by Toshi Silicone, 81
1-344, DC-845) is preferred, and the blending amount thereof is 5 to 90%, preferably 10 to 40% of the total composition amount.
It is.

The fine powder used in the present invention is required to not substantially absorb low molecular weight cyclic silicone. If the fine powder absorbs the low-molecular-weight cyclic silicone and swells, the smooth feel characteristic of the fine powder will be lost, and the addition of the fine powder will not increase the volatility of the silicone, but rather reduce it. This is because the object of the present invention cannot be achieved. Examples include fine powders of polyethylene, polystyrene, crosslinked polystyrene, nylon, acrylic resin, etc., preferably those with an average particle size of 500 μm or less, more preferably 100 to 400 μm, and still more preferably 10 to 50 μm. belongs to. It is also desirable to have water resistance and oil resistance.

In the present invention, by adding an appropriate gelling agent to the composition consisting of the oil and fat and low-molecular-weight cyclic silicone to form a lipogel, precipitation of the oil and fat at low temperatures is suppressed, and the ointment or cream feels even better when used. improves. As the gelling agent, dextrin fatty acid ester, sucrose fatty acid ester, cellulose derivative, phospholipid, etc. are used. Dextrin fatty acid ester is a dextrin in which a fatty acid having 12 to 18 carbon atoms is ester bonded to a hydroxyl group, and most of the hydroxyl groups are esterified. For example, Leopard KE and KL (manufactured by Chiba Flour Milling Co., Ltd.) are suitable. Sucrose fatty acid ester is one in which the hydroxyl group of sucrose is esterified with a fatty acid having 4 to 22 carbon atoms, and has an HLB of 1 to 2 (for example, DK-Ester FIO, F20° manufactured by Daiichi Chemical Co., Ltd.) , or one in which the remaining hydroxyl group is acetylated (for example, DK-ester FA-10E, manufactured by Daiichi Chemical Co., Ltd.) is used.

As the cellulose derivative, oil-soluble ones such as ethylcellulose and ethylhydroxyethylcellulose are preferably used. As the phospholipid, soybean lecithin, egg yolk lecithin, and hydrogenated products thereof can be used. It does not need to be composed of only a single phospholipid, but may contain two or more types of phospholipids, and components other than phospholipids (
For example, soybean oil, egg yolk oil) may be included, but the amount used is determined based on the amount of phospholipid contained therein.

The amount of gelling agent used is generally 1 to 10% of the total amount of the composition, but it varies somewhat depending on the type of gelling agent. For example, the content is 2 to 10% for dextrin fatty acid ester, 1 to 10% for sucrose fatty acid ester, and 1 to 3% for cellulose derivatives and phospholipids. These gelling agents can be used alone or in combination.
Combinations of more than one species can also be used.

When the semisolid composition of the present invention is produced as a cream base, a water-in-oil emulsion system is formed in which the external phase is an oil phase consisting of the semisolid oil and fat and low-molecular-weight cyclic silicone. Examples of the emulsifier used in this case include dimethylsiloxane/methyl(polyoxyalkylene)siloxane copolymer. In the present invention, desirable results can be obtained by further using an emulsifier consisting of a fatty acid ester of a polyhydric alcohol. Examples of such esters include glycerin monofatty acid esters and decaglycerin fatty acid esters, and esters in which the fatty acid is oleic acid are particularly preferred.

When producing the semisolid composition of the present invention as a cream base, various humectants can be added to the aqueous phase. Such wetting agents include glycerin, carbon number 2-4;
Glycols, polysaccharides and polysaccharide derivatives are preferred; glycerin is particularly preferred due to its high water retention capacity and non-irritating properties; Since it can be expected to have the effect of alleviating irritation, it is suitable for inclusion in hand creams and the like.

In addition, when manufacturing as a cream base, the ratio of the internal water phase to the external oil phase is 1:2 to 2:1, preferably 2:3.
A range of 2 to 1 is obtained as a stable water-in-oil emulsion system. It can be freely selected within this range depending on the purpose of use.

The semi-solid composition of the present invention can be produced as follows.

1) After stirring a mixture of solid fat and liquid fat (and gelling agent if necessary) at a high temperature, preferably 75°C or higher to make a homogeneous liquid, add preheated low-molecular-weight cyclic silicone and stir. to disperse it evenly. Then cool while stirring. After cooling to a temperature of 40 to 60° C., fine resin powder is added and uniformly dispersed by stirring to obtain a semi-solid composition as an ointment base.

2) After stirring a mixture of solid oil, liquid oil, and emulsifier (and gelling agent if necessary) at a high temperature, preferably 75°C or higher to make a homogeneous liquid, add a low-molecular-weight cyclic silicone that has been heated in the same way. Add and stir well to make a homogeneous liquid. Thereafter, an aqueous phase previously heated to 75°C or higher is added to emulsify at a high temperature, preferably 75°C or higher.

After emulsification, cool while stirring to a temperature of 40 to 80°C,
Next, fine resin powder is added and uniformly dispersed to obtain a semi-solid composition as a water-in-oil emulsion base, that is, a cream base.

3) After stirring the mixture of solid fat and liquid fat (and gelling agent if necessary) at high temperature, preferably 75°C or higher to make a homogeneous liquid, add low molecular weight cyclic silicone and fine resin powder to 75°C. Stir well at ~85°C.

Then, by cooling to room temperature while stirring, a semisolid composition as an ointment base is obtained.

In this case, care should be taken not to expose the raw material to a high temperature of 85° C. or higher for a long period of time. This is because some resins may swell, impairing the feeling of use.

4) After stirring a mixture of solid oil, liquid oil, and emulsifier (and gelling agent if necessary) at a high temperature, preferably 75°C, to make a homogeneous liquid, add low-molecular-weight cyclic silicone and fine resin powder. Stir well. Thereafter, while gradually adding an aqueous phase previously heated to 75°C or higher, the mixture is vigorously stirred and emulsified at 75 to 85°C. After emulsification, a semi-solid composition as a water-in-oil emulsion base, that is, a cream base, is obtained by cooling with rapid stirring.

Next, the present invention will be explained in more detail with reference to Examples and Test Examples.

(Left below) Example 1 Composition 1 Composition 2 Composition 3 Composition 4 Composition 5a) Vaseline 14 14
14 5 5b) Seishin purified lanolin
14 14 14 5 5C
) Liquid paraffin 14 14 14
5 5d) Isopropyl myristate 14
14 14 5 5e) Dextrin fatty acid ester 44422r) SH-3441) 25
25 25 7 7g) Dimethylsiloxane・
Methyl (polyoxyalkylene) siloxane copolymer ---33h) Monooleic acid glyceride ---111) Nylon fine powder
io -----j) Polystyrene fine powder
-10-10-k) Polyethylene fine powder
--10-101) Glycerin
55555m) Parabens---0,20,20
) Purified water --- Remaining amount meter too 100 100
100 to.

The mixture of a-e and g is stirred at 75° C. or higher to form a uniform liquid, and at the same time, preheated f is added and stirred to uniformly disperse the mixture. Thereafter, it is cooled to below 80°C while stirring, and then one of i- is added,
When uniformly dispersed by stirring, compositions 1 to 3 consisting of compositions 1 to 3 are obtained.

After the mixture of a-e is stirred at 75° C. or higher to form a uniform liquid, the mixture of f-h, which has been similarly heated in advance, is added and stirred to uniformly disperse the mixture. Thereafter, a mixture of l and n, which has been previously heated to 75°C or higher, is added and emulsification is carried out at 75°C or higher. After emulsification, cool while stirring, add either one of j- to below 60°C, and uniformly disperse by stirring to obtain compositions 4 and 5 consisting of compositions 4 and 5.

1) Manufactured by Toshi Silicone■ When each of the obtained compositions 1 to 5 was stored under recycling conditions where the same temperature of 0°C and 40'C was alternately repeated, the present composition as an ointment of compositions 1 to 3 was obtained. All the products were stable with no change observed for more than 3 weeks. In addition, the present compositions as water-in-oil emulsion bases obtained from Compositions 4 and 5 were also stable for over 3 weeks with no change observed at all.

It was confirmed that each of the compositions obtained from Compositions 1 to 5 above had a reduced slimy feel characteristic of silicone and quickly subsided onto the skin.

(Left below) Example 2 A) Vaseline
9.8 9.8 9.2b) Adsorption purification rough 1l 9.8 9.8 9
．． 2C) White beeswax 2.0
2.0 1.8d) Microcrystalline wax
2.0 2.0 1.8e) Cetanol
3.1 3.1 2.8f) Stearyl alcohol 1.0 1.0 1. Og) Cholesterol 1.6 18 L, 5h)
12-hydroxycholesterol 1.6 1
．． 8 1.51) Dextrin fatty acid ester
3.9 B, 9 3.7j) Isopropyl myristate 9.2 9.2 8.7k) Octyldodecanol Name, 4 8.4 7.8J)
S H-34432,831,1330a+) Ethylhydroxyethylcellulose -110) Polyethylene fine powder 10 10 100) Glycerin
□□□ Total 100 100 1o.

b) Seishin purified lanolin 4.5
4.5 6.750) White beeswax
0.9 0.9 1J5d) Microcrystalline wax 0.9 0.9 1.350
) Setanol 1.5 1.5 2.18r
) Stearyl alcohol 0.5 Q, 5 0.
72g) Cholesterol 0.7
0.7 1.08h) 12-hydroxycholesterol 0.7 0.7 1.081) Dextrin fatty acid ester 1.8 1.6 2
．． 7j) Isopropyl myristate 4.2
4.2 6.3k) Octyldodecanol 3.
8 3.8 5.781) SH-34410107,5 m) Dimethylsiloxane methyl (polyoxyalkylene) siloxane copolymer 5515n) Monooleic acid glyceride 1 1
10) Ethylhydroxyethylcellulose-11
p) Polyethylene fine powder 10 10 10q)
Glycerin 5515 r) Sodium citrate 0.9
0.9 0.9S) Citric acid
0.1 0.1 0.11) Parabens 0.2 0.2 0
．． 2U) Purified water Remaining amount Remaining amount (blank below) Stir the mixture of a-k and 0 at 75℃ or higher to make a homogeneous liquid, then add pre-heated g in the same way and stir to disperse uniformly. . Thereafter, the mixture is cooled while stirring, and n is added at a temperature of 60° C. or lower, and the mixture is uniformly dispersed by stirring to obtain Composition 6 having Composition 6.

A mixture of m and o is stirred in a- at 75° C. or above to form a uniform liquid, and then g, which has been heated in advance, is added and stirred to uniformly disperse the mixture. Then cool to 60℃ while stirring.
In the following, n is added and uniformly dispersed by stirring to obtain compositions 7 and 8 consisting of compositions 7 and 8.

After the mixture of a to k is stirred at 75° C. or higher to form a uniform liquid, the mixture of l to n, which has been heated in advance, is added and stirred to uniformly disperse the mixture. Thereafter, a mixture of q and u, which has been previously heated to 75°C or higher, is added and emulsified at 75°C or higher. After emulsification, cool while stirring, add p at below 60°C and disperse uniformly with stirring to obtain composition 9.
Composition 9 is obtained.

After the mixture of a-k and 0 is stirred at 75° C. or higher to form a uniform liquid, the mixture of g-n heated in advance is added thereto and stirred to uniformly disperse the mixture. Thereafter, a mixture of q and u previously heated to 75°C or higher is added and emulsified at 75°C or higher. After emulsification, the mixture is cooled with stirring, and p is added at a temperature below 60° C. and uniformly dispersed by stirring to obtain compositions 10 and 11 having compositions 10 and 11.

The bases made of compositions 6 and 9 spread well and have an excellent feel when used, and are suitable for skin creams.

The bases obtained from Compositions 7 and 1O contain cationized cellulose and are suitable for hand creams.

The bases made of compositions 8 and 11 contain a large amount of glycerin, which is a humectant, and are particularly effective for skin with advanced roughness.

Comparative Examples 1 and 2 Comparative Example Compositions 1 and 2 are two compositions obtained by removing each polyethylene fine powder from Composition 6 and Composition 9 in Example 2, and a base made of the compositions obtained therefrom. The feeling of use was compared with a base made of the composition of the present invention.

[Examination example]

In order to examine the usability of the composition of the present invention, the following tests were conducted. Four types of compositions, Compositions 6 and 9 of Example 2 and Comparative Compositions 1 and 2, were each placed in 5 g narrow-mouth tubes, and a group for comparing Composition 6 and Comparative Composition 1 was designated as A.
Group (7 people), group B comparing composition 9 and comparative composition 2
Each group (7 people) was randomly numbered and distributed to volunteers.

Two samples to be compared were applied for one day with a gap of 2 hours or more, and the evaluation at that time was recorded on a data sheet. The order in which the samples were applied was randomized and designated in advance. The evaluation items are "oily feel", "moist feeling", "stickiness", "slimy feeling", "resistance on the skin", "waxy feeling", "smell", "spreadability", "workability", and " The overall evaluation consisted of 10 items. Comparison results between Composition 6 and Comparative Composition 1 are shown in Figure 1 (1) (n), and Composition 9
The comparison results of Comparative Composition 9 and Comparative Composition 2 are shown in Figure 2 (1
, n). Each item has a rating of 100 or the best.
0 is the worst evaluation.

As is clear from FIGS. 1 and 2, a remarkable improvement in the feeling of use was observed, especially in FIG. 1, which is a comparison of the ointment base. In the cream base, the effect of adding fine powder was confirmed in terms of stickiness, slimy feel, and soothing effect on the skin.

[Effects of the Invention] The composition of the present invention, which contains a semi-solid oil and fat and a low-molecular-weight cyclic silicone, and further includes a fine powder that does not absorb the low-molecular-weight cyclic silicone and is uniformly dispersed therein, can be used as a base for ointments and creams. When used as an agent, it does not have the slimy or slippery feel characteristic of silicone that remains when applied to the skin.

Furthermore, the composition of the present invention has high water resistance, detergent resistance, and water retention ability.

In the present invention, when a gelling agent is further added, precipitation of fat and oil bones at low temperatures is prevented, and the usability as a base material is further improved.

Therefore, the composition of the present invention is suitably used as a base for dermatological and cosmetic ointments and creams.

[Brief explanation of the drawing]

FIG. 1 is a graph showing a comparison of the usability of the composition (ointment base) of the present invention (composition 6) and a conventional ointment base (comparison composition 1). Figure 2 shows the composition of the present invention (cream base) (composition 9).
It is a graph showing the evaluation of the usability of the conventional cream base (comparative composition 2) and the conventional cream base (comparative composition 2).

Claims (1)

[Scope of Claims] 1) A semi-solid comprising a semi-solid fat and oil and a low-molecular cyclic silicone, and further comprising a fine powder that does not substantially absorb the low-molecular cyclic silicone and is uniformly dispersed therein. Composition. 2) The semi-solid composition according to claim 1, wherein the low molecular weight cyclic silicone is octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, or a mixture thereof. 3) The semi-solid composition according to claim 1 or 2, wherein the fine powder is a fine powder of polyethylene, polystyrene, crosslinked polystyrene, nylon or acrylic resin. 4) The semi-solid composition according to any one of claims 1 to 3, which contains a gelling agent. 5) The semi-solid composition according to claim 4, wherein the gelling agent comprises one or more of dextrin fatty acid ester, sucrose fatty acid ester, cellulose derivative, and phospholipid.