JPS63225314A - Application agent for external use - Google Patents

Abstract

PURPOSE:To obtain an application agent for external use with remarkably reduced occurrence of contact dermatitis and hardly any skin irritation, by blending a specific amount of a water absorbing high polymer in a plaster component. CONSTITUTION:An application agent for external use obtained by blending 1-20wt.%, preferably 1-8wt.% water absorbing high polymer as an essential ingredient in a plaster containing a tacky high polymer, drug effective ingredient, etc. The water absorbing high polymer absorbs water in an amount of 10 times or more based on the own weight to gel and swell and, e.g. a polymer prepared by introducing slight crosslinkages in an aqueous polymer, is used and blended as particles having <=100mu, particularly <=30mu particle size. The above-mentioned application agent is capable of sufficiently absorbing sweat causing the contact dermatitis without swelling and breaking the plaster even after absorbing the sweat. The whole plaster is moderately gelatinized by absorbing the sweat to reduce physical action, such as pulling out of hair.

Description

[Detailed Description of the Invention] Emperor Chestnut-jo Oni Ushikai Kuni! The present invention relates to an external patch that significantly reduces the occurrence of skin irritation and causes less skin irritation by incorporating a water-absorbing polymer.

Traditionally, topical patches have been prepared by containing drugs in adhesive polymers and spreading them directly or indirectly onto a support such as flexible cloth, nonwoven fabric, or various plastic films. There are plasters, poultices, tapes, etc. In addition, surgical tape, adhesive plaster, taping, etc. have been used as drug-free patches. When using these external patches, there are physical effects such as hair pulling when removed, and stuffiness due to long-term application.

The occurrence of side effects such as redness and skin irritation due to physiological effects such as sweating has been a problem.

The main reason for this is that conventional topical patches are breathable.

It does not have moisture permeability or absorbency, and when applied to the skin, it causes the skin surface to become clogged, stopping moisture from evaporating, and causing irritation due to the irritating components contained in sweat and secretions. .

On the other hand, various attempts have been made to solve these problems.

For example, Japanese Patent Publication No. 58-52251 discloses a method of making ventilation holes in a plaster. Also, Japanese Patent Publication No. 58-47
No. 21, JP-A-60-56911, JP-A-Sho 6
No. 0-23312 and the like disclose drug combinations for preventing exposure or reducing skin irritation. Special Public Service 1984-
Japanese Patent No. 19528 proposes a method of reducing skin irritation by subjecting the base material to special treatment. However, in either case, there are problems in practicality, the manufacturing process is complicated, and the effects are insufficient. In addition, methods have been attempted in which sweat and secretions, which are the main causes of skin irritation, are absorbed or adsorbed into the base material. -19258 contains polysaccharide gum, Japanese Patent Publication No. 58-23846 and Japanese Patent Application Publication No. 60-4
In 1968, a method for compounding acrylic copolymers was disclosed. Also, JP-A-60-123416 and JP-A-6
No. 0-123417 attempts to reduce skin irritation by imparting sweat absorbency or water permeability to a patch by incorporating a water-soluble polymer and a polysaccharide. However, in reality, since it is water-soluble, the plaster may dissolve with sweat, and in any case, its water absorption and sweat absorption ability is insufficient, at most 1 to 10%. Because the water absorbing capacity is only 1,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000.

As mentioned above, although various methods have been tried, they are far from practical, and at present, an ideal external patch that does not cause any discomfort has yet appeared.

In view of this situation, the inventors of the present application have improved sweat absorption among the various improvement methods described above, in order to develop a topical patch that is unprecedented and has no unpleasant sensations. After focusing on this point and conducting extensive research, we discovered that the objective could be achieved by incorporating a water-absorbing polymer. That is, the present invention relates to a patch for external use characterized in that 1 to 20% by weight of a water-absorbing polymer is blended as an essential component in the plaster component. , absorbs sweat or secretions from the skin.

By adsorbing it, the problems that could not be solved by conventional compounding agents such as water-soluble polymer 2-M gum or acrylic copolymer, such as side effects such as stuffiness or feeling, are significantly reduced. The inventors have developed an external patch that alleviates pain when peeled off, and have completed the present invention.

Conventionally, water-absorbing polymers have been used in water-stopping agents for agricultural and civil engineering applications, and in order to produce water-absorbing and swelling effects, they have been incorporated in large amounts into plasters. However, there have been no examples of it being incorporated into external patches for the purpose of preventing skin irritation, and no known literature suggesting this has been found.

Normally, a large amount of water-absorbing polymer is required to absorb water, so when this is added to a plaster, the plaster swells significantly after absorbing water, resulting in destruction of its physical properties. Therefore, until now it has not been possible to incorporate it as a base component.

However, the inventors of the present invention have discovered that even with a small amount of addition, it can sufficiently absorb sweat and have the effect of preventing skin contact. In other words, in addition to sufficient sweat absorption only at a specific blending amount, which will be described later, the plaster does not swell and break even after sweat absorption, and the entire plaster gels appropriately by absorbing sweat, making it possible to absorb hair. Physical effects such as tension were also reduced.

That is, the use of a water-absorbing polymer as a medical patch preparation for the purpose of preventing exposure and improving adhesiveness is the first new finding made by the inventors of the present invention.

The amount of the water-absorbing polymer, which is an essential component of the present invention, is preferably 1 to 20% by weight, preferably 1 to 8%. If it is less than 1%, sufficient water absorption cannot be expected, and sweat and secretions A feeling arises.

On the other hand, if it is 20% or more, the water absorption power is sufficient, but the cohesive force and adhesive force of the plaster are greatly reduced, and it becomes easy to peel off.

Next, to explain specifically about water-absorbing polymers, water-absorbing polymers are those that absorb, gel, or swell more than 10 times their own weight in water, such as water-soluble polymers with mild cross-linking. may be formulated either singly or in combination of two or more. For example, ■ Sanyo Chemical's product name Sunwet IM-300, Sunwet IM-300M.
P.S.

Sunweft 1M-1000, Sunweft IM-10
0OMPS etc., Koji Seitetsu Chemical's product name Aqua Keep 4S,
Aqua Keep 4SH, etc., Sumikagel 5P-520, Sumikagel 5P-540, Sumikagel N, sold by Sumika Kagaku.
100, Sumikagel NP-1020, Sumikagel NP-
1040, etc., ■ Kuraray's Kl Gel-201, Kl Gel-201 -F2, etc., ■ Arakawa Chemical's trade name Arasorb 8
00, Arasorb 800F, etc., and those having a slight crosslinking are preferably used.

Among them, Sunwet IM-300MPS, Sunwet IM-1000MPS, Sumikagel NP-1020,
Sumikagel NP-1040, KI gel-201-F2
, Arasorb F is particularly preferred. Particle size is also an important factor when selecting a water-absorbing polymer. The particle size of the water-absorbing polymer must be adjusted to ensure uniform dispersion in the plaster and to maintain excellent water absorption, sweat absorption, and adhesive properties, that is, a good balance of adhesive strength, adhesion, and cohesion. It is preferably as small as possible, specifically 100μ or less, particularly preferably 30μ or less.

Next, in carrying out the present invention, there are no particular restrictions on the polymeric base used as the base component for the patch, and examples include silicone, styrene-isoprene-styrene, styrene-butadiene, and acrylic. , vinyl ether type, natural rubber type, urethane type, polyisobutylene type, etc. are used, and the preferred amount of these polymer substances contained in the plaster is 10 to 90% by weight.
However, in the case of so-called diene-based rubbers such as natural rubber, styrene-isoprene-styrene-based rubber, and polyisobutylene, the amount is particularly preferably 20 to 40% by weight. Gum (Arakawa Chemical), Harinister (Harima Kasei), Haritac (Harima Kasei)], Terpene resins (YS resin (cheap crude oil), Picolite (Vercules)), Petroleum resins [Alcon (Arakawa Chemical), Regalets (Vercules) , Escolette (Exxon), Wingtac (Gutsdoyer)], phenolic resin, xylene resin, etc. are used in an amount of 50% by weight or less.However, when using acrylic as the polymer base, depending on the type, it may be sufficient. has adhesive properties, so whether or not to use it is determined depending on the type. Plasticizers, fillers, and stabilizers may be added as appropriate. Other metal oxides include zinc oxide and aluminum oxide. , magnesium oxide, iron oxide, etc. may be appropriately blended.By adding these, it is possible to prevent destruction of the plaster due to swelling after absorption of water and sweat.

The drugs contained are not particularly limited as long as they are transdermally absorbable drugs, such as salicylic acid, methyl salicylate, glycol salicylate, etc. as skin irritants and analgesic and anti-inflammatory agents.
- Menthol, camphor, pepper oil, thymol, nicotinic acid benzyl ester, capsicum extract, kabsaicin, nonylic acid vanillylamide, felbinac, butyl flufenamate, piroxicam, indomethacin, ketoprofen, pranoprofen, febrazone, loxoprofen, anzenaf sodium, oxaprozin,
Emorphazone, tiaprofen, fenbufen, pranoprofen, fentiazac, diclozenaf sodium, diflunisal, ibuprofenpiconol, pendazac, and suprofen, and their ester derivatives, or buprenorphine hydrochloride, pendazac, butorphanol tartrate, etc.

Central nervous system acting agents (hypnotic sedatives, anti-epileptic drugs, neuropsychiatric drugs) include fluphenazine, thioridazine, diazepam, chlorpromazine, nitrazebam, estazolam, triazolam, nimetazepam, fludiazepam, haloxazolam, flurazepam, clonazepam, proberidiazine, Prochlorperazine, Albrasulam, Oxazepam, Oxazolam, Cloxazolam, Prazepam,
Flutazolam, mexazolam, lorazebam, fludiazepam, promazepam, metazebam, etc.

Diuretics include hydrothiazide, pendroflunathiazide, ethiazide, cyclopenthiazide, hydrochlorothiazide, penflutide, methyclothiazide, furosemide, metolazone 2 polythiazide, pendroflumethiazide, etc.

Antihypertensive agents include clonidine, altheroxiron, recinamine, dihydroergotoxin mesylate, reserpine, prazosin, captopril, pindolol, enalapril maleate, etc.

Coronary vasodilators include nitroglycerin, nitroglycol, isosorbite cinitrate, bababerine hydrochloride,
Dipyridamole, efloxate, trimetacin, nicorandil, cinnarizine, nyridone, molsidomine nifedipine, etc.

As an antitussive expectorant: codine phosphate, dihydrocodine phosphate, ephedrine hydrochloride, chlorprenaline hydrochloride, phenotyrol hydrobromide, salbutamol sulfate, dimemorphan phosphate, azelastine hydrochloride, clenbuterol hydrochloride, tulobuterol hydrochloride, trimetoquinol hydrochloride, hydrochloric acid Procaterol, fJ[7' romhexine, tranilast, tipepidine hibenzate, ketotifen fumarate, formotyol fumarate, pensbroverine phosphate, glycyrrhetinic acid, etc.

Antihistamines include diphenhydramine hydrochloride, triprolidine hydrochloride, isotibenzyl hydrochloride, promethacin hydrochloride, chlorpheniramine maleate, cibrohebutadine hydrochloride, lemastine fumarate, carbinoxamine maleate, dimethindene maleate, etc.

Antiarrhythmic agents include alprenolol, oxbrenolol, bucumolol, bupranolol, pindolol, indenolol, carteolol, bucumolol, propranolol, timolol, etc.

Cardiotropes include digitalis, ubidecarenone, digoxin, methyldigoxin, and deslanoside.

Estradiol enanthate, estradiol cibinate, levonorgestrel, estradiol, etc. as contraceptives.

Corticosteroids include hydrocortisone acetate, hydrocortisone, prednisolone, triamcinolone acetonide, dexamethacin phosphate, methylprednisolone, gyclorisine acetate, methylprednisolone acetate, fluocinolone acetonide, dexamethacin acetate, dexamethacin, fluorometholone, betametha phosphate cinsodium, betamethacin, betamethacin valerate,
Beclomethasone propionate, fludroxycortide,
Hydrocortisone butyrate, betamethacin dipropionate,
Fluocinonide, clobetapur propionate, diflucortolone valerate, haldinonide, amcinonide, prednisolone valerate, etc.

lidocaine, ethyl aminobenzoate, as a local anesthetic;
Examples include procaine hydrochloride, dibucaine, and procaine.

These medicinal ingredients may be used alone or in combination of two or more.

In addition, emergency bandages, surgical dressings to protect wounds after surgery, surgical drapes to prevent bacterial contamination of incisions, tapes for reinforcing and fixing incisions and sutures,
Furthermore, it can also be used for taping used during sports.

Examples of the support include films or sheets of polyethylene, polypropylene, polybutadiene, ethylene vinyl acetate copolymer, polyvinyl chloride, polyester, nylon, polyurethane, or porous bodies and foams thereof, as well as paper, cloth, nonwoven fabric, etc. Selected from stretchable or non-stretchable supports.

Next, the manufacturing method may be a conventional method, but for example, a water-absorbing polymer is added to the dissolved or kneaded base component and dispersed uniformly, and further medicinal ingredients are added as necessary. It can also be produced by directly spreading it on a tape or sheet substrate, or by first spreading it on a paper, film, etc. that has been subjected to a release treatment, and then pressure-transferring it onto the substrate to be used.

Shirai Tachikai In the patch of the present invention obtained in this way, as described in the test examples and examples below, it is essential to incorporate a water-absorbing polymer, and by incorporating it into the base component, the The water-absorbing polymer blended into the agent absorbs sweat, which causes irritation, and the gel-like nature of the paste does not involve body hair, and does not cause physical effects such as pulling hair when peeling off. It is presumed that the causes of discomfort caused by physiological and physical factors unique to patches are eliminated. In addition, because physical property values such as adhesive strength and cohesive strength change little over time, the initial moderate adhesive feeling remains for a long time, and therefore no redness or rash is observed when peeling off from the skin due to increased adhesive strength. I can't. These effects are due to the water-soluble polymer, Multi-I!, which is conventionally included in patches. ! 1 gum etc., which could not be obtained.

The external patch according to the present invention includes: 1) Elimination of physiological factors such as stuffiness and sweating.

2) Elimination of physical factors such as hair pulling during peeling.

This makes it an ideal non-irritating topical patch, which was unimaginable with conventional topical patches.

The above-mentioned functions and effects will be explained in more detail with reference to Examples and Test Examples.

Example 1 Arasorb was added to a base component consisting of 22 parts by weight of styrene-isoprene-styrene block copolymer Cariflex TR-1107 (shell chemical type), 40 parts by weight of Alcon-Ploo (manufactured by Arakawa Chemical), and 20 parts by weight of liquid paraffin. 800F (manufactured by Arakawa Chemical) was added and mixed, and then 3 parts by weight of methyl salicylate, 3 parts by weight of l-menthol, and 2 parts by weight of a-camphor were added and spread on a polyester nylon base fabric to a thickness of 100 μm. The mixture was rolled and covered with a silicone-treated polypropylene film and cut into a desired shape to obtain a non-irritating adhesive patch of the present invention.

When this adhesive patch was applied, a good cooling sensation persisted, there was no hair pulling during removal, and there was no redness or discomfort after removal.

Example 2 Sunweft IM was added to the base component consisting of 30 parts by weight of styrene-isoprene-styrene block copolymer Cariflex TR-1107 (Shell chemical type), 35 parts by weight of YS resin (Yasu Oil Co., Ltd.), and 13 parts by weight of liquid paraffin. -1
Add and mix 12 parts by weight of 000MPS (manufactured by Sanyo Chemical),
Next, 6 parts by weight of methyl salicylate! - Mix 3 parts by weight of menthol and 1 part by weight of a-camphor, spread on silicone-treated release paper to a thickness of 150 μm, cover with vinyl chloride film, press and transfer, and form into the desired shape. The sample was cut into a patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 3 A base component consisting of 29 parts by weight of styrene-isoprene-styrene block copolymer Turprene-418 (manufactured by Philips Vetroleum), 35 parts by weight of Regare Fluid (manufactured by Percules), and 15 parts by weight of liquid paraffin was added with Sumikagel NP- Add and mix 10 parts by weight of 1020 (manufactured by Sumitomo Chemical), then 5 parts by weight of methyl salicylate,! -Menthol 4
parts by weight and 2 parts by weight of a-camphor, spread on a non-woven fabric treated with impermeability to a thickness of 200 μm, and then covered with a PET film treated with silicone.
It was cut into a desired shape to prepare the adhesive patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 4 2 parts by weight of Arasorb 800F (manufactured by Arakawa Chemical Co., Ltd.) was added and mixed to a base component consisting of 27 parts by weight of natural rubber, 15 parts by weight of polybutene, 27 parts by weight of Harinister (manufactured by Harima Kasei), and 14 parts by weight of calcium carbonate. Next, 8 parts by weight of methyl salicylate, 6 parts by weight of l-menthol, and 1 part by weight of d-camphor were blended, spread on a nonwoven fabric to a thickness of 200 μm, and covered with release paper treated with silicone.
It was cut into a desired shape to prepare the external patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 5 20 parts by weight of Sumikagel NP-1040 (manufactured by Sumika Gel) was added and mixed to a base component consisting of 75 parts by weight of acrylic acid ester copolymer Binsol R-35 (manufactured by Ipposha Yushi Kogyo) and 2 parts by weight of glycerin. Then, 3 parts by weight of indomethacin was added, spread on a silicone-treated release paper to a thickness of 100 μm, covered with a polyethylene film, pressure-transferred, cut into a desired shape, and applied according to the present invention. It was used as a drug.

When this patch was applied, it showed the same effect as in Example 1.

Example 6 Styrene-isobrene-styrene copolymer Cariflex TR-1111 (shell chemical type) 27 parts by weight, ester gum (Arayo Kagaku) 28 parts by weight, liquid paraffin 20
Sanwet IM-100 is added to the base component consisting of parts by weight.
Add and mix 20 parts by weight of 0MPS (manufactured by Sanyo Kasei), then 5 parts by weight of clonidine, spread it on a silicone-treated PET film to a thickness of 120 μm, cover it with a nylon film, and press transfer. Then, it was cut into a desired shape to obtain the adhesive patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 7 Acrylic acid ester copolymer dicazole TS-444 (
Aqua Keep 4 was added to the base component consisting of 85 parts by weight (manufactured by Nippon Carbide Kogyo) and 6 parts by weight of 1゜3 butylene glycol.
Add and mix 5 parts by weight of SH (manufactured by Seitetsu Kagaku), then 4 parts by weight of ketoprofen, spread on a silicone-treated PET film to a thickness of 150 μm, cover with a polyethylene film, and press transfer. Then, it was cut into a desired shape to obtain the adhesive patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 8 22 parts by weight of natural rubber, 17 parts by weight of polybutene, 3 parts by weight of Escoresotu (manufactured by Exxon) (11 g of N (S, 20 parts of zinc oxide)
The base component consists of parts by weight of Sunweft IM-300.
Add and mix 3 parts by weight of MPS (manufactured by Sanyo Kasei), then add 3 parts by weight of methyl salicylate, 2 parts by weight of glycol salicylate, 2 parts by weight of l-menthol, and 1 part by weight of a-camphor to form a cloth with a thickness of 200 μm. After spreading like this,
It was covered with silicone-treated release paper and cut into a desired shape to obtain the external patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 9 Arasorb 800F ( Add and mix 12 parts by weight (manufactured by Arayo Kagaku), then 1 part of ketothiphen
After blending parts by weight and spreading it to a thickness of 50 μm on a silicone-treated PET film, cover with a polypropylene sheet, press and transfer, cut into desired shape,
A patch of the present invention was prepared.

When this patch was applied, it showed the same effect as in Example 1.

Example 10 Styrene-isoprene-styrene copolymer Cauliflex TR-1107 (Shell chemical type) 26 parts by weight, polyisobutylene (Exxon chemical type) 10 parts by weight, Picolite (Percules) 32 parts by weight, liquid paraffin 20 parts by weight
9 parts by weight of Aqua Keep 4S (manufactured by Seitetsu Kagaku Co., Ltd.) was added and mixed into the base component consisting of parts by weight, and then 3 parts by weight of Pindolol was added and spread on a silicone-treated PET film to a thickness of 150 μm. After rolling out, cover with polyvinyl chloride film, press and transfer, cut into desired shape,
A patch of the present invention was prepared.

When this patch was applied, it showed the same effect as in Example 1.

Example 11 Arasoap 800F (manufactured by Arayo Chemical Co., Ltd.) was pulverized into a base component consisting of 35 parts by weight of natural rubber, 10 parts by weight of polybutene, 27 parts by weight of ys resin (manufactured by Cheap Oil Co., Ltd.), and 16 parts by weight of zinc oxide. Add 1.5 parts by weight and mix, then 5 parts by weight of methyl salicylate! - Mix 4 parts by weight of menthol and 1.5 parts by weight of a-camphor, spread on cloth to a thickness of 200 μm, cover with silicone-treated release paper, cut into desired shape, and book. The invention was made into a patch.

When this patch was applied, it showed an effect equal to or better than that of Example 1.

Example 12 A base component consisting of 15 parts by weight of natural rubber, 25 parts by weight of polyisobutylene, 10 parts by weight of liquid impregnated rubber, 20.5 parts by weight of Alcon P-100 (manufactured by Arayo Kagaku), and 15 parts by weight of hydrated silica, Sunwet IM-1000MPS
(manufactured by Sanyo Chemical) 2 parts by weight were added and mixed, then 8 parts by weight of methyl salicylate,! - 3 parts by weight of menthol and 1.5 parts by weight of camphor were blended and spread on cloth to a thickness of 200 μm, covered with silicone-treated release paper and cut into the desired shape. did.

When this patch was applied, it showed an effect equal to or better than that of Example 1.

Example 13 To a base component consisting of 40 parts by weight of natural rubber, 5 parts by weight of liquid paraffin, 28 parts by weight of ester gum (manufactured by Arayo Kagaku), and 8 parts by weight of hydrated silica, 7 parts by weight of zinc oxide and fine powder of Arasop 800F were added in advance. 0.5 parts by weight of Kashitachi and 0.5 parts of Sunwet IM-1000MPS (manufactured by Sanyo Chemical)
Add and mix 8 parts by weight of methyl salicylate, and then 8 parts by weight of methyl salicylate! - 3 parts by weight of menthol was blended and spread on cloth to a thickness of 200 μm, covered with silicone-treated release paper, and cut into a desired shape to obtain the patch of the present invention.

When this patch was applied, it showed an effect equal to or better than that of Example 1.

Example 14 A base component consisting of 30 parts by weight of natural rubber, 1710 parts by weight of polyisobutylene, 7.5 parts by weight of liquid paraffin, 27.5 parts by weight of ester gum (manufactured by Arayo Kagaku), and 10 parts by weight of hydrated silica was oxidized in advance. 5 parts by weight of zinc, 0.95 parts by weight of finely powdered Arasorp F, and Hyaluronic Sun HA-
3 (manufactured by Kievi) 0.05 parts by weight was added and mixed, then 6 parts by weight of methyl salicylate,! -2 parts by weight of menthol and 1 part by weight of camphor were blended, spread on cloth to a thickness of 200 μm, covered with silicone-treated release paper, and cut into the desired shape to obtain the patch of the present invention. .

Example 15 Biohyaluron was added to a base component consisting of 20 parts by weight of natural rubber, 20 parts by weight of polyisobutylene, 5 parts by weight of liquid polyisoprene, 30 parts by weight of Alcon P-100 (manufactured by Arayo Kagaku), and 20 parts by weight of zinc oxide. Sodium acid (manufactured by Shiseido) 1
Then, 4 parts by weight of ketoprofen was added and mixed, and the mixture was spread on cloth to a thickness of 200 μm, covered with silicone-treated release paper, and cut into a desired shape to obtain the patch of the present invention. .

When this patch was applied, it showed an effect equivalent to or better than that of Example 1.

Example 16 Styrene-isoprene-styrene block copolymer Cauliflex TR-1111 (shell chemical type) 15 parts by weight, Vistanex MML-100 (Esso Standard Oil Co., Ltd.) 3 parts by weight, Vistanex LM-MH 8 parts by weight, fluid A base component consisting of 30 parts by weight of paraffin, 15 parts by weight of hydrogenated rosin ester (manufactured by Arayo Kagaku), 10 parts by weight of Sunwet IM-300MPS (manufactured by Sanyo Kasei), polyvinyl alcohol S M R-10t, ((KM 7 parts by weight of glycol salicylate and 7 parts by weight of !-menthol were added and mixed, spread on release paper to a thickness of 200 μm, transferred to non-woven fabric, and shaped into the desired shape. The sample was cut into a patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 17 Styrene-isobrene-styrene block copolymer Trublene-418 (manufactured by Philimbus Petroleum) 20 parts by weight, Vistanesox LM-MH (Esso Standard Sekiyu) 5 parts by weight, polybutene 31i parts, Claprene LIR-30 (Kuraray) ) 25 parts by weight, Alcon PT
6 parts by weight of Arasorb 800F (manufactured by Arayo Kagaku) and 3 parts by weight of Alcox E-30 (manufactured by Meisei Kagaku Kogyo) were added and mixed to a base component consisting of 30 parts by weight of OOC (manufactured by Arayo Kagaku),
Next, 5 parts by weight of methyl salicylate, 2.5 parts of E-menthol
part by weight, and 0.5 part by weight of chili pepper extract, spread it on a nonwoven fabric to a thickness of 150 μm, cover it with a silicone-treated polyester film, cut it into a desired shape, and apply the present invention. It was used as a drug.

When this patch was applied, it showed the same effect as in Example 1.

Example 18 Styrene-isoprene-styrene block copolymer Cauliflex TR-1107 (shell chemical type) 25 parts by weight, Vistanex LM-MH (manufactured by Esso Standard)
A base component consisting of 10 parts by weight, 25 parts by weight of liquid paraffin, and 18 parts by weight of hydrogenated rosin ester (manufactured by Arayo Kagaku),
Add and mix 3 parts by weight of Sumikagel NP-1020 (manufactured by Sumitomo Chemical) and 7 parts by weight of Soaresox BH (Nippon Gosei Chemical), then 5 parts by weight of glycol salicylate,! - After blending 7 parts by weight of menthol and 0.01 part by weight of nonylic acid vanillylamide and spreading it on release paper to a thickness of 100 μm,
The patch was covered with a PvC sheet, transferred, and cut into a desired shape to obtain the adhesive patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 19 Styrene-isoprene-styrene block copolymer Cauliflex TR-1112 (Shell Chemical M) 25 parts by weight, styrene-ethylene-butylene-styrene block copolymer Kraton 01657 (Shell Chemical Type) 4 parts by weight, polybutene 5 parts by weight of liquid paraffin, 25 parts by weight of hydrogenated rosin ester (manufactured by Arayo Kagaku Co., Ltd.), and 5 parts by weight of YS Resin px1000 (manufactured by Yasushi Kogyo Co., Ltd.). 10 parts by weight of Alcox E-30 (manufactured by Meisei Chemical Industry Co., Ltd.) and 5 parts by weight of Alcox E-30 (manufactured by Meisei Chemical Industry Co., Ltd.) were added and mixed. Next, 3 parts by weight of peppermint oil and 3 parts by weight of ketoprofen were added to the silicone-treated polyester film. After spreading it to a thickness of 100 μm, it was covered with a polyethylene film, transferred, and cut into a desired shape to obtain the adhesive patch of the present invention.

When this patch was applied, it showed the same effect as in Example 1.

Example 20 Silicone 355 (manufactured by Dow Corning) Solid content 90
Sunwet IM-1000MPS (by weight)
Sanyo Chemical Co., Ltd.) 3 parts by weight were added and mixed, then clonidine 7
Parts by weight were added and mixed and spread on a PET film so that the film thickness after drying was 50 μm to obtain an external patch of the present invention.

Example 21 Silicone 355 (manufactured by Dow Corning) Solid content 92
Add and mix 5 parts by weight of Sumikagel NP-1020 (manufactured by Sumitomo Chemical) to the parts by weight, then add and mix 3 parts by weight of diclofenac sodium, and spread on a polyethylene film so that the film thickness after drying is 75 μm. This was used as an external patch of the present invention.

Example 22 5 parts by weight of -F2 (manufactured by Kuraray) were added to 85 parts by weight of Silicone 4-4210 (manufactured by Dow Corning) and KI Gel-201, and then! - Add and mix 3.5 parts by weight of menthol and 3.5 parts by weight of glycol salicylate, then add 3 parts by weight of a crosslinking agent, and apply 11 parts by weight to a polyethylene film.
It was spread to a thickness of 00p to obtain the external patch of the present invention.

Example 23 Silicone 4-4210 (manufactured by Dow Corning) 77
Add and mix 6 parts by weight of Arasorb 800F (manufactured by Arayo Kagaku) to the parts by weight, then add and mix 7 parts by weight of liquid paraffin and 6 parts by weight of clonidine, and further mix 4 parts by weight of a crosslinking agent. It was spread to a thick layer to form the external patch of the present invention.

Reference Example 1 A base component consisting of 22 parts by weight of styrene-isoprene-styrene block copolymer Kaliflex TR-1107 (shell chemical type), 40 parts by weight of Alcon-Ploo (manufactured by Arayo Kagaku), and 20 parts by weight of liquid paraffin. , 10 parts by weight of polyvinyl alcohol were added and mixed, then 3 parts by weight of methyl salicylate, 3 parts by weight of l-menthol, and 2 parts by weight of d-camphor were added and spread on a polyester nylon base fabric to a thickness of 100 μm. It was covered with a treated polypropylene film and cut into a desired shape to prepare an external patch.

Reference Example 2 A base component consisting of 30 parts by weight of styrene-isoprene-styrene block copolymer Cariflex TR-1107 (Shell chemical type), 35 parts by weight of YS resin (Yasu Oil Co., Ltd.), and 13 parts by weight of liquid paraffin was added with hydroxyl. Add and mix 12 parts by weight of propylcellulose, then mix 6 parts by weight of methyl salicylate, 3 parts by weight of l-menthol, and 1 part by weight of -1-camphor, and spread on silicone-treated release paper to a thickness of 150 μm. After spreading, it was covered with a vinyl chloride film, pressure-transferred, and cut into a desired shape to prepare an external patch.

Reference Example 3 Add and mix 2 parts by weight of gum arabic to a base component consisting of 27 parts by weight of natural rubber, 15 parts by weight of polybutene, 27 parts by weight of Harinister (manufactured by Harima Kasei), and 14 parts by weight of calcium carbonate, and then 8 parts by weight of methyl salicylate. Department! - Blend 6 parts by weight of menthol and 1 part by weight of a-camphor, spread on a nonwoven fabric to a thickness of 200 μm, cover with silicone-treated release paper, cut into desired shape, and prepare an external patch. And so.

Reference Example 4 Arasorb 800F (manufactured by Arayo Chemical Co., Ltd.) 3 was added to a base component consisting of 30 parts by weight of natural rubber, 5 parts by weight of polybutene, 18.5 parts by weight of YS resin (manufactured by Chesai Oil Co., Ltd.), and 7 parts by weight of zinc oxide.
0 parts by weight added and mixed, then 5 parts by weight of methyl salicylate,
After blending 3 parts by weight of l-menthol and 1.5 parts by weight of a-camphor and spreading it on cloth to a thickness of 200 μm,
It was covered with silicone-treated release paper and cut into a desired shape to prepare an external patch.

Reference Example 5 Sunwet! M-300MPS
Add and mix 0.5 parts by weight (manufactured by Sanyo Kasei), then 8 parts by weight of methyl salicylate, 3 parts by weight of 1-menthol, and 1.5 parts by weight of camphor, and spread it on a cloth to a thickness of 200 μm. After spreading, it was covered with silicone-treated release paper and cut into a desired shape to prepare an external patch.

Test Example 1 Skin irritation test Examples 1 to 5 and Examples 11 to 30 of the present invention were administered to 30 subjects.
19 and Reference Examples 1 to 3, and commercially available anti-inflammatory and analgesic plaster A as a comparative example, 18 types were applied to the back for 48 hours, skin changes were observed 1 hour and 24 hours after peeling, and the degree of skin irritation was evaluated. I judged it.

The results are shown in Table 1.

(The criteria for determining skin irritation are as follows.) No change.
- Slight redness; ± Obvious redness; + Severe sensation; ++ Table 1 Test Example 2 Water Absorption Comparison Test Test Method; Each test sample (5 x 6 C1 liter) was immersed in water for 1 hour, and then taken out and weighed. Table 2 shows the amount of water absorbed by dividing the increased weight by the original weight.

2 Test Example 3 Sweat Absorption Test 10 subjects were tested on the back using Examples 1 to 5, 11 to 19 of the present invention and Reference Examples 1 to 5, and 20 types of commercially available anti-inflammatory and analgesic plaster A as a comparative example. After applying for a time and peeling off, immediately measure the weight part, divide the increased weight part by the original weight,
Expressed as incremental N (%).

Table 3 As is clear from Test Example 1.2.3, the non-irritating adhesive patch of the present invention must contain a water-absorbing polymer as in the present invention, and due to its limited formulation, it has excellent water absorption. In addition, as is clear from Test Example 3, the amount of sweat absorbed is extremely high.As a result, compared to reference examples and commercially available plasters, it has far less skin irritation and is a non-irritating topical patch. This fully demonstrates its usefulness as a.

Procedural amendment (voluntary) 1. Indication of the case 1988 Patent Application No. 79317 2 Name of the invention Topical patch 3 Person making the amendment 4 Date of order for amendment Voluntary action (1) In the specification, "3. Detailed description of the invention" column In the fourth line from the bottom of the fifth line, the word "other than" is corrected to "unexpected."

(2) In the same book, the phrase "water absorption or gelation" in lines 6 to 5 from just below the 6th page is corrected to "water absorption or gelation."

(3) In the same book, from the 7th purchase to the 9th line [Arasorb 8
Next to 00FJ, insert hyaluronic acid or its salt or its derivative j manufactured by Kewpie, Shiseido, etc.

(4) In the same book, from the 7th line above, the 9th line to the 10th line, ``Preferably, those with a slight cross-linking bond are preferably used.'' are deleted.

(5) In the same book, in the seventh line from the bottom of page 7, the phrase "Arasorb F is" is corrected to rArasorb 800 F, hyaluronic acid) (A-3 etc. is j).

(6) In the same book, the word "camphor" in the 7th line from just below the 9th line is corrected to r-camphor (d-form, β-form, d-form)j.

(7) In the same book, the word ``rash'' in the 9th line from the 15th purchase is corrected to ``rash.''

(8) In the same book, the 9th line from just above No. 23, "pulverized" is deleted.

(9) In the same book, in the fourth line from the bottom of the 24th line, "Arasorb 800FJ" is corrected to "Arasorb 800F (manufactured by Arakawa Chemical) J.

αφ In the same book, in the 8th line from just below No. 25, "Arasorb 800FJ" is corrected to "Arasorb 800F (manufactured by Arakawa Chemical)".

αυ In the same book, in the 7th line from the bottom of J 25, "Hyaluronic acid HA-3 (manufactured by Kewpie)" is corrected to "Hyaluronic acid HA-3 (manufactured by Kewpie)".

Claims (1)

[Claims] 1. An external patch characterized by containing 1 to 20% by weight of a water-absorbing polymer as an essential component in the plaster component.