JPS63210101A - キトサン又はキチン多孔質超微小粒状体の製造方法 - Google Patents
キトサン又はキチン多孔質超微小粒状体の製造方法Info
- Publication number
- JPS63210101A JPS63210101A JP62043998A JP4399887A JPS63210101A JP S63210101 A JPS63210101 A JP S63210101A JP 62043998 A JP62043998 A JP 62043998A JP 4399887 A JP4399887 A JP 4399887A JP S63210101 A JPS63210101 A JP S63210101A
- Authority
- JP
- Japan
- Prior art keywords
- chitosan
- particles
- ultrafine
- water
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 51
- 239000011882 ultra-fine particle Substances 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 229920002101 Chitin Polymers 0.000 title abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000012298 atmosphere Substances 0.000 claims abstract description 15
- 230000002378 acidificating effect Effects 0.000 claims abstract description 13
- 230000003472 neutralizing effect Effects 0.000 claims abstract description 6
- 239000003495 polar organic solvent Substances 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 4
- 239000007864 aqueous solution Substances 0.000 claims description 13
- 239000003637 basic solution Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 4
- 230000000397 acetylating effect Effects 0.000 claims description 2
- 239000002245 particle Substances 0.000 abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 30
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 9
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 abstract description 6
- 238000006640 acetylation reaction Methods 0.000 abstract description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract description 4
- 238000005406 washing Methods 0.000 abstract description 4
- 229960005215 dichloroacetic acid Drugs 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract description 2
- 235000019253 formic acid Nutrition 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000001694 spray drying Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 13
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 4
- 239000003929 acidic solution Substances 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000238557 Decapoda Species 0.000 description 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
- 230000021736 acetylation Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000006196 deacetylation Effects 0.000 description 2
- 238000003381 deacetylation reaction Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000238424 Crustacea Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000010299 mechanically pulverizing process Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62043998A JPS63210101A (ja) | 1987-02-26 | 1987-02-26 | キトサン又はキチン多孔質超微小粒状体の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62043998A JPS63210101A (ja) | 1987-02-26 | 1987-02-26 | キトサン又はキチン多孔質超微小粒状体の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63210101A true JPS63210101A (ja) | 1988-08-31 |
| JPH0212961B2 JPH0212961B2 (enrdf_load_stackoverflow) | 1990-04-03 |
Family
ID=12679382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62043998A Granted JPS63210101A (ja) | 1987-02-26 | 1987-02-26 | キトサン又はキチン多孔質超微小粒状体の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63210101A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061109A1 (fr) * | 1999-04-12 | 2000-10-19 | Shionogi & Co., Ltd. | Procede de production de composition medicamenteuse renfermant un compose medicamenteux hydrophobe basique |
| US6252003B1 (en) | 1998-06-04 | 2001-06-26 | Kao Corporation | Polymer emulsion and process for producing the same |
| KR100470715B1 (ko) * | 2002-04-04 | 2005-03-08 | 주식회사 자광 | 수용성 키토산 다공성 비드 캡슐과 그의 제조방법 |
| KR100486042B1 (ko) * | 2002-04-18 | 2005-04-29 | 강대인 | 효소 처리에 의한 키틴 저분자당 및 올리고당의 제조방법 |
| KR20050055643A (ko) * | 2005-04-25 | 2005-06-13 | 조석형 | 키토산 미립자을 포함한 다이어트제 제조 |
| CN102352047A (zh) * | 2011-06-27 | 2012-02-15 | 张会艳 | 一种甲壳素球的制备方法 |
| WO2024096016A1 (ja) * | 2022-10-31 | 2024-05-10 | 綜研化学株式会社 | 多糖類含有粒子の製造方法、前駆体多糖類含有粒子及び多糖類含有粒子 |
-
1987
- 1987-02-26 JP JP62043998A patent/JPS63210101A/ja active Granted
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6252003B1 (en) | 1998-06-04 | 2001-06-26 | Kao Corporation | Polymer emulsion and process for producing the same |
| US6359032B1 (en) | 1998-06-04 | 2002-03-19 | Kao Corporation | Polymer emulsion and process for preparing the same |
| WO2000061109A1 (fr) * | 1999-04-12 | 2000-10-19 | Shionogi & Co., Ltd. | Procede de production de composition medicamenteuse renfermant un compose medicamenteux hydrophobe basique |
| US6858230B1 (en) | 1999-04-12 | 2005-02-22 | Shionogi & Co., Ltd. | Process for producing medicinal composition of basic hydrophobic medicinal compound |
| KR100470715B1 (ko) * | 2002-04-04 | 2005-03-08 | 주식회사 자광 | 수용성 키토산 다공성 비드 캡슐과 그의 제조방법 |
| KR100486042B1 (ko) * | 2002-04-18 | 2005-04-29 | 강대인 | 효소 처리에 의한 키틴 저분자당 및 올리고당의 제조방법 |
| KR20050055643A (ko) * | 2005-04-25 | 2005-06-13 | 조석형 | 키토산 미립자을 포함한 다이어트제 제조 |
| CN102352047A (zh) * | 2011-06-27 | 2012-02-15 | 张会艳 | 一种甲壳素球的制备方法 |
| WO2024096016A1 (ja) * | 2022-10-31 | 2024-05-10 | 綜研化学株式会社 | 多糖類含有粒子の製造方法、前駆体多糖類含有粒子及び多糖類含有粒子 |
| WO2024095351A1 (ja) * | 2022-10-31 | 2024-05-10 | 綜研化学株式会社 | 多糖類含有粒子の製造方法、前駆体多糖類含有粒子及び多糖類含有粒子 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0212961B2 (enrdf_load_stackoverflow) | 1990-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |