JPS63189162A - Apparatus for removing components in blood - Google Patents
Apparatus for removing components in bloodInfo
- Publication number
- JPS63189162A JPS63189162A JP62020177A JP2017787A JPS63189162A JP S63189162 A JPS63189162 A JP S63189162A JP 62020177 A JP62020177 A JP 62020177A JP 2017787 A JP2017787 A JP 2017787A JP S63189162 A JPS63189162 A JP S63189162A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- plasma
- harmful components
- concentration
- harmful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 blood Anatomy 0.000 title claims description 39
- 239000008280 blood Substances 0.000 title claims description 39
- 239000000306 component Substances 0.000 claims description 35
- 239000007788 liquid Substances 0.000 claims description 19
- 238000001514 detection method Methods 0.000 claims description 17
- 239000012503 blood component Substances 0.000 claims description 12
- 230000008929 regeneration Effects 0.000 claims description 12
- 238000011069 regeneration method Methods 0.000 claims description 12
- 238000001179 sorption measurement Methods 0.000 claims description 11
- 239000003463 adsorbent Substances 0.000 claims description 9
- 210000000601 blood cell Anatomy 0.000 claims description 9
- 210000004180 plasmocyte Anatomy 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 42
- 235000012000 cholesterol Nutrition 0.000 description 21
- 210000002381 plasma Anatomy 0.000 description 19
- 230000001172 regenerating effect Effects 0.000 description 12
- 238000010586 diagram Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 238000010241 blood sampling Methods 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 108010093096 Immobilized Enzymes Proteins 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
く産業上の利用分野〉
本発明は、血液に含まれているコレステロール等の有害
成分を選択的に除去する血中成分除去装置に関する。DETAILED DESCRIPTION OF THE INVENTION Industrial Application Field The present invention relates to a blood component removal device that selectively removes harmful components such as cholesterol contained in blood.
〈従来の技術〉
従来、特開昭５９−１９７２５５号公報に開示されてい
るような血中成分除去装置が公知である。<Prior Art> Conventionally, a blood component removal device as disclosed in Japanese Unexamined Patent Publication No. 59-197255 is known.
この除去装置は、患者から採取した血液を送液する第１
ポンプと、血液を血漿と血球成分に分離する血漿分離部
と、血漿に含まれている有害成分（例えばコレステロー
ル）を選択的に除去する吸着器と、この吸着器に前記血
漿分離部で分離された血漿を送液する第２ポンプと、前
記血漿分離部で分離された血球成分に前記吸着器で有害
成分が除去された血漿を混合する混合部とを設け、上記
第１及び第２のポンプを手動操作でスピードコントロー
ルして、血液に含まれている前記有害成分を除去するよ
うにしている。This removal device has a first
a pump, a plasma separation section that separates blood into plasma and blood cell components, an adsorption device that selectively removes harmful components (for example, cholesterol) contained in the plasma, and a device that separates blood in the plasma separation section into the adsorption device. the first and second pumps; The speed is controlled manually to remove the harmful components contained in the blood.
このような装置では、治療にょ簀患者の血液から実際に
除去したコレステロールの総量を知ることが出来なかっ
た。With such devices, it was not possible to determine the total amount of cholesterol actually removed from the blood of the patient being treated.
〈発明が解決しようとする問題点〉
本発明の解決しようとする技術的課題は、前記血中成分
除去装置において、血液から実際に除去／、シた有害成
分の総量を検知できるようにすることにある。<Problems to be Solved by the Invention> A technical problem to be solved by the present invention is to enable the blood component removal device to detect the total amount of harmful components actually removed from the blood. It is in.
く問題点を解決するための手段〉
本発明の第１の発明の構成は、前記血中成分除去装置に
おいて、前記吸着器が有害成分で飽和したとき行われる
再生モード時、前記吸着器に流される再生液の流量に対
応した信号を発生する手段と、前記吸着器から排出され
る再生液中の有害成分の濃度を検出する濃度検出手段と
を設け、前記流山測定手段並びに濃度検出手段の出力に
基き演算により前記患者の血液から除去した有害成分の
総量を求めるようにしたことにある。Means for Solving the Problems> A first aspect of the present invention is that in the blood component removal device, during a regeneration mode that is performed when the adsorption device is saturated with harmful components, means for generating a signal corresponding to the flow rate of the regenerating liquid discharged from the adsorber; and a concentration detecting means for detecting the concentration of harmful components in the regenerating liquid discharged from the adsorber; The total amount of harmful components removed from the patient's blood is determined by calculation based on the above.
本発明の第２の発明の構成は、前記血中成分除去装置に
おいて、治療モード時、前記吸＠器に流される血漿の流
量に対応した信号を発生する手段と、前記吸着器の入口
及び出口に前記血漿中の有害成分のｍ１度を検出する濃
度検出手段を夫々設け、前記吸着器の入口及び出口にお
番プる前記有害成分の濃度差と前記血漿の流量とに基き
演算により前記患者の血液から除去した有害成分の総量
を求めるようにしたことにある。According to a second aspect of the present invention, the blood component removal device includes means for generating a signal corresponding to the flow rate of plasma flowing into the suction device in the treatment mode, and an inlet and an outlet of the suction device. are respectively provided with concentration detection means for detecting m1 degree of the harmful component in the plasma, and calculates the concentration of the harmful component in the blood plasma at the inlet and outlet of the adsorbent and the flow rate of the plasma. The aim is to calculate the total amount of harmful components removed from the blood of patients.
〈実施例〉
以下、図面に従い本発明の詳細な説明する。第１図は本
発明の第１の発明の実施例を示す構成図ある。１ａは患
者の腕等〈図示せず）から血液を採取する採血部、１ｂ
は患者の腕等に血液を戻す返血部、２ａ〜２！は血液、
血漿、再生液用のチャンバー、３ａ〜３ｇは圧力計、４
ａは血液を送液する第１のポンプ（血液ポンプ）、４ｂ
は血漿を送液する第２のポンプ（血漿ポンプ）、４ｃは
再生液を送液する第３のポンプ（充填液／再生液ポンプ
）、５は例えばチューブ状の膜によって内部が内室と外
室とに仕切られ、前記内室には流入口５ａと流出口５ｂ
Ｓ設けられ、前記外室には流出口５ｃが設けられたセパ
レータ、６ａ、６ｂは吸着剤が充填され、夫々に流入口
６ａ＋、６ｂ＋と流出口６ａ２．６ｂ２とが設けられた
吸着器、７は混合部、８ａ〜８ｈは吸着器６ａ、６ｂの
動作を血中成分除去動作と再生動作とに切換えるバルブ
、８ｔ、８Ｊは排出液径路を切換えるバルブ、８ｂ、８
ｔは充填液（リンゲル液）が入れられたバッグ９と吸着
器６ａ、６ｂを再生する再生液が入れられた再生液バッ
グ１ｏとを切換えるバルブ、１１は吸着器６ａ、６ｂの
再生状態をチェックする為の導電率計、１２は生理食塩
水が入れられた生食バッグ、１３は返血部１ｂに至る回
路に設けられた気泡検出器、１４はヒータである。<Example> The present invention will be described in detail below with reference to the drawings. FIG. 1 is a block diagram showing a first embodiment of the present invention. 1a is a blood sampling section for collecting blood from a patient's arm or the like (not shown); 1b
is the blood return part that returns blood to the patient's arm, etc., 2a~2! is blood,
Chamber for plasma and regeneration solution, 3a to 3g are pressure gauges, 4
a is a first pump (blood pump) that pumps blood, 4b
4c is a third pump (filling liquid/regenerating liquid pump) that sends plasma; 5 is a tube-like membrane that connects the inside with the outside; The inner chamber has an inlet 5a and an outlet 5b.
a separator having an outlet port 5c in the outer chamber; an adsorbent 7 filled with an adsorbent and having inlets 6a+, 6b+ and outlet ports 6a2 and 6b2, respectively; 8a to 8h are mixing parts, 8a to 8h are valves that switch the operation of the adsorbers 6a and 6b between blood component removal operation and regeneration operation, 8t and 8J are valves that switch the discharge liquid path, 8b and 8
t is a valve that switches between the bag 9 containing the filling liquid (Ringer's solution) and the regenerating liquid bag 1o containing the regenerating liquid for regenerating the adsorbers 6a and 6b; 11 is a valve that checks the regeneration state of the adsorbers 6a and 6b. 12 is a saline bag containing physiological saline, 13 is an air bubble detector provided in the circuit leading to the blood return section 1b, and 14 is a heater.
１５は吸着器６ａ、６ｂからの排出液径路に設けられた
、排出される再生液中のコレステロールの１１度を検出
する濃度検出手段である。この検出手段には、例えばコ
レステロールと酵素反応する固定化酵素が表面に形成さ
れた酵素電極が用いられ前記排出液径路に直接挿入して
使用される。Reference numeral 15 denotes a concentration detection means provided in the discharge liquid path from the adsorbers 6a and 6b for detecting 11 degrees of cholesterol in the discharged regenerated liquid. This detection means uses, for example, an enzyme electrode on the surface of which is formed an immobilized enzyme that enzymatically reacts with cholesterol, and is used by directly inserting it into the effluent path.
１６は演算制御部で、濃度検出手段１５からの検出出力
ＣＣ１並びに吸着器６ ａ ＊ ６ ｂに流される再生
液の流量に対応した第３のポンプ４ｃからの信号Ｑが与
えられている。尚、演算制御部１６には、この他にも各
種のセンサから測定入力が与えられ、バルブ等各種の操
作端を制御する制御信号が出力されるが、本図では説明
の便宜上、本発明に直接関係のある上記二つの信号だけ
が示されている。Reference numeral 16 denotes an arithmetic control unit, which is supplied with a detection output CC1 from the concentration detection means 15 and a signal Q from the third pump 4c corresponding to the flow rate of the regeneration liquid flowing into the adsorbers 6a*6b. Note that measurement inputs are also given to the arithmetic control unit 16 from various sensors, and control signals for controlling various operating ends such as valves are output, but in this figure, for convenience of explanation, the present invention is not shown. Only the two directly related signals are shown.
このような構成の本発明実施例装置の動作を以下に説明
する。血液回路に生理食塩水を充填した後、採血部１ａ
に接続された針を返血部１ｂに接続された針と共に患者
に穿刺し治療を行う。採血部１ａから血液回路に導かれ
た血液は血液ポンプ４ａによりセパレータ５に送液され
、血漿と血球成分に分離される。血漿は血漿ポンプ４ｂ
で吸着器６ａ、６ｂの一方に送液され、血球成分は混合
部７へ送液される。The operation of the apparatus according to the embodiment of the present invention having such a configuration will be described below. After filling the blood circuit with physiological saline, the blood sampling section 1a
The needle connected to the blood return unit 1b is punctured into the patient together with the needle connected to the blood return unit 1b to perform treatment. Blood led from the blood sampling section 1a to the blood circuit is sent to a separator 5 by a blood pump 4a, and is separated into plasma and blood cell components. Plasma pump 4b
The blood cell component is sent to one of the adsorbers 6a and 6b, and the blood cell component is sent to the mixing section 7.
吸着器６ａ或は６ｂに充填された吸着剤によって血漿中
のコレステロールのみが吸着される。処理された血漿は
混合部７で血球成分と合流され、返血部１ｂから患者に
返血される。Only cholesterol in plasma is adsorbed by the adsorbent filled in the adsorbent 6a or 6b. The treated plasma is combined with blood cell components in the mixing section 7 and returned to the patient from the blood return section 1b.
吸着器６ａ或は６ｂは、コレステロールの吸着が飽和し
たとき再生が行われる。吸着器６ａを再生する場合、バ
ルブ８ａ、８ｅを閏とし血液回路から切離し、バルブ８
ｃ、８ｓ、８ｆを開、バルブ８ｋを閉とし、再生バッグ
１０より再生液を吸着器６ａに流す。The adsorber 6a or 6b is regenerated when adsorption of cholesterol is saturated. When regenerating the adsorber 6a, the valves 8a and 8e are used as levers to disconnect it from the blood circuit, and the valve 8a is disconnected from the blood circuit.
c, 8s, and 8f are opened, valve 8k is closed, and the regenerated liquid is allowed to flow from the regeneration bag 10 to the adsorber 6a.
／パ このとき吸着器６・から再生液によ・
て洗い流されるコレステロールの量を検出する。酵素電
極を用いた濃度検出手段１５では、コレステロールが固
定化酵素膜に拡散し酵素反応を起す。これにより過酸化
水素を発生づると共に酸素を消費し、電極への酸素の流
れを減少させる。酸素の変化量とコレステロール量とは
関連しており、酵素電極における電気量の変化からコレ
ステロール濃度を測定する。コレステロール濃度を測定
する別な方法として、Ｎ素反応によって生じた過酸化水
素を電気化学反応電極によって測定する方法もある。/Pa At this time, the regenerated liquid is
detect the amount of cholesterol that is washed away. In the concentration detection means 15 using an enzyme electrode, cholesterol diffuses into the immobilized enzyme membrane and causes an enzyme reaction. This generates hydrogen peroxide and consumes oxygen, reducing the flow of oxygen to the electrodes. The amount of change in oxygen and the amount of cholesterol are related, and the cholesterol concentration is measured from the change in the amount of electricity at the enzyme electrode. Another method for measuring cholesterol concentration is to measure hydrogen peroxide produced by the nitrogen reaction using an electrochemical reaction electrode.
これら方法によって再生液によって洗い流されたコレス
テロールの濃度Ｃｃ （ｍｏ／ｍｅ ＞が測定出来る
。By these methods, the concentration of cholesterol Cc (mo/me >) washed away by the regenerating solution can be measured.
第２図は再生モードの動作説明図で、図（ａ）は再生が
行われる期間を表わし、図（ｂ）は濃度検出手段１５で
検出されるコレステロール濃度の変化を表わす。FIG. 2 is an explanatory diagram of the operation in the regeneration mode, in which FIG. 2A shows the period during which regeneration is performed, and FIG. 2B shows the change in the cholesterol concentration detected by the concentration detection means 15.
第３のポンプ４ｃの駆動信号は通常は固定であり吸着器
６ａに流される再生液の流ｆｆ１Ｑ（ｒｒｌ／ｍ１ｎ）
に対応している。従って、第３のポンプ４ｃからの信号
Ｑと濃度検出手段５の検出出力Ｃｃとを演算制御部１６
に与えて以下のｖ４算を行えば、治療において患者の血
液から除去したコレステロールの総Ｉ Ｗ ｃが求めら
れる。The drive signal of the third pump 4c is normally fixed, and the flow rate of the regenerating liquid flowing into the adsorber 6a is ff1Q (rrl/m1n).
It corresponds to Therefore, the signal Q from the third pump 4c and the detection output Cc of the concentration detection means 5 are calculated by the calculation control section 16.
, and perform the following v4 calculation to determine the total cholesterol I W c removed from the patient's blood during treatment.
尚、治療で２以上の吸着器が使用された場合には、夫々
の吸着器について再生を行い、上記の演算を行って得た
結果を合計したものが患者の血液から除去したコレステ
ロールの総量となる。In addition, if two or more adsorbers are used for treatment, the total amount of cholesterol removed from the patient's blood is calculated by regenerating each adsorber and summing the results obtained by performing the above calculation. Become.
第３図は本発明の第２の発明の実施例装置を示す構成図
である。図中、第１図における要素と同じ要素には同一
符号を付し説明は省略する。１７゜１８は吸＠器６ａの
入口と出口に設けられた血漿中の有害成分の濃度を検出
する濃度検出手段、１９．２０は吸着器６ｂの入口と出
口に設けられた血漿中の有害成分の１１度を検出する濃
度検出手段である。これら濃度検出手段には第１図の濃
度検出手段１５と同じものが使用され、ここからの検出
出力は演算制御部１６に与えられている。演算制御部１
６には、また血漿ポンプ４ｂからの信号Ｑ′が与えられ
ている。FIG. 3 is a configuration diagram showing an apparatus according to a second embodiment of the present invention. In the figure, the same elements as those in FIG. 1 are given the same reference numerals, and explanations thereof will be omitted. 17 and 18 are concentration detection means for detecting the concentration of harmful components in plasma, which are provided at the inlet and outlet of the suction device 6a, and 19.20 are harmful components in plasma, which are provided at the inlet and outlet of the adsorption device 6b. This is a concentration detection means for detecting 11 degrees of the temperature. These concentration detecting means are the same as the concentration detecting means 15 shown in FIG. Arithmetic control unit 1
6 is also provided with a signal Q' from the plasma pump 4b.
このような構成で、治療モード時、例えば吸着器６ａが
使用されている場合、この吸着器によって吸着されるコ
レステロール量は吸着器６ａの入口及び出口に設けられ
た１１度検出手段１７．１８で検出されるコレステロー
ルａｌｆｆｌの差Ｃｃ’で表わされる。このＣｃ′と血
漿ポンプ４ｂから与えられる、吸着ｒＡ ６ ａに流さ
れる血漿の流量に対応した信号Ｑ′ とから、
なる演算を行えば、吸着器６ｂに吸着されるコレステロ
ールの総量、即ち、患者の血液から除去したコレステロ
ールの総理が分る。With this configuration, in the treatment mode, for example, when the adsorber 6a is used, the amount of cholesterol adsorbed by this adsorber is determined by the 11 degree detection means 17.18 provided at the inlet and outlet of the adsorber 6a. The difference in detected cholesterol alffl is expressed as Cc'. From this Cc' and the signal Q' given from the plasma pump 4b and corresponding to the flow rate of plasma flowing into the adsorbent rA 6a, the following calculation is performed to determine the total amount of cholesterol adsorbed on the adsorbent 6b, that is, the total amount of cholesterol adsorbed by the patient The amount of cholesterol removed from the blood of people is known.
〈発明の効果〉
本発明によれば、患者の血液から実際に除去した有害成
分の総量を検知できる為、血中成分除去装置による治療
効果を正確に把握することが出来る。<Effects of the Invention> According to the present invention, since the total amount of harmful components actually removed from the patient's blood can be detected, the therapeutic effect of the blood component removal device can be accurately grasped.
第１図は本発明の第１の発明の実施例装置を示す構成図
、第２図は第１図の本発明実施例装置の動作説明図、第
３図は本発明の第２の発明の実施例装置を示す構成図で
ある。
１ａ・・・採血部、１ｂ・・・返血部、４ａ・・・加液
ポンプ、４ｂ・・・血漿ポンプ、４ｃ・・・再生液ポン
プ、５・・・セパレータ、６ａ、６ｂ・・・吸着器、７
・・・混合部、１５・・・濃度検出手段、１６・・・演
算制御部、１７〜２０・・・１１度検出手段、Ｑ・・・
再生液の流量信号、Ｃｃ・・・再生液中の有害成分濃度
、Ｑ′・・・血漿の流量信号
第２図FIG. 1 is a configuration diagram showing an apparatus according to a first embodiment of the present invention, FIG. 2 is an explanatory diagram of the operation of the apparatus according to an embodiment of the present invention shown in FIG. 1, and FIG. FIG. 1 is a configuration diagram showing an example device. 1a...Blood collection section, 1b...Blood return section, 4a...Liquid pump, 4b...Plasma pump, 4c...Regeneration liquid pump, 5...Separator, 6a, 6b... Adsorber, 7
...Mixing section, 15...Concentration detection means, 16...Arithmetic control section, 17-20...11 degree detection means, Q...
Flow rate signal of regenerating solution, Cc... Concentration of harmful components in regenerating solution, Q'... Flow rate signal of plasma Fig. 2
Claims (2)
に分離し、血漿に含まれる有害成分を吸着器を用いて選
択的に除去し、前記分離された血球成分に前記有害成分
を除去した血漿を混合して前記患者に返血するようにし
た血中成分除去装置において、前記吸着器が有害成分で
飽和したとき行われる再生モード時、前記吸着器に流さ
れる再生液の流量に対応した信号を発生する手段と、前
記吸着器から排出される再生液中の有害成分の濃度を検
出する濃度検出手段とを設け、前記流量測定手段並びに
濃度検出手段の出力に基き演算により前記患者の血液か
ら除去した有害成分の総量を求めるようにしたことを特
徴とする血中成分除去装置。(1) Collect blood from a patient, separate this blood into plasma and blood cell components, selectively remove harmful components contained in the plasma using an adsorbent, and remove the harmful components from the separated blood cell components. In the blood component removal device which mixes the collected plasma and returns the blood to the patient, the method corresponds to the flow rate of the regeneration liquid flowing into the adsorption device during a regeneration mode that is performed when the adsorption device is saturated with harmful components. and a concentration detection means for detecting the concentration of harmful components in the regenerated liquid discharged from the adsorption device, and a concentration detection means for detecting the concentration of harmful components in the regeneration liquid discharged from the adsorption device, and A blood component removal device characterized in that the total amount of harmful components removed from blood is determined.
に分離し、血漿に含まれる有害成分を吸着器を用いて選
択的に除去し、前記分離された血球成分に前記有害成分
を除去した血漿を混合して前記患者に返血するようにし
た血中成分除去装置において、治療モード時、前記吸着
器に流される血漿の流量に対応した信号を発生する手段
と、前記吸着器の入口及び出口に前記血漿中の有害成分
の濃度を検出する濃度検出手段を夫々設け、前記吸着器
の入口及び出口における前記有害成分の濃度差と前記血
漿の流量とに基き演算により前記患者の血液から除去し
た有害成分の総量を求めるようにしたことを特徴とする
血中成分除去装置。(2) Collect blood from the patient, separate the blood into plasma and blood cell components, selectively remove harmful components contained in the plasma using an adsorbent, and remove the harmful components from the separated blood cell components. In the blood component removal device, the blood component removal device mixes the collected plasma and returns the blood to the patient, the device further comprising: means for generating a signal corresponding to the flow rate of plasma flowing into the adsorption device in a treatment mode; and an inlet of the adsorption device. and a concentration detection means for detecting the concentration of the harmful component in the plasma at the inlet and outlet of the adsorber, and calculates the amount of the harmful component from the patient's blood based on the difference in the concentration of the harmful component at the inlet and outlet of the adsorber and the flow rate of the plasma. A blood component removal device characterized in that the total amount of removed harmful components is determined.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62020177A JPS63189162A (en) | 1987-01-30 | 1987-01-30 | Apparatus for removing components in blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62020177A JPS63189162A (en) | 1987-01-30 | 1987-01-30 | Apparatus for removing components in blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63189162A true JPS63189162A (en) | 1988-08-04 |
| JPH0588626B2 JPH0588626B2 (en) | 1993-12-22 |
Family
ID=12019895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62020177A Granted JPS63189162A (en) | 1987-01-30 | 1987-01-30 | Apparatus for removing components in blood |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63189162A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1033662A (en) * | 1996-07-25 | 1998-02-10 | Kanegafuchi Chem Ind Co Ltd | Ex vivo blood circulating device |
-
1987
- 1987-01-30 JP JP62020177A patent/JPS63189162A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1033662A (en) * | 1996-07-25 | 1998-02-10 | Kanegafuchi Chem Ind Co Ltd | Ex vivo blood circulating device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0588626B2 (en) | 1993-12-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100237946B1 (en) | Apparatus for assaying viscosity changes in fluid samples and method of conducting the same | |
| CN101791443B (en) | Vacuum assisted tissue treatment system | |
| JPH0367171A (en) | Apparatus for multianalysis | |
| US4266021A (en) | Method and apparatus for the measurement of the concentration of a compound in a liquid medium | |
| CN103765184A (en) | Fluid flow path pressure detection device | |
| JPH1033662A (en) | Ex vivo blood circulating device | |
| CN107708764A (en) | Apparatus for purifying blood and method for filling | |
| JPH067115B2 (en) | Automatic analyzer | |
| JP4282505B2 (en) | Circuit connection detection method and blood purification apparatus in blood purification apparatus | |
| JP2007282928A5 (en) | ||
| JPS63189162A (en) | Apparatus for removing components in blood | |
| JP2007282928A (en) | Extrasomatic circulation circuit, method of confirming connection condition of pressure measuring line with pressure measuring means and extrasomatic circulation apparatus | |
| JPH02289259A (en) | Method for detecting mal-mounting of membrane filter | |
| JP3377318B2 (en) | Blood purification device | |
| CN106726557A (en) | A kind of blood taking bag and the method that fibrinogen is removed with the blood taking bag | |
| JP6997582B2 (en) | Blood purification device | |
| JPS62254765A (en) | Blood treatment apparatus | |
| JPH06285157A (en) | Blood processing device | |
| JP2812460B2 (en) | Blood purification monitoring device | |
| JPH01274770A (en) | Performance test method for blood treatment device | |
| JP2000300665A (en) | Blood treating apparatus | |
| JP3492720B2 (en) | Single needle blood component collection device | |
| CN110494176A (en) | Apparatus for purifying blood | |
| JPH0341958A (en) | Device and method for washing medical instrument | |
| JP3035386B2 (en) | Plasma collection device |