JP2000300665A - Blood treating apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To make it possible to avoid the correspondence and judgment by a person in the event of the occurrence of trouble in regeneration and substitution and to lessen the risk of human error induction by making setting in such a manner that a substituting liquid introducing stage to a treating device after the regeneration treatment is added and carried out when the discharge of a regenerating liquid is judged to be insufficient. SOLUTION: If the plasma treatment in an adsorption treating vessel B is assumed to be set at a standby state when the additional substitution treatment is started since the discharge liquid conductivity of an adsorption treating vessel A subjected to the substitution treatment is off an adequate range, the plasma treatment is eventually interrupted at all times during the period before the additional substitution treatment in the adsorption treating vessel A ends and the trouble that a treatment is not executed during the time occurs. Thereupon, 80% of the adsorption performance intrinsically possessed y the adsorption treating vessel is determined as a permissible range in order to rise the remedy effect during the additional substitution treatment and the operation sequence is so constituted that the plasma treatment quantity may be added up to, for example, 200 mol with respect to the plasma treatment quantity (for example, 500 ml) at which the adsorption performance of the adsorption treating vessel is assured.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood processing apparatus for selectively removing harmful substances or unnecessary substances from blood,
Specifically, at least two or more processors for selectively removing harmful or unnecessary substances are used, and after the amount of removal processing in the first processor reaches a predetermined amount, the removal processing is performed in the second processor. To perform the process of regenerating the processing capability of the first processor during the removal process in the second processor, and the removal process and the regeneration process can be alternately repeated for the processor. The present invention relates to an improvement in a blood processing apparatus configured as described above.

[0002]

2. Description of the Related Art As a conventional example of a blood processing apparatus for selectively removing harmful substances or unnecessary substances from blood, a plasma component is separated from blood introduced outside the body by a plasma separator, and the low plasma content in the separated plasma component is reduced. 2. Description of the Related Art There is known a plasma purification device for selectively adsorbing and removing molecular cholesterol by using two adsorption processors alternately. In this device, in addition to the plasma separator and the adsorption processor, a plasma pump for introducing the plasma separated by the plasma separator to the adsorption processor, and a regenerating solution for regenerating the adsorption capacity are introduced to the adsorption processor. Replacement liquid pump, clamp valve for switching the flow path of plasma, replacement liquid and regeneration liquid between adsorption treatment unit for adsorption treatment and adsorption treatment unit for regeneration treatment, and adsorption treatment unit during regeneration treatment process Equipment for measuring the concentration of regenerated liquid in the discharged liquid (eg conductivity detector)
Etc. are provided.

A method for performing the plasma processing and the regeneration processing in parallel using the two adsorption processing units in the processing apparatus will be described. After the processing is started, first, the plasma processing is performed in the first adsorption processing device. During this time, the processing by the second adsorption processor is not performed. When a predetermined amount of plasma processing has been completed in the first adsorption processor, the flow path is switched to perform plasma processing in the second adsorption processor. While performing the plasma treatment in the second adsorption processor, a predetermined amount of the regenerating solution is introduced into the first adsorption processor,
A step of discharging this is performed. For example, a high-concentration saline solution is used as the regenerating solution. After the introduction of the regenerating solution, a predetermined amount of physiological saline is introduced into the first adsorption processor, and the regenerating solution is pushed out from the adsorption processor, and at the same time, the inside of the adsorption processor is replaced with physiological saline. When a predetermined amount of plasma processing has been completed in the second adsorption processor and the regeneration / replacement step of the first adsorption processor has been completed, the flow path is switched again to perform plasma processing in the first adsorption processor. .

The method of ending the regeneration / replacement step of the adsorption processor will be described below. The discharge of the regenerating solution from the adsorption treatment device is performed by introducing a predetermined amount of a physiological saline solution. At the end of the draining process, the conductivity of the discharged liquid is measured, and if the value is substantially equal to the conductivity of the physiological saline or within the allowable range, it is determined that the regenerated liquid has been discharged and replaced with the physiological saline. To switch the flow path. If the conductivity of the discharged liquid is larger than a predetermined value compared to the conductivity of the physiological saline, it is determined that discharge of the regenerated liquid is insufficient for some reason, and an alarm is issued. Also, when the conductivity of the drainage liquid is smaller than a predetermined value compared to the conductivity of the physiological saline, an alarm is similarly generated. The cause of the alarm is that if the conductivity detector makes a temporary erroneous detection due to electrical noise, etc., the regenerated solution will not be completely discharged due to drift in the adsorption processor or partial coagulation of plasma, etc. If the rate is slightly larger than the specified value, if the drainage of the regenerating solution is incomplete and the conductivity is significantly higher than the specified value for the same reason, the conductivity of the discharged liquid is lower than the specified value due to failure of other equipment or If so, there may be various reasons, such as a failure of the conductivity detector.

[0005] When an alarm is generated, the operator takes a countermeasure with reference to a guidance display or the like, but as a result, the conductivity becomes an appropriate value, or the conductivity remains smaller or larger than the appropriate value. Will be one of When the conductivity of the drainage liquid has reached an appropriate value by the corresponding action, that is, when the conductivity is corrected to a standard value of 15 mS / cm for the physiological saline, for example, within a proper range of 12 to 18 mS / cm which is set. Then, when the operator presses the alarm release / treatment resumption command key on the operation panel, the apparatus restarts the operation, switches the flow path to perform the plasma processing in the adsorption processor, and continues the plasma processing. If the conductivity value remains outside of the proper range despite taking corrective action, the operator may press the abort key to place the device in blood collection mode or seek medical advice. Then, the user presses the alarm release / treatment restart command key on the operation panel to select either restart or continue processing.

[0006]

As described above, in the conventional blood processing apparatus, in the regeneration / replacement process of the processor,
If the conductivity of the effluent at the end of the replacement step is out of the proper range set by the device even after taking the corresponding measures, leave the decision on whether to continue or stop the blood treatment to the doctor and the operator. It is supposed to be. However, there is no clear standard for this judgment, and the treatment may be stopped even if the deviation from the appropriate range is slight, or treatment may be performed in consideration of the remaining blood processing amount even if the deviation is slightly larger. It may be possible to continue. One of the problems caused by the ambiguity of such a criterion is that the process is continued when the effluent conductivity deviates to a side higher than an appropriate range set by the device, that is, to a side where the effluent has a higher salt concentration. Then, when the remaining blood processing amount is large, there is a risk that a large amount of high-concentration saline solution is returned. Another problem is that the treatment can be continued due to a temporary failure of the equipment, such as malfunction due to electrical noise or poor electrical contact of the conductivity detector, even though the treatment can be continued with appropriate response measures. Is stopped, and the expected therapeutic effect cannot be achieved. It is considered that all of these problems are caused by the fact that human error can be induced in order to entrust the handling of troubles in the conventional regeneration / replacement process to human judgment.

[0007]

SUMMARY OF THE INVENTION According to the present invention, in order to eliminate human error in blood processing, a conventional blood processing apparatus is improved so that a new process can be added to a regeneration / replacement process of a processor. Is added. That is, a feature of the present invention is that at least two processors for selectively removing harmful substances or unnecessary substances from blood are provided.
After the removal processing amount in the first processor reaches a predetermined amount, the removal processing is performed in the second processing unit, and the removal processing is performed in the first processing unit during the removal processing in the second processing unit. In the blood processing apparatus, which performs a regeneration process for regenerating the processing capacity by introducing a liquid, the removal process and the regeneration process can be repeatedly performed on the processor in order. It has a function to determine the completion of discharge of the regenerating solution discharged by introducing the replacement solution,
When it is determined that the discharge of the regenerating solution is insufficient, a setting is made such that an additional liquid introducing step into the processor after the regenerating process is additionally performed. With this configuration, the blood processing apparatus according to the present invention, when it is determined that the regenerating solution is not sufficiently discharged at the end of the regenerating / substituting step, generates, for example, an alarm in the same manner as in the related art, and then issues an alarm. Is canceled and a command to restart the process is issued, the flow of the replacement fluid is additionally introduced into the processor without executing the switching of the flow path to the processor after the regeneration.

In the blood processing apparatus, a function of judging the completion of discharge of the regenerating solution by measuring the conductivity of the discharged solution is provided. When the value of the conductivity of the discharged solution is not within a predetermined appropriate range, the regenerating solution is rejected. Is determined to be insufficient, and the replacement liquid introducing step can be set to be additionally performed. Furthermore, after the replacement liquid introduction step according to the addition is completed, a function of measuring the conductivity of the discharged liquid again to determine again the completion of discharge of the regenerated liquid can be provided.

Further, after the completion of the replacement liquid introducing step, if the conductivity value of the discharged liquid is not within a predetermined appropriate range, a removal process for selectively removing harmful substances or unnecessary substances from blood is performed. It may be provided with a function to stop or a function to select to stop or restart the removal processing.

As means for judging the completion of the discharge of the regenerating solution from the processing unit, in addition to measuring the conductivity of the regenerating solution, values such as the absorbance, refractive index, and pH of the regenerating solution may be used. It may be used as an indicator for determining the presence or absence. Which one to use as the determination index may be appropriately selected according to the type of the regenerating liquid.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS [First Embodiment] FIGS. 1 to 4
1 relates to an embodiment of the present invention. FIG. 1 is a configuration of a liquid circuit (hereinafter, simply referred to as “circuit”) of a blood processing apparatus used for plasma purification treatment, and FIG. FIG. 3 is an enlarged view of the lower half of the circuit shown in FIG.
1 shows a circuit configuration of a blood processing apparatus used for blood purification treatment. 5 is a block diagram showing a schematic configuration of a control system of the blood processing apparatus shown in FIG. 1, and FIG. 6 is a flowchart showing an operation procedure of the apparatus. The main operation of the blood processing apparatus according to the present invention is substantially the same in the blood purification apparatus shown in FIGS. 1 to 3 and the blood purification apparatus shown in FIG.
Of the blood processing apparatus for the plasma purification treatment described above.

The blood processing apparatus according to the present invention includes various pumps and actuators such as clamp valves V1 to V14,
Pressure detectors P1 to P7, liquid out detector, level detector,
Various parts such as blood leak detector, air bubble detector, conductivity detector, etc., mechanical parts with built-in heater, etc., and liquids such as blood, plasma, washing or replacement physiological saline, regenerating liquid, etc. And a circuit portion to be circulated. The circuit portion is arranged on a mounting panel of the machine portion. As shown in FIGS. 1 to 3, the circuit portion includes an anticoagulant injector, a plasma separator, two adsorption processors A and B, a filter, drip chambers D1 to D6, and a saline solution pack S1 and S2.
The regenerating liquid pack R and the like are connected by a tube, and these are detachable from the mechanical part so that they can be replaced after use. Note that, in principle, two adsorption processors A and B having the same liquid volume are used.

The blood processing apparatus has an operation panel comprising a liquid crystal display screen with a touch panel. As can be understood from the block diagram shown in FIG. 5, almost all operation commands and data display are performed on this operation panel. It is configured to be able to do it. Operation control of the blood processing apparatus, that is, control of actuators such as pumps and valves based on status signals from the detectors and operation command signals from the operation panel, activation of alarm buzzers and alarm lights, and status display on the operation panel Data output and the like are performed by a microprocessor mounted on the CPU board.

The operation procedure of the blood processing apparatus will be described below with reference to the flowchart of FIG. First, after the power is turned on, a self-diagnosis of the device is performed in order to prevent device failure during treatment (blood processing). Actuators such as pumps and valves are actually operated to perform self-diagnosis. That is, it is confirmed that there is no failure by the rotation signal from the encoder attached to the pump, and by the open / close detection signal attached to the valve for the valve. In the case of the bubble detector, since the circuit is not filled with the liquid at the time of the self-diagnosis, it is confirmed that the output signal is "bubble present". In the subsequent washing step or priming step, a physiological saline solution or the like is passed through the circuit, so that "bubble-free state" can be confirmed at that time. As for the pressure detectors P1 to P7, since the pressure receiving ports for pressure detection are open to the atmosphere, the zero point check and the zero point correction are performed simultaneously.

In the next circuit mounting step, the operator
Plasma separators, adsorption processors A and B, filters, drip chambers D1 to D
6. An anticoagulant injector, physiological saline solution packs S1 and S2, a regenerating solution pack R, and the like are mounted, and each is connected by a tube for fluid distribution to form a circuit portion. In the washing step, the circuit, the plasma separator, and the adsorption processor are washed using a physiological saline solution. In the priming step, a physiological saline solution to which an anticoagulant has been added is used to replace the physiological saline solution filled in the circuit, the plasma separator and the adsorption processor. The next treatment (blood processing) step will be described later. In the collection step after the treatment is completed, the blood and plasma remaining in the circuit, the plasma separator, and the adsorption processor are returned. Finally, in the circuit removal process, remove the circuit part from the device and discard it,
End a series of operations.

The operation of the blood processing apparatus during the treatment process will be described with reference to FIGS. First, a description will be given of a case where the regeneration / substitution process is performed normally in the process of selectively adsorbing and removing low-molecular cholesterol from the plasma components. In the drawings, the clamp valves V1 to V14 that are in the open state are shown in white, and those in the closed state are shaded. As shown in FIG. 7, immediately after the start of treatment, blood collected by a blood pump is introduced into the plasma separator in order to adapt the blood to the plasma separator, and the blood is simply passed through the plasma separator without performing plasma separation. Return blood. In this example, 200 to 300 ml of blood is first processed. The processing amount is measured by the microprocessor accumulating the number of revolutions of the pump, and the operation sequence is managed based on the processing amount integrated value obtained by multiplying the multiplication factor by a coefficient. Next, the plasma pump is rotated as shown in FIG.
A plasma separator separates plasma components from blood. In this example,
The flow ratio between the blood pump and the plasma pump is 0 to 0 on the operation panel.
It can be set in the range of 40%, usually 20
Used in the range of 40%. The plasma separated by the plasma separator is introduced into one of the adsorption treatment devices A, where low-molecular-weight cholesterol is selectively adsorbed and removed, and then merges with blood cell components derived from the outlet of the plasma separator and is returned. . In this example, 600 ml of the plasma processing by the adsorption processor A is performed.

When a predetermined amount of plasma processing is completed in the adsorption processor A, a physiological saline solution is introduced into the adsorption processor A by a replacement liquid pump as shown in FIG. The extruded plasma is extruded and returned. This physiological saline was prepared by adding an anticoagulant. In parallel with this,
Plasma is introduced into the adsorption processor B by a plasma pump, and the physiological saline solution in the processor B is extruded and discharged from the waste liquid channel. The above-mentioned liquid extrusion processing is performed for the liquid volume of the adsorption processors A and B, for example, 100 ml. When the extrusion process of a predetermined amount in the adsorption processors A and B is completed, as shown in FIG.
As for the adsorption processor B, the plasma processing is performed in the same manner as the adsorption processor A in FIG. On the other hand, in the adsorption processor A, during the plasma processing in the adsorption processor B, a regenerating solution, which is a high-concentration saline solution, is introduced in parallel with the replacement solution pump by a replacement liquid pump to perform the regenerating process of the adsorption capacity. By introducing the regenerating solution,
The adsorbed low molecular cholesterol is chemically desorbed and discharged from the adsorber A. In this example, this regeneration process is performed for the liquid volume of the adsorption processor, for example, 100 ml.

When a predetermined amount of regeneration processing is completed for the adsorption processor A, replacement processing of the adsorption processor A filled with the regenerating liquid is performed as shown in FIG. That is, a replacement solution, which is a physiological saline solution to which an anticoagulant has been added, is introduced into the adsorption treatment device A by a replacement solution pump, and a regenerating solution filling the inside thereof is pushed out and discharged from a waste liquid channel. In this example, 300 ml of the replacement liquid, which is about three times the liquid volume of the adsorption processor, is introduced to ensure that the replacement processing is performed. While the regeneration / replacement step is being performed in the adsorption processor A, the plasma processing is continued in the adsorption processor B, and the plasma processing volume in the adsorption processor B is 400 ml, which is equal to the sum of the amounts of the regenerating solution and the replacement solution. is there. The replacement process is determined to be terminated when the integrated processing amount of the replacement liquid has reached a predetermined processing amount and the conductivity of the discharged liquid at that time falls within an appropriate range. When the replacement process is completed, the process shifts to an operation sequence in which the replacement liquid is pushed out of the adsorption processor A and the plasma is pushed out of the adsorption processor B in parallel.

If the conductivity of the discharged liquid is not within the proper range at the end of the replacement process, the apparatus is set to an alarm state. That is, the alarm is generated when the replacement process in the adsorption processor is not sufficiently performed for some reason and a saline solution having a conductivity exceeding an appropriate range remains in the adsorption processor, and in the subsequent operation sequence, Another object of the present invention is to prevent a saline solution having a conductivity exceeding an appropriate range from being mixed with plasma and returned.

An example of the operation of the blood processing apparatus when the conductivity of the discharged liquid is not within the proper range will be described with reference to the sequence flow shown in FIG. After the end of the predetermined amount of plasma treatment in the adsorption processor A, plasma extrusion, regeneration treatment, and replacement treatment are performed in order, and then the conductivity of the discharged liquid is measured. An alarm condition is set. Then, when the discharge conductivity is not corrected within the appropriate range even though the operator performs the treatment with reference to the guidance on the operation panel, the following two options are available. One is to select to stop the treatment as in the past, and the other is to select the alarm release and the treatment restart when the drainage conductivity is not within the proper range.
The present blood processing apparatus has a feature in that an additional replacement process is performed on the adsorption processor A when the operator selects the latter alarm release / resume treatment. In this example, the upper limit of the additional replacement processing amount is set to 300 ml, which is the same as the predetermined value of the initial replacement processing amount. During the additional replacement processing, the conductivity of the discharged liquid is constantly monitored, and when the conductivity enters the appropriate range. It is set to end the additional replacement. If the discharge conductivity is not corrected to the appropriate range by the time when the predetermined amount of the additional replacement process is completed, the alarm state is set again at the time when the additional replacement process is completed.
In the present embodiment, the operation sequence is configured so that when the apparatus is in the re-alarm state, the treatment cannot be restarted by canceling the alarm, and the treatment is stopped. The reason why the conductivity of the effluent is still not corrected to the proper range even though the sufficient additional replacement process has been performed is because it is clearly determined that some trouble has occurred in the apparatus.

In this embodiment, as shown in FIG.
After the first replacement process, the regeneration / replacement process is not immediately terminated even if the effluent conductivity is within the appropriate range, but a determination based on the processing amount in the adsorption processor B on the plasma processing side is added. An operation sequence is configured to suspend the end of the regeneration / replacement process until the plasma processing amount of the processor B reaches a predetermined amount. The reason is as follows. In the present blood processing apparatus, the adsorption processing unit B on the plasma processing side and the adsorption processing unit A on the regeneration / substitution processing side generally have substantially the same flow rate, that is, the plasma pump and the replacement liquid pump are operated at substantially the same flow rate. It is controlled to operate. However, the operation of the plasma pump is controlled while monitoring the return blood pressure P7 and the pressure applied to the adsorption processor B, that is, the adsorption processor differential pressure (P4-P6). Since safety control such as down is performed, the plasma flow rate of the adsorption processor B during the plasma processing is not always constant. Therefore, if the plasma processing in the adsorption processor B slows down during the regeneration / replacement processing in the adsorption processor A, the throughput in the adsorption processor B becomes smaller than that in the adsorption processor A. As a result, at the end of the replacement process, a case may occur in which the predetermined amount of the plasma process has not been completed in the adsorption processor B. The plasma processing amount specified for the adsorption processor is a control value to be observed in achieving the therapeutic effect. In the present embodiment, the above operation sequence is configured for the purpose of observing the control value. .

Similarly, the present invention does not immediately set an alarm state even when the discharge fluid conductivity deviates from an appropriate range at the time of completion of the additional replacement process, but instead performs the process in the adsorption processor on the plasma processing side. Judgment based on processing amount is added. The reason is also described. If the slowdown control for the plasma pump does not occur during the execution of the plasma processing, the normal regeneration / replacement processing in the adsorption processor A and the plasma processing in the adsorption processor B end almost simultaneously. Here, if the discharge liquid conductivity of the adsorption processing unit A after the substitution processing is out of the appropriate range, and the additional substitution processing is started,
Assuming that the plasma processing in the adsorption processor B is in a standby state, the plasma processing is interrupted throughout the period until the additional replacement processing in the adsorption processor A is completed, and during that time, no treatment is performed. Failure occurs. Therefore, in the present embodiment, in order to improve the treatment effect even during the period of the additional replacement process, 80% of the original adsorption performance of the adsorption processor.
Is defined as an allowable range, and the plasma processing amount is set at 2 for the plasma processing amount (for example, 500 ml) at which the adsorption performance of the adsorption processing device is guaranteed.
The operation sequence was configured so that up to 00 ml could be added. Thereby, even if the treatment is stopped due to the re-alarm of the conductivity abnormality of the discharged liquid, the maximum treatment effect can be achieved.

[Second Embodiment] FIG. 13 shows another embodiment of the present invention. In the present embodiment, even when the drainage conductivity at the time when the additional replacement process is completed is out of the appropriate range and the device is in the re-alarm state, the operation sequence is configured so that the alarm can be released and the treatment can be restarted. is there.
In the present embodiment, it is assumed that a detachable and disposable conductivity sensor as disclosed in JP-A-10-33662 is used as the conductivity sensor to be set in the conductivity detector. In this case, one of the causes of the effluent conductivity deviating from the appropriate range may be a poor electrical contact between the conductivity sensor and the electrode portion of the conductivity detector. The embodiment of FIG. 12 mainly considers that the value of the effluent conductivity falls outside a proper range due to an incomplete replacement process for some reason. In other words, it can be said that the case where the value of the conductivity of the effluent deviates to a value smaller than the appropriate range is considered. When an alarm occurs due to poor electrical contact between the sensor and the detector electrode, it is basically possible to take a sufficient countermeasure by means of display guidance on the operation panel. That is, when an alarm is issued because the conductivity is smaller than the appropriate range,
By taking measures such as repeatedly attaching and detaching the conductivity sensor to and from the detector electrode, there is a very high possibility that a normal electrical contact state can be restored. Therefore, there is a very high possibility that the therapy can be restarted in both the alarm state at the end of the first replacement process and the re-alarm state at the end of the additional replacement process. If the re-warning occurs at the end of the additional replacement processing and only the treatment stop can be selected as in the embodiment of FIG. 12, the treatment may be performed even though the conductivity of the drainage fluid can be corrected within an appropriate range. Has to be stopped. In the present embodiment, in view of such a problem, an operation sequence capable of canceling the alarm and restarting the treatment even in the re-alarm state at the end of the additional replacement process is configured.

COMPARATIVE EXAMPLE 1 In both of the embodiments shown in FIGS. 12 and 13, the lower limit and the upper limit are set in the appropriate range of the discharge conductivity both at the end of the normal replacement process and at the end of the additional replacement process. ing. In order to avoid performing the additional replacement process due to the poor electrical contact between the sensor and the detector electrode unit described above, it is possible to set only the upper limit to the appropriate range of the discharge conductivity. I can deal with it.
That is, the operation sequence may be such that the measurement of the conductivity is small due to poor electrical contact. However, in such an operation sequence, in the event that both cases of insufficient replacement and poor electrical contact occur simultaneously, the actual value of the effluent conductivity may be larger than the appropriate range. Nevertheless, since the measured value of the conductivity is small, the apparent conductivity falls within an appropriate range, and as a result, an alarm state is not generated and no additional replacement processing is performed. The possibility of the blood being returned cannot be ruled out. This also indicates that the embodiment shown in FIG. 12 or 13 is excellent.

[Comparative Example 2] In the same way as in Comparative Example 1,
A method is conceivable in which a lower limit and an upper limit are set in the appropriate range of the discharged liquid conductivity at the end of the normal replacement process, and only the upper limit is set in the appropriate range of the discharged solution conductivity at the end of the additional replacement process. In this case, the possibility of returning a high-concentration saline solution can be somewhat reduced as compared with Comparative Example 1. However, the actual situation at the treatment site is to reduce the treatment time in order to reduce the burden on the treatment as much as possible, and it is demanded that the response procedure in the alarm state be as short as possible. Therefore, in the method of Comparative Example 2, if the alarm was canceled and the therapy was resumed without taking sufficient measures in the alarm state at the end of the first replacement processing, the alarm state was set again at the end of the additional replacement processing. Sometimes
It is conceivable that a situation may occur in which only treatment termination can be selected even though sufficient response measures have been taken. This also indicates that the embodiment shown in FIG. 12 or 13 is excellent.

[0026]

According to the present invention, the blood processing apparatus is provided with a function of judging the completion of the discharge of the regenerating solution discharged by introducing the replacement solution into the processor after the regenerating process. If it is determined that the process is insufficient, the replacement liquid introduction process into the processing unit after the regeneration process is set to be added. A possible operation sequence can be configured, and the risk of human error induction can be reduced.

Also, after the completion of the replacement liquid introduction step, if the conductivity value of the discharged liquid is not within a predetermined appropriate range, a removal process for selectively removing harmful substances or unnecessary substances from the blood. Function or a function that can select the suspension or restart of the removal process, by configuring an operation sequence that fully considers various factors that may occur in the reproduction / replacement process, Reduce the risk to the patient,
The maximum therapeutic effect can be improved while reducing the risk when a problem occurs in the regeneration / replacement process.

[Brief description of the drawings]

FIG. 1, showing one embodiment of the present invention, is a schematic configuration diagram of an entire blood processing apparatus.

FIG. 2 is an enlarged view of the upper half of the circuit shown in FIG.

FIG. 3 is an enlarged view of the lower half of the circuit shown in FIG. 1;

FIG. 4 illustrates another embodiment of the present invention,
It is a schematic structure figure of the whole blood processing device.

FIG. 5 relates to one embodiment of the present invention, and is a block diagram illustrating a schematic configuration of a control system of the blood processing apparatus.

FIG. 6 relates to one embodiment of the present invention, and is a flowchart showing an operation procedure of the blood processing apparatus.

FIG. 7 is a view showing an operation state of the blood processing apparatus shown in FIG. 1 and showing an operation of habituation of blood to the plasma separator.

8 is a view showing an operation state of the blood processing apparatus shown in FIG. 1 and showing an initial plasma processing operation in the adsorption processor A. FIG.

9 shows an operation state of the blood processing apparatus shown in FIG. 1, in which the plasma extruding process is performed in the adsorption processor A, and the replacement liquid extruding process is performed in the adsorption processor B in parallel with the plasma extruding process. It is a drawing showing a state.

10 is a view showing an operation state of the blood processing apparatus shown in FIG. 1, wherein a regeneration process is performed in an adsorption processor A,
5 is a diagram showing a state in which plasma treatment is performed in the adsorption treatment device B.

11 shows an operation state of the blood processing apparatus shown in FIG. 1, in which a substitution process is performed in an adsorption processor A,
5 is a diagram showing a state in which plasma treatment is performed in the adsorption treatment device B.

FIG. 12 relates to the blood processing apparatus according to the present invention, and is a view showing an example of an operation sequence flow for performing additional regeneration / replacement processing.

FIG. 13 relates to the blood processing apparatus according to the present invention, and is a view showing another example of an operation sequence flow for performing additional regeneration / replacement processing.

[Explanation of symbols]

 A, B: adsorption treatment device D1 to D7: drip chamber P1 to P7: pressure detector R: regenerating solution pack S1: physiological saline solution pack (for washing) S2: physiological saline solution package (for replacement) V1 to V15: clamp valve

Claims (5)

[Claims] At least two or more processors for selectively removing harmful substances or unnecessary substances in blood are used, and after the amount of removal processing in a first processor reaches a predetermined amount, a second processor is used. A removal process is performed in the processor, and a regeneration process is performed to regenerate the processing capacity by introducing a regenerating solution into the first processor during the removal process in the second processor. Blood processing apparatus, which can be repeatedly performed in order on the blood processing apparatus, has a function of determining completion of discharge of the regenerated liquid discharged by introducing the replacement liquid into the processing apparatus after the regeneration processing, A blood processing apparatus characterized in that, when it is determined that discharge is insufficient, an additional liquid introducing step into the processing device after the regeneration processing is additionally performed. 2. A function for judging completion of discharge of the regenerating solution by measuring the conductivity of the discharged solution. If the value of the conductivity of the discharged solution is not within a predetermined appropriate range, the discharging of the regenerated solution is not performed. The blood processing apparatus according to claim 1, wherein the blood processing apparatus is set to be determined to be sufficient and to perform the replacement liquid introducing step additionally. 3. The blood processing apparatus according to claim 2, further comprising a function of measuring the conductivity of the discharged liquid again after the completion of the replacement liquid introducing step according to the addition, and re-determining the completion of the discharge of the regenerated liquid. apparatus. 4. The apparatus according to claim 2, wherein after the completion of the replacement liquid introduction step, if the value of the conductivity of the discharged liquid is not within a predetermined appropriate range, the removal processing is stopped. 4. The blood processing apparatus according to 3. 5. A function for selecting whether to stop or restart the removal process when the value of the conductivity of the discharged liquid is not within a predetermined appropriate range after the completion of the replacement liquid introducing step relating to the addition. The blood processing apparatus according to claim 2, 3 or 4.