JPS63159821A - Detergent for contact lens - Google Patents

Abstract

PURPOSE:To facilitate washing of the titled lens, and to obtain the detergent which does not injure the contact lens by suspending a water soluble compd. of specific powders in a dispersible medium which is a water soluble and nonaqueous type. CONSTITUTION:The detergent is formed by suspending the water soluble compd. (polymer powders) which is composed of one or two kinds of methyl cellulose, hydroxy propyl methyl cellulose, sodium alginate and gelatin, and has particle size of 0.1-20mum, into the dispersion which is the water soluble and nonaqueous type. The compd. remained on the lens after washing it, can wash off, thereby facilitating the washing of the titled lens by using the water soluble compd. which is soluble to water and does not injure the lens. As the result, the detergent which does not injure the contact lens is obtd.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a contact lens cleaning agent.

More specifically, the present invention relates to a cleaning agent that is effective in removing proteins attached to non-hydroscopic contact lenses such as hard contact lenses and non-aqueous soft contact lenses.

[Prior Art] As a cleaning method using particles as an abrasive material in a contact lens cleaning agent, inorganic substances such as silica and alumina (see Japanese Patent Application Laid-Open No. 8215/1982), cellulose (
A method of suspending water-insoluble particles such as JP-A-80-159721), polyethylene and polysiloxane (see JP-A-57-195922) in an aqueous solvent to prepare a contact lens cleaning agent. etc. are known.

However, in this method, water-insoluble particles will remain on the surface of the contact lens if the contact lens is not rinsed thoroughly, so care must be taken when rinsing after cleaning.

In addition, water-soluble substances such as sodium chloride and sodium hydrogen carbonate can be added to
(U.S. Patent No. 4.588)
．． 444) is also known.

In this method, water-soluble particles are suspended in an aqueous solvent, so even if the adjustment time is short, the particles gradually dissolve in water, so it is necessary to suspend them immediately before use. Furthermore, with this method, particles begin to dissolve immediately after adjustment and the polishing effect weakens, so the cleaning effect is not constant, and the mixing ratio of water-soluble particles and aqueous solvent varies from person to person, resulting in large individual differences. There are drawbacks.

Additionally, if the particles used in this method are suspended in a non-aqueous organic solvent, the problems caused by the particles dissolving in the solvent are resolved, but when the contact lens is washed, the particle size is approximately 300 Since it is large (about 75cm), it has the disadvantage of causing scratches on contact lenses.

[Problems to be Solved by the Invention] In view of the above circumstances, an object of the present invention is to provide a cleaning agent that is easy to clean and does not leave any scratches on contact lenses.

[Means for Solving the Problems] The present invention relates to a contact lens cleaning agent characterized in that a water-soluble compound is suspended in a water-soluble non-aqueous dispersion medium.

[Function and Examples] The compound used in the present invention may be any compound as long as it is water-soluble and does not cause scratches on contact lenses.

Generally, organic polymer substances are soft powders and do not leave scratches on contact lenses.

Further, even if it is a low-molecular substance, a powder with a Mohs hardness of about 2 or less will not scratch contact lenses.

For powders with a Mohs hardness greater than 2, the particle size is 2.
If it is less than 0 times, it will not cause any damage to contact lenses.

As the low molecular weight substance, inorganic and organic compounds can be used. Examples of inorganic compounds include sodium chloride and sodium bicarbonate; examples of organic compounds include citric acid and glucose; however, they are water-soluble, do not damage contact lenses, and are not harmful to the eyes. There are no particular limitations as long as the compound is highly safe.

Further, as the powder having a Mohs hardness of 2 or less used in the present invention, salicylic acid, tyrosine, edetic acid (hereinafter referred to as rEDT)
A.J.) etc.

These powders are softer than contact lenses, so even if the particles are large, they will not cause scratches, but in order for the powder to rub smoothly on the lens during cleaning, the particle size of the powder must be approximately 300 particles. It is preferable that it is below.

Even if the powder has a Mohs hardness greater than 2, the particle size is 20.
．． If it is below, the flaw on the lens surface will be 1/100 am or less at most, will not be recognized as a flaw under an optical microscope, and will not cause any practical problems.

Regardless of the powder, the particle size is 0.1. If it is less than um, sufficient friction cannot be obtained to scrub dirt off the lens surface, so the cleaning effect is the same as when no powder is added.

The concentration of these powders used is 0, O1-2 relative to the solvent.
0 weight % is preferable, and 0.05 to 10 weight % is particularly preferable. If the l concentration is less than 0.01% by weight, there is very little opportunity for the powder to come into contact with dirt in one wash, so the cleaning effect is the same as when no powder is added, and is 20% by weight. If the size is larger, the friction between the contact lens and the powder will increase, making cleaning difficult.

As the organic polymer substance, a water-soluble organic polymer substance that is highly safe to the eyes is used.

Examples of such organic polymeric substances include methylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, sodium alginate, polyethylene oxide, polyacrylamide derivatives, polyvinylpyrrolidone, hydroxyethylcellulose, carboxymethylcellulose, chondroitin sulfate, dextran, pullulan, gelatin, and hyaluronic acid. , chitosan, ovalbumin, casein, soluble starch, carrageenan, and locust bean gum.

The particle size of the organic polymer substance is not particularly limited, and even a relatively large particle size will not cause scratches on contact lenses, but in terms of cleaning function, it is preferably about 1 to 600 nights, particularly 10 to 400 days. Evening is preferred. If the particle diameter is less than 1ρ, sufficient frictional force cannot be generated to remove dirt from the lens surface. Moreover, if the size is larger than 600 doors, the friction between the contact lens and the powder will increase, making cleaning difficult.

Further, the molecular weight of the polymer substance is 10,000 to 10 million, preferably about 30,000 to 1 million, but the more preferable molecular weight varies depending on the substance. For example, methylcellulose is about 30,000 to 700,000, and hydroxypropyl methylcellulose is about Approximately 30,000 to 900,000, sodium alginate is 3
Preferably, it is about 10,000 to 2,400,000, polyvinyl alcohol is about 20,000 to 80,000, polyethylene oxide is about 160,000 to 5,000,000, ovalbumin is about 66,000 to 72,000, and casein is about 70,000 to 370,000. .

Further, the concentration of the organic polymer substance used is preferably 1 to 20% by weight. If the concentration is less than 1% by weight,
If the amount of the contact lens is greater than 20% by weight, the friction between the contact lens and the powder increases, making cleaning difficult.

As the water-soluble non-aqueous dispersion medium, a water-soluble organic solvent is used that is highly safe for the eyes and does not affect the material of the contact lens. For example, polyethylene glycol, glycerin, ethylene glycol, propylene glycol and water-soluble silicone are preferred. However, since the water-soluble compound needs to maintain its particle shape in the solvent, it is necessary to select a solvent that does not dissolve the water-soluble compound.

As other additives, the preferred viscosity range is 30
0.1 to 5% by weight of cetyl alcohol to prepare the cleaning agent to 0 to 30,000 cP, anion such as sodium salt of alkyl sulfate, oxyethylene-oxypropylene block copolymer, alkyl glycine to remove lipid stains. 0.05 to 5% by weight of nonionic or amphoteric surfactant, EDTA, sodium salt of EDTA, potassium salt of EDTA, gluconic acid, citric acid, to prevent inorganic substances from sticking to the lens. Sequestering agent such as sodium salt of citric acid from 0.01 to 5
Preservatives such as potassium sorbate, sodium sorbate, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, etc. are added to prevent bacterial growth during storage.
~1 weight 96 may be added.

When water is added, the amount is 15% by weight or less, preferably 5% by weight or less in order to maintain the particle shape of the water-soluble compound used.

The cleaning method using the cleaning agent of the present invention may be the same as that of conventional cleaning agents. In other words, in the case of hard contact lenses, the method is to pour cleaning solution onto the contact lens and rub it between the thumb and index finger, while in the case of soft contact lenses, the method is to pour cleaning solution onto the palm of the hand and then rub the lens with the index finger. Methods such as

Alternatively, a method using a cleaning puff may be used.

After cleaning, simply rinse. This cleaning agent is highly safe, and even if contact lenses contain a small amount of cleaning agent, there will be no problem at all.

Another cleaning method using the cleaning agent of the present invention is to clean contact lenses with your fingers or with a puff, and then immerse them in purified water, tap water, or a solution containing other components without rinsing off the cleaning agent. You can store your contact lenses until the next day. For example, purified water, tap water, etc. are used as the solution for immersion. In addition, a dedicated dissolving solution can be used, in which case anionic, nonionic, and amphoteric surfactants such as sodium salts of alkyl sulfates, oxyethylene-oxypropylene block copolymers, and alkylglycine can be used. .05 to 5 weight (g)/volume (ml)% (hereinafter referred to as W/V%), the lens is stored at a pH close to that of tear fluid, and the pH is adjusted to 5 to reduce irritation immediately after wearing.
Add pH buffering agents such as phosphoric acid, boric acid, citric acid, and tartaric acid to 0.05 to iowl to adjust the pH to 9.
v%, and also included as a component. When using the method of immersing the lens in tap water, use EDTA, sodium salt of EDTA, potassium salt of EDTA, gluconic acid, citric acid, sodium salt of citric acid, etc. to prevent inorganic substances in the tap water from adhering to the lens. Sequestering agent of 0.01
~5W/V%, in order to prevent the lens from decolorizing or changing the specifications of the lens due to chlorine in tap water, residual chlorine such as sodium thiosulfate, ascorbic acid, sulfurous acid, sodium sulfite, potassium sulfite, etc. A removing agent may be added in an amount of 0.05 to 5 M/V%.

In that case, these additives are crushed to a size of 20 mol or less and blended so as not to damage the contact lenses.

Next, the present invention will be explained based on Examples, but the present invention is not limited to these Examples.

Example 1 Polyethylene glycol with an average molecular weight of 400 (hereinafter referred to as P
EG400) 95g, polyethylene glycol with an average molecular weight of 7500 (hereinafter referred to as PEG3000) 5
g1 surfactant Nonion MS-220 (manufactured by NOF ■)
0.75 g and 0.90 g of surfactant sodium lauryl sulfate (hereinafter referred to as SDS) were placed in a beaker and heated to 80°C to dissolve and form a homogeneous liquid. Separately,
Coarsely crushed in a porcelain mortar, then crushed in an agate mortar, and sized with a sieve, with a total particle size of 0.1 to 20 At.
5 g of sodium hydrogen carbonate within the range of m was placed in a mortar, a small amount of the above-mentioned 80° C. liquid was added, and the mixture was mixed until uniform. Next, the remaining liquid was mixed until it reached room temperature to form a cleaning agent.

The effectiveness of this cleaning agent was observed using the following method.

Artificial tear 1 (al17.4) was prepared with the following formulation.

Sodium chloride 0.83 g Lysozyme 0.129 g Albumin
0.394gγ-globulin
0.275 g Sodium dihydrogen phosphate (trihydrate) 0.08 g Calcium chloride (trihydrate) 0.022 sr Mucin, gastric mucosa 0.15 gIN Sodium hydroxide 1 ml water
A 300 ml oxygen permeable hard contact lens (manufactured by Toyo Contact Lens Co., Ltd., trade name: Menicon 02) was placed in the artificial tear fluid at 75°C.
After soaking at ±5° C. for 1 hour, hands were washed 10 to 15 times with the above-mentioned cleaning agent. This operation was repeated 8 times.

This operation was performed on two lenses, and the lenses were observed using a dark-field stereoscopic microscope (manufactured by Olympus Optical Magnetics), but no protein adhesion or scratches on the surface of the contact lenses were observed in either lens.

Example 2 90 g of PEG400 10 g of polyethylene glycol with an average molecular weight of 3000 (hereinafter referred to as PEG4000)
.

0.8 g of surfactant Pronone 204 (manufactured by NOF ■) and sequestering agent gluconic acid (manufactured by Wako Pure Chemical Industries ■, 50%)
gluconic acid) 0.1. Og was placed in a beaker and heated to 80°C to dissolve and form a homogeneous liquid.

Separately, 2 g of sodium chloride having an average particle size of 5 um, which had been ground with a Turbo Canter Jet Mill TJ-120 (manufactured by Turbo Industrial Magnetics), was placed in a mortar, a small amount of the above liquid at 80° C. was added, and the mixture was mixed until uniform.

The remaining liquid was then added and mixed until cooled to room temperature to form the cleaning agent.

The effect of this cleaning agent was observed in the same manner as in Example 1 using three lenses, but no protein adhesion or scratches on the surface of the contact lenses were observed in any of them. In addition, similar test operations were performed using a commercially available cleaning preservative (manufactured by Toyo Contact Lens Magnetic Co., Ltd., product name: 02 Care) instead of the above-mentioned cleaning agent, and comparisons were made. Protein adhesion was observed on the lens surface.

Example 3 95 g of ethylene glycol, 5 g of cetyl alcohol, and 0.4 g of surfactant Pronone 208 (manufactured by NOF ■) were placed in a beaker and heated to 60°C to dissolve and form a uniform liquid. Separately, 3 g of citric acid with an average particle size of 5 mm, which had been ground with the jet mill used in Example 2, was placed in a mortar, and
Add a small amount of liquid at °C and mix until homogeneous. The remaining liquid was then mixed into the cleaning agent until it cooled to room temperature.

The effect of this cleaning agent was observed in the same manner as in Example 2, and the same results as in Example 2 were obtained.

Example 4 95 g of glycerin, 5 g of cetyl alcohol, 1 nonionic surfactant Tween 60 (manufactured by Kao Atlas ■) 0
．． 5 g was placed in a beaker and heated to 60°C to dissolve and form a homogeneous liquid. Separately, 05g of EDTAo having an average particle diameter of 5ρ, which had been ground with the jet mill used in Example 2, and 245g of glucose were placed in a mortar, a small amount of the above-mentioned 60°C liquid was added, and the mixture was mixed until uniform. The remaining liquid was then mixed until cool to form a cleaning agent.

The effect of this cleaning agent was observed in the same manner as in Example 2, and the same results as in Example 2 were obtained.

Example 5 Two drops (approximately 0.0
．． 2 ml) and immersed in 1 ml of distilled water. After soaking for several hours, the lenses were removed and dried using an air pump.

When the contact lenses were observed under a dark-field stereomicroscope, almost no detergent particles were observed.

In place of the cleaning agent prepared in Example 1, Obticlean (manufactured by Alcon Society Canada φ Incorporated), a commercially available cleaning agent containing particles, was used and the same operation was performed, and the lens was examined using a dark-field stereoscopic microscope. When observed, many particles of detergent were observed.

Example 6 A hard contact lens (manufactured by Toyo Contact Lens Magnetic Co., Ltd., trade name: Menicon 02) that had been worn on the human eye for 16 hours was scrubbed using the cleaning agent of Example 2, and then immersed in tap water overnight. The next morning, after rinsing it lightly with tap water and observing it under a dark-field stereomicroscope, there was no residual dirt and the wearer felt good. Therefore, it was found that it also has the effect of a conventionally used preservative.

Example 7 Artificial tear fluid (pH 7.4) was prepared with the following formulation.

Sodium chloride 0.83 g Lysozyme O, 129 g Albumin
0.394srγ-globulin
0.275g Sodium dihydrophosphate (trihydrate) 0.08.

Calcium chloride (trihydrate) 0.022g mucin, gastric mucosa 0.15 gIN Sodium hydroxide 0.3ml water
100ml
After boiling a non-water-containing soft contact lens containing butyl acrylate and butyl methacrylate in an adjusted artificial tear fluid for 15 minutes, use a cleaning solution (Toyo Contact Lens Magnetic Co., Ltd., brand name: MeniClean) with a cleaning puff. (
Cleaned with Toyo Contact Lenses (product name: Menicon Buff). When this operation was repeated three times, protein was found to be completely attached to the lens surface, so the lens was divided into two parts, one piece of which was used as a test piece, and the other piece was used as a comparison piece.

The cleaning agent of Example 1 was applied to the test piece, and each side was washed five times with the above-mentioned cleaning puff, followed by rinsing with distilled water. This operation was repeated 6 times and visually compared with a comparison piece. As a result, no protein adhesion or scratches on the surface of the contact lens were observed.

Example 8 95 g of PEG400, 5 g of PEG4000, 0.0 g of surfactant Nonion H9-220 (manufactured by NOF ■).
75 g and surfactant Nikko Chemical O8-14
(manufactured by Nikko Chemicals) 0.45g in a beaker,
The mixture was heated to 80°C to dissolve and form a homogeneous liquid. Separately, 10 g of hydroxypropyl methyl cellulose (manufactured by Shin-Etsu Chemical Co., Ltd., trade name: Metrose 60S'1110.000) was placed in a mortar, a small amount of the above liquid at 80° C. was added, and the mixture was mixed until uniform.

The remaining liquid was then mixed into the cleaning agent until it cooled to room temperature.

The effectiveness of this cleaning agent was observed using the following method.

Menicon 02 was placed at 70° in the artificial tear fluid used in Example 1.
After soaking for 1 hour at C±5℃, 10-15
I washed my hands several times. This operation was repeated 8 times.

This operation was performed on two lenses, and the lenses were observed under a dark-field stereomicroscope, but no protein adhesion or scratches on the surface of the contact lenses were observed in either lens.

Examples 9 to 12 Cleaning agents were prepared in the same manner as in Example 8 using the formulations and heating temperatures shown in Table 1. Furthermore, in order to confirm the effectiveness of this cleaning agent, the same procedure as in Example 8 was carried out except that three lenses were used. As a result, no protein adhesion and no scratches on the surface of the contact lenses were observed.

In addition, similar test operations were performed using 02 Care (manufactured by Toyo Contact Lens Magnetic Co., Ltd.) as a cleaning agent, and comparisons were made.
Protein adhesion was observed on the entire surface of the lens treated with this cleaning preservation solution.

[See below for blank space Table 1 [Note] Methyl cellulose (manufactured by Shin-Etsu Chemical Co., Ltd., product name:
Metrose 5M4000) Example 13 Soft contact lenses containing 2-hydroxyethyl methacrylate as a main component and having a water content of about 40% (Toyo Contact Lenses Co., Ltd., trade name: Menicon Soft M) were prepared in Example 7.
After boiling for 15 minutes in the artificial lachrymal solution prepared above, the sample was washed with a cleaning puff (manufactured by Toyo Contact Lens Magnetic Co., Ltd., trade name: Menicon Buff) using a cleaning solution (manufactured by Toyo Contact Lens Magnetic Co., Ltd., trade name: MeniClean). After repeating this operation three times, the protein was completely adhered to the lens surface, so
The lens was divided into two parts, one of which was used as a test piece and the other as a comparison piece.

Separately, 0.5 g of sodium chloride with an average particle size of 5 um, which was ground with the jet mill used in Example 2, was placed in a mortar, and water-soluble silicone (manufactured by Matsumoto Yushi Seiyaku ■, trade name: MYZ) was placed in a mortar.
-50) log was mixed little by little until the mixture became uniform to prepare a cleaning agent.

The above-mentioned cleaning agent was applied to the test piece, and each side was washed 5 times with the above-mentioned cleaning puff, followed by rinsing with a soft contact lens soaking liquid (manufactured by Toyo Contact Lens ■, trade name: Menisolk). This operation was repeated 6 times and visually compared with a comparison piece. As a result, no protein adhesion or scratches on the surface of the contact lens were observed.

[Effects of the Invention] Since the contact lens cleaning agent of the present invention uses a water-soluble compound suspended in a water-soluble non-aqueous dispersion medium, the water-soluble compound that is the abrasive material does not dissolve during cleaning. The cleaning effect is always constant, and since the particles in the cleaning agent are water-soluble compounds, after cleaning, you can simply rinse with water and almost no particles in the cleaning agent will remain on the contact lens. It is something.

It can also be used in a method of preserving contact lenses by immersing them in purified water or tap water without rinsing off the detergent, that is, it can also be used as a preservative. The water-soluble compounds in this cleaning agent do not leave scratches on contact lenses during cleaning, and this cleaning agent is highly safe for the eyes, and even if contact lenses are contaminated with this cleaning agent, only a small amount If so, it's completely safe.

Claims (1)

[Scope of Claims] 1. A contact lens cleaning agent comprising a water-soluble compound suspended in a water-soluble non-aqueous dispersion medium. 2. The contact lens cleaning agent according to claim 1, wherein the water-soluble compound is a powder made of an organic polymer substance. 3. The contact lens according to claim 2, wherein the powder made of an organic polymeric substance is one or more selected from the group consisting of methylcellulose, hydroxypropylmethylcellulose, sodium alginate, and gelatin. Washing soap. 4. The contact lens cleaning agent according to claim 1, wherein the water-soluble compound is a powder having a particle size of 0.1 to 20 μm.