JPS6296585A - Lamellar liquid crystal structure - Google Patents

Abstract

PURPOSE:To provide the titled liq. crystal structure which is a homogeneous gel, is excellent in water-washability and touch, and is suitable for use as a base of cosmetic preparations and external preparations, by mixing a particular Guerbet alcohol-ethylene oxide adduct with a polyhydric alcohol, an oil component and water. CONSTITUTION:1-30wt% Guerbet alcohol-ethylene oxide adduct (A) having an HLB of 10 or more (e.g., polyoxyethylene octyldodecyl ether) and represented by the formula (wherein m is an integer of 6-10; and n is an integer of 10-40), 1-50wt% polyhydric alcohol (B) having three or more hydroxyl groups (e.g., glycerin), 1-90wt% oil component (C) (e.g., triglyceride of 2-ethyl-hexanoic acid), and 1-90wt% water (D) are mixed with each other in such proportions as will provide a liq. crystal structure having one phase.

Description

[Detailed Description of the Invention] [Field of Industrial Application] The present invention provides a novel lamellar liquid crystal structure, more specifically, a homogeneous gel that can be converted into a spreadable oil-based sol by evaporation of water. Moreover, the present invention relates to a lamellar liquid crystal structure useful as a base for cosmetics, external medicines, etc., which can be easily washed away with water.

[Conventional technology]

There are cleansing cosmetics, pine surge cosmetics, etc. as cosmetics that apply oil ingredients to the skin for the purpose of removing dirt and makeup cosmetics, or for pine surges, and these are applied to the skin and spread. , is removed from the skin after it has served its purpose.

Conventionally, these cosmetics have been commercially available based on oils or oil-in-water or water-in-oil emulsions, but recently, gel-like emulsions consisting of oil in surfactants have been used as cleansing agents. It was reported that it could be applied as a drug (Japanese Patent Application Laid-open No. 46123/1983).

[Problem that the invention seeks to solve]

In the case of oil-like products and water-in-oil emulsions, since the continuous phase is an oil component, it is extremely difficult to remove the cosmetics after use. A method of thoroughly rinsing is taken. However, the tissue-off operation removes dead skin cells (I cells), which is not good for the skin, and the oil components make the hands sticky, making it undesirable to use.In addition, in the case of oil-in-water emulsions, it may be possible to wash them off to some extent without the tissue-off operation. Although it is possible, it is extremely insufficient and the oil component remains on the skin.
The surface-active 6-component oil-in-oil gel emulsion disclosed in Publication No. 46123 has excellent emulsifying and dispersing properties in water and can be washed away with only water, but because it is a two-phase composition, it is sticky during use. There is a difference in storage stability over time.

Based on these facts, the amount of the base that can be completely removed with water alone without using a tissue, is non-sticky during use, and has good residual stability, such as a cleansing cosmetic, pine surge cream, or topical drug, is required. The situation was completely destroyed.

[Means for solving problems]

As a result of extensive research to obtain a base that meets the above conditions, the present inventor has discovered a one-phase region obtained from a hydrophilic nonionic surfactant, a water-soluble substance having a hydroxyl group in the molecule, an oil component, and water. It was discovered that the liquid crystal structure of can be used as a cosmetic base that satisfies the above-mentioned purpose, and a patent application was previously filed (Patent Application 1986-
No. 193426).

Will the inventor further research on this? As a result of TJ research, in the above invention, HL was used as a hydrophilic nonionic surfactant.
B. An ethylene oxide adduct of 10 or more Guerbet type alcohols (hereinafter sometimes referred to as "Guerbet type alcohol EO adducts") is used as a water-soluble substance having a hydroxyl group in the molecule, such as a trihydric or higher polyhydric alcohol. The present invention has been completed based on the discovery that a liquid crystal structure obtained using the method has particularly excellent properties.

That is, the present invention provides a lamellar liquid crystal structure obtained from an ethylene oxide adduct of a Guerbet alcohol having an LBIQ or higher, a polyhydric alcohol having a valence of 3 or higher, an oil component, and water.

The Guerbet type alcohol EO adduct used in the present invention is
For example, it is represented by the following general formula (11).

CmH2m++ Cm+2klzrn+z -CH-CH2-(OCHz
CHz ) n0H (in the formula, m represents a number from 6 to 10, and n represents a number from 10 to 40) Among these, those in the formula ([) where m is 7 to 9 and n is 20 to 30 are preferred, Specific examples include polyoxyethylene octyl dodecyl ether (25EO+), polyoxyethylene hebutyl undecyl ether (20EO+), and polyoxyethylene hebutyl undecyl ether (20EO+).
)1. l-'! J oxyethylene nonyl) IJ decyl ether (30EO1, etc.).This Guerbet type alcohol EO compound is usually 1 to 30% by weight based on the total composition of the liquid crystal structure of the present invention. ), preferably in the range of 10 to 20%.If it is less than 1 inch, the liquid crystal structure will not be formed, and if it exceeds 30 inches, the liquid crystal will solidify, which is not preferable.

In addition, examples of trihydric or higher polyhydric alcohols include glycerin, diglycerin, polyglycerin, tritylolpropane, erythritol, pentaerythritol, sorbitan, crucose, sorbitol, maltitol,
Examples include saccharose, trehalose, polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, polyethylene glycol, and ethanol, among which glycerin, sorbitol, and ethanol are particularly preferred. These may be used alone or in combination of two or more. The amount of polyhydric alcohol to be blended varies depending on the usability of the liquid crystal structure, the m distance, etc., but it is blended in an amount of 1 to 50%, preferably 5 to 15%, based on the total composition of the liquid crystal structure of the present invention.

These polyhydric alcohols can be used in combination of two or more types, but among these, ethylene oxide or propylene oxide adducts of sugar derivatives can significantly improve the feel during use by eliminating the heat sensation and stickiness caused by oil. can. Particularly preferred is an adduct of methyl glucoside with 10 to 30 moles of ethylene oxide. When an effect as a feel improver is expected, it is desirable that the core compound is present in the liquid crystal structure in an amount of 1.0% or more.

The oil component used in the present invention may be one commonly used in cosmetics, medicines, etc., such as hydrocarbons, higher alcohol higher fatty acid esters, higher alcohols 27% fatty acids, animal and plant fats, Cholesterol fatty acid esters, fragrances, etc. are mentioned, and preferred ones include lysate paraffin, isostearyl cholesteryl ester, and 2-
Examples include ethylhexanoic acid triglyceride, octadecyl myristate, and olive oil. These may be used alone or in combination of two or more. The oil component accounts for 1 to 90%, preferably 3%, of the total composition of the liquid crystal structure of the present invention.
It is blended in an amount of 0 to 80%.

In addition, the water content can be appropriately selected depending on the physical properties of the intended use of the liquid crystal structure of the present invention, but it is 1 to 9% of the total composition.
0%, preferably 5 to 30%.

The liquid crystal structure of the present invention has Guerbet type alcohol EO attached 1]
0 substance, polyhydric alcohol, oil component and water in 1-phase area 1g
, is produced by mixing in a composition that forms a crystal structure. Such a blending composition can be appropriately determined by blending tests of each component normally conducted by experts in this field.The primary point that must be kept in mind when selecting a blending composition is that The purpose is to select the type, amount, and mixing ratio of water-soluble substances that maximize the association of Guerbet-type alcohol EO adduct molecules.

The liquid crystal structure of the present invention can be produced by mixing and dissolving a Guerbet-type alcohol EO adduct, a polyhydric alcohol, an oil component, and water at a temperature higher than the melting point of each component, and cooling the mixture to around room temperature while stirring. Manufactured. In this case, unlike an emulsion composition consisting of two phases, a dispersed phase and a continuous phase, the liquid crystal structure of the present invention is a homogeneous one-phase liquid crystal structure, so the order of blending each component is the same regardless of the order of mixing. You can get the following.

[Effect]

When the liquid crystal structure of the present invention is applied to the skin, a portion of the liquid crystal structure changes due to temperature rise due to body temperature, changes in H L B due to moisture evaporation, and stress during stretching.

In this state, the oil component becomes a quaternary phase, and the continuous association of the Guerbet-type alcohol EO adduct becomes a dispersed phase, which softens or liquefies. Thereafter, when water is added, the Guerbet-type alcohol EO adduct immediately becomes a continuous phase via the homogeneous liquid crystal phase before application, and the oil component becomes a dispersed phase. In this state, the Guerbet-type alcohol EO adducts are oriented at extremely high density at the oil-water interface, so the interfacial tension between the oil and water drops significantly, and the oil component becomes fine oil-in-water emulsion particles and is released from the skin. easily removed.

[Effects of the Invention] The liquid crystal structure of the present invention has an easy-to-handle gel-like form, and when applied to the skin, it softens and becomes liquid, giving it an excellent feeling of use such as spreading and slipping. has good permeability. Furthermore, when the water is reduced to 7]11, the oil component becomes extremely fine oil-in-water emulsified particles and is easily removed from the skin. Therefore, if the liquid crystal structure of the present invention is used as a base and contains cosmetics, medicinal ingredients, etc., it will have good storage stability, will not be sticky when used, and will spread well and slip easily after use. Excellent cosmetics, external medicines, etc. that can be easily washed off with water can be prepared.

〔Example〕

Next, the present invention will be explained with reference to Examples, but the present invention is not limited to these Examples.

Example 1 Liquid crystal +8 bodies shown in Table 1 below were prepared by the following method, and their appearance, feel, hardness, storage stability, and washability were evaluated. The results are shown in Table 1.

(Manufacturing method) In the table, ① to ② are heated and melted and mixed at 80°C.

This is stirred and cooled to around room temperature to obtain each liquid crystal structure of the present invention.

Margin below @1 Table Oil-water phase ratio 8 = ■ / ■ + ■ Example 2 The liquid crystal structure shown in Table 2 below was prepared by the following method, and its appearance, feeling of use, hardness, storage stability, and water washability were evaluated. evaluated. The results are shown in Table 2.

(#Missing) As in Example 1, ① to ② in the table are heated and melted and mixed with SO'C. This was stirred and cooled to around room temperature to prepare a blend.

Example 3 The liquid crystal structure shown in Table 3 below was prepared by the following method,
The appearance, C rating after 1st wash, hardness, storage stability, and water washability were evaluated. The results are shown in Table 3.

(Manufacturing method) In the same manner as in Example 1, ① to ② in the table are heated and melted and mixed at 80°C. This was stirred and cooled to around room temperature to prepare a blend.

Table 3 with blank space below* Water-soluble substance concentration (■/■+■) x 100 Actual Example 4 The liquid crystal structure shown in Table 4 below was prepared by the following method,
The appearance, feeling of use, hardness, storage stability, and washability were evaluated. The results are shown in Table 4.

(Manufacturing method) In the same manner as in Example 1, ① to ② in the table are heated and melted and mixed at 80°C. This was stirred and cooled to around room temperature to make a mixture of 14
Manufactured.

In the case of the linear alcohol EO adduct of the comparison product, the gelation is insufficient, resulting in a non-uniform system, but in the case of the Guerbet type alcohol EO adduct of the product of the present invention, water and A homogeneous system in which the oil components are evenly mixed is obtained, and the stability is good, as well as the ease of phase transition during use, resulting in good usability and washability.

Reference Example 1 Cosmetic (for cleansing) (Composition) Sorbitol 10 (@polyoxyethylene methyl glucoside tlOE, o,) 5
Polyoxyethylene octyl dodecyl ether (2sz, o, r 1s
2-Ethylhexanoic acid triglyceride 60 Dibutylhydroxytoluene 0.1 Methylparaben 0.1 Butylparaben 0.1 Fragrance 0.1 Ethanol 1 Purified water
Since it liquefies during balance cleansing, it can disperse and dissolve dirt on the skin, and it is convenient because it can be washed away with just water after cleansing, and its ability to remove dirt is also excellent.

Reference Example 2 Pharmaceutical Base A one-phase pharmaceutical base was prepared by heating, dissolving, mixing, and cooling all the components of the following composition.

(Composition) Glycerin 15 (%) Polyoxyethylene octyl dodecyl ether (20E, 0.+15
squalane 60 purified water
By making this balanced preparation, various oil-soluble drugs can be incorporated.

Reference Example 3 Cosmetic (for pine surge) A one-phase liquid crystal cosmetic -A was prepared by heating and dissolving all the components of the following composition, mixing and cooling.

(Composition) Glycerin 10 (%) Propylene glycol 1 Polyoxyethylene to butyllandecyl ether (20E, O, + 15
Olive oil 30 squalane
30 dibutylhydroxytoluene
0.1 methylparaben
0.1 Butylparaben
0.1 fragrance
0.1 purified water
Balance-r It liquefied in the sauce, so it had good slippage, and after finishing the pine surge, it could be washed away with just water, and the storage stability was also good.

that's all

Claims (1)

[Scope of Claims] 1. A lamellar liquid crystal structure obtained from an ethylene oxide adduct of a Guerbet type alcohol with an HLB of 10 or higher, a polyhydric alcohol with a valence of 3 or higher, an oil component, and water. 2. The ethylene oxide adduct of Guerbet type alcohol has the following general formula (I), ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (I) (In the formula, m is a number from 6 to 10, and n is from 10 to 40. The lamellar liquid crystal structure according to claim 1, which is represented by the following formula.