JPS6025183B2 - Oil-in-polyhydric alcohol emulsion composition - Google Patents

Description

Detailed Description of the Invention The present invention aims to effectively utilize sucrose fatty acid ester, which is known to be highly safe as a food additive, in food additives and pharmaceuticals. The object of the present invention is to provide a polyhydric alcohol medium-bottle emulsion composition obtained by incorporating various oils into a gel-like composition formed by providing a polyhydric alcohol with a nonionic surfactant and a nonionic surfactant.

More specifically, 5-99% of one or more polyhydric alcohols having three or more hydroxyl groups in the molecule and 8-2 carbon atoms.
Degree of sucrose ester substitution consisting of 2 saturated or unsaturated fatty acids 1. Sucrose fatty acid ester below the thighs 0.5-30% and 3-18% nonionic surfactant that is liquid at room temperature
．． An oil-in-polyhydric alcohol type emulsion composition obtained by dispersing and incorporating an oil component into a gel-like composition obtained by heating and mixing and dissolving 1 to 20% of the composition, and a method of diluting or adding water to the emulsion composition of the present invention. Cosmetics such as oil-in-water type fine particles, creams, emulsions, and foundations, pharmaceuticals, quasi-drugs, and foods can be provided.

Sucrose fatty acid ester, which is the main substance of the present invention, is a tasteless and odorless edible surfactant composed of natural sucrose and fatty acids. Because of its excellent safety and biodegradability, its use is limited to foods. Extremely spacious in the center. In particular, its low irritation to the eyes and skin, its softness and protective effect on the skin due to thin lipopulence formation and appropriate hydration balance, are important for use in the development of bases for cosmetics and pharmaceuticals. Focusing on the characteristics of such sucrose fatty acid esters, they have been studied for a long time as hypoallergenic surfactants and as emulsion bases for pharmaceuticals. When used alone as the main surfactant in oil-in-water emulsions, the emulsification state is generally poor due to the phase compatibility with the continuous phase and the decrease in interfacial tension. Since it still has drawbacks in maintaining the uniform fine particles and long-term stability required for emulsion bases for pharmaceuticals, other surfactants have taken over the leading role.

The present inventors have developed an excellent emulsion that effectively utilizes sucrose fatty acid ester as a base or surfactant, which is hypoallergenic to the skin and eyes and has excellent softening and protective effects on the skin. In order to obtain this system, as a result of extensive research, we found that the sucrose fatty acid ester was combined with one or more polyhydric alcohols having three or more hydroxyl groups in the molecule and a nonionic surfactant that is liquid at room temperature. When mixed and heated, a gel-like homogeneous phase with a strong structure is formed due to the interaction of each component.

That is, this homogeneous phase structure is a stable, hard liquid crystal phase. The sucrose fatty acid ester here plays a role in forming a structure (such as hydrogen bonding) with a water-soluble polyhydric alcohol having three or more hydroxyl groups in the molecule. When the oil is encapsulated in a stable homogeneous phase due to the coexistence of these three components, the oil can exist stably. In other words, a stable oil-in-polyhydric alcohol emulsion composition with high viscosity in which a homogeneous phase consisting of the polyhydric alcohol, nonionic surfactant, and sucrose fatty acid ester disperses and encapsulates the oil classification described below in the outer phase is obtained. It will be done. Furthermore, if the product of the present invention obtained by the above method is diluted with water or mixed uniformly with water without adding any other emulsifier, a uniform oil-in-water emulsion of fine particles can be obtained without adding strong energy. It was found that this could be obtained, and based on this knowledge, the present invention was made. The sucrose fatty acid ester used in the present invention has an ester substitution degree of 1. Contains everything under the mother's name.

The degree of substitution refers to the average number of ester-bonded fatty acids per molecule of sucrose constituting the sucrose ester. The monoester content is about 20 to 80%. Further, the constituent fatty acids are saturated or unsaturated single or mixed fatty acids having carbon numbers of 8 to 22. The bran fatty acid ester in the present invention preferably has a degree of substitution of 1.65 or less, a monoester content of about 40% or more, and a composition ratio of 0.5 to 30%.
%, preferably 1 to 10%.

If it is less than 0.5%, it is difficult to form a primary gel composition of polyhydric alcohol and sucrose fatty acid ester, and if it is more than 30%, complete dispersion is impossible.

The polyhydric alcohol in the present invention is a water-soluble polyhydric alcohol having three or more hydroxyl groups in the molecule, such as glycerin, diglycerin, triglycerin, tetraglycerin,
These include bentaglycerin, hexaglycerin, octaglycerin, nonaglycerin, decaglycerin, glucose, sorbitol, maltitol, seurose, raffinose, trehalose, etc., and they are one type or a mixture of two or more types.

Particularly preferred are one or a mixture of two of glycerin, diglycerin, triglycerin, sorbitol, and maltitol. The composition ratio of the polyhydric alcohol varies depending on the feeling of use, safety, viscosity, etc. of the resulting emulsified composition, but is 5 to 99%, preferably 15 to 99%. If it is less than 5%, gel destruction occurs and an emulsified composition cannot be prepared.

In alcohols having one or two hydroxyl groups, that is, methanol, ethanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, etc., sucrose fatty acid ester, which is the basis of the present invention, is used. Since structure formation is not possible, it is not possible to obtain an oil-in-polyhydric alcohol emulsion composition as in the present invention. The nonionic surfactant in the present invention is
It is necessary to exhibit a liquid state at room temperature.

These nonionic surfactants have an HLB of 3 to 18, and contain higher alcohol polyoxyethylene ether compounds, higher fatty acid polyoxyethylene ester compounds, polyoxyethylene glycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters. Oxyethylene sorbitol fatty acid ester, glycerin hydroxy fatty acid ester polyoxyethylene adduct, sorbitan fatty acid ester polyoxyethylene adduct, sorbitol fatty acid ester polyoxyethylene adduct, glycerin fatty acid ester, sorbitan fatty acid ester, sorbitol These include fatty acid esters, trimethylolethane fatty acid esters, trimethylolpropane fatty acid esters, bentaerythritol fatty acid esters, phosphate esters of higher alcohols and higher alcohol ethylene oxide adducts, and higher fatty acid mono(di)eta/ruamides. Among these, particularly preferred are glycerin monoisostearate, diglycerin diisostearate, glycerin monooleate, diglycerin diolate, glycerin diricinolate, sorbitan mono(sesqui, di, tri) oleate, sorbitan monolaurate, etc. These include stellethylene oxide adduct, sorbitan monooleic acid ester ethylene oxide adduct, glycerol hydroxystearic acid ester ethylene oxide adduct, oleylalcohol polyoxyethylene ether adduct, and the like. The function of the nonionic surfactant described above, which is liquid at room temperature, is to act as an emulsifier for various oils added to the emulsified composition of the present invention, and at the same time, to coexist with the sucrose fatty acid ester and the water-soluble polyhydric alcohol. It also plays a role as a structure formation promoter.

For this purpose, when the nonionic surfactant is solid at room temperature, before it acts as a structure formation promoter,
The emulsified composition of the present invention cannot be formed because the nonionic surfactant itself destroys the gel-like fine product through coagulation and dissolves the oil.

However, when the nonionic surfactant used is a liquid, this is not the case at all, and an oil-in-polyhydric alcohol emulsion composition that is stable even at low temperatures (000) can be obtained. The composition ratio of the nonionic surfactant is 0.1 to 20%, preferably 0.5 to 10%. If it is less than 0.1%, it becomes opaque and solidified, and the oil-in-polyhydric alcohol emulsion composition intended for the present invention cannot be obtained.

Moreover, if it is more than 20%, the structure cannot be formed and the viscosity decreases significantly, which is not practical. The oil in the present invention may be any animal or vegetable oil, hydrocarbon compound, fragrance, etc. commonly used in cosmetics, medicines, foods, etc.
The respective composition ratios are arbitrarily selected depending on the objectives such as the appearance, usability, and stability of the system. The hardness of the emulsified composition of the present invention will be described in Examples 1 to 5, but it depends on the internal phase ratio and the amount of nonionic surfactant, and as the internal phase ratio increases, it becomes harder. It can be selected as appropriate depending on the usability.

Furthermore, as described in Examples 6 to 13 below, the production of the emulsified composition of the present invention is hardly affected by the polarity of the oil component. Next, the present invention will be explained in more detail with reference to Examples.

(Examples 1 to 5) However, the internal phase ratio is expressed as ■/■10■10■+■.

In the table, ① to ② were heated and mixed at 70°C to prepare a primary gel composition.

This was gradually mixed with (2) heated to 70°C in advance using a lab mixer. This is cooled down to 30 qo to obtain an oil-in-polyhydric alcohol emulsion composition of the present invention. (Examples 6 to 13) Transparent oil-in-polyhydric alcohol emulsion compositions having an internal phase ratio of 0.65. In the table, A, B, C, and D indicate comparative examples.

It was created in the same manner as Examples 1-5. Comparative Examples A to D show products other than those of the present invention, and in Comparative Examples A and C, a gel is formed, but it is white in color, and the emulsion obtained by adding water is unstable. In Comparative Examples B and C, gel-like compositions were not formed at all. (Examples 14 to 17) Transparent oil-in-polyhydric alcohol emulsion composition Example 1 with a unified internal phase ratio of 0.725
created in a similar manner.

(Example 18) In advance, 70 qo of transparent soft rice cake was heated and mixed and dissolved to 70 qo.
The mixture of evil dissolved in oo is gradually added to 30o.
Upon cooling to o, a transparent ointment is obtained.

Next, examples of cosmetics obtained by diluting or adding water to the oil-in-polyhydric alcohol emulsion composition of the present invention will be shown. Reference Example 1 Transparent ointment-like facial rinse A small amount of the emulsified composition of the present invention of Example 18 is taken into hand and diluted with an appropriate amount of water to prepare a facial rinse.

Reference Example 2 Milky lotion "Squalane - Skin T% [B]" was mixed and dissolved by heating to 7.
An emulsified composition of the present invention is obtained by gradually adding the soybean paste dissolved at 0°C.

Claims (1)

[Claims] 1. A polyhydric alcohol having three or more hydroxyl groups in the molecule, a sucrose fatty acid ester with a degree of ester substitution of 1.8 or less, and a nonionic surfactant that is liquid at room temperature. An oil-in-polyhydric alcohol emulsion composition obtained by adding an oil to a gel-like composition. 2. The polyhydric alcohol is one or more of glycerin, diglycerin, polyglycerin, trimethylolethane, trimethylolpropane, erythritol, pentaerythritol, sorbitan, glucose, sorbitol, maltitol, xyucrose, raffinose, and trehalose. The oil-in-polyhydric alcohol emulsion composition according to claim 1, wherein the composition ratio is 5 to 99%. 3. The polyhydric compound according to claim 1, wherein the sucrose fatty acid ester having a degree of ester substitution of 1.8 or less is a compound consisting of a saturated fatty acid having 8 to 22 carbon atoms, and the composition ratio thereof is 0.5 to 30%. Oil-in-alcohol emulsion composition. 4. The oil-in-polyhydric alcohol emulsion composition according to claim 1, wherein the nonionic surfactant is a compound exhibiting a liquid state at room temperature with an HLB value of 3 to 18, and the composition ratio thereof is 0.1 to 20%. . 5 The oil content is one or more of hydrocarbon compounds ranging from solid to liquid at room temperature, higher alcohol higher fatty acid monoester compounds, dibasic acid higher alcohol diester compounds, glycol higher fatty acid diester compounds, animal and vegetable oils, or synthetic triglyceride compounds. Claim 1
The oil-in-polyhydric alcohol emulsion composition described in 1. 6. The oil-in-polyhydric alcohol emulsion composition according to claim 1, which is a cosmetic.