JPS6267017A - 被膜形成型揮散性薬物含有軟膏剤 - Google Patents
被膜形成型揮散性薬物含有軟膏剤Info
- Publication number
- JPS6267017A JPS6267017A JP20538885A JP20538885A JPS6267017A JP S6267017 A JPS6267017 A JP S6267017A JP 20538885 A JP20538885 A JP 20538885A JP 20538885 A JP20538885 A JP 20538885A JP S6267017 A JPS6267017 A JP S6267017A
- Authority
- JP
- Japan
- Prior art keywords
- ointment
- film
- forming
- agent
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 51
- 229940079593 drug Drugs 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 16
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims abstract description 15
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960003711 glyceryl trinitrate Drugs 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000003883 ointment base Substances 0.000 claims abstract description 7
- 239000003349 gelling agent Substances 0.000 claims abstract description 6
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 claims abstract description 6
- 229920013820 alkyl cellulose Polymers 0.000 claims abstract description 3
- 239000002075 main ingredient Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 125000005907 alkyl ester group Chemical group 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 229920000609 methyl cellulose Polymers 0.000 claims description 5
- 239000001923 methylcellulose Substances 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 150000001298 alcohols Chemical class 0.000 claims description 4
- -1 dicarboxylic acid ester Chemical class 0.000 claims description 4
- 150000001991 dicarboxylic acids Chemical class 0.000 claims description 3
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 claims description 3
- 229940043276 diisopropanolamine Drugs 0.000 claims description 3
- 150000002334 glycols Chemical class 0.000 claims description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 2
- SAIKULLUBZKPDA-UHFFFAOYSA-N Bis(2-ethylhexyl) amine Chemical compound CCCCC(CC)CNCC(CC)CCCC SAIKULLUBZKPDA-UHFFFAOYSA-N 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 150000002763 monocarboxylic acids Chemical class 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000003002 pH adjusting agent Substances 0.000 claims 2
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 abstract description 2
- 239000000006 Nitroglycerin Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000009472 formulation Methods 0.000 description 4
- 241000700159 Rattus Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 239000004902 Softening Agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- BBEAQIROQSPTKN-UHFFFAOYSA-N pyrene Chemical compound C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 description 2
- 239000003871 white petrolatum Substances 0.000 description 2
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical class OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthrene Natural products C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- GQPLMRYTRLFLPF-UHFFFAOYSA-N nitrous oxide Inorganic materials [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20538885A JPS6267017A (ja) | 1985-09-19 | 1985-09-19 | 被膜形成型揮散性薬物含有軟膏剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20538885A JPS6267017A (ja) | 1985-09-19 | 1985-09-19 | 被膜形成型揮散性薬物含有軟膏剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6267017A true JPS6267017A (ja) | 1987-03-26 |
| JPH0371409B2 JPH0371409B2 (enrdf_load_stackoverflow) | 1991-11-13 |
Family
ID=16505993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20538885A Granted JPS6267017A (ja) | 1985-09-19 | 1985-09-19 | 被膜形成型揮散性薬物含有軟膏剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6267017A (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62263120A (ja) * | 1986-05-09 | 1987-11-16 | Sekisui Chem Co Ltd | 貼付剤 |
| JPS6450816A (en) * | 1987-08-21 | 1989-02-27 | Kanebo Ltd | Isosorbide nitrate agent for transcutaneous use |
| JPH01110623A (ja) * | 1987-10-22 | 1989-04-27 | Teikoku Seiyaku Kk | 保護膜形成型製剤 |
| US5441732A (en) * | 1990-06-15 | 1995-08-15 | Allergan, Inc. | Reversible gelation emulsion compositions and methods of use |
| US7189761B2 (en) | 1994-05-27 | 2007-03-13 | Gorfine Stephen R | Nitric oxide donor composition and method for treatment of anal disorders |
| JP2007217431A (ja) * | 1999-09-28 | 2007-08-30 | Zars Inc | 相変化処方の薬剤輸送 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5025725A (enrdf_load_stackoverflow) * | 1973-05-17 | 1975-03-18 |
-
1985
- 1985-09-19 JP JP20538885A patent/JPS6267017A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5025725A (enrdf_load_stackoverflow) * | 1973-05-17 | 1975-03-18 |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62263120A (ja) * | 1986-05-09 | 1987-11-16 | Sekisui Chem Co Ltd | 貼付剤 |
| JPS6450816A (en) * | 1987-08-21 | 1989-02-27 | Kanebo Ltd | Isosorbide nitrate agent for transcutaneous use |
| JPH01110623A (ja) * | 1987-10-22 | 1989-04-27 | Teikoku Seiyaku Kk | 保護膜形成型製剤 |
| US5441732A (en) * | 1990-06-15 | 1995-08-15 | Allergan, Inc. | Reversible gelation emulsion compositions and methods of use |
| US7189761B2 (en) | 1994-05-27 | 2007-03-13 | Gorfine Stephen R | Nitric oxide donor composition and method for treatment of anal disorders |
| JP2007217431A (ja) * | 1999-09-28 | 2007-08-30 | Zars Inc | 相変化処方の薬剤輸送 |
| JP2012246315A (ja) * | 1999-09-28 | 2012-12-13 | Zars Inc | 相変化処方の薬剤輸送 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0371409B2 (enrdf_load_stackoverflow) | 1991-11-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ishida et al. | Highly viscous gel ointment containing carbopol for application to the oral mucosa | |
| US5093133A (en) | Method for percutaneous delivery of ibuprofen using hydroalcoholic gel | |
| US5461068A (en) | Imidazole derivative tincture and method of manufacture | |
| JP4925103B2 (ja) | 経皮または経粘膜投与用の医薬組成物 | |
| JPH11512115A (ja) | 経口投与用製剤組成物 | |
| JPH026407A (ja) | 炎症抑制剤ゲル | |
| KR20000049125A (ko) | 외용 국소 마취제 | |
| JP2001518879A (ja) | 薬剤化合物の向上した浸透性のための溶媒システム | |
| JPH10513181A (ja) | 経皮製剤 | |
| JPS6267017A (ja) | 被膜形成型揮散性薬物含有軟膏剤 | |
| JPS6351326A (ja) | ニコランジル外用剤 | |
| CA2015585C (en) | Method and compositions for treatment of mast cell-mediated dermatologic disorders | |
| EP0416804B1 (en) | External preparation containing amusulosin | |
| EP0428352B1 (en) | Anti-inflammatory compositions for external use | |
| EP0255485A2 (en) | Transdermal compositions | |
| JPH04295428A (ja) | 抗アレルギー剤 | |
| JPS58172312A (ja) | ニフエジピン外用剤 | |
| JPH06256218A (ja) | 外用剤 | |
| WO1993024129A1 (en) | Composition for treating acne vulgaris | |
| CA1318598C (en) | Transdermal formulation containing 3-isobutyryl-2-isopropylpyrazolo [1,5-a] pyridine | |
| JPWO2014017411A1 (ja) | 爪白癬治療用外用剤 | |
| JPH05117141A (ja) | 副腎エキス含有消炎鎮痛ゲル剤 | |
| JPH0380774B2 (enrdf_load_stackoverflow) | ||
| JPH0772133B2 (ja) | 安定なケトプロフエン含有クリ−ム製剤 | |
| KR19980073629A (ko) | 투명액상 이부프로펜 조성물 및 이를 함유하는 연질캅셀제 |