JPS6256414A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic having improved remedying effect on senile xeroderma and improving effects on chapped skin, containing sphingolipid derived from organisms. CONSTITUTION:A cosmetic containing sphingolipid derived from organisms, extracted from preferably a mammal, especially from bovine brain. The amount of the lipid blended is generally <=0.001wt%, sufficiently 1-2wt% to show improving effect on chapped skin and about 5wt% for senile xeroderma. The cosmetic is suitable for senile xeroderma as body lotion or body cream and for curing cracks, chaps, chapped skin, chapped hands, etc.,in winter as skin cosmetic such as nutrient cream, hand cream, milky lotion etc.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to a cosmetic that has excellent effects on treating senile xeroderma and improving rough skin.

(Conventional technology) A thin film of sebum and water is formed on the surface of the skin, which prevents excessive evaporation of water. In general, the stratum corneum of the skin maintains a moderate amount of water, and it is said that the optimum amount of water is about 10 to 20%.

When this falls below 10%, the skin becomes dry and cracked.

To solve these problems, conventionally, moisturizers such as sodium lactate, glycerin, sodium pyrrolidone carboxylate, propylene glycol, soluble collagen and hyaluronic acid, etc. and emollients such as squalane, lanolin and jojoba oil have been used.

Cosmetics containing orencilanophyte oil and fatty acid esters have been used.

Furthermore, as we age, the secretion of sebum decreases, making the skin more prone to dryness, leading to symptoms such as senile xeroderma, which causes itching and scaling.

This symptom is particularly common in the lower legs.

No effective treatment has been established for this symptom, and at present, oral antihistamines and topical steroid ointments are used.

(Problems to be Solved by the Invention) These moisturizers are on the skin surface and have a physical effect of supplying moisture to the stratum corneum, and this effect is temporary. It has the disadvantage that it is greatly influenced by environmental conditions. On the other hand, emollients have a physical effect of preventing moisture evaporation on the skin surface, and the effect is also temporary.

Furthermore, no effective cure for senile xeroderma has been established, and the invention of an effective drug is desired.

(Means for Solving the Problems) In view of these circumstances, the present inventors have discovered that the effect of improving rough skin,
In order to obtain cosmetics that are effective in treating senile xeroderma, we conducted research on the skin of people with rough skin and patients with senile xeroderma, and found that sphingolipids derived from epidermal cells decrease with age. In particular, it has been revealed that there are fewer patients with senile xeroderma, and that people with rough skin also have less sphingolipids than healthy people.

As a result of intensive research into various sphingolipids, we discovered that the above objective could be achieved by incorporating sphingolipids extracted from the brains of mammals, especially cows.Based on this knowledge, we completed the present invention. It's arrived.

However, the present invention provides a cosmetic composition that preferably contains sphingolipids obtained from bovine brain.

The sphingolipid used in the present invention is extracted from the brain of a mammal, preferably a cow, and may be extracted by a conventional method, for example as follows.

Fresh cow brain was mixed with water-chloroform-methanol (8:1).
0:20) and homogenized (room temperature, 2 minutes).
Make it into a porridge. After centrifugation, the supernatant was collected, water-chloroform-methanol (8:10:20) was added to the remaining portion, and the mixture was homogenized again for 2 minutes. In the same way, the supernatant was separated and the remaining water-chloroform-methanol (8:
10:20) and homogenize again for 2 minutes. Collect the supernatant in the same way, add chloroform and water to it, and wait for it to separate into two layers. The lower chloroporum layer is taken and concentrated using a rotary evaporator to remove the solvent, and then proteins are removed by ultrafiltration or the like.

The molecular weight of the sphingolipid thus obtained was 10
It is less than 00.

The blending amount is generally 0.001% or more, 1 to 2% to improve rough skin, and 5% for senile xeroderma.
It is enough.

In addition to the essential ingredients listed below, the cosmetic of the present invention contains a surfactant, oil, water, a humectant, and an ultraviolet absorber.

Alcohols, chelating agents, pH adjusters, preservatives.

Thickener 2 Ingredients commonly used in cosmetics, such as pigments, powders, and perfumes, can be appropriately blended. Of course these are 2
It must be within a range that does not impair the effects of the present invention.

The cosmetics* of the present invention can be expected to have a therapeutic effect on senile xeroderma as a body lotion or body cream. It also has the effect of improving rough skin, and is used as a skin cosmetic such as nutritional creams, hand creams, emulsions, and punctures to treat stretchy, chapped, and rough skin during the winter.

(Example) Senile xeroderma treatment efficacy test method ill test method A patient with senile xeroderma appearing on the lower legs! 40 subjects were divided into two groups to test Example 1 and Comparative Example 2, with 20 subjects in each group. The period of use was 2 weeks, and the cosmetic of Comparative Example 1 was applied to the right foot, and the cosmetic of Comparative Example 2 or Example 1 was applied to the left foot.
I avoided using cosmetics three times a day.

(2) Judgment method On the day after the two-week application was completed, judgment was made based on whether there was any itching or scaling.

*Judgment: Excellent effect □ Compared to Comparative Example 1, itching and scaling were significantly improved.

Effectiveness - 1 - Compared to Comparative Example 1, itching and scaling were slightly improved.

Ineffective---m-No difference was observed compared to Comparative Example 1.

: Reduction--F Compared to Comparative Example 1, itching and scaling were worse.

Comparative Example 1.2 and Example 1 (3) Manufacturing method The ingredients of ① to ① were heated and dissolved at 70°C, and stirred to homogenize. Separately, dissolve the ingredients in ■ and 0 in half the amount of @,
Heat the sesame seeds at 70°, add the former to this, mix and emulsify with a homogenizer. -For strength, leftover talent■,
[Phase] was dissolved, and when the above emulsion had cooled down to 50°C, it was added to the emulsion and stirred with a homomixer to obtain the emulsions of Comparative Example 1.2 and Example 1.

The results are shown in Table 1. Note that the numerical values in the table represent the number of subjects judged for that item.

(4) Results table 1. As is clear from Table 1 of the effects of Example 1 and Comparative Example 2, the cosmetic *1 of the present invention has a superior effect on treating senile xeroderma compared to cosmetics containing other types of sphingolipids. It has been proven that there is.

Test method for resolving effect on rough skin (1) Test method 40 women aged 20 to 30 who have rough skin in winter
Example 2 and Comparative Example 4 were tested using the same person as the subject.
There were 20 participants in each group. The period of use was two weeks in winter, with the cosmetics of Comparative Example 3 on one cheek and the cosmetics of each group, Example 2 or Comparative Example 4 on the other cheek at 10:00 in the morning.
I applied it twice in the evening.

(2) Measurement and Judgment Method The next day after 2 weeks of application, measure the moisture content of the skin by 5 kin.
5surface Hydrometer Model
IB-355 (1, B, S.

(manufactured by).

* Judgment: Excellent effect - Moisture content increased by 30% or more compared to Comparative Example 3 Effective - 1 - Moisture content increased by 1094 or more compared to Comparative Example 3 Ineffective - 1 Difference in water content compared to Comparative Example 3 Less than 10% deterioration - m - Moisture content decreased by 10% or more compared to Comparative Example 3 (margins below) Comparative Examples 3 and 4 and Example 2 Sphingolipids extracted from brain in sphingolipids extracted from cow blood Lipid (3) Production Method Heat and dissolve ① to ②. To this, separately dissolved at 70°C, ■ to ■ were added and mixed, and the mixture was emulsified using a homomixer. A cream of Comparative Example 3.4 was obtained. The results are shown in Table 2. The numbers in the table indicate the number of subjects who were judged for that item.

(4) Results table 2. As is clear from Effect Table 2 of Example 2 and Comparative Example 4, it has been proven that the cosmetic of the present invention has a superior effect on improving rough skin compared to cosmetics containing other types of sphingolipids. It was done.

(Effects of the invention) As is clear from the above two examples, cosmetics containing sphingolipids extracted from the brains of mammals, especially cows, have the effect of curing senile xeroderma and rough skin. The improvement effect was excellent.

Claims (2)

[Claims] (1) Cosmetics containing sphingolipids derived from living organisms. (2) The cosmetic according to claim 1, wherein the biologically derived sphingolipid is extracted from the brain of a mammal.