JPS6250471B2 - - Google Patents

Info

Publication number
JPS6250471B2
JPS6250471B2 JP54042347A JP4234779A JPS6250471B2 JP S6250471 B2 JPS6250471 B2 JP S6250471B2 JP 54042347 A JP54042347 A JP 54042347A JP 4234779 A JP4234779 A JP 4234779A JP S6250471 B2 JPS6250471 B2 JP S6250471B2
Authority
JP
Japan
Prior art keywords
culture
medium
properties
streptomyces
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54042347A
Other languages
English (en)
Japanese (ja)
Other versions
JPS55136282A (en
Inventor
Junichi Shoji
Kentaro Tanaka
Yoshimi Kawamura
Mitsuo Hatsutori
Eiji Kondo
Koichi Matsumoto
Tadashi Yoshida
Naoki Tsuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP4234779A priority Critical patent/JPS55136282A/ja
Priority to US06/115,278 priority patent/US4292241A/en
Priority to CA000345633A priority patent/CA1153968A/en
Priority to AU56037/80A priority patent/AU528686B2/en
Priority to EP80101825A priority patent/EP0017246B1/en
Priority to DE8080101825T priority patent/DE3067408D1/de
Publication of JPS55136282A publication Critical patent/JPS55136282A/ja
Publication of JPS6250471B2 publication Critical patent/JPS6250471B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP4234779A 1979-04-06 1979-04-06 Novel antibiotic pa-31088-4 Granted JPS55136282A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP4234779A JPS55136282A (en) 1979-04-06 1979-04-06 Novel antibiotic pa-31088-4
US06/115,278 US4292241A (en) 1979-04-06 1980-01-25 Antibiotic PA-31088-IV and production thereof
CA000345633A CA1153968A (en) 1979-04-06 1980-02-14 Antibiotic pa-31088-iv and production thereof
AU56037/80A AU528686B2 (en) 1979-04-06 1980-02-29 Antibiotic pa-31088-iv
EP80101825A EP0017246B1 (en) 1979-04-06 1980-04-03 Antibiotic pa-31088-iv, its salts with bases, a process for its manufacture, pharmaceutical compositions containing this antibiotic, streptomyces tokunonensis pa-31088 and its mutants
DE8080101825T DE3067408D1 (en) 1979-04-06 1980-04-03 Antibiotic pa-31088-iv, its salts with bases, a process for its manufacture, pharmaceutical compositions containing this antibiotic, streptomyces tokunonensis pa-31088 and its mutants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4234779A JPS55136282A (en) 1979-04-06 1979-04-06 Novel antibiotic pa-31088-4

Publications (2)

Publication Number Publication Date
JPS55136282A JPS55136282A (en) 1980-10-23
JPS6250471B2 true JPS6250471B2 (enExample) 1987-10-24

Family

ID=12633486

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4234779A Granted JPS55136282A (en) 1979-04-06 1979-04-06 Novel antibiotic pa-31088-4

Country Status (6)

Country Link
US (1) US4292241A (enExample)
EP (1) EP0017246B1 (enExample)
JP (1) JPS55136282A (enExample)
AU (1) AU528686B2 (enExample)
CA (1) CA1153968A (enExample)
DE (1) DE3067408D1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01134170A (ja) * 1987-11-19 1989-05-26 Matsushita Electric Ind Co Ltd 冷凍サイクルの安全装置

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5683489A (en) * 1979-12-12 1981-07-08 Shionogi & Co Ltd New antibiotic pa-39504-x1 and it preparation
JPS5740485A (en) * 1980-08-25 1982-03-06 Shionogi & Co Ltd Novel antibiotic pa-39504-x3 and its preparation
JPS5764693A (en) * 1980-10-07 1982-04-19 Kowa Co Novel carbapenem compound and its preparation
ES8302711A1 (es) * 1980-10-24 1983-02-01 Kowa Co Proceso de produccion de un compuesto medicamentoso que con-tiene antibioticos de la serie ka-6643
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use
DE3146190A1 (de) * 1981-11-21 1983-06-16 Hoechst Ag, 6230 Frankfurt Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen
NZ213963A (en) * 1984-10-27 1989-01-06 Antibioticos Sa Production of clavulanic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172129A (en) * 1974-03-28 1979-10-23 Beecham Group Limited Antibiotics
GB1483142A (en) 1975-03-15 1977-08-17 Beecham Group Ltd Streptomycetal antibiotic
NL7802826A (nl) * 1977-04-08 1978-10-10 Merck & Co Inc Thienamycinederivaat, werkwijze voor het bereiden daarvan, alsmede farmaceutische preparaten.
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
DE2862419D1 (en) * 1977-11-12 1984-07-26 Beecham Group Plc Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates
EP0005349A1 (en) * 1978-05-06 1979-11-14 Beecham Group Plc Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01134170A (ja) * 1987-11-19 1989-05-26 Matsushita Electric Ind Co Ltd 冷凍サイクルの安全装置

Also Published As

Publication number Publication date
EP0017246A1 (en) 1980-10-15
JPS55136282A (en) 1980-10-23
CA1153968A (en) 1983-09-20
DE3067408D1 (en) 1984-05-17
AU5603780A (en) 1980-10-09
US4292241A (en) 1981-09-29
AU528686B2 (en) 1983-05-12
EP0017246B1 (en) 1984-04-11

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