JPS62289501A - Rodenticidal composition - Google Patents

Abstract

PURPOSE:To stable rodenticidal composition, containing a rodenticidal active ingredient and specific methylated cyclodextrin at a specific ratio, capable of suppressing offensive smell of the rodenticidal active ingredient and exhibiting improved repellent effect on noxious rodents, particularly rats in a small amount. CONSTITUTION:A rodenticidal composition obtained by blending 0.001-5wt% rodenticidal active ingredient, e.g. warfarin, fumarine, difunone, etc., with soluble methylated cyclodextrin, having the ability to form a clathrate compound and expressed by the formula (A is H or CH3; n is 6-9, provided that at least on of 3n A is CH3), preferably methylated cyclodextrin containing >=50wt% methylated beta-cyclodextrin having 8-11 ether substitution degree and having 8.0-11.0 weight-average ether substitution degree in an amount of 1/2-20 times based on the above-mentioned active ingredient. The above-mentioned blend can be dissolved in water, added to a kneading and hardening step in a production process for the rodenticidal composition and can be readily and uniformly dispersed.

Description

Detailed Description of the Invention 1. Detailed Description of the Invention [Field of Industrial Application] The present invention relates to a rodenticide composition, and more particularly, the present invention relates to a rodenticide composition that suppresses the characteristic odor of the active ingredient of the rodenticide, The present invention relates to an effective pesticide composition capable of lowering the repellency rate.

“ [Prior Art] Rodents, especially rodents and rats, are a widespread problem that occurs in residential areas and industrial areas, and poses a large sanitary and economic impact9. Trap methods and methods using pesticides have traditionally been used to exterminate harmful pests. Among these methods, methods using pesticides are easier to implement and more effective. It has been widely used because it is superior to other methods.

The expression of the insecticidal effect of a herbicide formulation is greatly influenced not only by the magnitude of the efficacy of the insecticidal active ingredient used as an active ingredient itself, but also by the types of various additives used during formulation. In particular, pesticides are ingested by harmful carnivores and exhibit their effects, so they contain attractant components,
It is also necessary to pay attention to odor, taste, etc. to avoid being repelled.

For this reason, attractants such as sugars are used to repel them and prevent them from stopping feeding.

[Problem that the invention seeks to solve]

However, harmful carnivores such as rats and rats generally have excellent senses of smell and taste, and the insecticide's juvenile ingredients are wrapped in attractants such as sugars.
Furthermore, even if it is contained in the feed of various livestock, grain foods, cheese, bread, and other attractant foods that are preferred by rodents, there are microscopic particles unique to the active ingredients of herbicidal agents that cannot be detected by humans. In many cases, the insects were able to detect the odor or taste and avoid it, or even if they ingested it, the dose was not lethal. Therefore, even if a powerful herbicidal active ingredient is used, there is a problem in that the effect cannot be fully exhibited. In the past, various research institutes have been working on the development of powerful insecticidal active ingredients, but it is impossible for these active ingredients to be effective unless they are fed to rodents. . For this reason, there is a strong desire for the emergence of highly effective insecticidal compounds that can be ingested by carnivores without being repelled by them.

[Means for solving problems]

The present inventors are not repelled by harmful carnivores,
In order to develop a pesticide composition that can contain a sufficient amount of the active ingredient of the herbicide to cause death, the woodcutter has conducted extensive research and found that the active ingredient of the herbicide has been added to the composition in advance. Formula (■n (in the formula, A represents a hydrogen atom or a methyl group, and n is 6 to 9
Indicates the number of However, at least one of the A's on the ant surface
If treated with methylated cyclodextrin represented by methyl group (indicates a methyl group) and added to a conventional insecticidal composition, it can be used to remove chemicals that humans can detect, which is the main reason why they are repelled by harmful carnivores. We discovered that it is possible to suppress the subtle odor of the active ingredient of the insecticide, which is difficult to detect, and the change in taste when ingested, and that it is more than effective as a insecticide. Completed the invention.

That is, the present invention comprises the following components (A) and (B) (A)
0.001 to 5% by weight of the active ingredient of the herbicide, (B) (A
The present invention provides a insecticidal composition containing methylated cyclodextrin represented by general formula (I) in an amount of z to 20 times the weight of component (1).

It has been known that cyclodextrins form clathrate compounds with other substances, and active ingredients of pesticides are also said to form clathrate compounds with cyclodextrins. JP-A-49-71132 discloses a method for suppressing the peculiar odor of anti-inflammatory analgesics such as menthol, camphor, and methyl salicylate in bag preparations using the principle of inclusion, but it is not effective as a disinfectant. No method has been shown to suppress the odor of the ingredients and reduce their repellent effect on harmful rodents. The compound in which the active ingredient of the insecticide is clathrated with cyclodextrin is a tasteless and odorless white powder that is insoluble in water, and can be used as it is in the base of the insecticidal composition (although it is possible to include it in the base). Since the clathrate is insoluble in water, it has been difficult to contain it uniformly.

However, like cyclodextrin, methylated cyclodextrin has the ability to form clathrate compounds with various substances, and this compound also has the property of being soluble in water, which is different from cyclodextrin. Therefore, by dissolving methylated cyclodextrin containing the active insecticidal ingredient in water and adding it in the kneading process of the manufacturing process of the insecticidal composition, the insecticidal composition can be easily and uniformly effective. The ingredients can be dispersed in the disinfectant composition. For this reason, the repellency of harmful rodents to the insecticidal composition is almost completely eliminated, and there is almost no cessation of feeding, and the insects continue to fully eat to the end, thereby exerting an effective killing effect.

In addition, in the manufacturing process of the insecticide composition, the active ingredient of the insecticide is mixed and stirred into various bases, but the stability of the active ingredient of the insecticide may be insufficient due to the type of base or the addition of water. However, as shown in the present invention, by including the active ingredient of a pesticide in methylated cyclodextrin and creating a pesticide composition, it can be used without being affected by the base or water. It was also confirmed that sufficient stability was maintained.

The methylated cyclodextrin which is the component (B) of the present invention is represented by the above general formula (I), and those where n is 6 are methylated α-cyclodextrin, and those where n is 7 are methylated I-cyclodextrin. , methylated γ-cyclodextrin when n is 8, and methylated δ-cyclodextrin when n is 9.
They are called cyclodextrins, and all of them exhibit clathrate-forming properties. Among these, methylated β-cyclodextrin having a degree of ether substitution of 8 to 11 is preferably 50 weight or more, and methylated β-cyclodextrin having a weight average degree of ether substitution of &0 to 11.0 is preferred.

Here, the degree of ether substitution refers to the number of methyl groups per cyclodextrin molecule, and in a mixture containing two or more methylated cyclodextrins with different degrees of ether substitution, the degree of ether substitution and the weight of each component From the above equation, the average degree of ether substitution is calculated.

Methylated cyclodextrin (D is produced by methylating cyclodextrin according to a conventional method. When cyclodextrin is methylated using a known methylating agent such as dimethyl sulfate, the hydroxyl group of the glucose group becomes 6 The compound is obtained by methylation in the order of 3-, 2-, and 3-positions.In the present invention, 3n in general formula (I) is obtained.
At least one of the A's in ljd may be a methyl group.

In addition, the active ingredients of the insecticide (A) used in the present invention include warfarin, sihuacinone, sihuacinone sodium, thumarin, tumazol, sulhaquinoline, zinc phosphate, strychnine, arsenic, fluorophacinone, coumachlor, Kumatetralyl, Discmarin, Pipal, Piparin, Valon, Valon Sodium, etc. can be produced.

In the present invention, the blending amount of component (A) is 0.001 to 5
Heavy Nl5 (hereinafter simply referred to as "chi"), preferably o, o
os~1, and component (B) is used in an amount of 4 to 20 times, preferably 1 to 10 times, relative to component (A).

The method for producing the pesticide of the present invention involves blending the above two components.
Therefore, component (A)′t−sufficient component (B
) In order to cause K inclusion, it is preferable to treat component (A) with component (B) in advance.As a method of treating component (A) with component CB), it is preferable to treat component (A) with component (CB) in a saturated aqueous solution of component (B). Saturated aqueous solution method of adding component (A), component (A) and component (B
) is mixed with relatively small amount of water using a kneader or the like.

[Effect]

The insecticidal composition of the present invention can eliminate the repellency of harmful rodents to the insecticidal insecticidal component of component (A), and improve the feeding rate of component (A), so that it has a insecticidal effect. is high. Its mechanism of action is that the active ingredient of the pesticide is included in the aforementioned methylated cyclodextrin (I), which is component (B), thereby preventing the spread of odors, etc. of component (A). Guessed.

〔Effect of the invention〕

Due to the development of the pesticide of the present invention, it has become possible to avoid repellence by harmful rodents and increase the stability of the effective pesticide. Therefore, harmful carnivores can be exterminated with a smaller amount of the insecticidal composition than in the past, which is advantageous in terms of economy and labor.

〔Example〕

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 A role agent composition having the following composition was prepared.

Composition; Warfarin inclusion methylated β-cyclo 0.1
(%) Dextrin* Grain mixture 90.0 Corn oil 4.0 Calcium propionate 1.0 Peanut swallow 0.2 Water
Total 100* Headquarters 90% methylated β-cyclodextrin with an average degree of ether substitution of 9.0, 5% water and 5% warfarin) Mixed using a strainer to include warfarin in methylated β-cyclodextrin. I forced it.

Manufacturing method: All ingredients except warfarin-encapsulated methylated β-cyclodextrin, corn oil and water are mixed in a mixer, and then corn oil is added and mixed.

Warfarin-clathrated methylated β-7 clodextrin dissolved in water was added to this mixture, and the mixture was further mixed. This was made into a gunpowder with a diameter of 3" using an extrusion molding machine, and after drying, it was made into a product.

Example 2 In the same manner as in Example 1, a pesticide f having the following composition was obtained.

Composition: Thumarin inclusion methylated β-cyclo 0.2
f%) Dextrin* Ground whole corn, 81.
2. Corn oil 4.
0 Sodium propionate 1.0
Apple flavor 1.0
Monosodium glutamate 1.0
Beenut flavoring 5.0
Water total 100*
90% methylated β-cyclodextrin with an average degree of ether substitution of 9.0, 5% water and 5% thumarin were mixed using a tumbler to include thumarin in the methylated β-cyclodextrin.

Manufacturing method: Same as Example 1.

Example 3 A pesticide composition having the following composition was obtained in the same manner as in Example 1.

Composition; Sihuacinone inclusion methylated β-cyclo 0.05
5 (%) Dextrin 8 Cereal mixture 88.5 Bean nut oil 5.5 Calcium propionate 0.5 Citric acid 1.0 Water
Total 100* 90% methylated β-cyclodextrin with an average degree of ether substitution of 9.4, 5% water and 5% siphacinone were mixed using a strainer, and siphacinone was included in the methylated β-cyclodextrin. I forced it.

Manufacturing method: Same as Example 1.

Example 4 Regarding the herbicide compositions prepared in Examples 1 to 3, Group 1
Feeding rate and mortality rate were examined using 0 rats. That is, the samples were allowed to be fed ad libitum to the mice for 24 hours, after which they were fed normal food. The feeding rate was determined from the reduction of the sample eaten during the feeding period of this sample, and the mortality rate after one week 1111 of the mice that had eaten was determined. i
As a comparative example, in each Example, methylated β-dextrin was not used, but a biocidal active ingredient was blended. The results are shown in Table 1.

As is clear from the results, the herbicide of the present invention is effective because it has a high rate of ingestion by mice and a high mortality rate.

Example 5 The product of the present invention and the comparative product were stored at 40°C for one month,
Its storage stability was investigated by measuring the amount of active ingredients. The results are shown in Table 2.

Table 2 As is clear from the results, the product of the present invention exhibited sufficient storage stability compared to the comparative product.

that's all

Claims (1)

[Scope of Claims] 1. The following ingredients (A) and (B) (A) 0.001 to 5% by weight of an active ingredient for a sorcicide; (B)
The following formula (I) is 1/2 to 20 times the weight of the component (A) ▲ Numerical formulas, chemical formulas, tables, etc. are available ▼ (I) (In the formula, A represents a hydrogen atom or a methyl group, and n is 6 to 9
Indicates the number of However, among the 3n A's, at least one represents a methyl group) A insecticidal composition containing a methylated cyclodextrin represented by 2. Methylated cyclodextrin has a degree of ether substitution of 8
50% by weight of ~11 methylated β-cyclodextrin
or more, and the weight average degree of ether substitution is 8.0 to 11.
0. The insecticidal composition according to claim 1, wherein