JPS62289501A - Rodenticidal composition - Google Patents
Rodenticidal compositionInfo
- Publication number
- JPS62289501A JPS62289501A JP13445986A JP13445986A JPS62289501A JP S62289501 A JPS62289501 A JP S62289501A JP 13445986 A JP13445986 A JP 13445986A JP 13445986 A JP13445986 A JP 13445986A JP S62289501 A JPS62289501 A JP S62289501A
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- methylated
- active ingredient
- rodenticidal
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 230000001119 rodenticidal effect Effects 0.000 title abstract 7
- 239000004480 active ingredient Substances 0.000 claims abstract description 25
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 19
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 13
- 125000001033 ether group Chemical group 0.000 claims abstract description 13
- 238000006467 substitution reaction Methods 0.000 claims abstract description 13
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 11
- 230000000749 insecticidal effect Effects 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 16
- 241000283984 Rodentia Species 0.000 abstract description 9
- 150000001875 compounds Chemical class 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 241000700159 Rattus Species 0.000 abstract description 5
- 229960005080 warfarin Drugs 0.000 abstract description 5
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 3
- 238000004898 kneading Methods 0.000 abstract description 2
- 239000005871 repellent Substances 0.000 abstract description 2
- 230000002940 repellent Effects 0.000 abstract description 2
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 abstract 2
- GWZYSXKZOOVIDP-UHFFFAOYSA-N 5-(dimethylaminomethylidene)-2-oxo-4-phenylfuran-3-carbonitrile Chemical compound CN(C)C=C1OC(=O)C(C#N)=C1C1=CC=CC=C1 GWZYSXKZOOVIDP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000001473 noxious effect Effects 0.000 abstract 1
- 239000000575 pesticide Substances 0.000 description 14
- 229920000858 Cyclodextrin Polymers 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 239000002917 insecticide Substances 0.000 description 8
- 230000002363 herbicidal effect Effects 0.000 description 7
- 239000004009 herbicide Substances 0.000 description 7
- 235000019645 odor Nutrition 0.000 description 7
- 241001466804 Carnivora Species 0.000 description 6
- 239000005667 attractant Substances 0.000 description 4
- 235000005687 corn oil Nutrition 0.000 description 4
- 239000002285 corn oil Substances 0.000 description 4
- 229940097362 cyclodextrins Drugs 0.000 description 4
- 229920001353 Dextrin Polymers 0.000 description 3
- 239000004375 Dextrin Substances 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 235000019425 dextrin Nutrition 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000003128 rodenticide Substances 0.000 description 3
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 235000010331 calcium propionate Nutrition 0.000 description 2
- 239000004330 calcium propionate Substances 0.000 description 2
- 230000031902 chemoattractant activity Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- HENZOLWOIZODCT-UHFFFAOYSA-N coumachlor Chemical compound OC=1OC2=CC=CC=C2C(=O)C=1C(CC(=O)C)C1=CC=C(Cl)C=C1 HENZOLWOIZODCT-UHFFFAOYSA-N 0.000 description 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- -1 fluorophacinone Chemical compound 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000003721 gunpowder Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 239000012022 methylating agents Substances 0.000 description 1
- 230000001035 methylating effect Effects 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 239000004223 monosodium glutamate Substances 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 235000019488 nut oil Nutrition 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 1
- 229910000165 zinc phosphate Inorganic materials 0.000 description 1
- WHGYBXFWUBPSRW-FEYSZYNQSA-N β-dextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)C(O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FEYSZYNQSA-N 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
【発明の詳細な説明】
1発明の詳細な説明
〔産業上の利用分野〕
本発明は殺ソ剤組成物に関し、さらに詳細には、殺ソ剤
有効成分の特異臭を抑制した結束、ネズミによる忌避率
を下げることのできる効果的な殺ン剤組成物に関する。Detailed Description of the Invention 1. Detailed Description of the Invention [Field of Industrial Application] The present invention relates to a rodenticide composition, and more particularly, the present invention relates to a rodenticide composition that suppresses the characteristic odor of the active ingredient of the rodenticide, The present invention relates to an effective pesticide composition capable of lowering the repellency rate.
“
〔従来の技術〕
げつ歯類、特にねずみ及びはつかねずみの沓は住宅地区
及び腸業地区に生じる広範な問題であり、衛生上や経済
上、大きな影9を与えている。このような有害げつ甫類
の、駆除方法として、従来よりトラップ法や殺ン剤を用
いる方法が用いられている。この中で殺ソ剤を用いた駆
除方法は施行の簡便性や有効性が他の方法に比較して優
れているためひんばんに使用されてきている。“ [Prior Art] Rodents, especially rodents and rats, are a widespread problem that occurs in residential areas and industrial areas, and poses a large sanitary and economic impact9. Trap methods and methods using pesticides have traditionally been used to exterminate harmful pests. Among these methods, methods using pesticides are easier to implement and more effective. It has been widely used because it is superior to other methods.
殺ン剤製剤の殺ソ効果の発現は、有効成分として用いら
れる殺ソ剤有効成分自身の効力の大小もさることながら
、製剤化に際して使用される各種添加剤の種類も大きく
影響を与える。特に殺ン剤は、有害げつ肉類に摂食され
、その効果が発現するものであるため、誘引剤成分や、
また忌避されないためにニオイ、味等に注意を払う必要
がある。The expression of the insecticidal effect of a herbicide formulation is greatly influenced not only by the magnitude of the efficacy of the insecticidal active ingredient used as an active ingredient itself, but also by the types of various additives used during formulation. In particular, pesticides are ingested by harmful carnivores and exhibit their effects, so they contain attractant components,
It is also necessary to pay attention to odor, taste, etc. to avoid being repelled.
このため砂糖類などの誘引剤を用いて忌避や摂食の中止
を防いでいる。For this reason, attractants such as sugars are used to repel them and prevent them from stopping feeding.
しかしながら、ねずみやはつかねずみといった有害げつ
肉類は一般に、臭覚や味覚に優れており、殺ソ剤有幼成
分がたとえば砂糖類などの誘引剤にくるまれていたり、
さらには各種家畜類の飼料、穀物食、チーズあるいはパ
ン等のげつ肉類の好む誘引性食物中に含まれていたとし
ても、人間には感知することのできない殺ソ剤有効成分
に特有の微細なニオイや味を感知して忌避したシ、ある
いは摂取したとしても致死量にまで至らない場合も多か
った。したがって、強力な殺ソ剤有効成分を利用したと
してもその効果を十分く発揮することができないという
問題点を有していた。従来よシ、強力な殺ソ剤有効成分
の開発が各種研究機関でなされてはいるが、これら役ン
剤有効成分はげつ肉類に摂食させなければその効果を発
揮することは不可能である。このためげつ肉類が忌避せ
ずに摂食する、有効性の高い殺ソ剤徂成物の出現が強く
熱望されている。However, harmful carnivores such as rats and rats generally have excellent senses of smell and taste, and the insecticide's juvenile ingredients are wrapped in attractants such as sugars.
Furthermore, even if it is contained in the feed of various livestock, grain foods, cheese, bread, and other attractant foods that are preferred by rodents, there are microscopic particles unique to the active ingredients of herbicidal agents that cannot be detected by humans. In many cases, the insects were able to detect the odor or taste and avoid it, or even if they ingested it, the dose was not lethal. Therefore, even if a powerful herbicidal active ingredient is used, there is a problem in that the effect cannot be fully exhibited. In the past, various research institutes have been working on the development of powerful insecticidal active ingredients, but it is impossible for these active ingredients to be effective unless they are fed to rodents. . For this reason, there is a strong desire for the emergence of highly effective insecticidal compounds that can be ingested by carnivores without being repelled by them.
本発明者等は、有害げつ肉類に忌避されることがなく、
η為つ致死にいたるに十分な量の殺ソ剤有効成分を摂賞
させることのできる殺ン剤組成物を開発すべく樵々倹討
を行った結果、殺ン剤肩効成分をあらかじめ次式(■ン
(式中、Aは水素原子又はメチル基を示し、nは6〜9
の数を示す。但し、ant面のAのうち、少なくとも1
個はメチル基を示す)
で表わされるメチル化シクロデキストリンで処理し、こ
れを従来の殺ソ剤組成物に配合すれば、有害げつ肉類に
忌避されてしまう主原因の、人間には感知することが困
難な殺ソ剤有効成分の有する微妙なニオイや、摂食した
場合の味の変化を抑制することができ、殺ン剤としての
効果が十二分に発揮されることを見出し、本発明を完成
した。The present inventors are not repelled by harmful carnivores,
In order to develop a pesticide composition that can contain a sufficient amount of the active ingredient of the herbicide to cause death, the woodcutter has conducted extensive research and found that the active ingredient of the herbicide has been added to the composition in advance. Formula (■n (in the formula, A represents a hydrogen atom or a methyl group, and n is 6 to 9
Indicates the number of However, at least one of the A's on the ant surface
If treated with methylated cyclodextrin represented by methyl group (indicates a methyl group) and added to a conventional insecticidal composition, it can be used to remove chemicals that humans can detect, which is the main reason why they are repelled by harmful carnivores. We discovered that it is possible to suppress the subtle odor of the active ingredient of the insecticide, which is difficult to detect, and the change in taste when ingested, and that it is more than effective as a insecticide. Completed the invention.
すなわち、本発明は次の成分(A)及び(B)(A)
0.001〜5重量%の殺ソ剤有効成分、(B) (A
)成分のz〜20重量倍の一般式(I)で表わされるメ
チル化シクロデキストリン
を含有する殺ソ剤組成物を提供するものである。That is, the present invention comprises the following components (A) and (B) (A)
0.001 to 5% by weight of the active ingredient of the herbicide, (B) (A
The present invention provides a insecticidal composition containing methylated cyclodextrin represented by general formula (I) in an amount of z to 20 times the weight of component (1).
従来シクロデキストリンは棟々の物質と包接化合物を形
成することが知られており、殺ン剤有効成分もシクロデ
キストリンと包接化合物を形成するといわれている。包
接の原理を利用してバッグ剤においてメントール、カン
フル、サリチル酸メチル等の消炎鎮痛薬の特異臭を抑制
する方法が特開昭49−71132号公報に開示されて
はいるが、殺ン剤有効成分のニオイヤ味を抑制し、有害
げつし類に対し忌避作用を減する方法は示されていない
。そして、シクロデキストリンをて殺ン剤有効成分を包
接させた化合物は無味無臭の水に不溶の白色の粉末であ
り、このまま殺ソ剤組成物として基剤中(含ませること
も可能ではあるが、該包接物は水に不溶性のため均一に
含ませることが難かしかった。It has been known that cyclodextrins form clathrate compounds with other substances, and active ingredients of pesticides are also said to form clathrate compounds with cyclodextrins. JP-A-49-71132 discloses a method for suppressing the peculiar odor of anti-inflammatory analgesics such as menthol, camphor, and methyl salicylate in bag preparations using the principle of inclusion, but it is not effective as a disinfectant. No method has been shown to suppress the odor of the ingredients and reduce their repellent effect on harmful rodents. The compound in which the active ingredient of the insecticide is clathrated with cyclodextrin is a tasteless and odorless white powder that is insoluble in water, and can be used as it is in the base of the insecticidal composition (although it is possible to include it in the base). Since the clathrate is insoluble in water, it has been difficult to contain it uniformly.
しかしながら、メチル化シクロデキストリンにはシクロ
デキストリンと同様に種々の物質と包接化合物を形成す
る能力を有し、さらに当該化合物はシクロデキストリン
とは異なシ水に可溶であるという性質を有しているため
、殺ン剤組成物の製造工程中の練り固める工程において
殺ン剤有効成分を包接したメチル化シクロデキストリン
を水に溶解し、加えることにより、簡単に、しかも均一
に殺ソ剤有効成分を殺ン剤組成物中に分散させることが
できる。このため、有害げつ肉類の殺ソ剤組成物に対す
る忌避率はほとんど消失するばかりかまた摂食中止もほ
とんど認められず、最後まで十分に摂食し、そのため効
果的な殺ン効果を発現する。However, like cyclodextrin, methylated cyclodextrin has the ability to form clathrate compounds with various substances, and this compound also has the property of being soluble in water, which is different from cyclodextrin. Therefore, by dissolving methylated cyclodextrin containing the active insecticidal ingredient in water and adding it in the kneading process of the manufacturing process of the insecticidal composition, the insecticidal composition can be easily and uniformly effective. The ingredients can be dispersed in the disinfectant composition. For this reason, the repellency of harmful rodents to the insecticidal composition is almost completely eliminated, and there is almost no cessation of feeding, and the insects continue to fully eat to the end, thereby exerting an effective killing effect.
また殺ソ剤組成物の製造工程において各種の基剤中に殺
ソ剤有効成分は混合攪拌されるが、基剤の種類や水の添
加により殺ソ剤有効成分の安定性が不十分なものが認め
られたが、本発明に示したように殺ン剤有効成分をメチ
ル化シクロデキストリンに包接させ、さらに殺ン剤組成
物とすることにより、基剤や水の影響を受けることなく
、十分な安定性が保たれていることがあわせて認められ
た。In addition, in the manufacturing process of the insecticide composition, the active ingredient of the insecticide is mixed and stirred into various bases, but the stability of the active ingredient of the insecticide may be insufficient due to the type of base or the addition of water. However, as shown in the present invention, by including the active ingredient of a pesticide in methylated cyclodextrin and creating a pesticide composition, it can be used without being affected by the base or water. It was also confirmed that sufficient stability was maintained.
本発明の成分(B)であるメチル化シクロデキストリン
は前記一般式(I)で表わされるものでnが6のものを
メチル化α−シクロデキストリン、nが7のものをメチ
ル化I−シクロデキストリン、nが8のものをメチル化
γ−シクロデキストリン、nが9のものをメチル化δ−
シクロデキストリンと称し、これらはいずれも包接化合
物形成性を示す。この中でエーテル置換度が8〜11の
メチル化β−シクロデキストリンが50重量−以上であ
り、重量平均エーテル置換度が&0〜11.0であるメ
チル化β−シクロデキストリンが好ましい。The methylated cyclodextrin which is the component (B) of the present invention is represented by the above general formula (I), and those where n is 6 are methylated α-cyclodextrin, and those where n is 7 are methylated I-cyclodextrin. , methylated γ-cyclodextrin when n is 8, and methylated δ-cyclodextrin when n is 9.
They are called cyclodextrins, and all of them exhibit clathrate-forming properties. Among these, methylated β-cyclodextrin having a degree of ether substitution of 8 to 11 is preferably 50 weight or more, and methylated β-cyclodextrin having a weight average degree of ether substitution of &0 to 11.0 is preferred.
ここでエーテル置換度とはシクロデキストリン−分子当
たり、尋人されたメチル基の数を示し、異なるエーテル
置換度を有するメチル化シクロデキストリンを2種以上
有する混合物では各エーテル置換度と各成分の重置チよ
り有量平均エーテル置換度が算出される。Here, the degree of ether substitution refers to the number of methyl groups per cyclodextrin molecule, and in a mixture containing two or more methylated cyclodextrins with different degrees of ether substitution, the degree of ether substitution and the weight of each component From the above equation, the average degree of ether substitution is calculated.
メチル化シクロデキストリン(Dは、シクロデキストリ
ンを常法に従いメチル化することにより製造される。シ
クロデキストリンをジメチル硫酸等の公知のメチル化剤
を用いてメチル化した場合、グルコース桟基の水酸基が
6位、2位、3位の順序でメチル化されたて1合物が得
られる。本発明においては、一般式(I)において3n
ljdのAのうち少なくとも1個がメチル基であればよ
い。Methylated cyclodextrin (D is produced by methylating cyclodextrin according to a conventional method. When cyclodextrin is methylated using a known methylating agent such as dimethyl sulfate, the hydroxyl group of the glucose group becomes 6 The compound is obtained by methylation in the order of 3-, 2-, and 3-positions.In the present invention, 3n in general formula (I) is obtained.
At least one of the A's in ljd may be a methyl group.
また、本発明において用いられる(A)成分である殺ソ
剤有効成分としては、ワーファリン、シフアシノン、シ
フアシノンナトリウム、ツマリン、ツマゾール、スルハ
キノリン、リン酸亜鉛、ストリキニン、ヒ素、フロロフ
ァシノン、クマクロール、クマテトラリル、ディスクマ
リン、ピパル、ピパリン、バロン、バロンナトリウム等
ヲアケル仁とができる。In addition, the active ingredients of the insecticide (A) used in the present invention include warfarin, sihuacinone, sihuacinone sodium, thumarin, tumazol, sulhaquinoline, zinc phosphate, strychnine, arsenic, fluorophacinone, coumachlor, Kumatetralyl, Discmarin, Pipal, Piparin, Valon, Valon Sodium, etc. can be produced.
本発明において、成分(A)の配合量は0.001〜5
重Nl5(以下単に「チ」で示す)、好ましくはo、o
os〜1チであり、成分(B)は、成分(A)に対し重
着比で4〜20倍量、好ましくは1〜10倍量で用込ら
れる。In the present invention, the blending amount of component (A) is 0.001 to 5
Heavy Nl5 (hereinafter simply referred to as "chi"), preferably o, o
os~1, and component (B) is used in an amount of 4 to 20 times, preferably 1 to 10 times, relative to component (A).
本発明殺ン剤の製法は上記2成分を配合せしめることK
よって行なわれるが、成分(A)′t−充分に成分(B
) K包接させるには、予め成分(B)で成分(A)を
処理しておくのが好ましい、成分CB)で成分(A)を
処理する方法としては、成分(B)の飽和水溶液に成分
(A)を添加する飽和水溶液法、成分(A)と成分(B
)を比較的少産の水とともにニーダ−等で練り合わせる
混線法等が採用される。The method for producing the pesticide of the present invention involves blending the above two components.
Therefore, component (A)′t−sufficient component (B
) In order to cause K inclusion, it is preferable to treat component (A) with component (B) in advance.As a method of treating component (A) with component CB), it is preferable to treat component (A) with component (CB) in a saturated aqueous solution of component (B). Saturated aqueous solution method of adding component (A), component (A) and component (B
) is mixed with relatively small amount of water using a kneader or the like.
本発明の殺ソ剤組成物は、成分(A)の殺ノ剤有幼成分
に対する有害げつ肉類の忌避を解消することができ、成
分(A)の摂食率が向上するので殺ソ効果が高い。その
作用機序は殺ン剤有効成分が前述の、成分(B)である
メチル化シクロデキストリン(I)に包接されることに
より、成分(A)のニオイ等の拡散を防いでいるものと
推測される。The insecticidal composition of the present invention can eliminate the repellency of harmful rodents to the insecticidal insecticidal component of component (A), and improve the feeding rate of component (A), so that it has a insecticidal effect. is high. Its mechanism of action is that the active ingredient of the pesticide is included in the aforementioned methylated cyclodextrin (I), which is component (B), thereby preventing the spread of odors, etc. of component (A). Guessed.
本発明の殺ン剤徂成′勿により、有害げつ肉類による忌
避の回避及び殺ソ剤有効戎分の安定性を増すことが可能
となった。このため、従来より少量の殺ソ剤組成物にて
有害げつ肉類の駆除がoT能となり経済上あるいは労力
上の面での利点は大きい。Due to the development of the pesticide of the present invention, it has become possible to avoid repellence by harmful rodents and increase the stability of the effective pesticide. Therefore, harmful carnivores can be exterminated with a smaller amount of the insecticidal composition than in the past, which is advantageous in terms of economy and labor.
次に実施例を挙げ、本発明を更に詳細に説明する。 Next, the present invention will be explained in more detail with reference to Examples.
実施例1 次に示す組成の役ソ剤組成物を調製した。Example 1 A role agent composition having the following composition was prepared.
組成;
ワーファリン包接メチル化β−シクロ 0.1
(%)デキストリン*
穀類混合物 90.0と
うもろこしオイル 4.0プロ
ピオン酸カルシウム 1.0ピー
ナツツバメー 0.2水
合計 100* 本
社平均エーテル置換度9.0のメチル化β−シクロデキ
ストリン90%、水5チ及びワーファリン5%’)らい
かい機を用いて混合し、ワーファリンをメチル化β−シ
クロデキストリンに包接せしめた。Composition; Warfarin inclusion methylated β-cyclo 0.1
(%) Dextrin* Grain mixture 90.0 Corn oil 4.0 Calcium propionate 1.0 Peanut swallow 0.2 Water
Total 100* Headquarters 90% methylated β-cyclodextrin with an average degree of ether substitution of 9.0, 5% water and 5% warfarin) Mixed using a strainer to include warfarin in methylated β-cyclodextrin. I forced it.
製法:
ワーファリン包渚メチル化β−シクロデキストリン、と
うもろこしオイル及び水を除く全組成をミキサーに入れ
混合し、次いで、とうもろこしオイルを加え混合する。Manufacturing method: All ingredients except warfarin-encapsulated methylated β-cyclodextrin, corn oil and water are mixed in a mixer, and then corn oil is added and mixed.
この混合物中に水に溶解したワーファリン包接メチル化
β−7クロデキストリンを加え、更に混合し、これを押
出し成型機を用いて直径3」の大きさの火剤とし、乾燥
後製品とした。Warfarin-clathrated methylated β-7 clodextrin dissolved in water was added to this mixture, and the mixture was further mixed. This was made into a gunpowder with a diameter of 3" using an extrusion molding machine, and after drying, it was made into a product.
実施例2
実施例1と同様にして、次に示す組成の殺ン剤f且成物
を得た。Example 2 In the same manner as in Example 1, a pesticide f having the following composition was obtained.
組成:
ツマリン包接メチル化β−シクロ 0.2
f%)デキストリン*
粉砕全とうもろこし、 81.
2とうもろこしオイル 4.
0プロピオン酸ナトリウム 1.0
リンゴ香料 1・0
グルタミン酸ナトリウム 1.0
ビーナツツ香料 5.0
水 合計 100*
重瞳平均エーテル置換度9.0のメチル化β−シクロ
デキストリン90%、水5%及びツマリン5%tらいか
い機を用いて混合し、ツマリンをメチル化β−シクロデ
キストリンに包接せしめた。Composition: Thumarin inclusion methylated β-cyclo 0.2
f%) Dextrin* Ground whole corn, 81.
2. Corn oil 4.
0 Sodium propionate 1.0
Apple flavor 1.0
Monosodium glutamate 1.0
Beenut flavoring 5.0
Water total 100*
90% methylated β-cyclodextrin with an average degree of ether substitution of 9.0, 5% water and 5% thumarin were mixed using a tumbler to include thumarin in the methylated β-cyclodextrin.
製法: 実施例1に準じる。Manufacturing method: Same as Example 1.
実施例3
実施例1と同様にして、次に示す組成の殺ン剤組成物を
得た。Example 3 A pesticide composition having the following composition was obtained in the same manner as in Example 1.
組成;
シフアシノン包接メチル化β−シクロ 0.05
5(%)デキストリン8
穀類混合物 88.5ビ
ーナツツ油 5・5プロ
ピオン酸カルシウム 0.5クエン
酸 1.0水
合計 100* 型破平均
エーテル置換度9.4のメチル化β−シクロデキストリ
ン90%、水5チ及びシフアシノン5%をらいかい機を
用いて混合し、シフアシノンをメチル化β−シクロデキ
ストリンに包接せしめた。Composition; Sihuacinone inclusion methylated β-cyclo 0.05
5 (%) Dextrin 8 Cereal mixture 88.5 Bean nut oil 5.5 Calcium propionate 0.5 Citric acid 1.0 Water
Total 100* 90% methylated β-cyclodextrin with an average degree of ether substitution of 9.4, 5% water and 5% siphacinone were mixed using a strainer, and siphacinone was included in the methylated β-cyclodextrin. I forced it.
製法: 実施例1に準じる。Manufacturing method: Same as Example 1.
実施例4
実施例1〜3で調製した殺ソ剤組成物について、1群1
0匹のはつかねずみを用い、摂食率及び死亡率を調べた
。すなわち、試料を24時間はつかねずみに自由に摂食
させ、その後正常な飼料で飼育した。この試料の摂食期
間中に摂食した試料の減少賦から摂食率を求め、摂食し
たねずみについて一週1111後の死亡率を求めた。i
お、比較例としては、各実施例においてメチル化β−デ
キストリンを用いず、殺ン有効成分を配合したものを用
いた。この結果を第1表に示す。Example 4 Regarding the herbicide compositions prepared in Examples 1 to 3, Group 1
Feeding rate and mortality rate were examined using 0 rats. That is, the samples were allowed to be fed ad libitum to the mice for 24 hours, after which they were fed normal food. The feeding rate was determined from the reduction of the sample eaten during the feeding period of this sample, and the mortality rate after one week 1111 of the mice that had eaten was determined. i
As a comparative example, in each Example, methylated β-dextrin was not used, but a biocidal active ingredient was blended. The results are shown in Table 1.
以下余ニア゛1
811表
この結果から明らかなように本発明の殺ノ剤はねずみの
摂食率が高く、しかも死亡率が高いので効果的である。As is clear from the results, the herbicide of the present invention is effective because it has a high rate of ingestion by mice and a high mortality rate.
実施例5
本発明品と比較品について、40℃で1カ月間保存し、
その保存安定性を有効成分量の測定から調べた。この結
果を第2表に示す。Example 5 The product of the present invention and the comparative product were stored at 40°C for one month,
Its storage stability was investigated by measuring the amount of active ingredients. The results are shown in Table 2.
第2表
この結果から明らかなように本発明品は比較品に比べ十
分な保存安定性を示した。Table 2 As is clear from the results, the product of the present invention exhibited sufficient storage stability compared to the comparative product.
以上that's all
Claims (1)
(A)成分の1/2〜20重量倍の次の式( I )▲数
式、化学式、表等があります▼( I ) (式中、Aは水素原子又はメチル基を示し、nは6〜9
の数を示す。但し、3n個のAのうち、少なくとも1個
はメチル基を示す) で表わされるメチル化シクロデキストリンを含有する殺
ソ剤組成物。 2、メチル化シクロデキストリンが、エーテル置換度8
〜11のメチル化β−シクロデキストリンを50重量%
以上含有し、重量平均エーテル置換度が8.0〜11.
0である特許請求の範囲第1項記載の殺ソ剤組成物。[Scope of Claims] 1. The following ingredients (A) and (B) (A) 0.001 to 5% by weight of an active ingredient for a sorcicide; (B)
The following formula (I) is 1/2 to 20 times the weight of the component (A) ▲ Numerical formulas, chemical formulas, tables, etc. are available ▼ (I) (In the formula, A represents a hydrogen atom or a methyl group, and n is 6 to 9
Indicates the number of However, among the 3n A's, at least one represents a methyl group) A insecticidal composition containing a methylated cyclodextrin represented by 2. Methylated cyclodextrin has a degree of ether substitution of 8
50% by weight of ~11 methylated β-cyclodextrin
or more, and the weight average degree of ether substitution is 8.0 to 11.
0. The insecticidal composition according to claim 1, wherein
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13445986A JPS62289501A (en) | 1986-06-10 | 1986-06-10 | Rodenticidal composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13445986A JPS62289501A (en) | 1986-06-10 | 1986-06-10 | Rodenticidal composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS62289501A true JPS62289501A (en) | 1987-12-16 |
Family
ID=15128825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13445986A Pending JPS62289501A (en) | 1986-06-10 | 1986-06-10 | Rodenticidal composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS62289501A (en) |
-
1986
- 1986-06-10 JP JP13445986A patent/JPS62289501A/en active Pending
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