JPS62224259A - Nourishing meal - Google Patents

Abstract

PURPOSE:To obtain a nourishing meal, readily and orally ingestible, having good digestibility and absorbability, high nutritive value and improved patalability and effective for improving hypoproteinemia and hypoalbuminemia. CONSTITUTION:A nourishing meal containing protein consisting essentially of albumin derived from animals, glucide and nucleic acid. The weight proportion thereof in the nourshing meal is preferably 10-90% protein, 1-90% glucide and 0.5-10% nucleic acid. At least one of one milk albumin and egg albumin may be used as the albumin derived from animals. At least one of animal and vegetable proteins other than such albumins may be contained as the protein in the meal.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to nutritional foods, and particularly to nutritional foods for various diseases such as liver disorders (
liver cirrhosis, chronic hepatitis, etc.), renal disorders (nephrosis, dialysis patients, etc.), gastrointestinal disorders (gastrointestinal ulcers, malabsorption syndrome, etc.),
The present invention relates to a nutritional food that is extremely suitable to be given to patients who suffer from poor nutritional status due to malignant tumors or the like, and as a result exhibit hypoproteinemia or hypoalbuminemia.

The nutritional food according to the present invention is suitable not only for patients as described above, but also for general healthy people, growing infants, and children for the purpose of nutritional supplementation and muscle strengthening.

(Prior art and its problems) Conventionally, in order to improve hypoproteinemia and hypoalbuminemia, parenteral measures include supplementation of proteins and amino acids through parenteral nutrition or enteral nutrition. Oral strategies include ingestion of high protein foods or protein supplements.

Parenteral nutrition is useful when a patient is unable to take oral intake, but it is a complicated procedure, imposes a large economic burden, and there is a concern that side effects such as infection may occur. Supplementation of protein and amino acids through enteral nutrition is free from infectious diseases and is less of an economic burden; however, long-term administration of enteral nutrition is painful for patients and tends to cause side effects such as diarrhea.

When compared with these parenteral supplements, oral supplementation is easy, physiologically superior, and has less economical burden, and is therefore most useful for patients who have the ability to digest it. . However, many of the high-protein foods and protein supplements currently available for oral supplementation of protein and amino acids are mainly based on soybean protein. The reality is that there is no oral nutritional food that is effective and appropriate for improving hypoproteinemia and hypoalbuminemia.

(Objective of the Invention) Therefore, the object of the present invention is to provide a product that is easy to take orally, has good digestion and absorption, has high nutritional value, and has excellent palatability, resulting in hypoproteinemia and low albuminemia. The aim is to provide nutritional food that is effective in improving blood pressure.

(Means and Effects for Achieving the Object) According to the present invention, the above object is achieved by a nutritional food containing protein, mainly albumin derived from an animal, carbohydrates, and nucleic acids. .

Regarding the proportions in the nutritional food according to the present invention, it is appropriate that the protein be 10-90%, the carbohydrate be 1-90%, and the nucleic acid be 0.5-10%.

The animal-derived albumin can be at least one of milk albumin and egg albumin. In addition to these albumins, the protein may contain at least one of animal and vegetable proteins, and in this case, the animal proteins include casein, gelatin, egg white, etc. Examples include soybean protein and wheat protein. The above-mentioned animal albumin has no limiting amino acids in its amino acid composition, so it is of high quality as a protein and has almost the same composition as albumin biosynthesized in the liver. Milk albumin has a high cystine and tryptophan content and a good amino acid composition, while egg albumin is also superior to other proteins in that it has a high amino acid content, especially methionine content.

Therefore, the nutritional food according to the present invention can effectively improve hypoproteinemia and hypoalbuminemia when administered to a patient.

Examples of carbohydrates include starch, dextrin, maltose, sorbitol, fructose, glucose, and sucrose. The addition of carbohydrates is not only for the purpose of replenishing the carbohydrates themselves;
It has the effect of improving the granulation properties of nutritional food raw materials and further improving the solubility of the powder formed by granulation.

Nucleic acids are added to promote protein synthesis and normalize protein metabolism in vivo.

When dissolving this nutritional food in water, milk, juice, black tea, etc., an emulsifier can be added if necessary to improve solubility. As the emulsifier, it is recommended to use polyglycerin fatty acid ester. preferable.

In addition to the above-mentioned components, various lipids, vitamins, minerals, etc. may be added to the nutritional food according to the present invention as required.

(Effects of the Invention) The nutritional food according to the present invention can be used for malnourished hypoproteinemic patients,
When orally ingested by patients with cirrhosis, chronic hepatitis, nephrosis, and ulcerative colitis associated with hypoalbuminemia, it has nutritional and disease-improving effects. That is, an increase in serum total protein and albumin levels, an increase in body weight, and a disappearance of edema are brought about.

(Manufacturing Examples, etc.) Next, the present invention will be described in more detail with reference to manufacturing examples of nutritional foods according to the present invention, animals in the case of oral ingestion, and clinical test examples.

11 Takumi Milk Albumin 69.0 (%) Egg Albumin 17.5 Gelatin
7.5 Nucleic acids
1.0 Dextrin 2.5 Sorbit 2.0 Polyglycerin fatty acid ester 0.5 Among the above ingredients, milk albumin,
Gelatin, nucleic acid and dextrin are first mixed in the above proportions. This mixture was sprayed with sorbitol dissolved in water and granulated, and then polyglycerol fatty acid ester dissolved in water was sprayed and granulated to produce a powdered nutritional food.

This powdered nutritional food can be dissolved in water, milk, juice, coffee, tea, etc. for drinking, or can be molded and used as a raw material for confectionery.

Production example 2 Milk albumin 3.5 (%) Egg albumin 0.8 Gelatin
0.4 nucleic acid
0.05 Dextrin 0.15
Sorbittu 0.1 milk fat
2.0 Polyglycerin fatty acid ester 0.05 Vanilla flavor 0
．． 25 water
92.7 Milk albumin 3500g, egg albumin 80
0 g of gelatin, 400 g of gelatin, 50 g of nucleic acid, 150 g of dextrin, and Tsurupi l-+00Jt were dissolved in 95 g of water.

Next, 50g of polyglycerin fatty acid ester, 2g of milk fat
000g and 250g of vanilla flavor are added to the above solution, and the ingredients are uniformly dispersed and then emulsified.

This emulsion was sterilized at 145°C for 13 seconds) and processed in a homogenizer to produce approximately 100 kg of liquid nutritional food.
I got it. This liquid nutritional food was left at room temperature for 24 hours, but no syneresis or oil grooves were observed, indicating good milk stability.

Tadarisen-1 10g of powdered nutritional food obtained according to Production Example 1 and 15g of sugar
g was dissolved in 60 ml of water. On the other hand, 30 g of beaten whole eggs were added to the above solution and mixed. This mixture was poured into molds and steamed on low heat for 15-20 minutes.

Next, this steamed product was taken out into a bowl and caramel sauce was poured over it to make a pudding confectionery.

Production example 4 15g of salad oil, 10g of beaten whole egg, °
10 g of the powdered nutritional food obtained in Production Example 1 and 25 g of wheat flour were added to the sugar and mixed thoroughly. This mixture was put into a piping bag, squeezed out to an appropriate size, and baked in the oven to obtain kutski.

(Animal test) Body weight is around 50 g and 3 Sle of withdrawal: SD male and female rats commercially available powdered feed CA-1 (manufactured by Nippon Flare)
The animals were preliminarily reared for 6 days with free access to food and water.

After 6 days of acclimatization, 3 oz of purified feed with a casein content of 3 oz.
The rats were made hypoproteinemic by giving them ad libitum for weeks. After generation of this hypoproteinemic rat, optionally one group 10
Two test groups (i and II) consisting of animals were created.

A test feed and a control feed were prepared by blending a nutritional food (Production Example 1) as a test substance and soybean protein as a control substance so that the casein content was 10%.

The test feed was orally ingested in Group 1 and the control feed in Group 1I for 1 Sleg each over a 3 week test period.

The results of measuring body weight, serum total protein amount, and albumin amount during the test period and investigating these changes are shown in Sections 1-3.
As shown in the graph in the figure, the body weight, total protein amount, and albumin amount in serum are significantly increased in Group 1 (test feed group) compared to Group 1I (control feed group). It was also found that hypoproteinemia was improved.

(Clinical trial) a) A patient (male, 51 years old) with decompensated liver cirrhosis with direct hypoalbumin was given the nutritional food according to Production Example 1 three times a day (
(20 g/day) was added to the liver meal.

Liver function tests were conducted as appropriate before and after administration of this nutritional food, and the results were as shown in Table 1 below. From this table, it is clear that the total protein and albumin levels in the serum begin to rise about one month after the administration of nutritional food, and that cholinesterase also tends to rise, so that the production of protein and cholinesterase in the liver is reduced. It turned out that it was progressing. Note that no significant changes were observed in test values other than the above three test values.

One to two months after the administration of the nutritional food, both the nutritional status and the medical condition improved, and no side effects such as diarrhea were observed.

b) Nutritional status! A patient with colitis who is not feeling well (male, 17 years old)
The nutritional food manufactured by PA1 was mixed with water, juice, etc., and administered three times a day (20 g/day). In addition, the animals were fed a whole porridge diet.

The patient mentioned above had previously been taking an Elemental diet, but due to frequent diarrhea, it was not possible to improve his nutritional status. The results of this change are as shown in Table 2 below, which shows the changes in liver function test values; total protein and albumin levels in serum increased, body weight increased, nutritional status improved, and disease symptoms also improved. He gradually recovered.

[Brief explanation of drawings]

Figure 1 is a graph showing the results of examining changes in body weight of hypoproteinemic rats 1 after ingesting test feed containing the nutritional food according to the present invention and control feed containing soybean protein;
The figure is the same as Figure 1, except that it is a graph showing the results of examining changes in the total protein amount in serum, and Figure 3 is the same as Figure 1.
However, this is a graph showing the results of examining changes in the amount of albumin in serum. Patent applicant: Sanwa Kagaku Kenkyusho Co., Ltd. Figure 1, elapsed time C tail) 1: Mu, Chikugayo group -: Todo Kiri Chikugayo group

Claims (4)

[Claims] (1) A nutritional food characterized by containing protein, mainly animal-derived albumin, carbohydrates, and nucleic acids. (2) Claim 1, characterized in that the amount ratio is 10-90% protein, 1-90% carbohydrate, and 0.5-10% nucleic acid. nutritional food. (3) The nutritional food according to claim 1, wherein the animal-derived albumin is at least one of milk albumin and egg albumin. (4) The nutritional food according to claim 1, wherein the protein contains at least one of animal protein and vegetable protein as a component other than albumin.