JPS62126137A - 流行性耳下腺炎に対する生ワクチン - Google Patents
流行性耳下腺炎に対する生ワクチンInfo
- Publication number
- JPS62126137A JPS62126137A JP6500586A JP6500586A JPS62126137A JP S62126137 A JPS62126137 A JP S62126137A JP 6500586 A JP6500586 A JP 6500586A JP 6500586 A JP6500586 A JP 6500586A JP S62126137 A JPS62126137 A JP S62126137A
- Authority
- JP
- Japan
- Prior art keywords
- mumps
- virus
- vaccine
- attenuated
- live vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 title claims description 30
- 238000004519 manufacturing process Methods 0.000 title claims description 14
- 206010034038 Parotitis Diseases 0.000 title claims description 3
- 241000700605 Viruses Species 0.000 claims description 30
- 208000005647 Mumps Diseases 0.000 claims description 23
- 208000010805 mumps infectious disease Diseases 0.000 claims description 23
- 241000711386 Mumps virus Species 0.000 claims description 18
- 230000002238 attenuated effect Effects 0.000 claims description 15
- 230000007918 pathogenicity Effects 0.000 claims description 11
- 206010061218 Inflammation Diseases 0.000 claims description 7
- 230000004054 inflammatory process Effects 0.000 claims description 7
- 230000001154 acute effect Effects 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 6
- 210000000991 chicken egg Anatomy 0.000 claims description 4
- 230000001018 virulence Effects 0.000 claims description 4
- 230000002062 proliferating effect Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 15
- 238000012360 testing method Methods 0.000 description 12
- 241000287828 Gallus gallus Species 0.000 description 9
- 235000013601 eggs Nutrition 0.000 description 8
- 229940095293 mumps vaccine Drugs 0.000 description 8
- 210000001840 diploid cell Anatomy 0.000 description 7
- 210000005260 human cell Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000003306 harvesting Methods 0.000 description 5
- 238000011081 inoculation Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 210000001161 mammalian embryo Anatomy 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 201000005505 Measles Diseases 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000003681 parotid gland Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 201000005404 rubella Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 206010024769 Local reaction Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 208000003926 Myelitis Diseases 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010058874 Viraemia Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 210000001691 amnion Anatomy 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229940030156 cell vaccine Drugs 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000007431 microscopic evaluation Methods 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 208000005963 oophoritis Diseases 0.000 description 1
- 201000005737 orchitis Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000003501 vero cell Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH05062/85-0 | 1985-11-26 | ||
| CH506285 | 1985-11-26 | ||
| CH00133/86-0 | 1986-01-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62126137A true JPS62126137A (ja) | 1987-06-08 |
| JPH0470288B2 JPH0470288B2 (enExample) | 1992-11-10 |
Family
ID=4287306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6500586A Granted JPS62126137A (ja) | 1985-11-26 | 1986-03-25 | 流行性耳下腺炎に対する生ワクチン |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS62126137A (enExample) |
| ZA (1) | ZA866843B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013101134A1 (en) | 2011-12-29 | 2013-07-04 | Michelin Recherche Et Technique S.A. | Tire operating surface for tire testing road wheel |
| EP2713153B1 (en) | 2012-09-30 | 2024-11-13 | Compagnie Générale des Etablissements Michelin | Method of applying particulate material along a tire footprint during tire testing on a tire testing surface |
| KR101706076B1 (ko) | 2012-10-31 | 2017-02-14 | 미쉐린 러쉐르슈 에 떼크니크 에스.에이. | 타이어 테스트 동안 타이어 풋프린트를 따라 입자상 물질을 분포시키는 방법 및 장치 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55147227A (en) * | 1979-05-04 | 1980-11-17 | Handai Biseibutsubiyou Kenkyukai | Preparrtion of attenuated live mumps vaccine |
-
1986
- 1986-03-25 JP JP6500586A patent/JPS62126137A/ja active Granted
- 1986-09-09 ZA ZA866843A patent/ZA866843B/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55147227A (en) * | 1979-05-04 | 1980-11-17 | Handai Biseibutsubiyou Kenkyukai | Preparrtion of attenuated live mumps vaccine |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0470288B2 (enExample) | 1992-11-10 |
| ZA866843B (en) | 1987-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |