JPS6156943A - Biochemical measuring apparatus - Google Patents

Biochemical measuring apparatus

Info

Publication number
JPS6156943A
JPS6156943A JP18007084A JP18007084A JPS6156943A JP S6156943 A JPS6156943 A JP S6156943A JP 18007084 A JP18007084 A JP 18007084A JP 18007084 A JP18007084 A JP 18007084A JP S6156943 A JPS6156943 A JP S6156943A
Authority
JP
Japan
Prior art keywords
test paper
remaining time
color reaction
signal
display
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18007084A
Other languages
Japanese (ja)
Inventor
Kaoru Okada
薫 岡田
Masato Arai
真人 荒井
Taisuke Ikeda
泰典 池田
Yasuhiro Nozoe
野副 康弘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omron Corp
Original Assignee
Omron Tateisi Electronics Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omron Tateisi Electronics Co filed Critical Omron Tateisi Electronics Co
Priority to JP18007084A priority Critical patent/JPS6156943A/en
Publication of JPS6156943A publication Critical patent/JPS6156943A/en
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

PURPOSE:To make the measuring operation accurate, by detecting the coloration degree of a test paper, processing the result by a signal processing system, displaying the measured value, counting the color reaction time after the test paper is set by a counting means, and displaying the remaining time of the reaction. CONSTITUTION:An optical system 3 optically detects the coloration degree of a test paper 2b, which is immersed in a sample to be detected and undergoes color reaction. The signal from the system 3 is operated and processed by a signal processing system 4. The measured value is displayed on a display system 5. After the test paper 2b is set, the color reaction time is counted based on an operation signal by a counting means. The remaining time with respect to the counted reaction time is displayed on a remaining time display means. Thus erroneous operation can be prevented, and the prevention of the erroneous detection can be ensured.

Description

【発明の詳細な説明】 (イ)産業上の利用分野 この発明は、尿糖などを測定する生化学測定装置に関し
、特に、試験紙における呈色反応時間の表示機能に係る
ものである。
DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application This invention relates to a biochemical measuring device for measuring urine sugar, etc., and particularly relates to a display function of color reaction time on a test strip.

(0)従来の技術 従来より例えば、尿検査においては、試験片を尿に浸漬
し、試験紙の呈色度合を肉眼によって比色表と比較して
行なっていた。しかし、これでは測定誤差等が多いとい
う問題があり、そこで、光学機器を用いた尿糖測定装置
が開発されている。
(0) Prior Art Conventionally, for example, in a urine test, a test piece was immersed in urine and the degree of coloration of the test paper was visually compared with a colorimetric table. However, this poses a problem in that there are many measurement errors, etc. Therefore, urine sugar measuring devices using optical instruments have been developed.

この尿糖測定装置は、光学系と信号処理系と表示系とよ
り構成され、試験片はスティックの先端部に試験紙が貼
着されて成り、この試験片を光学系に配置するようにな
っている。そして、この試験紙は尿に浸漬すると呈色反
応を生起し、この呈色度合を光学系で検知して電気信号
に変換する。
This urine sugar measuring device consists of an optical system, a signal processing system, and a display system.The test piece consists of a stick with a test paper attached to the tip, and this test piece is placed in the optical system. ing. When the test paper is immersed in urine, a color reaction occurs, and the degree of coloration is detected by an optical system and converted into an electrical signal.

この信号を信号処理系で処理して尿糖濃度を算出し、こ
の尿糖濃度を表示系より表示する。
This signal is processed by a signal processing system to calculate the urine sugar concentration, and this urine sugar concentration is displayed on the display system.

(ハ)発明が解決しようとする問題弘 上述した試験紙には、尿中の成分(尿糖)と反応して他
の物質を生じせしめ2色素の発色、て関与する酵素が用
いられている。この酵素は尿中成分と反応し始めた後、
所定時間経過しないと反応が完結しないものである。
(c) The problem that the invention aims to solve: The above-mentioned test strip uses an enzyme that reacts with components in urine (urine sugar) to produce other substances and is involved in the color development of two pigments. . After this enzyme begins to react with urine components,
The reaction is not completed until a predetermined period of time has elapsed.

ところが、従来の尿糖測定装置は、この呈色反応時間を
何ら表示していないため、所定時間が経過する前に測定
を実行するという誤操作を行う可能性があり、誤った値
を読み取る恐れがあった。
However, since conventional urine sugar measuring devices do not display any color reaction time, there is a possibility that the user may erroneously perform the measurement before the predetermined time has elapsed, leading to the risk of reading an incorrect value. there were.

この発明は、斯かる点に鑑みてなされたもので。This invention was made in view of this point.

呈色反応の残存時間を表示することにより、正確な測定
操作を行えるようにしだ生化学測定装置を提供すること
を目的とするものである。
It is an object of the present invention to provide a biochemistry measuring device that enables accurate measuring operations by displaying the remaining time of color reaction.

に)問題点を解決するための手段及び作用この発明は、
被検出試料に浸漬すると呈色反応を生起する試験紙と、
との試験紙の呈色度合を光学的に検知する光学系と、こ
の光学系からの信号を処理して測定値を演算する信号処
理系と、この信号処理系からの測定値を表示する表示系
と、前記試験紙を設置した後に動、作信号により呈色反
応時間をカウントとする計数手段と、この計数手段がカ
ウントした反応時間の残存時間を示す残存時、!   
  間表示手段とより構成され、試験紙を設置した後。
B) Means and operation for solving the problems This invention has the following features:
A test paper that causes a color reaction when immersed in the sample to be detected;
an optical system that optically detects the degree of coloration of the test strip; a signal processing system that processes signals from this optical system to calculate measured values; and a display that displays the measured values from this signal processing system. system, a counting means that counts the color reaction time based on an operation signal that operates after the test strip is installed, and a remaining time that indicates the remaining reaction time counted by the counting means.
After installing the test strip,

測定スイッチ等を押すと、計数手段が所定の反応時間を
カウントし始め9表示手段が残存時間を表示することを
特徴としている。
When a measurement switch or the like is pressed, the counting means starts counting a predetermined reaction time and the display means 9 displays the remaining time.

(ホ)実施例 以下、この発明の一実施例を図面に基づいて詳細に説明
する。
(E) Embodiment Hereinafter, an embodiment of the present invention will be described in detail based on the drawings.

第1図乃至第4図1で示すように、1は尿糖測定装置で
あって、試験片2の呈色度合よシ尿糖濃度を測定するも
ので、光学系3.信号処理系4及び表示系5を備えて携
帯型に構成されている。
As shown in FIGS. 1 to 4, 1 is a urine sugar measuring device, which measures the urine sugar concentration based on the degree of coloration of a test piece 2, and an optical system 3. It is configured to be portable and includes a signal processing system 4 and a display system 5.

この試験片2は、#I長い板状のスティック2aの先端
部に小片の試験紙2bが貼着されて構成されている。こ
の試験紙21)は、被検出試料である尿中の成分(尿糖
)と反応して他の物質を生ぜしめ9色素の発色に関与す
る酵素が用いられている。
This test piece 2 is constructed by sticking a small piece of test paper 2b to the tip of a #I long plate-shaped stick 2a. This test paper 21) uses an enzyme that reacts with a component (urine sugar) in urine, which is a sample to be detected, to produce other substances and is involved in the color development of 9 pigments.

この酵素と尿中成分との反応は所定時間経過して完結す
るので、試験片2は尿に浸漬した後この呈色反応時間(
例えば、60秒)放置するようになっている。
The reaction between this enzyme and urine components is completed after a predetermined period of time has elapsed, so the test piece 2 is immersed in urine for this color reaction time (
For example, 60 seconds).

一方、尿糖測定装@1のケース6はほぼ矩形体    
 ゛に形成され、第3図において左半分が測定部6aに
、右半分が操作表示部6bになっている。そ′して、光
学系6が測定部6aに1表示系5が操作表示部6bに、
更に信号処理系4が測定部6aと操作表示部61)に亘
ってそれぞれ収納されている。
On the other hand, case 6 of urine sugar measuring device @1 has an almost rectangular shape.
In FIG. 3, the left half is a measurement section 6a, and the right half is an operation display section 6b. Then, the optical system 6 is connected to the measuring section 6a, the display system 5 is connected to the operation display section 6b,
Further, a signal processing system 4 is housed over the measuring section 6a and the operation/display section 61).

測定部6aにはL字形の開閉蓋7が上下に回動自在に枢
支され、内部に試験片2の挿入部8が形成され、試験片
2が脱着自在な受は台(図示省略)を介して設置される
ように構成されている。
An L-shaped opening/closing lid 7 is pivotably supported on the measurement part 6a so as to be able to rotate up and down, and an insertion part 8 for the test piece 2 is formed inside. It is configured to be installed through the

光学系3は9発光ダイオード9とフォトダイオード10
とで透過光方式に構成されている。この発光ダイオード
9は開閉蓋7に、フォトダイオード10は挿入部8の床
板に相対峙してそれぞれ取付けられ9両ダイオード9,
10間に試験片2が設置されるように々っている。
Optical system 3 includes 9 light emitting diodes 9 and photodiodes 10
It is configured in a transmitted light system. The light emitting diode 9 is mounted on the opening/closing lid 7, and the photodiode 10 is mounted on the floor plate of the insertion section 8 facing each other.
The test piece 2 is placed between the 10 and 10 spaces.

操作表示部6bは、測定表示窓11.動作表示窓12が
設けられると共に、較正スイッチ1ろ及び”測定スイッ
チ14が設けられ、側部に電源スイッチ15.ACアダ
プタージャック16が設けられている。また内部には2
図示しないが、プリント基板が設けられると共に、バッ
テリ収納部が形成されている。
The operation display section 6b includes a measurement display window 11. An operation display window 12 is provided, as well as a calibration switch 1 and a measurement switch 14, and a power switch 15 and AC adapter jack 16 are provided on the side.
Although not shown, a printed circuit board is provided and a battery storage section is also formed.

前記表示系5は7セグメント発光ダイオードで構成され
、測定表示窓11に臨み、3桁で測定値を示すようにな
っている。尚、動作表示窓12は入力光量の過大小やバ
ッテリ電圧の低下を示すようになっている。
The display system 5 is composed of a 7-segment light emitting diode, faces the measurement display window 11, and is designed to indicate the measured value in three digits. Incidentally, the operation display window 12 is designed to indicate whether the amount of input light is too large or too small, or whether the battery voltage is low.

前記信号処理系4は、フォトダイオード10からの電流
値をI/V変換器17で電圧値に、A/D変換器18で
デジタル値にそれぞれ変換してCPUI 9に入力する
ように構成されている。更に。
The signal processing system 4 is configured to convert the current value from the photodiode 10 into a voltage value with an I/V converter 17 and into a digital value with an A/D converter 18, and input the converted values to the CPU 9. There is. Furthermore.

C’PU19には較’iE′&び測定スイッチ13.1
4よシスイツチング信号が入力され2発光ダイオード9
1表示系5及び反応終了ブザー20に動作信号が出力さ
れるように々っている。このCPU19には呈色度合の
電流値と尿糖濃度との関係を示す1次式の検量線が設定
されている。そして、較正スイッチ16の信号により未
使用試験紙2bの呈色度合が測定され、検量線のゼロブ
ランク補正が行なわれ、尿浸漬後の試験紙2bの呈色度
合から検量線に基づき尿糖濃度を検出するようになって
いる。
C'PU19 has comparison 'iE'& measurement switch 13.1.
4, a switching signal is input, and 2 light emitting diodes 9
An operation signal is output to the display system 5 and the reaction end buzzer 20. A linear calibration curve is set in the CPU 19 that shows the relationship between the current value of the degree of coloration and the urine sugar concentration. Then, the degree of coloration of the unused test strip 2b is measured by the signal from the calibration switch 16, zero blank correction of the calibration curve is performed, and the urine sugar concentration is determined based on the calibration curve from the degree of coloration of the test strip 2b after soaking in urine. It is designed to detect.

また、CPU19には呈色反応時間をあウントする計数
手段が構成され、この計数手段は測定スイッチ14の信
号により30秒間カウントダウンするようになっている
。この計数手段がカウントダウンした残存時間は残存時
間表示手段で表示され、この表示手段は表示系5が兼用
している。
Further, the CPU 19 includes a counting means for counting the color reaction time, and this counting means is adapted to count down for 30 seconds in response to a signal from the measurement switch 14. The remaining time counted down by the counting means is displayed by a remaining time display means, and the display system 5 also serves as this display means.

次に、この尿糖測定装置1の測定動作について説明する
Next, the measurement operation of this urine sugar measuring device 1 will be explained.

先ず、較正動作より説明すると、開閉蓋7を開放し、未
使用の試験片2を挿入部8に挿入して発光ダイオード9
とフォトダイオード10間に試験紙2bを配置し、開閉
蓋7を閉じる。
First, to explain the calibration operation, open the opening/closing lid 7, insert the unused test piece 2 into the insertion part 8, and insert the light emitting diode 9.
The test paper 2b is placed between the photodiode 10 and the photodiode 10, and the opening/closing lid 7 is closed.

続いて、電源スィッチ15を投入した後、較正スイッチ
13を押すと9発光ダイオード9が発光する。この光は
試験紙2b及びスティック2aを透過してフォトダイオ
ード10に受光される。この透過光量に対応した電気信
号はI/V変換器17゜:’    A / D工ゎ1
8□、。PU19いヵゎ。
Subsequently, after turning on the power switch 15, when the calibration switch 13 is pressed, the nine light emitting diodes 9 emit light. This light passes through the test paper 2b and the stick 2a and is received by the photodiode 10. The electrical signal corresponding to the amount of transmitted light is sent to the I/V converter 17:' A/D process 1
8□. PU19 is cool.

、この信号に基づいて検量線のゼロブランク補正が行な
われ、未使用試験紙2b自身の色に基づいて検量線を較
正する。これにより較正動作が終了し。
Zero blank correction of the calibration curve is performed based on this signal, and the calibration curve is calibrated based on the color of the unused test paper 2b itself. This completes the calibration operation.

開閉蓋7を開放して試験片2を取り出し、試験紙2])
を尿に浸漬する。
Open the opening/closing lid 7, take out the test piece 2, and test paper 2])
Soak in urine.

次に、実測動作に移り、この実測動作を第1図のフロー
図に基づいて説明する。先ず、ST1で尿に浸漬した試
験片2を較正時と同様に挿入部8に挿入する。そして、
ST2で測定ヌイツチ12をONすると、このスイッチ
ング信号によりSTろで計数手段が30秒カウントダウ
ンする。つまり、試験紙21)を尿に浸漬すると、尿糖
で呈色反応を生起し、この呈色反応が完結するまで、実
測動作の進行が中断する。そして、このカウントダウン
する30秒の各時刻はST4において9表示系5(残存
時間表示手段)よシ逐次表示され1例えば、20,19
.j8.・・・・・・のように示され。
Next, moving on to the actual measurement operation, this actual measurement operation will be explained based on the flow diagram of FIG. First, in ST1, the test piece 2 soaked in urine is inserted into the insertion section 8 in the same manner as during calibration. and,
When the measurement switch 12 is turned on in ST2, this switching signal causes the counting means to count down for 30 seconds in ST. That is, when the test strip 21) is immersed in urine, a coloring reaction occurs with urine sugar, and the progress of the actual measurement operation is interrupted until this coloring reaction is completed. Each time of this 30 second countdown is sequentially displayed on the 9 display system 5 (remaining time display means) in ST4.
.. j8. It is shown as...

測定者に報知される。The measurer will be notified.

その後、30秒が一□過して呈色反応が完結すると9表
示は0秒となり、ST5でブザー20が作      
1動し、測定者に報知する一方、ST6で発光ダイオー
ド9が発光して測定が行なわれる。この光は較正時と同
様に試験紙2b等を透過してフォトダイオード10に入
射し、透過光量に対応した電気信号に変換されてCPU
19に入力する。
After that, when the color reaction is completed after 30 seconds have passed, the 9 display becomes 0 seconds, and the buzzer 20 is activated in ST5.
1 to notify the measuring person, and at ST6 the light emitting diode 9 emits light and measurement is performed. This light passes through the test paper 2b etc. and enters the photodiode 10, as in the case of calibration, and is converted into an electrical signal corresponding to the amount of transmitted light and sent to the CPU.
19.

この面分により検量線に基づいて尿糖濃度が演算され、
その測定値がST7で表示系5よシ表示される(例えば
、32fQ/dJ)。これでもって測定が終了する。
Using this area, the urine sugar concentration is calculated based on the calibration curve,
The measured value is displayed on the display system 5 in ST7 (for example, 32 fQ/dJ). This completes the measurement.

尚、この実施例は尿糖測定装置1について説明したが、
この発明は血糖などを測定する他の生化学測定装置に適
用することができる。
In addition, although this embodiment described the urine sugar measuring device 1,
This invention can be applied to other biochemical measurement devices that measure blood sugar and the like.

また、計数手段のカウント時間は、測定対象物と試験紙
2bで設定され、残存時間表示手段は表示系5と別個に
設けてもよい。
Further, the counting time of the counting means is set by the measurement object and the test paper 2b, and the remaining time display means may be provided separately from the display system 5.

また、光学系6等は実施例に限られず9例えば反射光方
式にしてもよい。
Further, the optical system 6 and the like are not limited to those in the embodiment, but may be of a reflected light type, for example.

(へ)発明の効果 以上のようにこの発明の生化学測定装置によれば試験紙
の呈色反応が完結するまでの反応時間をカウントし、そ
の残存時間を表示するようにしたために1反応の完結前
に測定操作を行うことかにり、誤操作を確実に防止する
ことができるので。
(F) Effects of the Invention As described above, the biochemical measuring device of the present invention counts the reaction time until the color reaction of the test strip is completed and displays the remaining time. By performing measurement operations before completion, it is possible to reliably prevent erroneous operations.

誤った値を読み取るなどの誤検知を確実に阻止すること
ができる。
Erroneous detections such as reading incorrect values can be reliably prevented.

【図面の簡単な説明】[Brief explanation of drawings]

図面はこの発明の実施例を示しておシ、第1図は尿糖測
定装置の実測過程におけるフロー図、第2図は尿糖測定
装置の回路ブロック図、第3図は同斜視図、第4図は同
平面図である。 1:尿糖測定装置、 ′2:試験片。 2aニステイツク、  2b:試験紙。 3=光学系、  4:信号処郁系、  5:表示系。 9:発光ダイオード、  10:フォトダイオード、 
 14:測定ヌイッチ、   19:CPU。 20:ブザー。 特許出願人     立石電機株式会社代坤人  弁理
士  中 村 茂 信 rつ 寸 r)   −” へ   O
The drawings show an embodiment of the present invention, FIG. 1 is a flow diagram of the actual measurement process of the urine sugar measuring device, FIG. 2 is a circuit block diagram of the urine sugar measuring device, FIG. 3 is a perspective view of the same, and FIG. Figure 4 is a plan view of the same. 1: Urine sugar measuring device, '2: Test piece. 2a: test paper, 2b: test paper. 3 = optical system, 4: signal processing system, 5: display system. 9: Light emitting diode, 10: Photo diode,
14: Measurement unit, 19: CPU. 20: Buzzer. Patent applicant Tateishi Electric Co., Ltd. Patent attorney Shigeru Nakamura) -” to O

Claims (1)

【特許請求の範囲】[Claims] (1)被検出試料に浸漬すると呈色反応を生起する試験
紙と、この試験紙の呈色度合を光学的に検知する光学系
と、この光学系からの信号を処理して測定値を演算する
信号処理系と、この信号処理系からの測定値を表示する
表示系と、前記試験紙を設置した後に動作信号により呈
色反応時間をカウントとする計数手段と、この計数手段
がカウントした反応時間の残存時間を示す残存時間表示
手段とを備えていることを特徴とする生化学測定装置。
(1) A test paper that causes a color reaction when immersed in a sample to be detected, an optical system that optically detects the degree of coloration of this test paper, and a measurement value that is calculated by processing the signals from this optical system. a signal processing system for displaying the measured values from the signal processing system, a counting means for counting the color reaction time using an operation signal after the test strip is installed, and a reaction counted by the counting means. 1. A biochemical measurement device comprising: a remaining time display means for indicating the remaining time.
JP18007084A 1984-08-28 1984-08-28 Biochemical measuring apparatus Pending JPS6156943A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18007084A JPS6156943A (en) 1984-08-28 1984-08-28 Biochemical measuring apparatus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18007084A JPS6156943A (en) 1984-08-28 1984-08-28 Biochemical measuring apparatus

Publications (1)

Publication Number Publication Date
JPS6156943A true JPS6156943A (en) 1986-03-22

Family

ID=16076935

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18007084A Pending JPS6156943A (en) 1984-08-28 1984-08-28 Biochemical measuring apparatus

Country Status (1)

Country Link
JP (1) JPS6156943A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885839A (en) * 1997-04-15 1999-03-23 Lxn Corporation Methods of determining initiation and variable end points for measuring a chemical reaction

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885839A (en) * 1997-04-15 1999-03-23 Lxn Corporation Methods of determining initiation and variable end points for measuring a chemical reaction

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