JPS6156785B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a multi-item analysis device, and in particular, a liquid sample is mixed with a reagent solution in a reaction vessel to cause a reaction, and a sample containing a reaction product is analyzed. The present invention relates to a multi-item analysis device suitable for use when analyzing a plurality of test items using the chemical or physical properties of a liquid (reaction liquid).

The example to which the present invention is most preferably applied is a chemical analyzer for testing body fluids used in clinical tests, and therefore, for convenience, the following description will be made in connection with the application to such an apparatus.

[Conventional technology]

Body fluids such as blood and urine provide valuable data for determining whether the body's health status is normal or abnormal, so analysis and measurements of body fluids are often performed in clinical examinations. In a normal test, a plurality of test items are analyzed and measured for one specimen (hereinafter sometimes referred to as a sample).

As a typical example of an analyzer that analyzes and measures a plurality of items, a discrete clinical automatic analyzer, such as that disclosed in Japanese Patent Application Laid-Open No. 70085-1985, is known. In this analyzer, a plurality of reaction containers are arranged to correspond to the number of test items, and such reaction container rows are sequentially transferred. A reagent solution that causes a reaction between the specimen to be analyzed and the test item is added to the reaction container. Since one reaction container usually corresponds to one test item, one specimen is distributed to multiple reaction containers for analysis of multiple items. When a reaction of the specimen, such as a coloring reaction or a fading reaction, has progressed to a certain extent, or during the reaction, the specimen liquid in which the reaction has occurred, that is, the reaction liquid, is optically measured. Based on the optical measurement results, the concentration of the test item contained in the sample, the reaction rate or activity value of the test item, etc. are determined.

Incidentally, in this type of analyzer, a number of dispensing pumps corresponding to the respective reagent containers are provided in order to supply reagent liquid to the reaction containers. Normally, 1 to 4 types of reagent solutions are used to analyze one test item, so if the analyzer has the ability to analyze 20 items and the average required reagent solution for each test item is 2 types, In total, 40 dispensing pumps will be installed to supply reagent solutions.

An increase in the number of dispensing pumps leads to an increase in the size of the analyzer and a complicated configuration, so in JP-A-54-5790,
The number of pumps was reduced to simplify the reagent supply system. In this example, a configuration is adopted in which a plurality of reagent solutions are dispensed using the same pipette nozzle. However, when dispensing various reagent solutions repeatedly using the same pipette nozzle, there were cases in which large errors occurred in the analysis results depending on the analysis items. The cause of this error is that a small amount of special reagent remaining on the inner wall of the reagent nozzle has an adverse effect on the reactions of other analysis items. In order to reduce the error, it is possible to perform particularly thorough cleaning of the nozzle, but this is not very practical as it would consume a large amount of cleaning liquid.

[Purpose of the invention]

An object of the present invention is to provide a multi-item analyzer that can reduce the adverse effects of dispensing multiple reagents on the measured values of other analysis items, despite having a configuration that allows the number of reagent dispensing pumps to be reduced. It's about doing.

[Summary of the invention]

In the present invention, a plurality of communication auxiliary tubes are arranged in correspondence with a plurality of reagent containers containing reagent liquids, and are connected to the suction/discharge mechanism, and are dedicated to the reagent liquid to be inhaled from among the plurality of communication auxiliary tubes. A common connection pipe is provided to which a communication auxiliary pipe can be selectively attached, and after the dedicated communication auxiliary pipe is attached to this common connection pipe, the reagent liquid in a specific reagent container is exclusively used as the suction operation of the suction/discharge mechanism is performed. The reagent solution is inhaled and held only in the communication auxiliary tube of the reagent, and then, as the suction and discharge mechanism discharges, the reagent solution held in the dedicated communication auxiliary tube is discharged into the corresponding reaction container. The present invention is characterized in that a detachment device is provided for detaching the communication auxiliary tube from the common connection tube after discharging the reagent liquid.

The sample liquid in which a reaction has occurred in the present invention refers to a liquid contained in a reaction vessel when a test item in the sample undergoes a change in chemical or physical properties in the reaction vessel. Therefore, this liquid is usually a mixture of the original sample liquid, reagent liquid, and reaction product. As a special case, there are cases where the test item itself in the sample acts as a catalyst during a reaction, changing the coexisting reagents etc. without changing the test item itself. It is included in the concept of the sample liquid in which the reaction occurred because it utilizes physical properties.

The suction/discharge mechanism connected to the common connecting tube in the present invention does not come into direct contact with the reagent liquid that contributes to the reaction of the test item. The suction/drainage mechanism is communicated with the reagent liquid when the common connecting pipe sucks the reagent liquid. The suction/discharge mechanism may be provided with a cleaning liquid tank containing a cleaning liquid for flowing inside the pipe for cleaning the inside of the common connecting pipe after discharging the reagent liquid. As the suction/discharge mechanism, a cylinder, a pressurized tank, a depressurized tank, or the like, which transmits liquid suction force and liquid pushing force to a connecting pipe, is used.

In the present invention, by relatively moving the reagent container and the common connecting tube, inhalation is carried out into a dedicated communication auxiliary tube that is positioned and attached so that the reagent container containing a specific reagent solution and the common connecting tube correspond to each other. This is to select the appropriate reagent solution. In this case, there is a method in which the connecting tube is positioned at a specific location and the necessary reagent containers are transferred to that specific location, and multiple reagent containers are left stationary without being moved when reagent liquid is inhaled. There is a method of transporting the reagent to the location of the reagent container.

In a preferred embodiment of the present invention, a rotary member loaded with a plurality of reagent containers is configured to rotate, and the rotary member is configured to stop when a required reagent container is transferred to a position where the common connecting tube moves up and down. However, as a reagent container transfer device, a plurality of reagent containers may be held by a flexible chain-like holding member, and this holding member may be driven by a pulley to transfer a row of reagent containers. Alternatively, a plurality of reagent containers may be placed on a belt conveyor and reciprocated so as to pass through the inhalation position. A plurality of reagent containers may be integrated. That is, a rack equipped with a plurality of reagent solution storage parts is used. The rack may be loaded with a plurality of reagent containers, or the reagent solution may be directly stored in a plurality of reagent solution storage chambers. In this case, a plurality of racks may be prepared, for example racks with combinations of reagent types, such as a rack for a group of liver function test reagents and a rack for a group of renal function test reagents. In the case of the above-mentioned rotating member, the functional test reagent groups can be exchanged for each rotating member, and can be used in the same way as this rack.

In a preferred embodiment of the invention, a plurality of reagent containers are removably held. For example, a recess for positioning may be provided on the rotating member and the reagent container may be placed in this recess. Detachable retention means that the reagent container remains easily replaceable. Therefore, in addition to placing the reagent container on the container, there are other ways to hold the reagent container, such as providing a protrusion on the container, inserting the container into a hole, and supporting the container with the protrusion, and holding or pinching the container with an elastic member such as a spring. It can also be used.

[Embodiments of the invention]

1 and 2 are diagrams for explaining one embodiment of the present invention, with FIG. 1 being a schematic plan view and FIG. 2 being a partial vertical sectional view thereof.

This embodiment includes a reagent supply preparation section in which a plurality of reagent containers 3 each containing reagent solutions corresponding to a plurality of test items to be analyzed are arranged, a sample collection section having a sample suction position A, It is equipped with a reaction vessel row section having a liquid receiving position or a liquid discharging position (b). The common connecting pipe 10 is horizontally reciprocated between the position A, the sample suction position a, the liquid receiving position b, and the cleaning tank 31.

The common connecting pipe 10 having an open end 11 is fixedly held by an arm 25 which is vertically and horizontally moved by a drive device 26 so that the opening faces downward. The connecting pipe 10 is connected via a flexible tube 9 to a suction/discharge mechanism 30 consisting of a cylinder or the like. When the piston of the cylinder 30 performs a suction operation, liquid flows into the cylinder 30 from the tip opening 11.
The fluid is sucked in in the direction of , and the fluid is discharged outside from the tip opening 11 where the piston performs the extrusion action. Since the amount of fluid taken in and discharged depends on the volume moved by the piston of the cylinder, the amount of fluid sucked and removed can be adjusted by adjusting the distance the cylinder moves. The communication auxiliary tube detachment device, for example, the stopper 29 is located near the position A, and is moved in and out in the horizontal direction by the drive section 27.

On the table 40, a low temperature holding table 20, a cleaning tank 31,
A constant temperature holding table 24, a driving gear 15, etc. are provided.
A ring-shaped groove 12 and a ring-shaped groove 2 are formed in the low temperature holding table 20, a plurality of containers 14 containing samples are inserted into the ring-shaped groove 12, and a plurality of reagent containers 3 are inserted into the rectangular groove 2. is inserted. The low temperature holding table 20 is maintained at a temperature of 2 to 8° C. to keep the sample and reagent solution at a low temperature to prevent deterioration. A ring-shaped groove 42 is formed in the constant temperature holding table 24, and this groove 42
A plurality of reaction vessels 22 are inserted into the chamber. The constant temperature holding table 24 is maintained at a constant temperature of, for example, 37° C. in order to incubate the liquid contained in the reaction vessel 22. Further, a light source 33 is housed in the constant temperature holding table 24, and an optical path 43 is formed that is oriented toward a multiwavelength photometer 32 installed outside. The light from the light source 33 reaches the multi-wavelength photometer 32 through the optical path 43 so as to pass through the reaction vessel located at the position C. The photometer 32 is configured to extract monochromatic light of a specific wavelength depending on the item to be tested, and measure changes in absorbance of the light of that wavelength.

Cleaning liquid is constantly supplied to the cleaning tank 31,
The cleaning liquid in excess of a predetermined amount passes through the pipe 36 to the waste liquid hole 3.
7 to the outside, so that the cleaning liquid in the cleaning tank 31 is always kept clear.

A donut-shaped rotary table 13 is disposed on the low temperature holding table 20 so as to rotate around the upper protrusion of the low temperature holding table 20 . A plurality of holes 8 into which sample containers 14 are inserted are formed along the ring-shaped groove 12 in the table 13 . table 1
Teeth are provided on the outer periphery of 3, and rotational force is transmitted by meshing with a drive gear rotated by a drive device 16. Therefore, as the table 13 rotates, the sample containers inserted into the holes 8 are rotated and transferred all at once. In this case, the bottom surface of the reagent container 14 slides on the surface of the ring-shaped groove 12. The table 13 is fed intermittently with the interval between adjacent holes being advanced by one step.

A reagent rotary table 1 is arranged above the low temperature holding table 20, and this table 1 is moved by a drive device 5 via a rotary shaft 6. The table 1 has a plurality of holes 4 into which reagent containers 3 are inserted.
It is formed along the ring-shaped groove 2. As the table 1 rotates, the bottom surface of the reagent container 3 slides on the surface of the ring-shaped groove 2. The reagent solution corresponding to the test item is subject to the inhalation operation only when the corresponding reagent container is at position A. The combination of a mechanism for positioning the connecting tube 10 at a predetermined position and a mechanism for positioning a necessary reagent container at the predetermined position constitutes a reagent liquid changing device.

For example, A,
Six reagent containers B, C, D, E, and F are inserted. That is, reagent solutions corresponding to six items can be prepared. When multiple types of reagent solutions are required to proceed with a reaction based on a test item, containers containing the multiple reagent solutions are arranged on the rotary table 1, and the multiple reagent solutions are placed in one reaction container 22. It is also possible to supply a reagent solution.

An auxiliary communication tube 28 dedicated to each reagent is placed near each reagent container 3. The auxiliary communication tube 28 is connected to the reagent container 3
It must be moved along with the transfer of the reagent, and it is usually hung from a hook provided on the reagent container, so that the lower end does not come into contact with the reagent solution.
Here, for convenience of explanation, it is assumed that it is inserted into the reagent container 3. Both ends of the communication auxiliary tube 28 dedicated to each reagent are open, and the inside of the tube is tapered so that the upper part fits into the lower part of the common connecting tube 10. The opening at the lower end serves as an inlet and outlet for the reagent solution.

A reaction rotary table 21 is placed on the constant temperature holding table 24.
is arranged so as to be intermittently rotated by a drive device 23 via a rotating shaft 7. The table 21 has a plurality of holes 4 into which reaction vessels 22 can be inserted.
4 is formed along the ring-shaped groove 42.
The table 21 is rotated in the direction of the arrow, and as the table 21 rotates, the bottom surface of the reaction container 22 slides on the ring-shaped groove 42 surface. On the transfer path of the reaction container 22, there are a light irradiation position C, a liquid waste discharge position D, a cleaning liquid supply position H,
and a cleaning liquid discharge position. At the liquid discharge position 2, the pipe 45 is moved up and down, and with the pipe 45 inserted into the reaction vessel 22, the liquid in the reaction vessel is discharged through the pipe 45 by the operation of the sipper 34. At the cleaning liquid supply position E, the cleaning liquid is injected into the empty reaction vessel through the cleaning device 35 and the pipe 46. At the cleaning liquid discharge position, the pipe 47 is moved up and down,
With the tube 47 inserted into the reaction container, the cleaning device 35 operates to drain the cleaning liquid inside the reaction container into the tube 47.
be disposed of through

The operation of analyzing a plurality of items of one sample using such an embodiment apparatus will be explained.

The sample container 14 containing the sample liquid to be analyzed remains at the sample suction position A, and the reagent container 3 containing the reagent liquid corresponding to the test item to be measured first remains at the reagent suction position A, and the same test item Reaction vessel 2 for
2 in the liquid receiving position B. The common connecting tube 10 is moved horizontally to the reagent suction position A.

In this state, the connecting tube 10 is lowered, the auxiliary communication tube 28 is engaged with the connecting tube 10, and the tip of the auxiliary communication tube 28 is inserted into the corresponding reagent solution. Suction and exhaust mechanism 30
A certain amount of reagent liquid is sucked into the middle of the communication auxiliary tube 28 by the suction operation, and then a small amount of air is sucked in. The auxiliary communication tube 28 is raised while being attached to the connecting tube 10 while holding the inhaled reagent solution, and
Subsequently, it is moved to the sample suction position A. Here, the auxiliary communication tube 28 is lowered, and the tip of the auxiliary communication tube 28 is inserted into the sample liquid in the sample container 14. The suction/exhaust mechanism 30 is operated to suction again, and the auxiliary communication pipe 28
Aspirate a certain amount of sample solution halfway through. At this time, the reagent solution is inhaled through the air layer toward the tip side of the reagent solution that was inhaled earlier. While holding the inhaled reagent solution and the reagent solution, the communication auxiliary tube 28 is raised while attached to the connecting tube 10, and then moved to the liquid receiving position. At this position, the auxiliary communication tube 28 descends a little and discharges both the sample liquid and the reagent liquid held into the empty reaction container 22. The liquid discharge operation is performed by the discharge operation of the suction and discharge mechanism 30.

After the discharge operation is completed, the auxiliary communication pipe 28 is raised to its original height and then transferred to the position of the cleaning tank 31. At this point, the auxiliary communication tube 28 is lowered and immersed in the cleaning liquid to wash away the sample and reagent liquid that have adhered around the tube. At this time, the cleaning liquid is caused to flow out through the tube 9 from the opening at the tip of the auxiliary communication tube 28. Air is then sucked into the auxiliary pipe as shown in Japanese Patent Application Laid-Open No. 52-43487. After cleaning, the auxiliary communication tube 28 is raised, moved to the reagent suction position A, which is the original mounting position, and then lowered. At this time, the stopper 29 comes out to press the upper end of the auxiliary communication pipe 28. When the connecting tube 10 rises again, the auxiliary communication tube 28 is separated from the connecting tube 10 so as to remain within the original reagent container.

This completes the operation of distributing the sample and reagent solution for the first test item to the reaction containers.Next, the analysis item changes and the reagent container at position B is transferred to position A. At the same time, the row of reaction vessels 22 is advanced one step. The reagent container remains at the sample intake position a. Thereafter, the communication auxiliary tube 28 corresponding to the reagent positioned at A is similarly moved, and the operation of distributing the sample and reagent liquid for the next test item is performed. When the dispensing operations corresponding to all the test items to be analyzed for this sample are completed, the sample rotary table 13 is advanced one step, and the next reagent container is moved to the sample suction position A.

The mixed liquid of the sample liquid and reagent liquid received in the reaction container 22 is incubated until it reaches the light irradiation position C, and the reaction proceeds. The reaction vessel 22, which has reached the position C after a predetermined time after receiving the sample, is irradiated with light from the light source 33, and the photometer 32 detects a change in the light intensity of the wavelength light corresponding to the test item, that is, the test item. The absorbance corresponding to the measured value is measured, processed and displayed as the concentration of the test item on a display unit such as a printer or display. The sample liquid (reaction liquid) on which the optical measurement was performed is discharged by the sipper 34. The reaction vessel cleaned by the cleaning device 35 becomes empty and ready to be supplied to the liquid receiving position B.

In the embodiment described above, not only can a plurality of types of reagent liquids be distributed using one suction/drainage mechanism, but also a sample liquid can be distributed. Therefore, a large number of dispensing pumps, etc. can be eliminated, and the device can be made smaller. Since the reagent solution is held only in the dedicated auxiliary communication tube, no other reagent solution is introduced into the auxiliary communication tube. Therefore, since the specific reagent that causes measurement errors for other analysis items does not remain on the inner wall of the auxiliary communication tube for other reagents, cleaning can be easily performed. Changing the test item is accomplished by transferring the reagent container to the reagent suction position, and the test item can be easily replaced by simply replacing the reagent container with a reagent containing a different reagent solution. Because
Changing test items is very easy.

3 and 4 are diagrams for explaining other embodiments based on the present invention, with FIG. 3 being a schematic plan view and FIG. 4 being an explanatory diagram of the vicinity of the reaction line.

The reaction line 59 is provided with a constant temperature liquid bath 51 maintained at, for example, 37° C., and a plurality of reaction vessels 58 are immersed in this constant temperature liquid. The reaction vessels 58 are held by a chain 55, and the reaction vessel row rotates around a pulley 52 to be reversed downward, and around a pulley 53 to be rotated upward in the normal direction. On the other hand, light from the light source 101 passes through the reaction container and reaches the photometer 103. A change in the absorbance of light of a specific wavelength based on the reaction solution in the reaction container 58 is measured by the photometer 103, and the concentration or activity value of the test item is determined based on the change. The reaction liquid in the reaction vessel is discharged when the reaction vessel is inverted by the pulley 52. After being inverted, the reaction vessel 58 whose opening faces downward is cleaned by being sprayed with a cleaning liquid by the cleaning device 56, and then dried by hot air from the drying device 57. The reaction vessel thus purified is again supplied to the discharge position 50.

The sample liquid is delivered to the discharge position 50 by the sample distributor 65.
is injected into the reaction vessel 58 of. bending chain 6
2 has a large number of container holders, and sample containers 61 containing samples are loaded into the holders to form a row of sample containers. The sample container row is transported by rotating bodies 63 and 64 so as to pass through the sample suction position 60 . While a sample container containing a specific sample liquid remains at the sample suction position 60, a number of reaction containers corresponding to the number of items to be analyzed in the sample are intermittently transferred to pass through the discharge position 50.
The sample distributor 65 distributes a certain amount of sample liquid to each of the plurality of reaction vessels. When all sample liquids have been distributed to a plurality of reaction containers corresponding to the number of test items to be analyzed, the nozzle of the sample distributor 65 is immersed in a cleaning tank 67 to be cleaned. Then, a sample container containing a sample liquid to be analyzed next is transferred to the sample suction position 60, and remains there until sample distribution for a plurality of items is completed.

a first reagent liquid supply system including a common connection pipe 80;
The second reagent liquid supply system including the common connection pipe 100 operates in the same manner. This example is an example in which two types of reagents are added efficiently, and the timing of adding the second reagent solution can be changed as necessary. In addition, depending on the test item, the addition of a second reagent may not be necessary.
Alternatively, some require the addition of a third reagent,
Not operating the second reagent liquid supply system depending on the test item can be easily controlled by the control device, and on the other hand, it is also easy to add a third reagent liquid supply system or the like.

Each common connection tube 80, 100 includes communication auxiliary tubes 200A, 20 dedicated to each reagent, similar to those in FIG.
0B can be installed. The common connecting pipe 80 is solidly held by an arm 77 that can be moved vertically and horizontally by a drive device 78. The suction and discharge mechanism 75 includes a reagent liquid suction and discharge pump and a cleaning liquid suction and discharge pump, and these pumps are connected through a valve. The reagent liquid suction/drainage pump is connected to the connecting pipe 80, and the cleaning liquid suction/drainage pump is connected to the cleaning liquid contained in the cleaning liquid tank 76 through a flow path.

On a reagent tray (not shown), a plurality of reagent containers 71 are formed into a container row by a bendable chain 72, and this container row is rotated horizontally by rotating bodies 73 and 74. Each of the plurality of reagent containers 71 contains reagent liquids corresponding to a plurality of test items to be analyzed. A dedicated communication auxiliary pipe is installed corresponding to each reagent container, and the reagent suction position 70
There is a communication auxiliary pipe 200 from the common connecting pipe 80 near the
A detachment device for detaching A is provided.

At the time when the sample liquid for analysis of the first test item of a specific sample is injected into the reaction container 58 located at the discharge position 50, the reagent liquid for the test item is stored in the first reagent suction position 70. The container 71 is positioned, and the auxiliary communication pipe 2 attached to the common connecting pipe 80
00A causes a certain amount of the reagent solution to be delivered to the discharge position 5.
0 to reaction vessel 58.

First, the auxiliary communication tube 200A attached to the common connection tube 80 is lowered at the suction position 70 and inserted into the reagent liquid. By the suction operation of the reagent liquid suction/drainage pump of the suction/drainage mechanism 75, a certain amount of reagent liquid is sucked halfway into the communication auxiliary pipe 200A. This communication auxiliary tube is lifted from the reagent container by the arm 77 while holding the reagent liquid, and then moved to the discharge position 50. Here, the communication auxiliary pipe 200A is lowered a little, and the held reagent liquid is discharged into the reaction container 58 by the discharge operation of the reagent liquid suction and discharge pump of the suction and discharge mechanism 75. Communication auxiliary pipe 20 after completion of discharge
0A is raised to its original height and the reagent suction position 70
It is separated from the connecting pipe 80 by a separating device near . Accordingly, if necessary, the communication auxiliary pipe 20
0A is immersed in a cleaning liquid in a cleaning tank 79 to be cleaned.

After the communication auxiliary tube 200A is removed, the reagent container row is moved step by step, and the reagent container 71 containing the reagent solution for the test item to be analyzed is subsequently placed at the suction position 70 along with the dedicated communication auxiliary tube. The empty reaction vessels 58 are being fed to the discharge position 50 as the reaction vessel row is being fed step by step. At this stage, the reagent liquid supply operation for the first test item is completed, and then the reagent liquid supply operation for the second test item is executed in the same manner as described above.

The reagent container 71 is held in a removable manner by the holder of the chain 72, and the chain 72 itself is detachable, so it is easy to replace the reagent container or change the arrangement of the reagent containers. It's easy.

Since the operation of the second reagent liquid supply system is also similar to that of the first reagent liquid supply system described above, detailed explanation of the operation will be omitted. The common connecting tube 100 can attach and detach a communication auxiliary tube 200B dedicated to each reagent, and a second reagent suction position 90
and the discharge position 105 and the cleaning tank 9 as necessary.
It will also be moved to 9. A row of reagent containers 91 connected by a bending chain 92 is intermittently rotated in a horizontal plane by rotating bodies 93 and 94. Connecting pipe 100
The arm 97 holding the is moved vertically and horizontally by a drive device 98. Connecting pipe 10
A cleaning liquid tank 96 is attached to the suction/discharge mechanism 95 connected to the cleaning liquid tank 96 .

According to such an embodiment, there is no wasteful consumption of reagent solution due to changing the reagent solution when changing the test item, and the number of reagent solution injection pumps can be increased even if the number of test items is increased. In addition to the benefits such as almost no increase in the number of reagents required, and no cross-contamination of reagent solutions even though multiple types of reagent solutions can be added using one common connection tube, the sample distribution system and multiple Since the reagent solution supply systems are provided independently, there is also the advantage that efficient analysis operations can be performed.

FIG. 5 is an explanatory diagram of another embodiment of the present invention, in which the same reference numerals are given to parts having the same functions as those of the respective parts of the apparatus explained in the previous embodiments.

In FIG. 5, the configurations of the reagent rotary table 1, the sample rotary table 13, and the reaction rotary table 21 are the same as those in the embodiment shown in FIG. The sample distributor 65 is moved between the sample suction position a to which the sample container 14 is transferred, the sample discharge position b to which the empty reaction container 22 is transferred, and the cleaning tank 31. Sample container 1 in
A certain amount of the sample liquid in 4 is dispensed into the reaction container located at the sample discharge position b. At approximately the same time as this sample liquid distribution operation, the common connection pipe of the reagent liquid supply device 110 is
a reagent suction position c to which the reagent container 3 is transferred;
The reaction container 22 into which the sample has been injected is moved between the reagent liquid discharge positions d to which it is transferred, and can also be stopped at the position of the cleaning tank 31 if necessary. Reagent solution supply device 1
10 has a common connecting pipe connected to the suction/discharge mechanism, and the reagent liquid is sucked from the reagent container located at the suction position c into the communication auxiliary pipe attached to this connecting pipe, and the fixed amount of the sucked and retained amount is Inject the reagent solution into the reaction container at the discharge position d. The multiwavelength photometer 32, sipper 34, and cleaning device 35 are the same as those shown in FIG.

Even in such an embodiment, there is no cross-contamination between reagents, and sample distribution and reagent solution addition can be performed in parallel, so processing capacity can be increased, and the above-mentioned embodiment A similar effect can be achieved.

FIG. 6 is an explanatory diagram of still another embodiment based on the present invention, in which the reaction rotary table 21, multi-wavelength photometer 32, sipper 34, cleaning device 35, etc. have the same functions as those in FIG. ing. A reagent rotary table 115 equipped with dedicated communication auxiliary tubes corresponding to each reagent is intermittently rotated by a drive device (not shown), and a plurality of reagent containers 120 loaded on this table 115 are at the reagent suction position c. They are stopped sequentially. At the sample suction position a, there is a sample mounting table on which a sample container 130 containing a sample liquid is placed manually. The dispensing device 125 is equipped with a common connecting tube to which the auxiliary communication tube can be attached and detached in sequence, as in the example shown in FIG. , and is moved back to the reagent liquid suction position c.
At the reagent suction position c, a fixed amount of reagent liquid is sucked up to the middle of the auxiliary communication tube, at the sample suction position a, a certain amount of sample liquid is sucked through an air layer, and at the discharge position b, it is held in the middle of the auxiliary communication tube. Discharge the reagent solution and sample solution into the reaction container.

Although such an embodiment is inferior in terms of sample processing capacity, it can be used as an analyzer with a simple configuration, so it can be applied as a multi-item analyzer when the number of test samples is small or when an emergency test is required.

In any of the embodiments described above, it is preferable to place a specific reagent container at a predetermined location, such as on a reagent rotary table. In other words, by being able to specify the type of reagent placed at a predetermined position on the rotary table, the relationship between the table position and the test item type can be stored in the control storage device, allowing analysis to be performed on the operating table of the analyzer. By simply selecting the desired item, it becomes easy to automatically combine a specific sample and a specific reagent. By storing multiple reagent types in the storage device so that they correspond to one location on the rotary table, the reagent container at that location can be replaced, and the container corresponding to the replaced reagent can be displayed on the operation table. You can select the inspection items.

〔Effect of the invention〕

In the present invention, dedicated auxiliary communication tubes are provided for each of a plurality of reagents selected according to the analysis item, and these auxiliary communication tubes are selectively attached to a common connection tube to supply the necessary reagents. Since the reagents are dispensed, the number of reagent dispensers connected to the common connection tube can be reduced, and cross-contamination of reagents within the pipette nozzle can be prevented, thereby improving measurement accuracy.

[Brief explanation of the drawing]

FIG. 1 is a plan view showing a schematic configuration of an embodiment of the present invention, FIG. 2 is a partial vertical sectional view of the embodiment of FIG. 1,
FIG. 3 is a plan view showing a schematic configuration of another embodiment of the present invention, FIG. 4 is an explanatory diagram of the vicinity of the reaction line of the embodiment of FIG. 3, and FIG. 5 is a plan view of another embodiment of the present invention. FIG. 6 is a diagram illustrating a schematic configuration of yet another embodiment of the present invention. 1, 13, 21, 115... rotary table, 3,
71,91,120...Reagent container, 10,80,1
00...Common connection tube, 14,61,130...Sample container, 22,58...Reaction container, 25,77,97...
Arm, 28, 200A, 200B... Communication auxiliary pipe, 30, 75, 95... Suction/exhaust mechanism, 31... Cleaning tank, 32... Photometer, 50, 105... Discharge position, 7
0,90...Reagent suction position, 110...Reagent liquid supply device, 125...Distribution device.

Claims (1)

[Claims] 1 In a multi-item analyzer that allows a reaction between a sample and a reagent to proceed in multiple reaction vessels and analyzes multiple test items using the chemical or physical properties of the sample liquid in which the reaction has occurred, a reagent is added to each of the test items. A plurality of reagent containers containing liquid, a plurality of communication auxiliary tubes arranged in correspondence with each of the reagent containers, and a suction/drainage mechanism are connected to the reagent liquid to be aspirated from among the plurality of communication auxiliary tubes. A common connecting pipe to which a corresponding dedicated communication auxiliary pipe can be selectively attached is provided, and after the dedicated communication auxiliary pipe is attached to the common connection pipe, the specific reagent container The reagent solution in the reactor is sucked and held only in the dedicated communication auxiliary pipe, and then, as the suction and discharge mechanism discharges, the reagent solution held in the dedicated communication auxiliary pipe is discharged into the corresponding reaction container. A multi-item analysis device configured as follows, further comprising a detachment device for detaching the communication auxiliary tube from the common connection tube after discharging the reagent liquid at the mounting position of the communication auxiliary tube.