JPS6132041B2 - - Google Patents
Info
- Publication number
- JPS6132041B2 JPS6132041B2 JP14563180A JP14563180A JPS6132041B2 JP S6132041 B2 JPS6132041 B2 JP S6132041B2 JP 14563180 A JP14563180 A JP 14563180A JP 14563180 A JP14563180 A JP 14563180A JP S6132041 B2 JPS6132041 B2 JP S6132041B2
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- spinning
- specific gravity
- coagulable
- spinning dope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007788 liquid Substances 0.000 claims description 65
- 238000009987 spinning Methods 0.000 claims description 65
- 239000012510 hollow fiber Substances 0.000 claims description 50
- 230000005484 gravity Effects 0.000 claims description 30
- 239000011550 stock solution Substances 0.000 claims description 21
- 229920002678 cellulose Polymers 0.000 claims description 20
- 239000001913 cellulose Substances 0.000 claims description 20
- 230000001112 coagulating effect Effects 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 18
- 238000000502 dialysis Methods 0.000 claims description 16
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 238000005345 coagulation Methods 0.000 claims description 6
- 230000015271 coagulation Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 5
- 230000008929 regeneration Effects 0.000 claims description 4
- 238000011069 regeneration method Methods 0.000 claims description 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 239000007864 aqueous solution Substances 0.000 description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 5
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- -1 alkyl methacrylates Chemical class 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229910017604 nitric acid Inorganic materials 0.000 description 3
- 239000004627 regenerated cellulose Substances 0.000 description 3
- 238000007711 solidification Methods 0.000 description 3
- 230000008023 solidification Effects 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- 229920003043 Cellulose fiber Polymers 0.000 description 2
- 229920001202 Inulin Polymers 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 125000005250 alkyl acrylate group Chemical group 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
- 229940029339 inulin Drugs 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 235000010265 sodium sulphite Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical group ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003633 blood substitute Substances 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- BQJTUDIVKSVBDU-UHFFFAOYSA-L copper;sulfuric acid;sulfate Chemical compound [Cu+2].OS(O)(=O)=O.[O-]S([O-])(=O)=O BQJTUDIVKSVBDU-UHFFFAOYSA-L 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000009998 heat setting Methods 0.000 description 1
- LNMQRPPRQDGUDR-UHFFFAOYSA-N hexyl prop-2-enoate Chemical compound CCCCCCOC(=O)C=C LNMQRPPRQDGUDR-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000003350 kerosene Substances 0.000 description 1
- PBOSTUDLECTMNL-UHFFFAOYSA-N lauryl acrylate Chemical compound CCCCCCCCCCCCOC(=O)C=C PBOSTUDLECTMNL-UHFFFAOYSA-N 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229940094933 n-dodecane Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pentâ4âenâ2âone Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- LYBIZMNPXTXVMV-UHFFFAOYSA-N propan-2-yl prop-2-enoate Chemical compound CC(C)OC(=O)C=C LYBIZMNPXTXVMV-UHFFFAOYSA-N 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
- LITQZINTSYBKIU-UHFFFAOYSA-F tetracopper;hexahydroxide;sulfate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Cu+2].[Cu+2].[Cu+2].[Cu+2].[O-]S([O-])(=O)=O LITQZINTSYBKIU-UHFFFAOYSA-F 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/08—Hollow fibre membranes
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Artificial Filaments (AREA)
Description
ãçºæã®è©³çŽ°ãªèª¬æã
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ãããDETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for manufacturing hollow fibers. More specifically, the present invention relates to a method for producing a novel hollow fiber for dialysis used in artificial kidney devices and the like.
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éèŠãªéšæãšãªã€ãŠããã In recent years, artificial kidney devices that utilize osmotic action, ultraviolet action, etc. have made remarkable progress and are widely used in the medical world. Therefore, in such an artificial kidney device, the extremely thin hollow fiber for dialysis is the most important component.
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ããã Typical hollow fibers for dialysis include: (1) total fiber length and circumference ranging from several ÎŒm to 60 ÎŒm;
Uniform wall thickness of m and outer diameter from 10 ÎŒm to several hundred ÎŒm
Hollow fibers made of copper ammonia cellulose fibers having a uniform perfect circular cross section and a hollow portion that extends continuously over the entire length of the stretched and oriented fibers (Japanese Patent Publication No. 40168/1989), (2) ) Hollow artificial fiber body made of copper ammonia regenerated cellulose, in which the sectional structure has a denser porous structure in which the component parts near the outer surface are closer to the inner surface and the middle part (Special Publication No. 1363 of 1983) , (3) Electron microscopic observation of a cuprammonium regenerated cellulose tube having a hollow core when wet shows that the entire cross section and longitudinal section are substantially homogeneous and dense porous structures with microscopic gaps of at most 200 Ã
or less. There is also a hollow fiber for dialysis made of cuprammonium regenerated cellulose (Japanese Patent Application Laid-open No. 134920/1983), which has a skinless and smooth surface on both the inner and outer surfaces. Therefore, all of these hollow fibers extrude the copper ammonia cererose spinning stock solution into the air from the annular spinning hole and let it fall under their own weight, and at that time, the internal center of the spinning stock solution that is spun linearly. It is manufactured by introducing and filling a non-coagulable material into the spinning dope and discharging it, and then sufficiently stretching it by its own gravity and then immersing it in a dilute sulfuric acid solution to perform coagulation and regeneration.
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眮ã«é¡äŒŒããæ§æã®ãã®ãšãããŠããã To make a dialysis device such as an artificial kidney device using these hollow fibers, for example, after inserting the bundle of hollow fibers into a tubular body having an artificial tube and an outlet tube near both ends, This is done by sealing both ends of the tubular body with a resin such as polyurethane, respectively, and
For example, it has a structure similar to a shell-and-tube type device in a heat exchanger.
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åãèµ·ãé£ããšããæ¬ ç¹ããã€ãã However, all of the hollow fibers have a wall thickness of several ÎŒm to 60 ÎŒm and an outer diameter of 10 ÎŒm to several hundred ÎŒm, so they are not only insufficient in strength, but also have a straight shape, so they cannot be bundled together to form a dialysis device. When inserting it into a tubular body and sealing both ends thereof with resin together with both ends of the main body, it is extremely difficult to uniformly distribute and arrange it in the sealed part because of its low bulk. Therefore, the hollow fibers are concentrated in a certain part of the tubular body, and the other part becomes a cavity. Therefore, during use, the dialysate primarily short-circuits through this cavity, causing the Only a portion of the dialysate flows through the bundled hollow fiber portion where the dialysate should flow the most, resulting in a significantly lower dialysis effect. Furthermore, even if such linear hollow fibers could be dispersed and arranged in a somewhat uniform manner within the tubular body, the dialysate flows linearly through the gaps along the hollow fibers, making it difficult for sufficient mixing to occur. There were flaws.
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ã©ã®æ¬ ç¹ããã€ãã In order to eliminate these drawbacks, the linear hollow fibers are twisted in advance to give them a curl, thereby making the hollow fibers bulky when bundled. A uniformly distributed arrangement of threads is being measured. However, this method requires extra steps such as a twisting step and a heat setting step, which complicates the manufacturing process of the dialysis device.
It ended up being expensive and had the drawbacks of poor dialysis performance.
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ãã Furthermore, the hollow fibers are manufactured by extruding the copper ammonia cellulose spinning dope into a gaseous atmosphere such as air, allowing it to fall under its own weight, and then immersing it in a coagulation solution to coagulate and regenerate it. While falling through the atmosphere, ammonia separates to some extent and begins to solidify from the surface. Therefore, the resulting hollow fibers all have skins on their outer surfaces to varying degrees depending on the manufacturing method, so it is impossible to obtain a hollow fiber that is homogeneous on both the inner and outer surfaces and inside. For this reason, when such hollow fibers are used in a dialysis device, the pore diameters of the micropores generated on the inner surface and inside and outside surfaces are different, so the performance is inconsistent and it is difficult to obtain a good dialysis effect. There was a drawback.
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ãããŠååºåçãè¡ãªãããšã«ãã補é ã§ããã The present invention was made in order to eliminate the various drawbacks of the conventional products as described above. The spinning stock solution is directly extruded from the annular spinning hole into the non-coagulable liquid of the two-layer solution with the lower layer filled with After introducing and filling a coagulating liquid and adjusting the specific gravity of the linear spinning stock solution extruded from the spinning hole to be larger than the specific gravity of the non-coagulating liquid and smaller than the specific gravity of the coagulating liquid, and then discharging it,
It can be produced by running the liquid along the interface between the non-coagulable liquid and the coagulable liquid to perform solidification and regeneration.
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å·¥çšãžéãã Next, the present invention will be explained in more detail with reference to the drawings. That is, the hollow fiber according to the present invention is manufactured by the following method. That is,
As shown in FIG. 1, a bath 10 is provided with a coagulating liquid 11 having a higher specific gravity than the copper ammonia cellulose spinning dope as a lower layer and with respect to the spinning dope, and a coagulating liquid 11 containing the copper ammonia cellulose spinning dope and the coagulating liquid as an upper layer. A bath solution consisting of two layers is formed by supplying a non-coagulable liquid 12 having a specific gravity smaller than that of the spinning stock solution. A cuprammonium cellulose-based spinning stock solution is directly extruded into the non-coagulable liquid in the upper layer through a circular spinning hole (not shown) of the spinneret device 13, and at this time, the internal central part of the spinning stock solution extruded in a circular shape is A non-coagulable liquid for the spinning stock solution is introduced and filled into the spinning dope and discharged. The linear spinning stock solution 14 extruded from the annular spinning hole, while containing the non-coagulable liquid inside, advances downward through the upper layer of the non-coagulable liquid 12 without coagulating at all. In this case, while the linear spinning dope 14 receives the buoyancy of the non-coagulable liquid,
Since the liquid itself has a higher specific gravity than the non-coagulable liquid 12, it settles. Therefore, since the coagulable liquid 11 in the lower layer has a higher specific gravity than the linear spinning dope 14, the linear spinning dope 14 has a density of, for example, 20~ Proceeding at a linear speed of 50 m/min, preferably 50 to 80 m/min, the solidifying liquid 11
After sufficiently passing through the coagulable liquid 11 by a deflection rod 16 provided therein, it is pulled up from the roll 17 and sent to the next process.
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Soak in 2. Therefore, the portion 3 that is in contact with the coagulable liquid 11 is quickly solidified from the outer surface, but the portion 14 that is in contact with the non-coagulable liquid 12 is not solidified, resulting in less volumetric shrinkage. However, in reality, this portion 4 does not come into contact with the coagulable liquid 11 at all, and the volume shrinkage due to solidification of the portion 3 that is in contact with the coagulable liquid 11 and the portion 4 that is in contact with the non-coagulable liquid 12 occur. Due to the difference in volumetric shrinkage, the linear spinning dope 14 twists to form a gentle spiral. Therefore, the portion 4 that is in contact with the non-coagulable liquid 12 also comes into contact with the coagulable liquid 11 and is finally completely coagulated.
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ãããšéææ§èœãäžåäžã«ãªãã In this way, the ratio of the length l to the entire circumference of the protrusion 4 and the ratio of the wall thickness d 3 of this portion 4 to the wall thickness d 1 of the other portion 3 are determined based on the coagulable liquid 11 and the non-coagulable liquid. Since it depends on the contact ratio of the linear spinning dope 14 to 12 and the advancing speed, any ratio can be obtained by appropriately selecting each specific gravity and advancing speed. However, if the length l is less than 10% of the total circumference, the strength and twist will be insufficient, while if it exceeds 40%, the dialysis performance may become uneven. Further, if d 3 /d 1 is less than 1.3, the reinforcing effect and twisting will be insufficient, while if it exceeds 3 times, the dialysis performance will become uneven.
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As shown in the figure, in a hollow fiber 2 made of copper ammonia cellulose fiber having a hollow portion 1 continuously extending through the entire fiber length, the wall thickness d 1 of the wall portion 3 is 1 to 0 ÎŒm over the entire fiber length. , preferably 3~
5 ÎŒm, and has an outer diameter d 2 of 50 to 1000 ÎŒm, preferably 200 to 700 ÎŒm, and further 10 to 40%, preferably 20 to 35% of the total circumference.
The protrusion portion 4 is formed to have a thickness d 3 that is 1.3 to 3 times, preferably 1.5 to 2.5 times, the wall thickness d 1 . That is, the wall 3 having a wall thickness d 1 has a substantially uniform thickness, while the protrusion 4 having a wall thickness d 3 has a substantially uniform thickness.
It serves as a reinforcing structure for Therefore, the hollow fibers 2 have a slightly undulating and slightly spiral shape.
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2500 is preferably used. Thus, the cuprammonium cellulose solution is prepared by a conventional method. For example, first, aqueous ammonia, a basic aqueous copper sulfate solution, and water are mixed to prepare an aqueous cupric ammonia solution, an antioxidant (e.g., sodium sulfite) is added to this, then raw cellulose is added and dissolved with stirring, and then An aqueous sodium hydroxide solution is added to completely dissolve undissolved cellulose to obtain a cuprammonium cellulose solution. This cuprammonium cellulose solution may further be mixed with a permeation performance controlling agent for coordination bonding.
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ã玡糞å液ãåŸãã As the permeation performance controlling agent, for example, it contains 10 to 70 equivalent %, preferably 15 to 50 equivalent % of carboxyl groups in the constituent monomer positions, and has a number average molecular weight of 500 to 500.
200,000, preferably from 1,000 to 100,000. There are various types of such polymers, but examples include copolymers of carboxyl group-containing unsaturated monomers such as acrylic acid and methacrylic acid with other copolymerizable monomers, and polyacrylonitrile. There are partial hydrolysis products. Therefore, as copolymerizable monomers, alkyl acrylates such as methyl acrylate, ethyl acrylate, isopropyl acrylate, butyl acrylate, hexyl acrylate, lauryl acrylate, alkyl methacrylates such as methyl methacrylate, ethyl methacrylate, butyl methacrylate, acrylamide, methacrylate, etc. Amide,
Examples include acrylonitrile, methacrylonitrile, hydroxyalkyl acrylate (or methacrylate), dialkylaminoacrylate (or methacrylate), vinyl acetate, styrene, vinyl chloride, etc., and alkyl acrylate and alkyl methacrylate are particularly preferred. Therefore, the most preferred copolymers are acrylic acid-alkyl acrylate (or methacrylate) copolymers, methacrylic acid-alkyl acrylate (or methacrylate) copolymers, and partial hydrolysis products of polyalkyl acrylates (or methacrylates). It is. These permeability control agents are
Usually 1 to 40 parts by weight, preferably 2 to 30 parts by weight, most preferably 3 parts by weight, per 100 parts by weight of cellulose.
~15 parts by weight are used. For example, this permeability control agent is mixed and dissolved in an ammonia cellulose solution, and the temperature is 8 to 30°C, preferably 14 to 25°C.
A spinning stock solution is obtained by stirring for 120 minutes, preferably 60 to 100 minutes, to coordinate the copper ammonia cellulose.
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1.08ã§ããã奜ãŸããã¯1.01ã1.04ã§ããã Such spinning dope usually has a specific gravity of 1.05 to 1.15.
and preferably 1.06 to 1.10. However, as will be described later, the inside of the linear spinning dope extruded from the spinning hole is filled with a non-coagulable liquid, so the specific gravity is usually lower than that of the spinning dope, with a specific gravity of 1.00 to 1.00.
1.08, preferably 1.01 to 1.04.
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žçãããã The coagulating liquid for copper ammonia cellulose is
Its specific gravity is higher than the bulk specific gravity of the linear spinning dope, usually 1.03 to 1.31, preferably 1.05 to 1.31.
It is 1.18. To give an example, for example, a concentration of 5 to 40
%, preferably 8-25% sulfuric acid aqueous solution, concentration 5-25%
50%, preferably 10-30% nitric acid aqueous solution, concentration 6
-47%, preferably 9-30% phosphoric acid, etc.
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ãã®ãã®ãããã The non-coagulable liquid for cuprammonium cellulose used as the upper layer has a specific gravity smaller than the bulk specific gravity of the linear spinning dope and is immiscible with the coagulable liquid, and its specific gravity is usually less than 0.71, preferably is less than 0.69. For example, n-hexane, n-heptane, n-
Examples include octane, n-decane, n-dodecane, liquid paraffin, light oil, kerosene, benzene, toluene, xylene, styrene, perchlorethylene, trichlorethylene, etc. Furthermore, the selection of the non-coagulable liquid to be spun into the linear spinning dope greatly influences the maintenance of the hollow portion of the hollow fiber and the presence or absence of irregularities on the wall surface of the hollow fiber. That is, when the non-coagulable liquid filled in the hollow fiber passes through the membrane and suddenly exits to the outside when the hollow fiber is dried, the pressure inside the hollow becomes reduced, causing hollow collapse or unevenness on the inner wall. The non-coagulating liquid used is selected to have low permeability during drying. Suitable non-coagulating liquids include those described above.
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管å£ã«åœ¢æãããã The hollow fibers that have been coagulated and regenerated in this way are washed with water to remove the adhering coagulating liquid, and then, if necessary, subjected to decopper treatment to remove copper remaining in the hollow fibers. , then washed with water.
Copper removal treatment is usually carried out by immersion in a dilute sulfuric acid solution or nitric acid solution with a concentration of 3 to 30%. However,
When the spinning stock solution contains a permeation performance controlling agent as described above, the hollow fibers are immersed in a strong alkaline aqueous solution to remove the controlling agent, thereby forming fine particles corresponding to the molecular weight of the polymer used. Holes are formed in the tube wall of the hollow fiber.
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ãªã€ãŠææã®äžç©ºç³žãåŸãã The hollow fibers after washing with water or after removing the permeability control agent may be further treated with warm water at 5 to 100°C, preferably 50 to 80°C, or 1 to 10% by weight, preferably 2 to 15% by weight. % concentration of glycerin aqueous solution to remove remaining copper, cupric sulfate, copper hydrogen sulfate, medium-low molecular weight cellulose, etc., and then dried and wound to form the desired hollow. get thread.
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šã«åäžã®ãã®ãåŸãããã As described above, the method for producing hollow fibers according to the present invention comprises filling the upper layer with a non-coagulable liquid relative to the copper ammonia cellulose-based spinning dope, and further filling the lower layer with a coagulating liquid having a higher specific gravity than the non-coagulating liquid. The spinning dope is directly extruded from the annular spinning hole into the non-coagulable liquid of the two-layer solution, and the non-coagulable liquid corresponding to the spinning dope is introduced and filled into the center of the annularly extruded spinning dope. After adjusting the specific gravity of the linear spinning dope to be extruded from the spinning hole to be larger than the specific gravity of the non-coagulable liquid and smaller than the specific gravity of the coagulable liquid and discharge it, the non-coagulable liquid and the coagulable liquid are Since this is carried out by coagulation and regeneration by running along the interface with the liquid, it not only generates the above-mentioned protrusions, but also causes a difference in shrinkage due to the difference in solidification rate due to the formation of the protrusions. , which causes twisting or curling, producing the effect described above. In addition, since the spinning stock solution is not spun into a gaseous atmosphere such as air but directly into a non-coagulable liquid, there is no volatilization of ammonia when passing through a gaseous atmosphere as in conventional methods. Therefore, the hollow fibers obtained are completely uniform on both the inside and outside surfaces and inside.
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ã¯ãç¹ã«ããšãããªãéããã¹ãŠééã«ããã Next, the present invention will be explained in more detail by giving Examples. In addition, in the following examples, all percentages are by weight unless otherwise specified.
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1900 g of cotton linter pulp (±100) was added and dissolved with stirring, and then 1600 ml of a 10% aqueous sodium hydroxide solution was added to prepare an aqueous cuprammonium cellulose solution (specific gravity 1.08), which was used as a spinning stock solution.
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0.68). The spinning dope was introduced into a spinneret device 13 equipped with an annular spinning hole, and directly discharged from the spinning hole into the upper layer of n-heptane under a nitrogen pressure of 2 kg/cm 2 . The diameter of the spinning hole is 3.8mm,
The discharge rate of the spinning dope was 13.7 ml/min. on the other hand,
Isopropyl myristate (specific gravity 0.854) was introduced from a non-coagulable liquid introduction tube attached to the spinneret device, encapsulated in the spinning dope, and discharged. The diameter of the introduction tube was 1.2 mm, and the discharge rate of isopropyl myristate was 4.22 ml/min. Then,
Discharge stock solution (linear spinning stock solution containing non-coagulable liquid)
14 (specific gravity 1.025) was precipitated in n-heptane,
Furthermore, the interface between n-heptane and sulfuric acid aqueous solution was run. At this time, the temperature of both liquids was 20â, the running linear speed was 80m/min, and the running distance was 2.
It was hot. After taking it out of the bath, it was decoppered in a 20% sulfuric acid bath (bath length approximately 4 m) and then wound onto a winding case. The yarn wound into a skein is placed in a tank, filled with hot water, heated to 30â, and then heated to 10â.
I washed the time. After further alkaline washing and subsequent glycerin treatment with an 8% glycerin aqueous solution, the resulting yarn was passed through a tunnel drying oven (length 5 mm) maintained at 120°C ± 10°C at a running speed of 10 m/min. It was run and dried to obtain a hollow fiber.
ãã®ããã«ããŠåŸãããäžç©ºç³žã¯ã第ïŒå³ã«ç€º
ãããã«å€åŸ200ÎŒïœãå£å12ÎŒïœãå
šåšå²ã®ã
ã¡çŽ30ïŒ
ã®éšåãåèšå£åã®çŽ1.6åã®åã¿ãæ
ããçªæ¡ã圢æããŠãããè¥å¹²ã®ã«ãŒã«æ§ãæ
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å€äž¡è¡šé¢éšããã³å
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ãªã¹ãã³ã¬ã¹ã®ãã®ã§ãã€ãããŸãããã®åŒåŒµåŒ·
床10KgïŒmm2ã§ãã€ãã As shown in Figure 5, the hollow fiber thus obtained has an outer diameter of 200 ÎŒm, a wall thickness of 12 ÎŒm, and approximately 30% of the entire circumference has protrusions that are approximately 1.6 times the wall thickness. It had a slight curling property, and was uniform and skinless over both the inner and outer surfaces and the inside. Moreover, its tensile strength was 10 Kg/mm 2 .
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ïŒBUNïŒïŒååé60ããªã³é
žã€ãªã³ïŒååé95ã
ã¯ã¬ã¢ããã³ïŒååé113ããã¿ãã³B12ïŒååé
1355ããã³ã€ããªã³ïŒååé5200ãã«ã€ããŠãã€
ã€ãªã¶ã³ã¹è©Šéšãè¡ãªã€ããšããã第ïŒè¡šã®çµæ
ãåŸãããããªãããã®ãšãã®éæ液ã¯æ°Žã§ã
ãããã®æµéïŒïŒ±DïŒã¯500mlïŒminã§ããããŸ
ããã€ããªã³ããã¿ãã³B12ãã¯ã¬ã¢ãã³ãå°¿
çŽ ãPO4 --çã®ææšç©è³ªãå«ã代çšè¡æ¶²ã®æµé
ïŒïŒ±BïŒã¯200mlïŒminã§ãããUFRã¯4.6mlïŒmm
Hgã»hrã§ãã€ãã Using the hollow fiber thus obtained (membrane area: 1.0 m 2 ), an indicator substance with a known molecular weight [urea (BUN): molecular weight 60, phosphate ion: molecular weight 95,
Creatinine: molecular weight 113, vitamin B 12 : molecular weight
1355 and inulin: molecular weight 5200], the results shown in Table 1 were obtained. Note that the dialysate at this time was water, and its flow rate (Q D ) was 500 ml/min. Further, the flow rate (Q B ) of the blood substitute containing indicator substances such as inulin, vitamin B 12 , creatine, urea, and PO 4 -- is 200 ml/min. UFR is 4.6ml/mm
I had Hg/hr.
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ãã¿ãããªãã€ãã Further, in a dialysis device manufactured by inserting this bundle of hollow fibers into a cylindrical main body, the hollow fibers were uniformly dispersed within the main body, and no short circuit was observed during the passage of the dialysate.
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å®æœäŸïŒã®çŽ¡ç³žå液ã«17.8åœéïŒ
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玡糞å液ãåŸããExample 2 155 g of an ammonium salt of an acrylic acid-methyl methacrylate copolymer having a number average molecular weight of about 50,000 and having 17.8 equivalent % of carboxyl groups was added to the spinning stock solution of Example 1, and the mixture was heated at a temperature of about 25° C. while cooling.
The mixture was reacted for 60 minutes with stirring, and then thermally formed to obtain a spinning stock solution.
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济ã«æµŽé·20ïœã§èµ°è¡ãããããšã«ããåèšå
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äœå¡©ãé€å»ããã€ãã§æ°ŽæŽããå·»åã€ãããã®ãš
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ã€ã糞æ¡ã¯å®æœäŸïŒãšåæ§ã®æ¹æ³ã§æž©æ°ŽåŠçãã
ã®ã¡ã也ç¥ãè¡ãªã€ãŠäžç©ºç³žãåŸãã The spinning stock solution thus obtained was prepared in Example 1.
After spinning and regenerating coagulation in the same manner as above, the obtained yarn was run in a copper removal bath filled with a 5% aqueous sulfuric acid solution at a bath length of 10 m. After washing with water, the copolymer salt was removed by running it in an alkaline bath filled with 4% sodium hydroxide at a bath length of 20 m, followed by washing with water and winding. The processing speed at this time was 10 m/min. The thread wound around the skein was treated with hot water in the same manner as in Example 1, and then dried to obtain a hollow fiber.
ãã®ããã«ããŠåŸãããäžç©ºç³žã¯ã第ïŒå³ã«ç€º
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9.5KgïŒmm2ã§ãã€ãã As shown in Figure 6, the hollow fiber thus obtained has an outer diameter of 200 ÎŒm, a wall thickness of 11 ÎŒm, and approximately 25% of the entire circumference has protrusions that are approximately 1.4 times the wall thickness. It had a slight curling property, and was uniform and skinless over the inner and outer surfaces and inside. Also, its tensile strength
It was 9.5Kg/ mm2 .
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ãªãã€ãã A dialysance test was conducted on the hollow fiber thus obtained in the same manner as in Example 1, and good results were obtained. Also,
In a dialysis device manufactured by inserting this bundle of hollow fibers into a cylindrical body, the hollow fibers were uniformly dispersed within the body, and no short circuit was observed during the passage of the dialysate.
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Fig. 1 is a schematic diagram of an apparatus for carrying out the method of the present invention, Fig. 2 is a sectional view for explaining the principle of producing hollow fibers according to the invention, Fig. 3 is a schematic diagram of another apparatus, and Fig. 4 FIG. 5 is a partial perspective view showing the schematic structure of a hollow fiber obtained by the method of the present invention;
The figure is a micrograph of hollow fibers obtained by the method of the present invention. DESCRIPTION OF SYMBOLS 1... Hollow part, 2... Hollow fiber, 3... Wall part, 4... Projection part, 10... Bathtub, 11... Coagulating liquid, 12... Non-coagulating liquid, 13... Spinneret device, 14... Linear spinning dope .
Claims (1)
éååºæ§æ¶²ãäžå±€ã«ãããã«è©²éååºæ§æ¶²ããæ¯
éã®å€§ããååºæ§æ¶²ãäžå±€ã«å å¡«ããŠãªãäºå±€ã
ããªã济液ã®è©²éååºæ§æ¶²äžã«ãåèšçŽ¡ç³žå液ã
ç°ç¶çŽ¡ç³žåããçŽæ¥æŒåºãããã€è©²ç°ç¶ã«æŒåºã
ãã玡糞å液ã®å éšäžå€®ã«è©²çŽ¡ç³žå液ã«å¯Ÿããé
ååºæ§æ¶²ãå°å ¥å å¡«ããŠè©²çŽ¡ç³žåããæŒåºããã
ç·ç¶çŽ¡ç³žå液ã®æ¯éãåèšéååºæ§æ¶²ã®æ¯éãã
倧ããããã€åèšååºæ§æ¶²ã®æ¯éããå°ãã調æŽ
ããŠååºãããã®ã¡ãåèšéååºæ§æ¶²ãšååºæ§æ¶²
ãšã®çé¢ã«æ²¿ã€ãŠèµ°è¡ãããŠååºåçãè¡ãªãã
ãšãç¹åŸŽãšããéæçšäžç©ºç³žã®è£œé æ¹æ³ã ïŒ çŽ¡ç³žå液ã¯ééæ§èœå¶åŸ¡å€ãå«æããŠãªãç¹
èš±è«æ±ã®ç¯å²ç¬¬ïŒé ã«èšèŒã®æ¹æ³ã[Scope of Claims] 1. The non-coagulation of a bath liquid consisting of two layers, the upper layer being filled with a non-coagulating liquid for the copper ammonia cellulose-based spinning dope, and the lower layer being filled with a coagulating liquid having a higher specific gravity than the non-coagulating liquid. A line extruded from the spinning hole by directly extruding the spinning dope through the annular spinning hole, and introducing and filling a non-coagulable liquid with respect to the spinning dope into the center of the annularly extruded spinning dope. After adjusting the specific gravity of the shaped spinning stock solution to be larger than the specific gravity of the non-coagulable liquid and smaller than the specific gravity of the coagulable liquid and discharge it, the solution is made to travel along the interface between the non-coagulable liquid and the coagulable liquid. 1. A method for producing a hollow fiber for dialysis, characterized by performing coagulation and regeneration. 2. The method according to claim 1, wherein the spinning stock solution contains a permeation performance controlling agent.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14563180A JPS5771408A (en) | 1980-10-20 | 1980-10-20 | Preparation of hollow fiber |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14563180A JPS5771408A (en) | 1980-10-20 | 1980-10-20 | Preparation of hollow fiber |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5771408A JPS5771408A (en) | 1982-05-04 |
JPS6132041B2 true JPS6132041B2 (en) | 1986-07-24 |
Family
ID=15389466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14563180A Granted JPS5771408A (en) | 1980-10-20 | 1980-10-20 | Preparation of hollow fiber |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5771408A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03123849U (en) * | 1990-03-28 | 1991-12-16 | ||
JPH0635148U (en) * | 1992-10-14 | 1994-05-10 | æ ªåŒäŒç€Ÿäžå€®è£œäœæ | Tube squeezer |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0263531A (en) * | 1988-05-30 | 1990-03-02 | Terumo Corp | Production of hollow fiber membrane |
US5084349A (en) * | 1988-09-07 | 1992-01-28 | Terumo Kabushiki Kaisha | Hollow cellulose fibers, method for making, and fluid processing apparatus using same |
DE69735925T2 (en) * | 1996-12-25 | 2007-02-15 | Asahi Kasei Medical Co., Ltd. | Process for producing a hollow fiber membrane, hollow fiber membrane and hollow fiber dialyzer |
DE69839622D1 (en) | 1997-12-17 | 2008-07-31 | Asahi Kasei Kuraray Medical Co | Process for the preparation of an artificial organ, hollow fiber membrane, and hollow fiber dialyzer |
-
1980
- 1980-10-20 JP JP14563180A patent/JPS5771408A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03123849U (en) * | 1990-03-28 | 1991-12-16 | ||
JPH0635148U (en) * | 1992-10-14 | 1994-05-10 | æ ªåŒäŒç€Ÿäžå€®è£œäœæ | Tube squeezer |
Also Published As
Publication number | Publication date |
---|---|
JPS5771408A (en) | 1982-05-04 |
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