JPS6125383B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to the field of medical technology, in particular to the administration of drugs. BACKGROUND OF THE INVENTION Recently, in the field of medicine, compressed bottles containing fixed doses have been increasingly used for the administration of drugs to the skin, mucous membranes and bronchial tubes. Some single-injection packs on the market include powdered drugs and solvents that are mixed with a solvent and dissolved by vibration just before injection. The injectate is also packaged for multiple use in small volume fill bottles, which are used by squeezing out sterile air before filling the injection. Oral drug therapy according to the present invention eliminates the need for the patient or caregiver to count drops and eliminates the need for additional irrigation containers. Particularly in the case of psychiatric patients, this is advantageous since it is not necessary to inform the patient of the dosage of the drug. It is preferable to improve the cumbersome single-time pack in the field of injection, and to use it as a substitute for conventional injections which also have a cumbersome injection mechanism like a needle, at least in the subcutaneous injection area. . In order to achieve these objectives, it is necessary to reduce the technical waste used in dosing devices. First, the function of subcutaneously dispensing medicine from the dispensing chamber is made almost automatic. The purpose of these is to provide a sealed container having a gas chamber filled with pressurized gas and a drug storage section adjacent to the gas chamber via an isolation member, and a container that communicates with a communication port opened in the drug solution storage section. This is achieved by a drug solution dispensing device characterized by comprising a dosage chamber and an adjusting means for supplying a predetermined amount of the drug solution in the drug solution storage portion to the dispensing chamber. That is, the movement of the drug in the dispensing piston begins with the lowering of the dispensing piston, where the outflow of the drug is controlled;
This is followed by the lowering of a valve located at one end of the filling tube through the neck of the bottle neck closure device inside the drug, and on top of its oval shape a shutoff disc prevents the closure of the valve before pressure equalization. This is typically achieved by rotation of a dosing piston with an eccentric valve seat, evacuation of the drug under the restriction of the piston's trajectory by a chord finally placed in a resilient coating, etc.
The outflow of the medicament from the dosing chamber is carried out entirely under the valve movement of the dosing cylinder, either by tension on the chord or by spring force or pressure in the medicament bottle. In practice, relatively large compression bottles are utilized in clinical use. At this time, the drug is injected into the syringe by the syringe piston up to a certain scale by operating the outflow valve of the syringe cone introduced by the rising or falling movement (in the case of a fixed piston, the drug is injected by the syringe piston to a certain scale). (It is also possible due to relative syringe cylinder movement). Air blocking of the drug outlet opening may also be achieved by a capping structure that springs back to its original position in the closed position. Furthermore, according to the invention, the suction of liquid or air, the zonal movement of the wafer in the vicinity of the drug outlet opening (with or without a through hole for the syringe cone), the fixed area or the dispensing chamber and the conduit previously In some configurations, a gas or liquid stream may be used to eject the agent from the cannula, which may be variously utilized through heating or cooling operations. For single use, installation of a cannula with a sterile putty edge on the conical part;
Closing the tip of the cannula with a covering cushion seems to be a convenient means of allowing the cannula to be left alone after use. EXAMPLE 1 FIG. 1 shows a two-compartment dispensing mechanism associated with a drug vial as a closed container with an air expansion section as a gas chamber surrounded by a membrane as a separator.
The metering is adjusted via fixed screws 1 which have a right-hand thread and a left-hand thread at the top and bottom, respectively. At this time, by operating the fixed screw 1, the distance between the cylinder cap 3 and the metering cylinder cap 15 can be determined as appropriate. A filling tube 5 is immersed in the drug, and the air above the drug is restricted by a coating 6 and communicates with the atmosphere through an opening 9 and a check valve 10, and the drug bottle is immersed in a filling tube. Dosing chamber 1 as metering chamber via pipe 5
It is connected to 1. The dosing chamber 11 is closed by a check valve 12 and a covering valve 13 which is actuated by compression with a syringe. The prerequisites for starting the work of this device are to release the bar 2 and to open the air cylinder cap 3 as an adjusting means so that the opening of the valve 4 which is in the compressed state in the filling pipe 5 is opened. It operates as a pump. During dosing, the movement of the cylinder cap 3 is again coupled in situ to the screw 1, so that
A volume of air equivalent to the volume of drug removed by the drug vial is pumped through an elastomeric membrane having different wall strengths designed to effect expansion from one end to the other. During this time, the check valve 7 prevents air from leaking through the ventilation pipe 8.
The pumping action of the air cylinder cap 3 is enabled by a check valve 10 and the syringe cone 1
After opening the cover valve 13 by compression on 4, the dosing cylinder cap 15 is lowered and passes through the check valve 12, allowing the supply of drug from the dosing chamber 11. When the dosing chamber 11 is empty, the cylinder of the dosing chamber is clamped onto the toothed rack 16. The dosage is read off on a dial 17. EXAMPLE 2 FIG. 2 shows, by way of example, a one-chamber dispensing device utilizing a drug container already under gas pressure. Examples of drug containers under gas pressure include those shown in FIGS. 2a and 2b. In FIG. Gas compression has an effect on the drug contained in the coating. The gas film also surrounds the short filling tube extension 5. FIG. 2b shows a cylindrical drug container in which the piston 18 propels the drug toward the outlet tube by means of gas compression. The function of the dosing device (FIG. 2) is to use a piston 19 as an adjustment means via a knurled screw 20.
On the other hand, the worm threaded portion 21 is movable in close contact with the filling tube 5. The upper rim of the knurled screw limits the upward movement of the dosing cylinder cap 15 as a dosing chamber. The inner rim of the screw carries out a spring action via a projection with an acute angle of descent, which is connected to a dosing scale so that dosing adjustment can be made by ear or finger. Rotation of the dosing piston 19 during dosing adjustment is prevented by a guide groove 22 between the piston tube 23 and the filling tube 5. Liquid filling in the dispensing chamber is performed using needle 2.
7. The needle can only be used after passing through the closed check valve 25 and stopper 26, which is protected and sterilely held by a membrane or cap and restrained by a spring. The valve is closed only when the maximum volume of liquid has entered the dosing chamber, since a frictional delay in passing through the guide ring 28 in the valve cone occurs and obstructs the valve cone. It will also happen. 1 intermediate ring 2
4 allows the piston tube 23 to move freely. membrane 29
protects the dosing room from contamination. In the example of FIG. 2c, the skin is attracted by the suction cylinder 35 in connection with the water injection pump 36. The medicine bottle is in a movable inner cylinder 3
7 and said cylinder 37 is held by a groove and a snap 38 before injection. By suction, the drug vial with the dispensing mechanism 39 and the cannula fixed above is moved to the skin. When the cannula is held by the stopper 40, the dispensing cylinder 37 is lowered, and the dispensing mechanism itself is actuated by a piston mechanism substantially similar to the dispensing shown in FIG. 1, and the medicine flows out. FIG. 2d shows a dosing device similar to the example shown in FIG. 2, with dosing taking place via a worm screw. The inflow from the filling pipe 5 passing through the regulating means 19 is caused by pushing downwardly the movable rod 31 connected via the valve 30, which opens the valve, thereby causing the inflow, and then The cylinder cap 15 as a dosing chamber as well as the filling tube are fastened to the drug vial by means of a clamp 32. The lifting height of the piston is adjusted by the worm screw 21 (for metering) in the cylinder cap 20 attached to the shaft, while rotation of the shaft is prevented by a guide groove and a channel between the worm screw 21 and the piston tube. . In FIG. 2e, a valve 30 for the inflow of medicament is located inside the dosing piston 19 as a regulating means in order to allow the medicament to flow into the dosing chamber. After adjusting the metering as in FIGS. 2 and 2d, the rotation of the metering cylinder cap 15 as an oval metering chamber under the valve plate fixed in the valve 30 and with it Through the rotating dosing piston 19 the opening of the valve plate is covered, such as by one valve plate in the valve seat. After injection of the drug, the dosing piston 19 is pulled back again to its starting point by the spring 33. Figure 2f shows a clamp with the indicia ``Morning'' on one end and ``Night'' on the other end. The difference between the two ends can also be easily seen as one end is circular and the other end presents a square shape. The clamp has the function of receiving two dispensing mechanisms or syringe cylinders and can avoid confusion with each other. FIG. 2g shows details of a modification of embodiment 2e. The valve seat of the valve 30 is centrally located on the surface of the dosing piston 9 and is held by a tension spring 95. Disc (eccentric disc) located at a location slightly off center with respect to the metering piston 9
6 has a notch for the passage of the valve cone (valve plate). After adjusting the dosage, the screw 97 is tightened and together with it the disk is tightened against the spring 33 by means of a square pin in the center of the disk and in a square bore. Spare container (not shown)
After the valve cone has been lifted into the notch in the disc by the overpressure present therein, rotation of the disc is prevented until a pressure equilibrium occurs between the compression vessel and the dosing chamber. (The valve cone is now drawn back into the valve seat by the spring, and the disc is moved by the spring 3 after rotation.)
3 to stop the movement of the valve cone). However, in this embodiment, a translucent metering cylinder is used. Embodiment 3 FIG. 3 shows a device similar to the example shown in FIGS. 2e and 2g, but the dosing cylinder has a dish-shaped edge 41 which is connected to a projecting container wall 42. They are in close contact with each other and form a chamber between them. When the dosing cylinder is lowered, the air passes through the antibacterial belt 5
The injection tube 43 is led to the above-mentioned chamber through the injection adapter part located at the lower part of the injection tube 43. Covering disc 46
turns laterally with respect to the spring 47,
The arm 48 with a notched edge on the upper side corresponds to a conveyor wheel with a partly notched edge and a belt 51.
move. The belt 51 itself has equally spaced holes for syringe cones. When the syringe cone is introduced, the dosing cylinder is lowered, so that air escapes from the bellows coupling located on the side of the syringe until the cap pivot arm in the tightening bolt 52 engages and the dosing cylinder is lowered. Lifting movement of the cylinder is prevented by a blank bolt. The dose flows into the syringe. When the syringe is removed, the cover disk 46 pivots back to its original position, the belt 51 is propelled by the action of the spring-like lower notch edge 49 (and thus also the hole), and the tightening bolt is released. The metering cylinder is also lifted. The developing low pressure also draws the belt into the syringe barrel. Propulsion of the drug is provided by the membrane of the compressed bottle. Figure 3a shows an example of fixed dosing. Dosing takes place inside a plastic cylinder 53 as a dosing chamber which is folded in accordion-like fashion. The plastic cylinder 53 is fitted into a corresponding recess in the bottom of the bottle. Filling tube 5
By applying pressure to the bottom edge of the plastic cylinder the bottom edge of the plastic cylinder is closed and the contents are released through the opening of the valve 12 through the syringe adapter part, while the air pipe leading to the chamber is sealed off by the membrane 6 as an isolation member. Air flows in through. The closure cap is sealed to the bottle neck by a hinge 54 under spring pressure. Figure 3b shows an example of fixed dosing in the bottle neck. When the filling pipe 5 is lowered, the check valve 30 is lowered because it is lowered into the metering piston 19.
Upon opening, the inflow opening 56 is sealed. If the filling tube is lowered further, the metering piston will also be lowered. The dosing chamber is then filled via the tube 57 located in the compression bottle. When the pressure applied to the filling tube decreases, the check valve closes and
The inlet opening 56 in the dosing chamber is open. The pressure of the liquid against the dosing piston 19 lifts said piston 19 and empties the dosing chamber. The filling tube 5 is protected by a belt 51 with elastic rollers, which belt 51 is pulled out of the cassette 59 and wound onto a roller 60. This series of actions is carried out before the syringe is inserted into the lever 6 equipped with a claw.
This is carried out through a downward movement of 1. The downward movement is caused by fluid friction caused by closing the opposite direction before introduction of the syringe cone. When the syringe cone is removed, it is closed by a spring-loaded clamp, ie showing one means for closing the drug outlet opening. Figure 3c shows the adhesive or adhesive foil being stacked inside the capping device to close the drug outlet opening. The closure cover with the laminated plate inside in the guide groove 62 relative to the spring 58 is lifted up and bent laterally, with one plate tightly attached to the edge of the cannula adapter part. and remain. After separating the platelets, the syringe cone can be introduced. The bottom surface of the platelet and the outer layer of the cushion 63, which is filled with air or liquid,
For example, it may be one containing metal powder such as aluminum. Figure 3d shows a closure using a movable magnet 55. Check valve 30 is actuated by direct pressure from the syringe cone. Embodiment 4 In Fig. 4, the dispensing mechanism
It is shown that the dosing piston is released by blocking 64 of the syringe piston rod located on the syringe. In this case, the protrusion of the syringe cylinder of the compression bottle is
The protrusion is on the syringe fixed holder 65 (or under the syringe fixed holder when the syringe fixed holder is resiliently connected to the compression bottle and is lowered for filling, see Figure 4a). ). In FIG. 4a, the blocking rod 64 is removable from the reservoir vessel. FIG. 4a shows an example in which the blocking rod 64 is fixed to the compression bottle by the holding part 66. The locking rod 64 of the piston can be returned to its original position elastically and then adjusted in height along the dosing scale 17. A nail can be inserted into the corresponding borehole. FIG. 4b shows a modified embodiment of the connection with the medicine bottle, showing an embodiment with a pre-set bendable connection. In this example, it is possible to pivot or meter at least two blocking rods 64 of different heights. In Figure 4c, the syringe to be filled is inserted into the cylindrical jacket. In this cylindrical covering part, a screw having a metering seal and a spring mechanism as shown in FIG.
7, an accurate pre-dispensing amount can be determined. In Figure 4c, the syringe to be filled is inserted into the jacket. Precise predosing is possible in this jacket by means of a threaded bolt 64 with a dosing scale and a catch 17 as described in FIG. Figure 4d shows an example of a suction injection mechanism.
The syringe cylinder is pushed into the suction cylinder 35 to the position of the stopper 67, and the sealing piston with ram 68 adjusts its height along the scale and the catch 17 by engaging the dosing recess 69 in the catch 70. will be carried out. When the syringe cone is introduced into the syringe barrel of the compression bottle, the check valve is actuated and the syringe piston is lifted to a position within the adjustment range. Pulling on the handle 71 releases the stopper 67 and the catch 70 and the syringe can be raised by the leading clamp 72 of the rod 68 until the dosing recess snaps into the spring tension bolt 38. When the jet pump is connected to the device and the skin is sealed against the suction cylinder, the suction pressure is eventually released and the skin remains elevated if the downward movement of the sealing piston and syringe is unimpeded. An injection is made. FIG. 4e shows the dosing in which the upward movement of the piston is prevented by an adjustable stop 23 inside the syringe. The syringe of Figure 4f shows an embodiment in which movement of the syringe piston is stopped by fitting a spring-driven nail 64 into the piston rod bore. The blocking of nail 64 is removed by pulling on the nail. Figure 4g shows a blocking rod with a syringe clamp removably attached to the cylinder of the syringe, the blocking rod being fixedly or movably attached to the piston end and the cylinder end. The distance between the parts is determined by the metering scale 17. FIG. 4h shows an example of joining a plurality of compression bottles (containers), each of which forms a square;
Guide grooves and channels are provided at appropriate positions on the sides of the containers, and the containers are aligned and fit into each other to form blocks. Figure 4i shows a joint container with a common fill neck and separate drug supply, i.e. at least two different drugs are discharged from separate drug containers through a common drug outlet opening. An example is shown below. The fill tube neck is located above the check valve 30 and its function depends on the length of the fill tube. The opening 82 in the side meets the suction tube 73 when the fill tube is extended to its maximum length. When the dispensing mechanism of the second drug container is actuated by the handle 71, the second drug is injected and the area near the fill tube neck is flushed to remove the first drug. In Figure 4j there is a dosing recess on the end of the drug container. The syringe is inserted into the valve case, the syringe and the valve case 13 are pulled upward, and the valve portion set corresponding to the length of the pull is also opened. After dispensing on the lift of the syringe piston, the valve case is pressed down with a finger, allowing the syringe to be removed. That is, this embodiment is a typical example in which the dispensing mechanism is connected to a drug container. Figure 4k shows the solution with the syringe piston in contact with the holding chamber fixed via the drug pressure bottle and the syringe cylinder being lowered under actuation of the drug outflow valve to the adjustable dosing stop; There is.
A resilient bellows coupler pushes up the filler connection and filler tube after use. Embodiment 5 FIG. 6 is an electronic application of the example shown in FIG. The syringe cone is introduced and the magnetic valve 7
6 is opened by pressure switch 77. The magnetic valve is closed by the control element 80 when the end of the syringe piston blocks the light between the lamp 78 and the optoelectronic cell 79. In FIG. 6a, the vibration of the liquid cushion in the fill neck actuates the magnetic valve 76 immediately after the syringe piston crosses the protruding syringe cylinder wall marking. Example 6 Figure 7 shows a filling neck extending into a cylinder which is closed by a sealing cap. The cylinder is adapted for fluid flow and has an opening sealed and adapted to receive the front of a syringe. With the liquid aspirated, the syringe cone passes through the resilient cushion and is inserted into the check valve. In Figure 7a, the suction flow passes through the sealing cushion and moves behind the diaphragm through which the syringe cone can pass. Embodiment 7 FIG. 8 shows a drug storage hose as a dosing chamber, which is divided into doses by solid bodies 74 as separating elements and regulating means. When the hose is pressurized at one end, the separator in the other end of the hose is pushed through the seal 63 below the closed cap and can be removed by interrupting the pressure supply. The syringe cone is introduced and the pressure is increased again so that the amount of drug contained flows into the next separator in the hose. Example 8 Figure 9 shows a drug vial with an oral dispensing mechanism. The clamp 32 has a leg-shaped part which is used for downwardly installing the device with the dosing device. The valve cover 13 is connected to a two finger actuated fastener. As a result, the two closing portions 76 become one individual body, which, in view of the symmetry of its structure, opens to the spring 25 as a bird's beak-shaped hinge. The check valve and therefore the metering piston are subsequently activated. FIG. 9a shows the medicament being dispensed as it flows through the opening 82 into the dosing cylinder 15 and lowers the dosing piston 19 via the action of the spring 83 to the position of the piston stop 84. It is a supply device. When the cam 85 is actuated by the handle, the dosing cylinder is lifted and the annular opening 82 meets the outflow opening 87. Dosing is carried out by the crank 17 with a dosing scale via a worm gear spindle 86. Compressed gas fills the sac-like membrane 9 via an inlet with a check valve. Example 9 Figure 10 shows a single ampoule under the influence of compressed gas. This ampoule injects its contents into a syringe after the stopper is pierced by a cannula 600 (in front of the movable grid covering) or by a cannula adapter part. Embodiment 10 In this embodiment, a liquid or gas stream is provided for purification inside the introduction channel which is connected to the metering chamber. That is, FIG. 11 shows a cannula adapter part which is similar to the jacket part and is held by a spring mechanism 8 in a water swirling intermediate position between the check valve 25 and the cushion-type seal 63 when not in use. ing. small wing 8
9 assists rotation in the wash liquid stream. When the sheathing cylinder 90 with a cushion-type closure is lowered, a fitting similar to the sheathing of the check valve 25 opens and forms a sealed connection with the filling tube 5 for filling the syringe. After use, the spring 91 returns the covered cylinder 90 to its starting position. Example 11 FIG. 12 shows a dosing piston (dosing device) that can be connected to a drug storage bottle through a valve connection (tube) 92.
It shows. The dosing piston (dosing device) is itself connected at an edge 98 to another dosing device as a cleaning system. This system is operated periodically through a magnetic valve 76 by a timer 94, which is a known technique. When the valve connection is introduced into a drug vial (ie, a drug storage bottle) which is sterically closed with a cap, the check valve 25 of the drug storage bottle is opened by means of the shaft 99. The contents of the drug vial are placed under pressure or placed under pressure, for example through a washing system. In the mechanical solution for controlling the valve 30 located at the end in the dosing piston 19, shown in FIG.
2/2-Slider valve (2/2-Schiebevenfil) 100
is located in position A, so that when the magnetic valve 76 is in position A, medication can flow into the dispensing cylinder 15. Due to the pressure of the spring 83, the dosing piston moves so that the convex part of the valve 30 strikes the outflow tube slider 101, so that the valve 30 is moved to an open position in which it is more easily held than in its final position. is propelled forward until it is moved. Due to the operation of the outflow pipe slider 101, the 2/2-slider valve 100 is placed at position B, so that the inflow of the drug is blocked. During the downward movement of the dosing piston under the influence of the spring 83, the medicament is passed through the valve 30 by the dosing piston. The valve 30 is closed by the impact of the valve protrusion on the inflow pipe slider 102, and 2/
2-Slider valve is returned to position A. Meanwhile, in position B, through the magnetic valve 76, the supply of cleaning liquid is free in place of the drug, so that during the next movement of the dispensing piston, the drug is emptied through the outlet pipe under the influence of that movement. By closing the cover 54, the control element 80 holds the magnetic valve 76 in position B. The contact switch 77 on the cover switches the magnetic valve in position A by pressure actuation, after the outflow pipe slider has been actuated through the metering piston.
By opening the cover, the key bolt 103 is removed and opened. In FIG. 12a (variant A) the sealed piston plate 104 at the location of the screw 105 is adjustable in height to vary the dose. The outflow connection is centrally located on the piston plate 104. Mechanical slider valve 100 is electrical contactor 10
7 is replaced by an electromechanical valve 106. EXAMPLE 12 FIG. 13 shows a compressed bottle in which the compressed bottle containing the medicament compressed bottle and the juxtaposed cleaning liquid container or sterilizing gas have a common chamber. The common chamber may be closed by a resilient cap 54 and contain a cannula. A valve 108 that forms a lever connection with the cover 54
briefly connects the interior of the cannula with the irrigation fluid container 530 under pressure. The 2/2-valve 109 connects the interior of the cannula with the drug reservoir by suction (such as with a suction injection device) or by manual operation. The position in which the cap opening is maximized allows the device to be worn on the skin. Spring 111
When the cover is closed, the cover is briefly moved into position so that the valve 108 is opened and then closed again (back to configuration 1). The 2/2-valve was previously returned to position B by spring 110. In FIG. 13a, upon closure of the cover 54, a compressed bottle containing cleaning liquid or sterilizing gas is opened for a predefined period (as is conventional in spray bottles). The clean flow is then directed counter-current to the drug effluent flow. In FIG. 13b, the compression bottle valve is actuated by lowering the cannula coupling cover 112. The cover is surrounded by a cleaning liquid or sterilizing gas when the cover 54 is closed by a spring after actuation of the valve 108. EXAMPLE 13 In FIG. 14, the impact of the end of the metering piston on the resilient shut-off shaft causes the valve 108 to open for a short time. This involves compressed gas, so that the drug in the cannula adapter part, or in the cannula, is replaced by gas directly after or during the injection. The cannula adapter part 114 is surrounded by a closed movable cylinder, which is closed upwardly by an eccentric capping device. Rotation of the cylinder as it is lowered over the male thread orientation device opens the cover 54 via the impact axle 115. The sterilizing liquid or agent surrounding the cannula extension also contacts the cannula adapter edge and cap and is directed back into the space below the porous guide disk which is secured to the cannula adapter. During the descent of the cylinder, the pressure switch 118 of the valve 108 is actuated via the slotted steam piston 119. As a result, the pressure gas is discharged onto the metering piston via an outlet pipe 120 with an annular cutout. After injection, the valve 108 operates in a capped lever connection so that the interior of the cannula is coupled to the irrigant reservoir, which remains under pressure for a short period of time, as described above. 2/2-valve 109 is moved from point B to point A by suction (e.g., a suction syringe) or by manual actuation of spring 110.
As a result, the interior of the cannula is bound to the storage drug. The maximum cap opening in position allows the syringe to press against the skin. The problem regarding the sealing of the cannula adapter section can be solved as follows. That is, 2
% to 3% COK84 Aerosil (Degusa)
The reflux fluid of Lysol and 97% to 98% is mixed by the "snowball method" and flows backwards around the cannula adapter part by reducing the box chamber as the cylinder rotates. In addition, hydrophobic aerosil (2-3%
For example, R927 is mixed in a gel state, or in other compositions such as Helago, 97% ~
Can be used with 98% oil. The cannula adapter part is washed with a silicone oil solution in a known manner and then left in a drying cabinet at 300 DEG C. for 6 hours to make it hydrophobic. “Manuseptgel” (Bacillolfabrik Dr.Bode & Co. Hamburg)
Co. Hamburg) is used dissolved with 1% formaldehyde before hardening additives or silicone to produce a hard surface impregnum (especially Seefeld, Oberbayerm, Oberbayer), said material is used to inhibit coli bacteria. is effective. (Professor Grossgebauer FU) Figure 14a shows the upper part of a dosing device as in Example 2. However, in Example 2, the syringe tube has a wide valve plate (stopper 2) for ventilation.
6) is closed. The injection cone is inserted and the pressure lowers the valve plate 121 as well as the entire valve sheath simultaneously. As a result, the drug is pushed back into the syringe as the dosing cylinder descends. In Figure 14b, the cannula is coupled to a dosing device. The cannula is located within a space 114 containing sterile oil. After opening the cap, the cannula is moved through said space. At this time, the sterilizing oil is allowed to flow back in a sealed manner, and the evacuated bellows type connector is compressed. In FIG. 14c, the space for oil backflow is adjusted by rotating a cylinder 122 whose chamber is enlarged in the form of a drawer. The bottom cylinder is then stationary and evacuation takes place from the cylinder via the opening 123. Within the cannula extension (FIG. 14b) is a resilient sealing surface that is germicidal or provided with germicidal conjugates. EXAMPLE 14 FIG. 15 shows a dosing device similar to FIG. 9a, but showing a compression bottle that can be connected without a roll membrane. At the position of the cylinder 15, the passage 133 for the traction 125 is sealed by a rubber tube of a valve, and the opening around the axis of the roll 128 is sealed by a sterilizer. When the valve 30 is open, the dosing piston is drawn downwardly through the roll 128 by traction towards the spring 124. At this time, the membrane 126 prevents pressure from affecting the valve 127, displacing the drug to the front of the cannula extension.
Towing operation is performed by using the handle 129 to move the roll 12.
It is carried out after 8. This operation takes place with a small amount of play as the two cams engage lightly between the resilient gear stop and the fixed cut-off gear, and the protrusion of the gear stop on the cam allows the handle to Prevent subsidence. By pulling the piston 130 (e.g. by suction of a suction injection device having a cylindrical outlet to receive the piston)
From the opening of the pressure equalizing valve 131, the dispensing piston is displaced by the drug entering the cylinder into the cannula adapter section, where it expels the drug. The traction then releases the gear block and the lever lowers to its starting point. Dosing takes place in a plurality of fixed doses along the scale 17. At this time, the blocking shaft, which is located at a different distance from the lever shaft, butts against the equally located screw and blocks the lever movement.
The closure cap and the cannula adapter part or other flexible member are provided with a sterile covering. Figure 15a shows drug delivery through a bellows coupler. Embodiment 15 In FIG. 16, the hole plate 13 between the plates 135
4 mediates the transport of the powdered drug or tablets to the mixing cylinder. The piston is then lifted onto the shaft of the borehole 134 by the ramp, leaving space for movement and solids. Movement of valve 108 causes an inflow of solvent through tube 137 and under movement of piston 19 against spring 138. A resilient plate 139 in the piston acts as a mixer and is actuated by the reciprocating movement of a piston rod 140 on a lever 141. on the other hand,
As the valve 108 moves, the solvent is continuously or intermittently introduced with the outflow valve 25 closed. The shaft opening is closed with a sterilizing agent, or the lever is covered with a thin film layer. In the latter case the thin film layer also covers the shaft opening. Example 16 Figure 17 has a thermally insulating cannula adapter portion onto which a cannula with a metal extension can be inserted. The contact spring 142 to the cannula adapter part is connected to the DC generator 1.
It is connected to 43. When this generator is connected, a current short circuit occurs in the cannula with intense heating. EXAMPLE 17 In FIG. 18, the Verteil member 144 surrounds the cannula adapter part and the cannula for cooling in cylindrical fashion and can be pushed back towards the opening via the metering cylinder. . EXAMPLE 18 In FIG. 19, two liquids from containers 15 and 98 for oral use by actuation of valve 145 are drained by a common outflow valve. The amount of medicament is then predetermined by means of a dosing piston, and the amount of rinsing liquid can be varied by the length of time the valve is actuated. EXAMPLE 19 In FIG. 20, the reservoir 145 is configured such that two medicament compression bottles can be delivered therein, one medicament compression bottle being firmly connected to one of the dispensing cylinders 15a through an insertion tube 146a. are combined. The other adjacent drug compression bottle with the insertion tube 146b is connected to the dispensing cylinder 15b after the lid 147 is removed and the check valve 25 is opened. The drug outflow into the dosing cylinder is controlled by a lever device 14.
Occurs after opening of valve 166 by 8b. This is achieved, for example, by a wall cladding 180 in which a reservoir associated with the telescoping device of the guide shaft 152 surrounds both dosing cylinders.
This means that drug outflow occurs during the sinking in the guide groove. The movement of the metering pistons 19a, 19b is limited by the length of the chords 125a, 125b. The chord length can be determined along the metering scale 17 by means of the cut-off device 154a. The space between the chord extension of the dosing piston and the opening for the chord is closed by an elastic plug 155a. This plug is inserted into the central cavity of the dosing piston when the dosing cylinder is in the discharge state. A cover disk 160 with a compression spring 158 is fixed above the valve ring. The reverse movement of the dosing piston is caused by the spring 12 during ventilation of the cylinder.
4a, 124b, either after the opening of the valve 30 by the pressure of the cannula, or, as in variant A of detail A, by the suction of the suction syringe of the piston ring 161 against the control spring 162. The decoupling of both dosing cylinders of the common cannula adapter part takes place via a movable cover. The cover part 54 is connected to the movable sheathing part by means of an elastic ring 163 and separates only after the removal of the sterilizer by the movement of the sheathing relative to the spring 164, releasing the cannula adapter part. As a disinfectant, mastic drops are dissolved in a disinfectant such as Lysol or Melfen to the desired concentration. Emulsions are also suitable for this mixing. In the solution of variant B of detailed view A, the used cannula is not removed, but is settled in the sterilizing liquid reservoir 165 until the device is reused, or is it settled in the sterilizing body to block the inside of the cannula? It is. The counting mechanism 168 is actuated via the journal 167 and itself acts on the alarm device depending on the adjustment of the eyepiece 173 from which the number of possible uses can be read in the case of a given dose. The above usable quantities are shown in the table below, corresponding to the dosing unit.

[Table] In modification A of detailed view B (however, Fig. 20z), the drug outflow pipe (however, Fig. 20) 146
The space between a, 146b and the drug outlet opening in the dosing cylinder is covered with a membrane. This membrane is expanded by drug pressure into the trough-like cavity of the valve annulus, allowing filling of the cylinder. on the other hand,
The movable valve disc edge presses a rubber (silicon) membrane against the outside of the tank structure. FIG. 20A shows three dosing cylinders 15a, 15
b, 15c shows a schematic diagram of a solution with three different drug reservoirs; FIG. 20B shows a solution with one drug reservoir and two dosing cylinders 15, 15'. FIG. 20C shows a solution comprising two drug reservoirs in which each reservoir is equipped with two dosing cylinders 15a, 15a' and 15b, 15b' respectively. EXAMPLE 20 FIG. 21 shows a variant of the invention with a double membrane (valve) feature 145 similar to FIG. 19 for oral use. EXAMPLE 21 FIG. 22 shows a tube injection device with two electromagnetic valves 76 for alternate outflow of drug and wash water and a U-tube 175 for water circulation for valve purification. . (Motor drive is also possible)
FIG. 22a shows two wash water tubes 176 leading to the metering pump 146. A mechanical check valve 30 is located in front of the metering pump 39. A counting unit with a metering pump will produce a
It is equipped with a contact switch that sends control impulses. Figure 22b shows a piston arrangement within a drug container with an internal piston 178 whose movement is prevented by a spring-loaded shut-off plug 179. After the contents of the drug container have been used, upon opening of the connecting sheath 181, the load on the shut-off plug 179 is relieved, thereby freeing the movement of the internal piston. A piston 195, which rests loosely on it via a ram, is introduced into the drug delivery tube, from where it is forced by gas pressure through the gap 182 in contact with the internal piston. Example 22 FIG. 23 shows the dosing created via subsidence of the covering plate. In FIG. 23a, the dosing is formed through the subsidence of the cover plate, which accommodates the cannula with the pouch 186, the sealing device 187 for preventing drug backflow, and the storage chamber at the tip of the cannula in the rubber cone 188, and in the base plate. Around the tethered spindle,
This occurs as a result of the drug compression bottles in the metering chamber being arranged in a circular shape. Example 23 In Figure 24, a drug compression bottle is fitted into an aspiration/injection device. Propulsion of the drug vial occurs by means of a spring 189 after actuation of the suction switch 190 by the jet low pressure of the water jet pump. Figure 24a shows an example of dispensing from two drug vials with a key-operated dispensing device in which the cap of the aspiration bell 240 is opened and sealed via a clamp. The drug outflow valves 150 are each actuated by a suction switch in which the slider is alternately blocked. Embodiment 24 FIG. 25 shows the piston 191 being moved by the gas pressure from the compression bottle against the spring 192 after actuation of the 2/2-valve 193. If this load is removed, a suction is created in the suction chamber by the action of the spring during the ventilation through the 2/2-valve. Once the cover has been opened and the suction evacuation bell 25 has been placed on the skin, dispensing and injection is actuated by pressure on the medication vial. Embodiment 25 FIG. 26 shows a situation with direct suction generation via the gas pressure effect on the double piston. Gas is drawn from around the suction and exhaust bell via a bellows coupler under the action of a sliding piston 196 of the compression bin. Injection of drug into the dispensing cylinder occurs via depression of the lever arm, and dosing adjustment is
This is done by means of a tightening ring 194 through the length restriction of the straightened string. A knot at the end of the string acts on a vent valve 197. The order of operation is that the device is placed on the skin, the drug is injected and the bellows type coupler is forcibly activated, and the slider type piston 1 is activated.
96 is carried away, so that suction is generated via the piston 191. Movement of the piston stretches the spring until an increased suction force opens the suction valve 150. After venting, the piston 191 returns to the starting point by the force of the spring. The suction covering can be removed. A series of auxiliary devices have recently been developed specifically for the purpose of self-injection in diabetic patients. The device facilitates pain control when a pre-prepared injection syringe approaches the patient's body and punctures the patient by means of a spring mechanism. This device, which has recently been produced in Stuttgart, allows the depth of the puncture to be adjusted as desired by the patient. This insulin injection cannot be interrupted midway. Making full use of such devices is not desirable. This is because there is no guarantee that the syringe will not puncture blood vessels, nerves, or bones. In particular, since this device is cleaned using a disinfectant, it can easily be confused with insulin. Dosing takes place here by puncturing a conventional air syringe into a storage bottle in an attached glass cylinder and then pulling it back to a stop. In the present invention, the skin is separated from the dangerous area by suction draft and then pulled up into the cannula. The cannula is designed to deflect as much pain as possible and also aids in the injection of medication. In the UK patent application (No. 49990/
No. 74) Added new relevance to the above principle. The safety of three-point skin contact, the provision of suction ventilation chambers, the use for the blind, or automatic dispensing represent excellent adaptations to technological advances. Next, some reference examples will be described below to help understand the present invention. Reference Example 1 Figure 1X shows a cylinder 1, in which a tension lever 2 inside the cylinder relieves the tension of a spring 3. The oblique position of the pin 4 allows this axis to remain in the suction chamber, and the arrangement as a three-point pin ensures a balanced load on the skin. The retaining pins 5 (two of which are spring-shaped, their central part is prevented from rotational movement, and are connected to the piston rod via a plate) are pins The cut end of the bottle engages with the notch on the horizontal bottle. Two traction springs 6 on the strut 7 cause the fork-like part 11 attached to the strut to sink. Removable dosing container facilitates insertion of different types of syringes,
The wide opening for the suction bell, in particular the connection from the head with the suction ventilation switch 8 and the rubber tube connection 9, depending on the length of the column, also facilitates the insertion of the drug compression bottle together with the dosing device. If a drug compression bottle is used, a suction vent switch 8 retarding friction allows for ventilation of the suction vent chamber. After raising the fork-shaped part 11 to the extent that it engages the suction draft brake pin 14, the fork-shaped support clamp 12 will be pushed back. After placing the rubber plate together with the metal ring 13, the dispensing syringe with cannula is mounted on the head and fixed using a support clamp. After the pull lever has been operated in the pin until it engages with the support pin 15, the pull lever is again pulled back to the support column by the spring. Once the suction bell is thus placed on the skin, the pin begins to work,
Along with this, the piston 16 also begins to operate. The skin is pulled up by the suction ventilation and the pin is retracted into the suction ventilation chamber due to the pressure of the spring. The suction draft through the rubber tube connection acts on the membrane of the suction draft switch and releases a fork-like part, which spring-like fork catches the clamping rod 17 in the casing of the doser. and empty the syringe. This is because the spring formation of the fork allows the fork-like part to sink further, and the ventilation valve 18 is actuated by one pin. Reference Example 2 Figure 2X shows one device with three pins 4. The three pins are located outside the suction ventilation chamber and are arranged around the elastic tight edge of the absorption bell. On the slope of one square crosspiece 19, the pin movement is transmitted per one spring-shaped push rod 20. That movement releases the brake lock 21 and with it the piston 16.
It also opens up movement. Reference Example 3 Figure 3X shows the hydraulic manifestation of the suction ventilation piston, which is due to the expansion 22 of the three pillows of the elastic ring tube together with the liquid, which reaches the maximum displacement. In some cases, the piston rod 20 is opened, thereby affecting the spring-like propulsion piston. Reference Example 4 Figure 4X shows the expression of air compression through an airflow, which is generated within one blower. The closure by the ring-shaped tube with the three openings on the edge of the absorption bell affects the propelling piston, which is likewise spring-shaped by the skin, as shown in FIG. 3X. Instead of the piston 16, a blower consisting of a bellows coupling can also be used. Reference Example 5 FIG. 5 shows an example in which a solid substance is dissolved by a solvent introduced into a pipe through a filling pipe neck. At this time, the flow is diverted to the reservoir 500, the powder is dissolved, and the syringe is finally filled. Reference Example 6 Figure 5a shows a tube section 500 filled with a fibrous material or multiple filter layers acting like a filter.
It shows a. The tube end is coated with a solid material that dissolves when introduced into the flow between the fill tube neck and the syringe cone. The effect of the drug dispensing device and the assembly of the drug dispensing device and the injection device of the present invention is that the pressure of the pressurized gas forces the drug solution from the closed container into the dispensing chamber. A dosing chamber can be arranged on top of the dosing chamber, so that the dosing chamber faces the operating side when the drug solution in the dosing chamber is injected into an injection device etc., and the said operation is carried out. In addition, in a device in which a closed container is placed above the dispensing chamber in normal use, the device functions even when the device is turned upside down, so injecting into the injection device should also be performed from this point of view. There are things that can be done to make it easier. The embodiments are listed below. (1) Bellows type couplings with lifting or forward movement by means of piston-cylinder type pumps or partially automatic (actuated by pre-stored or hydraulically or pneumatically or electrically generated power); at least one device for variable pre-positioning by or by a flow restrictor of a rotary pump is fixed or fixed in front of or behind or between at least one drug storage container having a volume larger than a single dose. provided in a rigid connection with a movable or partially fixed and partially movable enclosure, or connected in accordance with regulations;
This is a power source that generates or transmits a driving force from a drug that is prescribed according to its dosage for immediate use using devices based on membranes or pistons or gears (i.e. via motion transmission devices of moving mechanical parts). It can also be carried out by means of a syringe as an intermediary during separation or by means of a connected hollow chamber cannula and also by means of an external movement limiting body or hollow chamber limiting body, and if necessary with a washing liquid for oral use. At least one container or inlet tube is firmly or detachably connected in front of the drug outflow opening or in front of the outflow valve, and has biological utility by preventing bacterial retention in the stored drug during injection use. Devices are provided for the closure of drug outlet openings when not in use, and this closure may be accomplished by sealing, including the use of bactericidal or bactericidal substances or additives; shaping the area of the drug outflow opening, which also encompasses the outflow valve, to a shape that reduces air contact through a container surrounding the drug outflow opening that is placed under the influence of a sexually active substance and sealed against outside air; or by devices for suction of said area or for mechanical mass transfer (including gas or liquid cleaning) or for increasing the adhesion of the closure device; or by a device that automatically regenerates the closed state (actuated by power generated by electricity) or by a device that exerts a thermal influence, all said protective devices being fixed or removably connected. 2. Device according to claim 1, characterized in that a cannula can also be included or a single dose is provided with a driving force generating power pre-stored inside the container. (2) The device according to claim 1 and the preceding paragraph (1), characterized in that at least one compression bottle is used as a power source. (3) The device according to claim 1 and the preceding paragraphs (1) and (2), wherein the drug container has one or more openings only toward one side. (4) The device according to claim 1 and the preceding paragraphs (1) to (3), wherein the drug inflow/outflow conduit is firmly connected to the container or forms a part of the container. . (5) Claim 1 and the preceding paragraphs (1) to (4), characterized in that the volume of the drug to be administered is replenished within the coating, and this coating acts to separate the drugs. The device described in. (6) The device according to claim 1 and the preceding items (1) to (5), characterized in that the membrane under pressure expands from the bottom of the container. (7) Claim 1 and the preceding paragraph characterized in that the outflow of the drug is caused by the pressure of the liquid or gas or a mixture of liquid and gas against the membrane.
The device described in (1) to (6). (8) Claim 1 and the preceding paragraph characterized in that the power source for transmitting the drive acts from inside or outside the membrane, and the membrane extends along the enclosure wall of the container.
The device described in (1), (2), and (5). (9) The gas or liquid chamber for volume replenishment of the drug and the used drug may be provided by means of a membrane or a piston or a structure with a fork-like function, or by a membrane and a structure with a piston function. The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the two parts are separated. (10) The device according to claim 1 and items (1) and (2) above, wherein the power source for generating the driving force is a compressor. (11) The device according to claim 1 and the preceding paragraphs (1) and (2), wherein the outflow valve operates by penetrating the drug outflow opening. (12) the connection to the syringe or cannula inside the drug outlet opening is actuated to operate the outlet valve;
The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the device is moved toward or away from the drug container. (13) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the valve in front of the drug inlet inside the dispensing chamber is operated through the drug outlet opening. . (14) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the valve in front of the drug inlet in the dispensing interior is actuated via a rotational movement of the valve. (15) The periphery of the drug outlet opening is constructed in such a way that a syringe or cannula can be connected to the periphery directly or via an adjustment part. ), the device described in (2). (16) A connecting part is inserted between the drug outlet opening and the syringe or cannula, which connecting part contains the solid or liquid drug or the substance necessary for the action of this drug in a predefined amount. The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the device is dissolved by the effluent liquid. (17) Claim 1 and the preceding paragraphs (1), (2), and (16) characterized in that the swirling of the liquid by the off-center flow guide effectively acts on the dissolution of solid or liquid substances. The device described in. (18) The device according to claim 1 and the preceding paragraphs (1), (2), and (16), wherein the filter device has an advantageous effect on dissolving solid substances. (19) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that a semipermeable dispensing container is used. (20) The transfer of the drug into and out of the dosing chamber for dosing may occur directly or indirectly via the medium of a spring or via liquid pressure as a driving power source. The device characterized by claim 1 and the device described in the preceding paragraphs (1) and (2). (21) Claim 1 and the preceding paragraph characterized in that the drug is transferred from the dispensing chamber by means of previously stored power through the drug outlet opening.
The device described in (1) and (2). (22) The device according to claim 1 and the preceding paragraphs (1) and (2), wherein the dispensing container is movably attached to the drug storage container. (23) Claim 1 and the preceding paragraphs (1) and (2), characterized in that the movement of the drug into the dispensing chamber takes place via a valve having an off-centre valve slit. The device described. (24) The valve generally temporarily obstructs the transfer of the drug into the dosing chamber via a disc or mechanical obstruction, said obstruction being temporarily influenced through rotation of the dosing container; The device according to claim 1 and the preceding paragraphs (1), (2), and (23), characterized in that the device loses its effectiveness due to pressure equalization between the drug storage chamber and the dispensing chamber. (25) Claim 1 and the preceding paragraph (1), characterized in that the drug outlet opening is sealed by a sealing membrane or a plug or an elastic cushion (filled with air or a liquid that can dislodge to the side). , the device described in (2). (26) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that at least one dosing device is present in the neck of the medicine bottle or inside the medicine container. (27) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the metering is carried out using a hollow body with an elastic wall. (28) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the boundary of the metering chamber is fixed to a single volume value. (29) It is assumed that the dosing boundaries are fixed at two volume values which can be predefined or are fixed at or within the drug container at a volume value which cannot be predefined by the user. The device characterized by claim 1 and the device described in the preceding paragraphs (1) and (2). (30) The device according to claim 1 and the preceding paragraphs (1) and (2), wherein the drug container is hexagonal. (31) Claim 1 and the preceding paragraph (1), characterized in that the dosing is carried out through limiting the syringe piston movement outside the drug outlet opening;
The device described in (2). (32) Dosing takes place via restriction of the piston movement of the syringe at a fixed or movable obstruction, which is rigidly connected or connectable to the drug container, or which Claim 1 and the preceding paragraph characterized in that it is given by the shape of the container (e.g. recess in the wall)
Devices described in (1), (2), and (31). (33) Dosing is effected by means of a device through restriction of the syringe piston movement, said device consisting of a holding chamber for the syringe and a bar for the end of the piston, the latter being fixed or freely fixable. Claim 1 and the preceding paragraphs (1), (2),
The device described in (31). (34) A patent claim characterized in that the device for limiting the syringe piston movement and actuating the medicament outflow valve can be or is connected to the holding chamber by a spring or to the medicament container without a spring. Scope 1 and the preceding paragraph (1), (2),
The device described in (31) and (33). (35) Claim 1 characterized in that the device for limiting the syringe piston movement can be arranged around at least one axis in order to save space or to facilitate access to the drug outlet opening.
and the devices described in the preceding paragraphs (1), (2), (31) to (34). (36) Claim 1 and the preceding paragraphs (1), (2), (31) to (35), characterized in that several devices for limiting the syringe piston movement are fixed to the drug container.
The device described in. (37) at least one for syringe piston movement;
The device according to claim 1 and the preceding paragraphs (1), (2), (31) to (36), characterized in that several mechanical obstacles can be moved or inserted along the metering scale. . (38) Claim 1 and the preceding paragraphs (1) and (2), characterized in that a covering with fixed or movable obstacles for the movement of the syringe piston is used, surrounding the syringe cylinder. , (31) to (36). (39) The valve between the dosing chamber and the drug outlet opening is characterized in that it is actuated by being pulled back into its original position by a spring or by being pulled without returning to its original position by a spring. The device according to claim 1 and the preceding paragraphs (1), (2), (31) to (38). (40) Claims characterized in that a syringe with a piston rod with limited movement or a movement limiting device is used movably or non-movably within or in a part of the syringe cylinder. 1 and the devices described in the preceding paragraphs (1), (2), and (31). (41) Claim 1 and the preceding paragraphs (1), (2), (31) characterized in that the obstruction to the movement of the piston rod can be disabled, in particular in order to inhale air into the veins. ) to (40). (42) The restriction of the movement of the syringe piston is carried out inside a suction injection device, characterized in that the skin is moved by suction towards and through the cannula, i.e. along the cannula. Claim 1 and the preceding paragraph (1),
The device described in (2) and (31). (43) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that a solenoid valve is used. (44) A patent claim characterized in that the control of the valve in front of the drug outflow opening is carried out using electromagnetism or sound waves in the insensible range, such as subaudible or ultrasonic waves, via a guide stop rod. Scope 1 and the equipment described in the preceding paragraphs (1), (2), and (31). (45) Connection mechanisms requiring rocking can affect (actuate) the drug outflow valve during uneven impacts in a predefined position between the syringe piston and the cylinder or surroundings. ) Claim 1 and the preceding paragraph (1),
The device described in (2) and (31). (46) Separators inside the hollow chamber connector (particularly inside the tube) can partition the stored drug into equal or varying or increasing or decreasing doses, or from other liquids or as a source of transmission power. The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the device separates from a gas or a gas mixture. (47) Claim 1 and the preceding paragraphs (1), (2), (46) characterized in that a device for removing the drug separator is disposed in front of the drug outflow opening or through the opening. ). (48) Claim 1, characterized in that the drug container having a drug outflow opening is stored downward.
and the equipment described in the preceding paragraphs (1) and (2). (49) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the liquid or gas flow is directed outward from the drug outlet opening or above the opening. . (50) The covering of the plate-shaped or goblet-shaped drug outlet opening is removed by rotation on a vertical or horizontal axis or by a lateral displacement and is moved upwardly by the pre-stored power. The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that it is returned to the closed state. (51) Claim 1 and the preceding paragraphs (1) and (2), characterized in that the adhesive or adhesive foil closes the drug outflow opening in a stacked state inside the covering device.
The device described in (50). (52) Claim 1 and the preceding paragraphs (1) and (2) characterized in that the blocking of the drug outflow opening is strengthened by the suction action from a special device, reducing the effect of air inflow into the stored drug. , (50). (53) The blocking of the drug outflow opening is carried out by a belt, which is passed through the opening and has a channel for the drug outflow opening or syringe cone. The device according to claim 1 and the preceding paragraphs (1) and (2). (54) Claim 1 and the preceding clause, characterized in that at least one belt is coupled to a belt pressing device and moves in a direction passing through the drug outflow opening in order to mechanically remove the settled dirt. (1),
The device described in (2). (55) Claim 1 and the preceding paragraph, characterized in that for blocking the drug outflow opening, a surface-metallized substance or metal is used with or without magnetic force for the closing action. Equipment described in 1) and (2). (56) Claim 1 and the preceding paragraph (1), characterized in that the drug outflow valve is operated by a tube probe, and the tube probe is introduced into the interior of the syringe to be dispensed to restrict the piston movement of the syringe. , (2). (57) Claim 1 and the preceding paragraphs (1), (2), and (12), characterized in that a device for manual operation of the outflow valve is provided near the drug outflow opening. Device. (58) Claim 1 and the preceding paragraphs (1) and (2) characterized in that the tubular extension between the dosing chamber or the outflow valve and the drug outflow opening is arranged in a straight or curved manner. ). (59) In order to avoid confusion, the dosing should be perceivable and audible by easy movement, and the holding device for at least two drug containers (if the latter is used) should also have a left and right hand for the dosing. Device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that a device is provided to facilitate the differentiation of the two, and confusion can be further avoided by means of symbols or color markings. (60) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that at least two different drugs are discharged from separate drug containers through a common drug outlet opening. . (61) Claim 1 and the preceding paragraphs (1) and (2) characterized in that the square drug container is used individually or connected to a dispensing mechanism via a holding device or a special wall device. ). (62) Claim 1 and the preceding paragraph (1), characterized in that a liquid stream or a gas stream is arranged for purification inside the arrangement chamber or inside the introduction passage connected to the metering chamber; The device described in (2), (49). (63) Liquid or gas is automatically circulated periodically or via a repeating timer into the metering chamber or the space in front of the inlet passageway or outlet valve connected to the metering chamber or into all said hollow chambers. Claim 1 and the preceding paragraphs (1), (2), (49),
The device described in (62). (64) Claim 1 and the preceding paragraph (1), characterized in that the dispensing device or drug container is replaceable;
The device described in (2). (65) At least two dispensing devices are connected to a common purification device, which purification device can also be a driving power source for drug transfer. ), (2) and (62) to (64). (66) Claim 1 and the preceding paragraphs (1), (2) and (62) to
The device described in (64). (67) The configuration with a space in front of and around the drug outflow opening protects the cannula left there from contamination and damage by blocking it between uses; this configuration also seals the tip of the cannula. may be subjected to the action of gas or liquid when
It can also operate without the action of gas or liquid, but
The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that in this case, the device does not need to be sealed. (68) The device according to claim 1 and the preceding items (1), (2), (62) to (65), characterized in that the gas or liquid is propelled by a common driving force source. (69) A gas container or a spray or cleaning liquid container connected or connected in a prescribed manner with a drug container, or a drug opposed in a container that collapses under pressure inside an elastic tube or other container. characterized in that the drug or cleaning liquid is present inside a common container which has an opening common to the outflow opening or in the vicinity of the outflow opening or which is closed at least when the outflow opening is circumferentially closed. Claim 1 and the preceding paragraphs (1) and (2)
The device described in. (70) The intermediate part to the syringe cone or cannula adapter part is characterized in that, when not in use, it is drawn down behind the cover of the drug outlet opening and is under the influence of the gas or liquid flow. Claim 1
and the preceding paragraph (1), (2), (49), (62) to (65), (68)
The device described in. (71) The opening between the drug container and the outside air is closed by a deformable substance with properties between solid and liquid, which substance has bactericidal or antimicrobial properties. Claim 1 and the preceding claim characterized in that they may contain certain admixtures.
The device described in (1) and (2). (72) The periphery of the drug outlet opening, which comes into contact with the outside air during drug release, does not allow the cannula to remain fixed, even if it is configured as a device for receiving a syringe cone or a cannula adapter. In this case, the device is also at least occasionally under the influence of a purifying flow of gas or liquid behind the cover when not in use.
Devices described in (1), (2), and (49). (73) After the solid substance is introduced into the hollow chamber via a conveying device in the form of tablets or compressed bodies of various sizes, it has been supplemented with a dissolving liquid in the prescribed manner and the effect of the mixing machine has been foreseeable. The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the air is discharged by contracting the hollow chamber. (74) Claim 1 and the preceding paragraphs (1) and (2), characterized in that a hole disk, which may be provided with holes of various sizes, is used for transporting solid substances.
The device described in (73). (75) Claim 1 and the preceding paragraphs (1) and (2), characterized in that the hollow chamber is reduced by a piston that may also be driven by the flow of the solution.
The device described in (73). (76) The device according to claim 1 and the preceding items (1), (2), and (75), wherein the piston for reducing the hollow chamber is propelled forward by a spring. (77) The container surrounding the cannula or cannula adapter or syringe cone may be filled with a liquid or free substance in chemical, physical, or spatial bond, or a combination thereof, with or without the addition of a disinfectant. Before and during use, the opening may be moved in the direction of the drug container under the passage of the cannula or cannula adapter part or filling connection for the syringe cone by a sealed or covered opening, said opening being moved in the direction of the container. The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that it can also be generated and operated by. (78) Any agglomeration between gas and deformable solids of the material surrounding the cannula or cannula adapter or filling connection prevents the material from mixing with the drug to be administered. At least one device is provided to prevent this, and this prevention can also be effected by a mechanical seal, or by a suction device or by the creation of a hollow chamber into which said substance can return, or by a gap between the outflow valve and the drug outflow opening. Claim 1 and the preceding paragraph (1), characterized in that it may be carried out by a possible liquid or gas flow,
(2), the device described in (77). (79) Claim 1 and the preceding paragraph ( 1), (2),
The device described in (78). (80) Claims 1 and (1), characterized in that, if a chamber suitable for the introduction of a syringe cone is required, a valve device is provided directly behind the drug outlet opening. The device described in 2). (81) Claim 1 and the preceding paragraph characterized in that a bactericidal or antibacterial covering is utilized in the device, particularly around the drug outlet opening.
The device described in (1) and (2). (82) Claim 1 and the preceding paragraph (1), ( The device described in 2). (83) Claims 1 and 2, characterized in that the substance or mixture surrounding the cannula or the cannula adapter part or the filling connection for the syringe cone becomes more liquefied (teixotropic) under the influence of movement or pressure. Devices described in the preceding paragraphs (1), (2), and (78). (84) At least one substance containing a solid substance or a liquid
The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that each container is firmly connected to a container containing a dissolving liquid or a cleaning liquid. (85) Device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the metering piston is moved via a tension device consisting of one chord. (86) Claims characterized in that the piston, which may for example consist of glass or plastic material, separates the drug from a membrane as a source of transmission power, which membrane may also be a bellows type coupling. 1 and the equipment described in the preceding paragraphs (1) and (2). (87) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that at least two dispensing devices are connected to a common drug container. (88) The device according to claim 1 and the preceding paragraphs (1), (2), and (87), characterized in that the metering devices are mounted spatially close and parallel. (89) The device according to claim 1 and the preceding paragraphs (1), (2), and (82), wherein the suction that opens the outflow valve acts in the direction toward the drug outflow opening. (90) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the suction that opens the outflow valve acts in the opposite direction to the direction of the drug outflow opening. (91) A flexible connection to the dosing piston or, in short, to the dosing chamber to the limiting body (e.g. in the case of the use of a bellows coupler) is provided with a shut-off device or a dosing device in the flexible connection. It is possible to make dosing possible by predefining the distance that can be introduced into the dosing cylinder depending on the permissible range of movement for the chamber-limiting container (e.g. when using a bellows coupling). Characteristic Claim 1 and the preceding paragraph
Devices described in (1), (2), and (85). (92) Claim characterized in that the flexible coupling body is fixed to the dosing piston surface or the dosing container surface arranged in the direction of the drug outflow opening and acts in the direction of the drug outflow opening. Scope 1 and the preceding paragraph
Devices described in (1), (2), (85), and (91). (93) Flexible connection means between the fixed position on the dosing piston or dosing container and the stopper limit position of the dosing movement around the fixed edge, leading from the dosing cylinder or dosing container to the outflow valve. Claim 1 and the preceding paragraphs (1), (2), (85),
The device described in (91) and (92). (94) It is provided that the medicament is introduced into the dosing cylinder or the dosing container on the side of the drug outflow opening or, in short, into the space between the outflow opening and the dosing piston or the movement limiter of the dosing container. The device characterized by claim 1 and the device described in the preceding paragraphs (1) and (2). (95) The introduction of the medicament into the dosing cylinder or dosing container or at least one space takes place via a rotationally operated valve control device, in which case the various valves may be activated one after the other in a number of dosing cylinders or dosing containers. Device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that sometimes only one type of valve is used to operate the device. (96) Claim 1 and the preceding paragraph characterized in that the rotational direction of the device acting on the valve control changes.
Devices described in (1), (2), and (95). (97) Claim 1 and the preceding paragraph (1), characterized in that the valve control of drug inflow is performed inside the telescope device in the surrounding wall container;
Devices described in (2), (95), and (96). (98) Claim 1 and the preceding paragraph characterized in that at least one drug container is replaceable.
Devices described in (1), (2), (60), and (84). (99) Claim 1 and the preceding paragraphs (1) and (2), characterized in that a sealant mass that may also contain a substance having a bactericidal or antibacterial effect is present inside the cannula adapter part. The device described in. (100) Between uses or after use, the cannula remains connected to the device according to regulations before fixing a new cannula just before use, which may also be attached to the cap and which has a bactericidal or antimicrobial effect. Claim 1 and the preceding paragraphs (1) and (2), characterized in that the cannula syringe is sealed in a customary manner by immersion inside a container or a sealing device which may contain the active substance.
The device described in (99). (101) Claim 1 and the preceding paragraphs (1) and (2), characterized in that there is a device for leaving a sealed cannula inside the suction injection device.
The device described in (99), (100). (102) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the usable number of stored drugs can be read from a list. (103) The device according to claim 1 and the preceding paragraphs (1), (2), and (102), wherein the alarm device is activated during or before use of the stored drug. (104) A water or solvent or cleaning agent conduit is provided in front of the drug outlet opening in connection with an open or closed, rigid or at least partially flexible container for oral use. The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that: (105) According to claim 1 and the preceding paragraphs (1) and (2), the outflow of the drug and solution or cleaning agent is operated through a common valve device behind the drug outflow opening. equipment. (106) Claim 1 and the preceding paragraph (1), characterized in that the drug outflow is operated through a double valve.
(2), the device described in (105). (107) Claim 1 characterized in that a bactericidal or antibacterial elastic material is used instead of the sealing putty mass inside the cannula adapter part.
and the devices described in (1), (2), and (99) above. (108) In similar quantities after the preceding paragraph (32),
The syringe piston is held at a stable spatial distance relative to the medicament container via the retaining device, and the syringe cylinder is moved toward a predefined fixed or variable stop while the outlet valve for the stored medicament is opened. The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the metering is carried out by opening or opening the device. (109) Claim 1 characterized in that it is at least sometimes effective in the area of the cannula or drug outlet opening for heat or cold generation.
and the equipment described in the preceding paragraphs (1) and (2). (110) Claim 1 and the preceding paragraph (1), characterized in that the drug is propelled by a bellows-type coupler or similar device, and the bellows-type coupler or similar device serves as a drive transmission power source; The device described in (2). (111) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the single dose is prepared in the cannula and the connecting container. (112) The device according to claim 1 and the preceding paragraphs (1), (2), and (111), characterized in that the single dose is prepared in a bag-like container. (113) The device according to claim 1 and the preceding paragraphs (1), (2), (11), and (112), characterized in that the container has a device for preventing backflow from the cannula. . (114) Claim 1 and the preceding paragraphs (1), (2), (11) - characterized in that the cannula tip is stored in an elastic pad or behind a membrane in the rest state. (113). (115) Claim 1 and the preceding paragraph (1), characterized in that the dosage is determined within one container by selecting or adjusting the dimensions of the container, or by limiting the range of dimensions. (2), (11)～
The device described in (114). (116) Claim 1 and the preceding paragraph (1), characterized in that the coupling device is used with the possibility of a syringe or with the possibility of draining the drug through a cannula, The device described in (2). (117) Device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that it is dispensed from an at least partially movable hollow connection part or tube. (118) Claim 1 and the preceding paragraphs (1) and (2), characterized in that the separator between doses is used in the same or previously changed doses;
The device described in (117). (119) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that a rotary pump is used. (120) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that a solenoid valve is used. (121) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that a valve controlled by a liquid is used. (122) The device according to claim 1 and the preceding paragraphs (1), (2), and (117), characterized in that a cleaning hollow chamber or a water tube is used. (123) Claim 1 and the preceding paragraph (1), characterized in that the device for separating the gas or liquid from the flow of the drug from the drug container in the direction of the outlet opening is activated only after the main store has been used. ,(2),
The device described in (117). (124) The device according to claim 1 and the preceding paragraphs (1) and (2), characterized in that the separation device is used in one or more suction/injection devices. (125) The device according to claim 1 and the preceding paragraphs (1), (2), and (124), wherein the suction and exhaust bell for replacing the cannula is made so that the lid can be opened. (126) Claim 1 and the preceding paragraph characterized in that the triggering of the suction generating action or the triggering of suction into the suction exhaust bell is caused through a manual valve.
Devices described in (1), (2), and (124). (127) The triggering of the suction-generating action or the induction of suction into the suction exhaust bell is caused by placing the suction exhaust bell on the skin through a mechanical device (a device using compressed air). The apparatus according to claim 1 and the preceding paragraphs (1), (2), and (124). (128) Claim 1 and the preceding paragraph characterized in that the main part of the suction and exhaust bell is made to be removable for replacing the cannula.
Devices described in (1), (2), and (124). (129) Claim 1 and the preceding paragraph characterized in that the suction is caused via compressed gas storage or a pressure generating device, either constantly or as appropriate (or occasionally) in connection with the pressure generating device.
Devices described in (1), (2), and (124). (130) Claim 1 and the preceding paragraphs (1), (2), characterized in that the ventilation of the suction chamber occurs via a (frictionally delayed) device.
(124). (131) Claim characterized in that the suction is generated via one or more pistons movable by gas pressure and moved by a piston (connected to a piston operated by gas pressure) Scope 1 and the preceding paragraph (1), (2), (124)
The device described in. (132) The device according to claim 1 and the preceding paragraphs (1), (2), and (124), characterized in that the device for ventilation of the suction chamber is operated by a manual lever. (133) Claim 1 and the preceding paragraphs (1), (2), (124) characterized in that the ventilation in the suction chamber occurs as a result of the movement of mechanical parts moved by gas pressure.
The device described in. (134) The device according to claim 1 and the preceding paragraphs (1), (2), and (124), wherein the gas pressure is used for the purpose of reducing the size of the drug storage chamber. (135) The device according to claim 1 and the preceding paragraphs (1), (2), and (124), wherein the mechanical slide tube device is used for the purpose of reducing the size of the drug storage chamber. (136) The device according to claim 2, wherein the occurrence of piston traction or the occurrence of blower expansion occurs at or around three points on the suction bell edge. (137) The device according to claim 2 and the preceding item (136), wherein the piston traction or blower expansion is caused by three pins. (138) Claim 2 and the preceding paragraph (136 ), (137). (139) Claim 2 and the preceding paragraph (136)-- characterized in that the expression of piston traction or the expression of blower expansion is caused by three oblique pins within the suction ventilation chamber.
(138). (140) The device according to claim 2, characterized in that the onset of piston traction or the onset of blower expansion is caused by a pin outside the area of the suction ventilation chamber. (141) Device according to claim 2, characterized in that the development of piston traction or the development of blower expansion is caused by a displacement of liquid volume from the edge of the suction draft chamber, ie by water pressure. (142) The development of piston traction or the development of blower expansion occurs through the air pipe with a ring-like progression at the edge of the suction ventilation chamber after the opening is closed. equipment. (143) Device according to claim 2, characterized in that the emptying of the cavity containing the drug is by the influence of a spring mechanism. (144) Claim 2 characterized in that the cavity containing the drug is emptied by the influence of a braking mechanism on which suction ventilation is applied.
and the device described in the preceding sections (136) to (143). (145) One lever transmission is a suction ventilation piston,
or for the spring tension driving the blower.
The device described in. (146) The device according to claim 2, characterized in that the suction ventilation chamber after the injection is ventilated by a single valve mechanism. (147) Claim 2 and the preceding paragraphs (136) to (146), characterized in that the valve mechanism for ventilation of the suction ventilation chamber is operated by a mechanism for emptying the cavity chamber. The device described. (148) A dosing device or a hollow body together with a cannula can be inserted or installed in the suction ventilation chamber with one sealing plate. Device. (149) Device according to claim 2, characterized in that an internally dosed drug container can be used.

[Brief explanation of the drawing]

Fig. 1 is a cross-sectional illustration of a two-chamber dispensing device in connection with a drug bottle with a ventilation device connected to the membrane, and Fig. 2 is an example of a two-chamber dispensing device using a drug container already under gas pressure. Cross-sectional explanatory diagram of the dispensing device, second
Fig. 2a is a sectional view showing a coating containing a drug and a pin wall containing gas surrounding the coating and the filling tube extension; Fig. 2b is an explanatory cross-sectional view of a cylindrical drug container with a piston; Fig. 2c is Figure 2d is a cross-sectional diagram showing the skin being lifted up by a suction cylinder connected to a water injection pump; Figure 2d is a cross-sectional diagram showing a dispensing device similar to the illustrated example in Figure 2c; Figure 2e is a diagram showing the inflow. FIG. 2f is a cross-sectional illustration of the device in which the valve for the dosing is located in the dosing chamber in the dosing piston; FIG. The figure is a detailed sectional illustration of a modification of the embodiment shown in Figure 2e, and Figure 3 is a detailed cross-sectional view of a modification of the embodiment shown in Figure 2e.
Figure 3a is a cross-sectional diagram showing an example of a fixed dosage; Figure 3b is a cross-sectional diagram of an example of a fixed dosage in the neck of the bottle; Fig. 3c is a cross-sectional illustration of a closure using a small plate that fits tightly on the syringe cone, Fig. 3d is a cross-sectional illustration of a closure using a magnetic slider, and Fig. 4 is a blocking of the piston rod of the syringe. Illustration of the example in which the dosing piston is released by the bar, No. 4a
Figure 4b is an explanatory diagram showing an example in which the blocking bar is fixed to the compression bottle, Figure 4b is an explanatory diagram showing an example in which the medicine bottle has a bendable connection, and Figure 4c is an explanatory diagram showing an example in which the syringe to be filled is connected to the cover part. Figure 4d is a cross-sectional diagram showing an example of a single aspiration injection device; Figure 4e is a cross-sectional diagram showing an example of a single aspiration injection device; Figure 4e shows a detent in the syringe on the upward movement of the piston; Fig. 4f is a cross-sectional illustration showing an example of dosing in which the elastic shaft is engaged with the piston; A cross-sectional explanatory view showing the shutoff shaft attached to the holding chamber of the syringe, Figure 4h is an example in which a plurality of bell-shaped compression bottles are connected to the corresponding wall part by a spring or nut, or in a block shape by a plastic ring. Figure 4i is a cross-sectional diagram showing a double bottle with a common filling connection and separate drug reservoir; Figure 4j is a cross-sectional diagram showing a dosing recess fitted into the corner of the compression bottle. FIG. 4K is a cross-sectional explanatory diagram showing an example of a dispensing device; FIG. FIG. 5a is a cross-sectional illustration showing a jacket filled with fibrous material or multiple filter layers; FIG. 6 is an illustration of an electronic application of the embodiment according to FIG. 4; FIG. 6a shows a syringe piston in a cylinder. An illustration showing an example in which a magnetic valve is actuated by vibrations of the liquid cushion in the closure when it crosses a wall marking; FIG. 7 shows an example with a filling connection extending into a cylinder closed by a cover; Figure 7a is a cross-sectional diagram showing the suction flow passing through the rear of the diaphragm and the sealing cushion; Figure 8 is an example with a drug tube reservoir between the separators; An explanatory diagram showing
FIG. 9 is a medicine bottle with an oral dispensing mechanism,
Figure a is a cross-sectional explanatory diagram showing a modification of Figure 9;
The figure shows a cross-sectional illustration of an example of a single ampoule under the influence of compressed gas, and FIG.
12 is an explanatory cross-sectional view showing an example of a cannula adapter section held by a spring mechanism located underwater between the check valve and the cushion-type seal in case of inactivity; FIG. A cross-sectional explanatory view showing an example of a dispensing piston (dosing device) that can be connected, FIG. 12a is a cross-sectional explanatory view of a modification in which the height of the piston plate is adjustable, and FIG. FIG. 13a is a cross-sectional explanatory diagram of a compressed bottle containing a cleaning liquid or sterilizing gas, etc.; FIG. Figure 13b is a cross-sectional explanatory view of a compression bottle that is operated by lowering the cannula connecting cover, Figure 14a is a cross-sectional explanatory view showing the upper part of the metering device, and Figure 14b is the metering device and cannula combined. Fig. 14c is an explanatory drawing showing a structure for adjusting the space for oil retrogression, Fig. 15 is an explanatory drawing showing a dispensing device similar to Example 9a, and Fig. 15a is an explanatory drawing showing a dispensing device similar to Example 9a. Explanatory diagram showing the feeder, 1st
FIG. 6 is an explanatory diagram showing an embodiment of the dispensing device, FIG. 17 is an explanatory diagram showing a thermally insulating cannula adapter part,
Fig. 18 is an explanatory diagram showing a cylindrical perteil member, Fig. 19 is an explanatory diagram showing an embodiment of the dispensing device, Fig. 20XYZ is an explanatory diagram showing an embodiment of the dispensing device, and Fig. 20A is an explanatory diagram showing an embodiment of the dispensing device. Schematic representation of a solution with a dosing cylinder and three drug reservoirs, FIG.
FIG. 20C is a schematic diagram showing a solution with two drug reservoirs and two dosing cylinders, FIG. FIG. 21 shows an example in which the space between the chord extension of the dosing piston and the opening for the chord is closed off by an elastic plug; FIG. FIG. 22 is a cross-sectional view showing a variant of the invention with double valve functionality as in FIG. 22 is a cross-sectional view showing a tube injection device; FIG. 2nd cross-sectional diagram
2b is a cross-sectional explanatory view of the piston device in the drug container, FIG. 23 is a cross-sectional explanatory view showing the dosing formed through the sinking of the covering plate, and FIG. 23a is a cross-sectional explanatory view of one embodiment. Fig. 24 is a cross-sectional explanatory view of a drug compression bottle fitted into a suction injection device, Fig. 24a is a cross-sectional explanatory view showing an example in which two types of drug bottles are attached, and Fig. 25 is a cross-sectional explanatory view showing an example in which two types of drug bottles are attached. 26 is a cross-sectional view showing a state in which it is actuated by pressure; FIG. 26 is a cross-sectional view showing a state with a direct suction device via gas pressure; FIG. 26a is a cross-sectional view showing one embodiment. Explanatory diagram,
Figure 1X is a cross-sectional explanatory diagram showing a cylinder, Figure 2X is a cross-sectional explanatory diagram showing an expression pin device equipped with three pins, Figure 3X is a cross-sectional explanatory diagram showing hydraulic expression of a suction ventilation piston, and Figure 4X is an explanatory cross-sectional diagram showing a hydraulic expression of a suction ventilation piston. The figure is a partially cross-sectional explanatory diagram showing hydraulic expression via airflow. 1... Spindle, 4, 12, 106, 10
8,150,166...Valve, 5...Filling pipe, 6
... Coating, 7, 10, 12, 25, 30 ... Check valve, 14 ... Syringe cone, 17 ... Scale, 18, 19, 130, 191, 195, 2
00... Piston, 39... Metering device, 35...
suction cylinder.

Claims (1)

[Scope of Claims] 1. A closed container having a gas chamber filled with pressurized gas and a drug solution storage section adjacent to the gas chamber via an isolation member, and a container that communicates with a communication port opened in the drug solution storage section. 1. A drug solution dispensing device comprising: a drug solution dispensing chamber; and an adjusting means for supplying a predetermined amount of a drug solution in a drug solution storage portion to the dispensing chamber. 2. A closed container having a gas chamber filled with pressurized gas and a liquid medicine storage part adjacent to the gas chamber via an isolation member, and a metering chamber communicating with a communication port opened in the liquid medicine storage part; A drug solution dispensing device and an injection device characterized by comprising: an adjusting means for supplying a predetermined amount of the drug solution in the drug solution storage portion to the dispensing chamber; and an injection device for injecting the drug solution in the dispensing chamber. assembly.