JPS6124518A - Remedy for hermorrhoids - Google Patents

Abstract

PURPOSE:A remedy for hemorrhoids containing linoleic acid, linolenic acid, eicosapentaenoic acid, etc. as an active ingredient. CONSTITUTION:0.1-100wt% linoleic acid, linolenic acid, eicosapentaenoic acid and their glycerin esters is blended with an antioxidant substance (e.g., dl-alpha- tocopherol, nordihyroguaiaretic acid, buthylhydroxyanisole, etc.), to give a remedy for hemorrhoids. The remedy can be mixed with a drug having analgesic action, antipruritic action, sterilizing action, anti-inflammatory action, locally styptic action, etc. A suppository, ointment, spray using an oil base, etc. may be used as a dosage form for administration. The action of the active ingredient is considered to improve blood circulation in the varix of the surrounding parts of the anus, which is the cause of hermorrhoids.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a novel therapeutic agent for hemorrhoids.

[Conventional technology]

Hemorrhoid disease is said to be common among Japanese people, and is thought to be caused by factors such as diet, lifestyle, defecation position, pregnancy, and Japanese-style birth control. Therapeutic drugs are diverse, such as Zenkai, ointments, and oral medications, and these include active ingredients such as analgesic, antipruritic, bactericidal, antiinflammatory, local hemostasis, infection prevention, peripheral blood promotion, wound healing, and antiallergy. It contains a drug that has active effects on cells and tissues, so it can be said that it should theoretically be effective in treating hemorrhoids.

[Problem that the invention seeks to solve]

However, these therapeutic agents have not yet been satisfactory in terms of their practical therapeutic effects.

[Means for solving problems]

In view of this situation, the present inventor conducted extensive research to obtain a hemorrhoid treatment agent that is effective in alleviating and treating hemorrhoid symptoms, and as a result, the inventors used linoleic acid, linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, etc. as active ingredients. If you do this, you can prevent hemorrhoids.
The inventors have discovered that there is a therapeutic agent for hemorrhoids that is extremely effective for treatment, and have completed the first invention. In history, he discovered that the therapeutic effect of this hemorrhoid treatment agent can be further enhanced by combining it with an antioxidant, and completed the second invention.

That is, the first uninvented invention is a therapeutic agent for hemorrhoids containing as an active ingredient one or more of the following from the group consisting of linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and glycerin esters thereof. It is something that provides.

Furthermore, the second invention of the present invention has as an active ingredient one or more selected from the group consisting of an anti-inflammatory substance and linoleic acid, linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, and glycerin esters thereof.
- #Provides therapeutic agents.

Linoleic acid and linolenic acid used in the present invention can be obtained by known methods such as hydrolysis and fractionation of natural triglycerides. In addition, linoleic acid monoglyceride and linoleic acid monoglyceride may be α-monoglyceride or β-7sonoglyceride, and may be prepared by fractionation, esterification, transesterification of natural monoglyceride, or the corresponding triglyceride, diglyceride portion, 7JII water decomposition, etc. It can be obtained in this way.

As the glycerin ester of unsaturated carboxylic acid such as linoleic acid used in the present invention, monoester or monoester can be used.
Among these, monoesters are preferred.

The amounts of linoleic acid, linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and glycerin esters thereof to be added to the hemorrhoid treatment agent of the present invention are not particularly limited, and include o,
i to 100% by weight (hereinafter expressed as %).

By adding an antioxidant to the hemorrhoid treatment agent of the present invention, its therapeutic effect can be further enhanced. Antioxidants used for this purpose may be those commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., such as d
Examples include t-α-tocopherol, nordihydroguaceretic acid, butylated hydroxyanisole, sibutylated hydroxytoluene, zolobyl gallate, erythorbic acid, sodium erythorbate, crude drug extracts having antioxidant ability, and the like. Examples of crude drug extracts with antioxidant ability include All Suno Q-isu, anise, pasol, caraque, cardamom, cinnamon,
Clove (Choji), Korean paste (&I), fennel, garlic (garlic), sinshar (main), sardine, pepper, mustard, nutmeg,
Onion, NoQ Seri, Heno Q-, Saffron, Rosemary, Salvia, Thyme, Turmelink (premium)
, vanilla, / e Nori Chikara, clove, sesame, yokuinin,
Examples include saiko, huanglian, schisandra, gobaiko, thick boku, large quantity, zuei broiled, and peony, among which rosemary, salvia, allsnos, silica, sesame, and thyme are preferred.

The antioxidant is preferably 0.1 to 10X of linoleic acid, linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and their glycerin esters.

In addition to the above-mentioned active ingredients, the hemorrhoid treatment agent of the present invention has, for example, analgesic action, antipruritic action, bactericidal action, anti-inflammatory action, local hemostatic action, infection prevention action, peripheral blood promoting action, wound healing action, and anti-inflammatory action. It is also possible to mix and use existing drugs that have allergic effects and cell and tissue activating effects.

Examples of administration methods include administration as a full-stripe solution, an ointment, a spray using an oily base, and the like.

[Effect]

Mechanism by which linoleic acid, linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and their glycerin esters used in the present invention are effective in treating hemorrhoids #i Although it is not clear, the mechanism by which linoleic acid, linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and their glycerin esters are effective in treating hemorrhoids #i Although it is not clear, the perianal area, which is the cause of hemorrhoids, This is thought to improve the congestion of varicose veins and promote local blood circulation.

〔Effect of the invention〕

The therapeutic agent for hemorrhoids of the present invention is effective in treating hemorrhoids, as shown in the Examples below.

〔Example〕

Next, the present invention will be explained with reference to examples.◎Example 1 Composition: ■Linole & 98.95 parts by weight■
Hydrocortisone 0.05■ Acetic acid dt
-Tocopherols 1.00■~■ were heated at 45°C, mixed well, and then filled into 500#v soft gelatin to prepare soft gelatin capsules for hemorrhoid treatment.

The product of the present invention was used by 20 people suffering from hemorrhoids once a day for ziM. Change in symptoms #'i As shown in Table 1, a considerable reduction in symptoms was observed.

Table 1 Example 2 Composition: ■ Linoleic acid monoglyceride io, o
xOkibe ■ Zolednisolone 0.
05■ Ethyl aminobenzoate 0.5■
dl-α-tocopherol 1.0 total 1
00 ■～■ were heated at 6θ℃, mixed well, and then heated to 1.5f.
Formulate into a mold for making suppositories.

Example 3 Composition: ■ Vaseline lO1θ Heavy View Part Lanoli 7 4.5, ■
Inzolovir myristate 5,0■ Linole ridge monoglyceride 1O10■ Linoleic acid
5.0 ■ Zorobyl benzoate ester
0.1゛■ Sorbitan monostearate
2.0■ Criserol monostearate
2.0 ■ Purified water Balance meter 100 ■■ is heated to 70℃, and while gently stirring, gradually add the same (70'CK heated ■～■) and emulsify it.Next, cool this and Used as a hemorrhoid ointment @ Ten people with mild hemorrhoids who have itching around the anus used the product every day after taking a bath.
Itching disappeared in all patients in ~5 days.

Example 4 An acetone extract of 0-zumary was produced, and a therapeutic agent for hemorrhoids having the following composition was prepared using the extract.

Rosemary acetone extract: Add 3 parts of acetone to rosemary powder, extract at room temperature for 3 hours, and then pour the extract.

By concentrating this p liquid using a rotary evaporator and completely removing the bath medium, a rosemary extract 170f having antioxidant ability is obtained.

Composition: ■ Linolenic acid 50.01 parts ■ Silicone 20.0 ■ Rose mariacetone extract 05 ■ Squalene 29
．． 5. Heat the ■■■ to 50°C, mix well, then cool to room temperature, add the ■■, and stir well.

The product of the present invention is filled into a spray bottle and used in the following manner. That is, in a person suffering from hemorrhoids, the uninvented product is used to wipe the area around the anus and areas affected by hemorrhoids after defecation or after bathing. After using the product of the present invention on 10 hemorrhoid patients with internal hemorrhoids who had defecated, they wiped it with toilet paper/Q- as usual, and then wiped the anal area with toilet paper/Q- containing the product of the present invention.

As a result, the gong-shaped changes were as shown in Table 2, and a considerable reduction in symptoms was observed.

Table 2 Example 5 Composition: ■ dt-)copherol acetate 10.0■
After heating ~■ at 45℃ and mixing well, 330W
The product was filled into soft gelatin capsules to prepare soft gelatin capsules for the treatment of hemorrhoids.

The product of the present invention was used by 10 people with mild hemorrhoid disease (individuals with 1st grade internal hemorrhoids) using 2 pieces twice a day for 1 week. As a result, all symptoms of hemorrhoids improved.

Example 6 The same effects as in Example 5 were obtained when a monoglyceride containing a mixed fatty acid of eicosapentaenoic acid and docosahexaenoic acid as a constituent fatty acid was used instead of the eicosapentaenoic m, do:yt hexaenoic acid mixture in Example 5. Obtained.

that's all

Claims (1)

[Claims] 1. Linoleic acid, linolenic acid, eicosapentaenoic acid,
A therapeutic agent for hemorrhoids, characterized in that it contains one or more selected from the group consisting of docosahexaenoic acid and their glycerin esters as an active ingredient. 2. A therapeutic agent for hemorrhoids, which contains as an active ingredient one or more antioxidants and one or more selected from the group consisting of linoleic acid, linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, and glycerin esters thereof.