CN1095278A - Tripterygium wilfordii plaster - Google Patents
Tripterygium wilfordii plaster Download PDFInfo
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- CN1095278A CN1095278A CN 93105368 CN93105368A CN1095278A CN 1095278 A CN1095278 A CN 1095278A CN 93105368 CN93105368 CN 93105368 CN 93105368 A CN93105368 A CN 93105368A CN 1095278 A CN1095278 A CN 1095278A
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- plaster
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- radix
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- Medicines Containing Plant Substances (AREA)
Abstract
A kind of tripterygium wilfordii plaster, be to get Radix et Rhizoma Tripterygii, use earlier alcohol extraction, gained extract reuse ethyl acetate extraction, wash with ether behind the precipitation, Radix Tripterygii Wilfordii extract dissolve with ethanol after the washing, then with penetrating agent be added to together stir in the substrate rubber cement coating, spread upon and be processed into plaster on the fabric.The present invention has anti-inflammatory analgesic action, and rheumatoid arthritis is had significant curative effect, and skin is had no stimulation, also do not have irritated reaction.
Description
The invention belongs to a kind of external used medicine novel formulation, exactly is a kind of tripterygium wilfordii plaster of specially controlling rheumatoid arthritis.
Rheumatoid arthritis is a kind of systemic disease that shows as local arthropathy, and the patient who is in a bad way will lose the job and self care ability.At present various therapies both domestic and external all are to delay or stop joint deformity, can not effect a radical cure.
The Thunder God Calamus is defended the Mao Ke tripterygium plant, and the popular name Gelsemium elegans Benth. has severe toxicity.According to " Chinese medicine voluminous dictionary " record, Radix et Rhizoma Tripterygii is mashed external application can treat rheumatoid arthritis, and in view of the above, the someone works out external agent such as tripterygium wilfordii magma, rubber plaster in succession, and human ethyl acetate extract processing extractum sheet for oral administration was arranged afterwards.Above patient's external has strong stimulation to skin, and causes allergic reaction, and for oral administration have bad side reactions such as nauseating, vomiting, stomachache.
Purpose of the present invention is intended to the change by dosage form, on the one hand gives full play to the curative effect of Radix Tripterygii Wilfordii to rheumatoid arthritis, reduces its toxicity on the other hand and avoids injury that human body is caused.
The present invention is achieved in that and gets the extract of Radix et Rhizoma Tripterygii through the collection gained, use anhydrous alcohol solution, the adding penetrating agent, then with substrate be mixed together stir rubber cement coating, be reprocessed into the plaster of the usefulness of applying ointment or plaster with this rubber cement coating.
Described penetrating agent is dimethyl sulfoxide or azone, and both can use separately, also can mix use.
Described substrate promptly is rubber plaster stickum commonly used, is modulated in proportion by rubber, zinc oxide, Colophonium, vaseline, lanoline, white oil to form.
The percentage by weight of the used prescription of the present invention is as follows:
Radix Tripterygii Wilfordii extract 1～6%
Dehydrated alcohol 5～10%
Penetrating agent 2～4%
Substrate 80～90%
Described matrix formulations percentage by weight is:
Rubber 20～30%
Colophonium 20～30%
Zinc oxide 30～40%
Lanoline 3～6%
Vaseline 1～3%
White oil 1～2%
The present invention proves through pharmacological testing.Aspect anti-inflammatory analgesic, adjuvant-induced arthritis there is preventive and therapeutic effect, non-specific active chronic inflammation is had significant inhibitory effect.Influencing aspect the immunologic function, non-specific immunity and specific cellular immunity, humoral immunization there is obvious inhibitory action.Above-mentioned effect all is dose dependent, and dosage is big, good effect some.The present invention has no stimulation, does not also have irritated reaction to skin, and after 40 ℃, room temperature ,-40 ℃ of storages took out in three months, its character, pulling force, paste containing amount, curative effect did not all have influence, also chafe not.
Embodiment:
One, the extraction of prepared from active ingredients of tripterygium wilfordii:
Get 1 kilogram of Radix et Rhizoma Tripterygii, add ethanol and soak more than 8 hours for 3～4 kilograms, reflux is 4 hours then, filters, and filtering residue refluxes twice again, adds 2～3 kilograms of ethanol at every turn, refluxes 4 hours.Merge three filtrates and obtain extract, distill this liquid, slough and reclaim ethanol, time extract of winning.
Gained extract for the first time extracts again, add 1～2 kilogram of ethyl acetate, reflux 4 hours, repetitive operation twice merges three filtrates and obtains acetic acid ethyl acetate extract, distill this liquid, slough and reclaim ethyl acetate, obtain about 20～25 grams extract for the second time, the sepia flowing soaking paste, with the ether such as the washed twice such as ether, petroleum ether of liquid state, promptly get Radix Tripterygii Wilfordii extract (A).
Method of extraction, except that refluxing, also can extracting extraction in extractor.
Two, the preparation of substrate.
Get rubber 270 grams, Colophonium 260 grams, zinc oxide 370 grams, lanoline 50 grams, vaseline 30 grams, white oil 20 grams.Rubber section refining is added gasoline then soak, other compositions are added stirs then promptly gets 1000 gram substrate.(volatilization totally in the gasoline course of processing afterwards)
Three, the preparation of plaster:
1, get A10 gram, with 50 gram anhydrous alcohol solutions, add dimethyl sulfoxide 10 grams again, azone 10 grams stir, be mixed together with 920 gram substrate then to stir, 1000 restrain the rubber cement coating.By per 100 centimetres, the ratio that is coated with 1.5～2 gram rubber cement coating is coated with cream, promptly is coated on the fabric.Last cutting, lid lining, be cut into little and promptly get tripterygium wilfordii plaster, its effective ingredient is 1%.
2, get the A20 gram, dehydrated alcohol 60 grams, dimethyl sulfoxide 10 grams, azone 15 grams, substrate 895 grams.Other operations are with embodiment 1.
3, get the A30 gram, dehydrated alcohol 70 grams, dimethyl sulfoxide 15 grams, azone 15 grams, substrate 870 grams.Other operations are with embodiment 1.
4, get the A40 gram, dehydrated alcohol 80 grams, dimethyl sulfoxide 15 grams, azone 20 grams, substrate 845 grams.Other operations are with embodiment 1.
5, get the A50 gram, dehydrated alcohol 90 grams, azone 30 grams, substrate 830 grams.Other operations are with embodiment 1.
6, get the A60 gram, dehydrated alcohol 100 grams, azone 30 grams, substrate 810 grams.Other operations are with embodiment 1.
Claims (1)
1, a kind of tripterygium wilfordii plaster is that Radix et Rhizoma Tripterygii is extract obtained with the ether washing behind twice extraction precipitation, and the same dehydrated alcohol of the extract after the washing, penetrating agent, substrate are made rubber cement coating post-treatment together and become plaster, it is characterized in that the proportioning of plaster is as follows:
Radix Tripterygii Wilfordii extract 1～6%
Dehydrated alcohol 5～10%
Penetrating agent 2～4%
Substrate 80～90%
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93105368 CN1095278A (en) | 1993-05-14 | 1993-05-14 | Tripterygium wilfordii plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93105368 CN1095278A (en) | 1993-05-14 | 1993-05-14 | Tripterygium wilfordii plaster |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1095278A true CN1095278A (en) | 1994-11-23 |
Family
ID=4985680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93105368 Pending CN1095278A (en) | 1993-05-14 | 1993-05-14 | Tripterygium wilfordii plaster |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1095278A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1007066A4 (en) * | 1996-09-27 | 2002-10-23 | Olsen Nancy J | Steroid receptor binding compositions and steroid-sparing preparations thereof in immunosuppression and inflammation |
| CN1107507C (en) * | 1999-05-10 | 2003-05-07 | 中国医学科学院药用植物研究所 | Immunosuppressive medicine |
| CN101991585A (en) * | 2009-08-25 | 2011-03-30 | 福建省医学科学研究所 | Percutaneous absorption film coating agent for treating rheumatoid arthritis and preparation method thereof |
| CN102085199A (en) * | 2009-12-08 | 2011-06-08 | 福建省医学科学研究所 | Percutaneous absorption biological patch for treating rheumatoid arthritis and preparing method thereof |
-
1993
- 1993-05-14 CN CN 93105368 patent/CN1095278A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1007066A4 (en) * | 1996-09-27 | 2002-10-23 | Olsen Nancy J | Steroid receptor binding compositions and steroid-sparing preparations thereof in immunosuppression and inflammation |
| CN1107507C (en) * | 1999-05-10 | 2003-05-07 | 中国医学科学院药用植物研究所 | Immunosuppressive medicine |
| CN101991585A (en) * | 2009-08-25 | 2011-03-30 | 福建省医学科学研究所 | Percutaneous absorption film coating agent for treating rheumatoid arthritis and preparation method thereof |
| CN101991585B (en) * | 2009-08-25 | 2014-04-16 | 福建省医学科学研究院 | Percutaneous absorption film coating agent for treating rheumatoid arthritis and preparation method thereof |
| CN102085199A (en) * | 2009-12-08 | 2011-06-08 | 福建省医学科学研究所 | Percutaneous absorption biological patch for treating rheumatoid arthritis and preparing method thereof |
| CN102085199B (en) * | 2009-12-08 | 2014-05-28 | 福建省医学科学研究院 | Percutaneous absorption biological patch for treating rheumatoid arthritis and preparing method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |