JPS61215316A - External agent for skin - Google Patents

Abstract

PURPOSE:To provide an external agent for skin, composed of a specific ultraviolet absorber in combination with the ester of an acid and an alcohol each having 9-31C straight or branched unsaturated alkyl residue, having improved compatibility to base, preventing the deterioration caused by the precipitation of crystals and having excellent ultraviolet-shielding effect and high quality. CONSTITUTION:The objective agent can be produced by adding the ester of an acid and an alcohol each having 9-31C straight or branched unsaturated alkyl residue such as 2-hexyldecyl myristate to a dermatic agent for external use containing preferably 0.01-10% 4-(1,1-dimethylethyl)-4'- methoxydibenzoylmethane as an ultraviolet absorber capable of absorbing sunlight, especially ultraviolet ray having relatively long wavelength and harmful to the skin (UV-A). The amount of the ester is >=1/2 of the UV-absorber. The obtained external agent for skin has improved compatibility of the above UV- absorber to the base of the external agent and excellent ultraviolet-absorbing effect and quality and is storable stably for a long period with little deterioration.

Description

Detailed Description of the Invention [Industrial Field of Application] The present invention relates to 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane, which has 9 to 3 carbon atoms;
By blending an acid with a linear, branched, or unsaturated alkyl residue of 1 and an ester of an alcohol with a linear, branched, or unsaturated alkyl residue of 9 to 31 carbon atoms, it has an excellent UV protection effect and excellent UV protection. This topic relates to external skin preparations with superior quality.

[Prior Art] It is known that sunlight not only causes sunburn, but also accelerates skin aging due to the sunburn.

There are many external skin preparations that are carefully designed to protect against sunlight, but all of them contain powder that mainly protects against sunlight.
Some methods used scattering methods to deal with the problem, or others included substances such as salicylic acid derivatives, aminoaminobenzene, and dizoic acid derivatives that absorb only ultraviolet rays with relatively short wavelengths called UV-B.

[Problems to be solved by the invention] 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane is harmful to sunlight, especially U, which is harmful to the skin.
In recent years, it has been attracting attention as a substance called VA that absorbs relatively long wavelength ultraviolet rays, but it has poor compatibility with the base of external skin preparations, and even if it is incorporated into external skin preparations in a dissolved state, it has a relatively short lifespan. It often precipitates as crystals over time.

If it precipitates as crystals, it goes without saying that the quality of the external skin preparation will be significantly impaired, and the originally intended ultraviolet absorbing ability will not be achieved.

Means for Solving the L Problem] In view of the circumstances, the present inventor has conducted intensive research and found that 4-(1,
1-dimethylethyl)-4'-methoxydibenzoylmethane, an acid having a straight chain, branched or unsaturated alkyl residue having 9 to 31 carbon atoms, and a straight chain having 9 to 31 carbon atoms;
It was discovered that by blending an alcohol ester with a branched, unsaturated alkyl residue, it is possible to obtain an external skin preparation that not only has excellent ultraviolet absorption effects but also has long-term stability and is less prone to quality deterioration.The present invention has been made. I was able to complete it.

That is, the present invention provides an external preparation for skin that has an excellent ultraviolet absorption effect and excellent quality.

Hereinafter, the configuration of the present invention will be explained in detail.

4-(1,1-dimethylethyl)- used in the present invention
4°-Methoxydibenzoylmethane is disclosed in JP-A-55-6
6535, and is supplied by Sibodan Co., Ltd. under the trade name "Pulsol 1789".

The amount to be added to the skin external preparation is arbitrary depending on the expected ultraviolet absorption effect, but if the amount is extremely large, the amount of the skin external preparation base will be reduced, which is not preferable. Preferably it is 0.01 to IQ%. If it is less than 0.01%, the UV absorption effect is small and the original purpose cannot be achieved.
If it exceeds 10%, the amount of the skin external preparation base decreases and the quality of the skin external preparation itself is impaired.

Also, carbon number 9 is blended for the purpose of exhibiting the effects of the present invention.
Examples of the ester of an acid having a straight chain, branched or unsaturated alkyl residue having 9 to 31 carbon atoms and an alcohol having a straight chain, branched or unsaturated alkyl residue having 9 to 31 carbon atoms include 2-
hexyldecyl myristate, 2-year-old cutyldodecyl-
These include synthetic oils such as 2°-isohebutyl isoundecanoate, oleyl oleate, and 2-hebutyl undecyl palmitate, and natural oils such as vegetable oil jojoba oil, deep sea fish oil orange roughy oil, and peace wax. .

One or more of these esters may be blended, but the amount blended for the purpose of exhibiting the effects of the present invention is 4-
It is necessary to use at least 1/2 of the amount of (1,1-dimethylethyl)-4°-methoxydibenzoylmethane, and even if it is added in excess, the effects of the present invention will not be impaired.

In the present invention, 4-(1,1-dimethylethyl)-4°
- A mixture of methoxydibenzoylmethane, an acid having a straight chain, branched, or unsaturated alkyl residue having 9 to 31 carbon atoms, and an ester of an alcohol having a straight chain, branched, or unsaturated alkyl residue having 9 to 31 carbon atoms. As the base for external skin preparations, any conventional skin external preparation base can be used.

That is, it is in the form of liquid, gel, paste, cream, etc., and the ingredients that modify the external skin preparation include moisturizers, oils, surfactants, thickeners, sequestering agents, other ultraviolet absorbers, drugs, Needless to say, dyes, fragrances, etc. can be used in combination.

[Example] <Example 1> Sunscreen oil 4-(1,1-dimethylethyl) 2wt%-
4°-Methoxydibenzoyl methane glyceryl monooleate 2 Jojoba oil
20 liquid paraffin
76 [Effects of the Invention] Example 1 shows that according to the present invention, 4-(1,1-dimethylethyl)-4''-methoxydibenzoylmethane,
This is an external skin preparation containing an acid having a straight chain, branched, or unsaturated alkyl group having 9 to 31 carbon atoms and an ester of an alcohol having a straight chain, branched, or unsaturated alkyl residue having 9 to 31 carbon atoms.

On the other hand, the case where 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane is not blended and the case where ester is not blended are shown below as control examples.

<Control example 1> 4-(1,1-dimethylethyl) 2wt%
-4'-methoxydibenzoylmethane glyceryl monooleate 2 liquid paraffin 96 Control example 2> Glyceryl monooleate 2 wt% jojoba oil 20 liquid paraffin
78 Table 1 shows the storage stability and UV protection effect.

The skin external preparations of Example 1 and Control Examples 1.2 are both used as sunscreen oils.

Control example 1 was a homogeneous liquid after production, but 4-(
1,1-dimethylethyl)-4[deg.]-methoxydibenzoylmethane gradually precipitates, deteriorating its quality as an external skin preparation and reducing its ultraviolet protection effect.

In Control Example 2, no crystals were precipitated, but of course no UV protection effect could be expected.

On the other hand, in Example 1, no crystals were precipitated not only after production but also after long-term storage, excellent UV protection effect, and stable quality.

This is a result of applying the technology according to the present invention.

(Left below) Table 1. Evaluation of crystal precipitation of products stored at room temperature O: No precipitation ×: Fair precipitation Next, the present invention will be described in detail with more examples, but the present invention is not limited thereto.

(Leaving space below) Example 2 Example 2 A, Setanol 3 wt% glyceryl monostearate 2 Stearin M3 Vaseline 3 Jojoba oil 3 2-hexyldecyl myristate 4 Squalane 5 4- (1,1-dimethylethyl) 2-4' -Methoxydibenzoylmethane fragrance Appropriate amount B, Propylene glycol 3. Potassium hydroxide (12 Purified water Amount, taking the whole as 100) Heat and dissolve the oil phase part of A and the water tank part of B at 70℃, then add A. Emulsify and then cool to obtain cream.

Example 3 4-(1,1-dimethylethyl) 5wt%-4'
-Methoxydibenzoylmethane Solid paraffin 2° Vaseline 20 Castor oil
4゜oleyl oleate 5 Mixed coloring agent (red color) 7 Fragrance
Appropriate amounts of each of the above raw materials are heated and melted at 80°C, and then poured into a predetermined container to obtain a lipstick.

(Left below) Example 4 A, Stearyl alcohol 2wt% glyceryl monostearate 2 POE (50) Oleyl ether 2 Stearic acid 2 Purified lanolin 22-Hebutylundecyl 2 Palmitate 2-Octylthothiyl 2-5 Isoto Butyl isoundecanoate 4-(1,1-dimethylethyl) 2-4'-methoxydibenzoylmethane Preservative Appropriate amount Fragrance
Appropriate amount of B5 glycerin
5 Potassium hydroxide 0.2 Purified water Amount to make the whole 100 C1 Mixed powder
1°A oil phase raw material and B water phase raw material were each added at 70°C to dissolve, and then A was added to emulsify. The powder part of C is dispersed therein and then cooled to obtain a cream-like foundation.

Example 5 Orange roughy oil 50wt% jojoba oil
30 Liquid paraffin 10 4-(1,1-dimethylethyl)10-4'-methoxydibenzoylmethane dye aiM fragrance
Appropriate amounts of each of the above components are heated and dissolved at 50°C, and then cooled with stirring to obtain a body oil.

(Left below) Example 6 Solid paraffin 10wt% liquid paraffin Amount to make the whole 100 Vaseline
20 glyceryl monomyristate 10 oleyl oleate 0.054- (
(1,1-dimethylethyl) 0.1-4'-methoxydibenzoylmethane dye (appropriate amount) Perfume (appropriate amount) Each of the above components was dissolved by heating at 50°C, and then cooled with stirring to obtain a body gel.

*The external skin preparations of Examples 2 to 6 had excellent ultraviolet absorption effects, and there was no deterioration in quality due to crystal precipitation even 3 months after production.

This is a result of applying the technology according to the present invention.

Claims (1)

[Claims] 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane, an acid having a straight chain, branched, or unsaturated alkyl residue having 9 to 31 carbon atoms, and 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane;
A skin external preparation characterized by containing an alcohol ester having a linear, branched, or unsaturated alkyl residue.