JPH04352708A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic, stably containing kojic acid without any coloring with time, especially coloring by heat with time by blending kojic acids together with superoxide dismutase and/or sodium hydrogensulfite. CONSTITUTION:A safe cosmetic containing kojic acid expressed by the formula (R<1> and R<2> are H, 3-22C acyl or 3-22C alkyl) or its derivative [e.g. kojic acid monobutyrate or kojic acid dibtyrate (in an amount of preferably about 0.0001-5.0wt.% based on the whole composition)] and superoxide dismutase (which is a superoxide eliminating enzyme used in an amount of preferably about 0.00001-1 pt.wt. based on 1 pt.wt. kojic acids) and/or sodium hydrogensulfite (used in an amount of preferably about 0.0001-1 pt.wt. based on 1 pt.wt. kojic acids). The aforementioned cosmetic has high beautifying and whitening effects and can be used as milky lotions, creams, packs, toilet water, foundations, etc.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics that stably contain kojic acid and prevent coloring over time due to heat.

0002

BACKGROUND OF THE INVENTION Recently, the harmful effects of ultraviolet rays have become a topic of discussion, and the perception of sunburn, that is, age spots, freckles, and aging has become widespread. For this reason, women are extremely interested in cosmetics that have a whitening effect, and there is an increasing demand for cosmetics that are safe and have a high whitening effect.

[0003] As a result, research on melanin has progressed,
Suppression of tyrosinase activity involved in melanin production,
Whitening ingredients that have the effect of reducing or eliminating activated melanocytes and cosmetics containing the same have been developed.

[0004] For example, kojic acid and its derivatives obtained by culturing strains of the genus Aspergillus are known to have an effect of suppressing melanin production and have an excellent whitening effect (Japanese Patent Application Laid-open No. 18739/1983). Publication, JP-A-56-7
776, JP-A-56-79616, JP-A-59-33207, etc.).

[0005]

[Problems to be Solved by the Invention] However, it is known that kojic acids have extremely high chemical reactivity and undergo chemical changes when exposed to heat or light. For this reason, when incorporated into cosmetics, there is a problem in that coloring occurs over time during storage and distribution of the product. It goes without saying that cosmetics must have excellent efficacy, but it is also important to have stability of the ingredients and a beautiful appearance.

[0006] Therefore, attempts have been made to prevent coloring over time due to light by incorporating a chelating agent, but no effective means for preventing coloration over time due to heat has yet been known.

[0007]Therefore, there is a need for the development of cosmetics that stably contain kojic acids and that prevent discoloration over time.

[0008]

[Means for Solving the Problems] Under these circumstances, the present inventors have conducted intensive research to solve the above problems, and as a result, we have developed a cosmetic product that uses superoxide dismutase (SOD) and/or sodium bisulfite together with kojic acids. The present invention was completed based on the discovery that coloring caused by heat over time can be prevented by blending the resin into the liquid.

That is, the present invention provides a cosmetic material containing kojic acid and/or a derivative thereof, and SOD and/or sodium bisulfite.

Kojic acid or its derivative used in the present invention has the following general formula:

[0011]

[Chemical formula 1]

(In the formula, R1 and R2 may be the same or different and represent a hydrogen atom or an acyl group or alkyl group having 3 to 22 carbon atoms.)

[0013] Kojic acid may be extracted and purified from a fermentation product by microorganisms such as Aspergillus, Penicillium, or Acetobacter, or it may be an extract without the purification process, or it may be obtained by synthesis. It may also be something you have.

Further, as the kojic acid derivative, those synthesized from the above-mentioned kojic acid can be used, such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate. , monoesters such as kojic acid monobenzoate; and diesters such as kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, and kojic acid dioleate.

These kojic acids and their derivatives can be used alone or in combination of two or more, and are preferably blended in an amount of 0.0001 to 5.0% by weight in the total composition of the cosmetic.

[0016] SOD used in the present invention is a superoxide scavenging enzyme that is widely distributed in living organisms such as animals, plants, and microorganisms, and catalyzes the disproportionation reaction of superoxide anion (O2-) by the following reaction. It is something. 2O2-+2H+→H2O2+O2 SOD is CuZn-S due to the metal serving as the active center.
There are three types: OD, Mn-SOD, and Fe-SOD, and recently they have been produced in large quantities using genetic engineering technology. The number of amino acids in all biological products is 1.
51 to 155, and this forms a dimer or tetramer and has activity. For example, in the case of bovine CuZn-SOD, 1
Monomer with one atom of Cu and one atom of Zn (molecular weight approximately 1
6kDa) and has a molecular weight of approximately 32,00
It is 0.

These SODs can be used alone or in combination of two or more, and are preferably blended in an amount of 0.00001 to 1 part by weight per 1 part by weight of kojic acid or its derivative.

[0018] Also, it is preferable that sodium bisulfite be blended in an amount of 0.00001 to 1 part by weight per 1 part by weight of kojic acid or its derivative.

[0019] When the pH of the cosmetic composition of the present invention is set to 7.0 or less, the prevention of discoloration due to heat becomes more effective. It is preferable to do so. Such pH adjustment is preferably carried out using organic acids such as citric acid, succinic acid, lactic acid, dl-malic acid, and pyrrolidonecarboxylic acid, or salts thereof.

In addition to the above-mentioned ingredients, the emulsified cosmetic of the present invention contains ingredients used in ordinary cosmetics, such as oils, surfactants, buffers, water, lower alcohols, polyhydric alcohols, powders, and cosmetics. Ingredients such as thickeners, preservatives, pigments, antioxidants, ultraviolet absorbers, fragrances, chelating agents, etc. can be added within ranges that do not impair the effects of the present invention.

The cosmetic composition of the present invention is not limited to its form, and can be suitably used as, for example, a milky lotion, a cream, a pack, a lotion, a foundation, and the like.

[0022]

[Examples] The present invention will be explained in more detail with reference to Examples, but the present invention is not limited thereto.

Example 1 A lotion having the following composition was prepared, and its coloring over time was observed. (composition)
(weight%
) 1. Kojic acid (manufactured by Sansei Pharmaceutical Co., Ltd.)
1.0 2. 1,3-butylene glycol
20.0 3. Polyoxyethylene monoisostearate Hydrogenated castor oil (50E.O.
) 1
．． 0 4. lactic acid
0.
05 5. sodium lactate
0.03 6
．． purified water
Remaining amount 7. test substance
Amount to achieve the concentration shown in Table 1 (manufacturing method) (1) No. Mix and dissolve 1, 4 to 7. (2) No. Mix and dissolve 2 and 3. (3) Mix (1) and (2) with stirring to obtain a lotion. (Test method) Each lotion was left in a constant temperature bath at 40° C. or room temperature for 3 months, and the degree of coloration was determined by measuring the absorbance at 400 nm. The results are shown in Table 1.

[0024]

[Table 1]

From Table 1, sodium bisulfite was more effective at high temperatures, and SOD was more effective at lower temperatures.

Example 2 Lotion: (Formulation)
(weight%
) 1. Kojic acid (manufactured by Sansei Pharmaceutical Co., Ltd.)
1.0 2. 1,3-butylene glycol
20.0 3. Polyoxyethylene monoisostearate Hydrogenated castor oil (50E.O.
) 1
．． 0 4. lactic acid
0.
05 5. sodium lactate
0.03 6
．． purified water
Remaining amount 7. sodium bisulfite
0.25 (manufacturing method) (1) No. Mix and dissolve 1, 4 to 7. (2) No. Mix and dissolve 2 and 3. (3) Mix (1) and (2) with stirring to obtain a lotion. (Results) The lotion obtained as described above had improved coloring over time due to heat.

Example 3 Cream: (Formulation)
(weight%
) 1. Polyoxyethylene (20E.O.) cetyl ether 2.0 2. Glyceryl stearate 2.
0 3. Cetostearyl alcohol
1.0 4. liquid paraffin
10.0 5. macadamian nut oil
10.0
6. Propylene glycol
10.0 7. Paraben
0.1 8. lactic acid

0.05 9. sodium lactate
0.03 10. sodium bisulfite
0.0
5 11. Kojic acid (manufactured by Sansei Pharmaceutical Co., Ltd.)
1.0 12. purified water
Remaining amount (manufacturing method) (1) No. 1 to 5 are mixed and dissolved at 70°C. (2) No. 6 to 12 are mixed and dissolved at 70°C. (3) Add (2) to (1), emulsify, and then cool to obtain cream. (Results) The cream obtained as described above had improved coloring over time due to heat.

Example 4 Pack: (Formulation)
(weight%
) 1. polyvinyl alcohol
20.0 2. ethanol
10.0 3. malic acid

0.1 4. sodium malate
0
．． 02 5. SOD
0.
0001 6. Kojic acid (manufactured by Sansei Pharmaceutical Co., Ltd.)
1.0 7. glycerin
10.0 8. purified water

Remaining amount (manufacturing method) (1) No. 3 to 7 as No. Mix and dissolve in 8. (2) No. in (1). 1 and 2 are added, heated and swollen, and then cooled to obtain a pack. (Results) The pack obtained as described above had improved discoloration over time due to heat.

[0029]

As described above, the cosmetic composition of the present invention stably contains kojic acid, and the problem of coloring over time, especially over time due to heat, can be improved.

Claims (1)

[Claims] 1. A cosmetic comprising kojic acid and/or a derivative thereof, and superoxide dismutase and/or sodium bisulfite.