JPS6113162A - Biochemical analyser - Google Patents

Abstract

PURPOSE:To make the temp. distribution in a main body constant, by making it possible to reflux the hot air generated from a hot air generator from the vicinity of the peripheral edge part of an intermittent rotor through the jacket covering the outer periphery of the main body. CONSTITUTION:When a motor 23 is started, each test tube 29 is shaken by the centrifugal force of a high speed rotor 20 to separate the whole blood in said tube 29 into blood corpuscles and serum on the basis of the specific-gravity difference thereof. All of analytical slides 15 receive the distribution of serum on their measuring surfaces and reach the position of the photometric head 38 of a photometric optical means 32 to be successively subjected to photometry and, subsequently, operation is performed by an operation apparatus while the measured values are displayed on a display window. The interior of a main body 10 is held to a predetermined temp. by a hot air generator 43 but hot air generated from the generator 43 is discharged into the upper chamber of the main body 10 through the through-holes of an intermediate floor plate 11 and rises in the main body 10 to be guided to the jacket 47 of the main body 10 from the air passing apertures 48 in the vicinity of the peripheral edge part of a rotor 14 and falls therethrough to be refluxed to the lower chamber of the main body 10 to keep the temp. distribution in the main body 10 constant.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a biochemical analyzer, specifically an analysis slide element in which an element impregnated with a reaction reagent is sandwiched between mounts.
Supply the sample to be tested on the surface.

The present invention relates to an apparatus for chemically analyzing a change in color density and the like by measuring a change in color density due to a reaction with the test sample.

[Conventional technology]

1 shows a conventional biochemical analyzer in FIGS. 4 and 5, 1 is the device body, 2 is an intermittent rotating body, and 3 is an intermittent rotating body that is a warm air generator installed in the device body 1. 2 has a plurality of through holes (not shown) for fitting an analysis slide arranged in a row at equally spaced positions on the peripheral edge 2a, and the rotation is stopped intermittently at each installation angle of the through holes. Around the periphery is a supply section 4 for fitting an analysis slide (not shown) into the through hole when stopped. 5. Dispensing section that drips the test sample onto the element surface of the analysis slide after it has been fitted into each through hole.5. A photometry unit 6 that chemically analyzes the progress state or result of the reaction of the element due to the dropping of the test sample by measuring the change in color density caused by the reaction.
It is equipped with The hot air generator 3 is used to maintain the inside of the apparatus main body 1 at a temperature at which the elements of the analysis slide easily react, and may be installed at the inner bottom of the apparatus main body 1 as shown in FIG.
As shown in FIG. 5, it is installed on the lower surface of the center of the intermediate floor plate 1a of the main body 1 of the apparatus. The hot air generated by the hot air generator 3 shown in FIG. 4 circulates in the lower space of the intermittent rotating body 2 in the main body 1 of the apparatus as shown by the arrow, and the peripheral edge of the intermittent rotating body into which the analysis slide 1 is fitted. Warm air does not reach the vicinity of the 2 main units 1
In the case of the hot air generator 3 shown in Fig. 5, a heat dissipation plate 1-c with an electric heating element buried therein is attached to the intermediate floor plate 1a via a mounting frame 1b. A fan 1d is provided in the space between the intermediate floor plate 1a and the heat sink 1c, and the rotation of the fan 1d heats the air in the lower room through the ventilation hole IC' of the heat sink IC, thereby increasing the ventilation in the center of the intermediate floor plate 1a. The heated air is discharged into the upper chamber through the air holes 1a', and the air in the upper chamber is returned to the lower chamber through the ventilation holes 1a'' on the outer periphery of the intermediate floor plate 1a. The hot air only circulated as shown by the arrow, but the hot air did not reach the vicinity of the periphery of the intermittent rotating body into which the analysis slide was fitted, causing variations in the temperature distribution within the main body 1.

[Object of the Invention] The present invention is intended to solve the above-mentioned problems, and its purpose is to provide a biochemical analyzer in which the temperature distribution within the main body of the apparatus is constant.

[Structure of the invention]

This invention provides an intermittent rotating body in which a plurality of through holes for fitting analysis slides are arranged on one peripheral edge of the apparatus main body, and an intermittent rotating body is provided which rotates intermittently at each installation angle of the through holes. a supply unit that fits an analysis slide into the through hole when the body is stopped;
A dispensing unit that drops the test sample onto the element surface of each fitted analysis slide, and chemically measures the progress or result of the reaction of the element due to the dropping of the test sample by measuring the change in color density caused by the reaction. In a biochemical analyzer equipped with a photometric section for analysis, warm air generated from a hot air generator disposed within the apparatus main body can be circulated from near the periphery of the intermittent rotating body through an outer shell covering the outer periphery of the main body. It is configured as follows.

〔Example〕

Next, the present invention will be explained based on an embodiment shown in FIGS. 1 to 3.

Reference numeral 10 denotes a biochemical analyzer main body (hereinafter simply referred to as the main body), and an intermediate floor plate 11 is provided within the main body 10. A pedestal 12 is provided on the upper surface of the central part of the intermediate floor plate 11.
At the same time, a shaft rod 13 stands vertically on the upper surface of the Fi mount 12.

Reference numeral 14 denotes an intermittent rotating body having a plurality of stepped through holes 16 arranged at equal positions on its periphery into which analysis slides 15 fit, and the intermittent rotating body 14 is rotatably fitted to the shaft rod 13. There is 0
An annular protrusion 18 having a gear 17 on the circumferential surface is provided on the lower surface of the intermittent rotating body 14, and the gear 17 has a
A driving gear 19b fixed to a spindle shaft 19a of a motor 19 attached to the motor 19 meshes with the spindle 19a. The motor 19 is an intermittent rotating body 14
can be driven by a predetermined angle (the arrangement angle of the stepped through hole 16),
Furthermore, it is possible to accurately stop at a predetermined position by a fixed position stopping means (not shown).

Reference numeral 20 denotes a high-speed rotating body, and the high-speed rotating body 20 has a rotating shaft 21 passing through the center of the shaft 13 that pivotally supports the intermittent rotating body 14.
is fixed at the top of the

A pulley 22 that can rotate within the pedestal 12 is fixed to the lower end of the rotating shaft 21 . The boo I722 is connected via a timing belt 24 to a pulley 23b fixed to a spindle 23a of a motor 23 attached to the intermediate floor plate 11. The motor 23 is designed to rotate at a high speed of, for example, 3000 rpm or more.

Reference numeral 25 denotes a test tube holding container which swingably hangs down from a plurality of holes 26 and 26- equally spaced on the periphery of the top plate 20H of the high speed rotating body 20. The centrifugal force causes the lower end to swing outward as shown by the two-dot chain line.

27 is an exterior cover of the high-speed rotating body 20, and the exterior cover 2
7 is removably mounted on the top surface of the main body I, and
An opening/closing lid 28 is provided on its upper surface. The opening/closing lid 2
8 is a hole 26 on the periphery of the high-speed rotating body 20 due to its opening.
The opening of the test tube holding container 25 hanging down becomes exposed, and the test tube 29 containing blood or the like is attached.

It is possible to take out the sample separated in the test tube by exchanging and piventing.

Reference numeral 30 denotes a supply section that supplies the analysis slide 15 to the stepped through hole 16 of the intermittent rotating body 14;
It is provided in the main body 1 corresponding to the stop position of G. It is also possible to provide this supply unit 30 with a pusher device (not shown) that is linked to stop the rotation of the intermittent rotating body 140 so that automatic supply can be performed.

31 is analysis slide 1 that revolves with the intermittent rotating body 14
A dispensing hole for dispensing separated serum into the dispensing hole 31.
is provided in a penetrating manner on the upper surface of the main body 1 corresponding to the stopping position of the analysis slide 15 and the outer cover 47 to be described later.

Note that the dispensing hole 31 provided in the outer shell 47 is closed after dispensing.

32 is a photometric optical means, and the photometric optical means 32 is a second
As shown in the figure and FIG. 3, a light source 3 such as a halogen lamp
The light beam generated from 3 is converted into a photometric beam of a desired wavelength through a lens 34 and a filter 35, and the photometric beam is bent through a mirror 36, and then passed through an optical fiber 37 and placed close to the measurement surface (back surface of the element) of the analysis slide 15. The light is guided to the photometric head 38 and irradiated.

This irradiation light is reflected from the measurement surface and transmitted to the light receiving element 40 through the optical fiber 39, and is calculated by a calculation device (not shown) such as a microcomputer, and the measured value is displayed in the display window ( This measured value may be printed on a roll of recording paper (not shown) if necessary.

The photometric head 38 is adapted to move upward during irradiation with the photometric light beam and press against the measuring surface of the analysis slide 15 as shown in the third figure.

In addition, 41 is a transparent glass tilted at 45° installed in the optical path of the photometric light beam in order to eliminate as much as possible errors in measurement values due to changes in the light intensity of the photometric light beam over time.
A part of the light reflected by the transparent glass 41 is referred to a correction circuit (not shown) via a light receiving element 42 so that the measured value of the photometric light beam reflected from the measurement surface of the analysis slide 15 can be corrected to a correct value. are doing.

Reference numeral 43 denotes a hot air generator, and the hot air generator 43 is installed at the center of the lower surface of the intermediate floor plate 11. is attached to the intermediate floor plate 11 via the mounting frame 45, and the intermediate floor plate 1
A fan 46 is provided in the space between 1 and a heat sink 44. The intermediate floor plate 11 and the heat sink 44 have a large number of through holes 11a.

44a, and air heated through the holes in the heat sink 44 by the rotation of the fan 460 is discharged into the upper chamber of the main body 10 through the holes in the intermediate floor plate 11.

Reference numeral 47 denotes an outer skin body that covers the outer periphery of the main body 10, and the outer skin body 47
A ventilation hole 48 provided in the main body 10 near the peripheral edge of the intermittent rotating body 14 communicates with a ventilation hole 49 provided in the side wall of the lower chamber of the second main body 10.

Hot air entering the upper chamber from the hot air generator 43 is sent to the intermittent rotating body 1
Analysis slide 15 fitted into the stepped through hole 16 on the periphery of 4
It passes through the periphery and is led out of the main body 10 through two ventilation holes 48, descends inside the outer skin 47, and is allowed to flow back into the lower chamber through the ventilation holes 49. The flow state of this hot air is shown by an arrow.

Next, the effect will be explained.

First, open the opening/closing lid 28 on the top surface of the exterior cover 27 of the main body 10, and the test tube holding container is swingably suspended from a plurality of holes 26, 26- equally distributed on the periphery of the top plate 20a of the high-speed rotating body 20. A test tube 29 containing an appropriate amount of whole blood is attached to the test tube 25, and the opening/closing lid is closed. On the other hand, the intermittent rotating body 14 in the main body 10
The analysis slides 15 are sequentially supplied from the supply section 30 to the stepped through holes 16 at the peripheral edge of the slider.

Next, when the motor 23 is started, the high-speed rotating body 20 is rotated at high speed by the motor 23, and the test tube 29 is swung together with its holding container 25 under the centrifugal force.
Whole blood in the test tube 29 is separated into blood cells and serum due to the difference in blood concentration. After the time required for this separation.

The motor 23 stops driving and is braked by a braking means (not shown). Thereafter, the opening/closing lid 28 is opened again, the separated serum in the test tube 29 is aspirated with a pipette (not shown), and the motor 19 is operated to stop rotating at a predetermined angle (the angle of arrangement of the stepped through hole I6). The solution is dropped onto the element surface of the analysis slide 15 fitted into the stepped through hole 16 at the periphery of the intermittent rotating body 14 .

After the serum is dispensed onto the element surface of the entire analysis slide 15, the photometric head 38 of the photometric optical means 32 is placed at the installation position.
The light is measured sequentially. In this photometry, after the photometry head moves up and comes into close contact with the measurement surface of the analysis slide, the measurement surface is irradiated with a photometry light beam from the light source 33, and the reflected light is calculated by a calculation device such as a microcomputer via a light receiving element. The measured values are displayed on the display window of the main unit. At the same time, the information is recorded on a roll of recording paper as required.

After the measurement of all the elements of the analysis slides on the intermittent rotating body 14 is completed, the above operation is repeated.

In the above case 1, the inside of the main body 10 is maintained at a predetermined temperature by the hot air generator 43, and the warm air generated by the hot air generator 43, ie, the rotation of the fan 46, passes through the through hole of the heat sink 44 and is heated. The air enters the main body 10 through the holes in the intermediate floor plate 11.
It is discharged into the upper chamber of the main body 10, rises inside the main body 10, and enters the main body 10 and the outer skin 4 through the ventilation hole 48 near the periphery of the intermittent rotating body 140.
7, descends inside the outer shell 47, and returns to the lower chamber through the ventilation hole 49, so that the temperature distribution within the main body 10 becomes constant.

〔Effect of the invention〕

As described above, according to the present invention, a plurality of through holes for fitting an analysis slide are provided at one peripheral edge of the apparatus main body, and the slides are rotated intermittently at each installation angle of the through holes. A supply unit that includes an intermittent rotating body and fits an analysis slide into the through hole when the intermittent rotating body is stopped; a dispensing unit that drops the test sample onto the element surface of each fitted analysis slide; and a sample to be tested. In a biochemical analyzer equipped with a photometry unit that chemically analyzes the progress state or result of a reaction in an element due to the dropping of a substance by measuring a change in color density due to the reaction, a hot air generator disposed within the apparatus main body. This is because the hot air generated from the intermittent rotor can be circulated from near the periphery of the intermittent rotating body through the outer shell covering the outer periphery of the main body.

The hot air from the hot air generator installed inside the main body circulates throughout the main body, and has the excellent effect of being able to quickly raise the temperature of one analysis slide to a temperature at which the element can easily react. .

[Brief explanation of drawings]

The figures show an embodiment of the present invention, in which Fig. 1 is a cross-sectional front view of the main body, Fig. 2 is a schematic diagram showing the photometric optical means, and Fig. 3 is a cross-sectional view showing the relationship between the photometric head and the analysis slide. 4 and 5 are schematic cross-sectional views of conventional examples. 10--Device body 14-Intermittent rotating body 15--
- Analysis slurry, ID 16-/Through hole 30- Supply section
31-Dispensing unit 32-・Optical means for photometry 38-Photometry henode 20・-High-speed rotating body 43-Hot air generator patent applicant
Konishiroku Photo Industry Co., Ltd. Figure 1 Figure 2 Figure 1 To Figure 3 Omission

Claims (1)

[Claims] A plurality of through holes for fitting analysis slides are provided in the device body on the periphery, and an intermittent rotating body is provided that rotates intermittently at each installation angle of the through holes, and the intermittent rotating body is stopped. At times, there is a supply unit that fits the analysis slide into the through hole, a dispensing unit that drops the test sample onto the element surface of each fitted analysis slide, and a dispensing unit that drips the test sample onto the element surface of each fitted analysis slide. In a biochemical analyzer equipped with a photometric unit that measures and chemically analyzes changes in color density caused by the reaction, hot air generated from a hot air generator placed inside the device body is applied to the periphery of an intermittent rotating body. A biochemical analyzer characterized in that reflux is allowed to flow from the vicinity through the outer shell covering the outer periphery of the main body.