JPS61122570A - Automatic chemical analysis instrument - Google Patents

Abstract

PURPOSE:To make possible the high-speed treatment of specimens by a random access method while maintaining the high accuracy of measurement by providing a reagent table part and reagent dispensing nozzle parts in such a manner that these parts can be housed in a small space. CONSTITUTION:The reagent table part 14 and the reagent dispensing nozzle parts 19, 20, etc. are provided. The 1st nozzle part 19 absorbs the assigned reagent from the inside of a reagent cup 15. The reagent is dispensed by the prescribed nozzle of the nozzle part 19 into the reaction tube to be dispensed with the 1st reagent when said reaction tube arrives at the 1st reagent dispensing position. On the other hand, the 2nd nozzle part 20 sucks the 2nd reagent from the inside of a cup 15 in the 2nd turntable 16b into the corresponding nozzle by the operation similar to the operation of the part 19. This reagent is dispensed into the corresponding reaction tube in the 2nd reagent dispensing position. The nozzle parts 19, 20 move respectively to nozzle cleaning tanks 24a, 24b, upon completion of the dispensing, where the inside and outside walls of the nozzles are washed. The table part 14 is thus made smaller in size and the high-speed treatment is made possible with the high accuracy.

Description

DETAILED DESCRIPTION OF THE INVENTION [Technical Field of the Invention] The present invention relates to an automatic chemical analyzer, and particularly to one using a random access method.

[Technical Background of the Invention] In recent years, analysis of enzyme components in blood in clinical tests has become an important decisive factor in disease diagnosis.

For example, enzymes that escape from liver cells into the blood during liver disease include glutarate oxaloacetate transamylase (hereinafter referred to as rGOTJ), glutarate pyruhinate transamylase (hereinafter referred to as rGPTJ), and 9γ-glutamyl transpeptidase (hereinafter referred to as [ γ-GTPJ), and the test results have become important information for diagnosis.

According to the recommendations of the International Federation of Clinical Chemistry (IFCG), it is correct to determine the activity value rather than the concentration when measuring enzymes.

Enzyme activity values are expressed in fixed units, and one unit of enzyme' is 1 μI per minute under optimal conditions! It is defined as the amount of enzyme required to change 1 Oj2 of substrate.

A typical method for measuring enzyme activity is a reagent system that uses the coenzyme reduced form of nicotinamide adenine nucleotide (hereinafter referred to as rNADH2J).The reagent is mixed with serum and exposed to ultraviolet light due to the oxidation of NAD H2. The ultraviolet reaction rate method (hereinafter referred to as the "rate method") is known, which monitors changes in light absorption in the region over time and determines the activity value.

By the way, the enzyme activity value in serum is extremely low, for example, GOT is 10 to 30 μU/mi in healthy people (ILJ
(international average).

The change in absorbance of NADH2 at 340 nm, which corresponds to this activity value, is approximately o,ooi to 0.003 (AbS), and monitoring for one minute or more is required for highly accurate measurement.

In this case, if a one-channel discrete automatic chemical analyzer is used, only 60 samples can be processed per hour.

In addition, in order to accurately measure the activity value of the enzyme, it is necessary to monitor the reaction state and confirm that the reaction is proceeding linearly, and it is desirable that the observation time be at least several minutes.

- On the other hand, the number of specimens and items for clinical tests has increased in recent years, and there is a need to process a large number of specimens in a short time.

[Problems with Background Art] In order to meet the above-mentioned demands, devices are commercially available that process a large number of specimens in many different ways.

Examples include large-scale automatic chemical analyzers with multi-channel reaction lines, and automatic chemical analyzers that process multiple items in one channel.

However, in the former case, the items are fixed for each reaction line, and the reaction liquid is transferred from the reaction container to the photometric observation cell for measurement, so it is necessary to improve measurement accuracy. However, this method has the disadvantage that the observation time becomes longer and the sample processing speed is limited.

Furthermore, since test items differ for each patient, if the items are fixed for each reaction line, the reaction tube will be empty.

For example, considering a device that can test up to 24 items, if the actual average test items per patient is 12 items, the disadvantage is that half of the reaction tubes will be empty and the actual processing capacity will be halved. There is also.

If it were possible to measure any item in any reaction line, it would be possible to process samples one after another without creating empty reaction tubes (this method is called the "random access method"). doubles the processing power.

On the other hand, in the latter case, the above-mentioned drawbacks are improved. In other words, the reaction tubes arranged on the circumference are directly observed while rotating, and the observation of the reaction tubes is repeated at regular intervals from the start of the reaction to the end of the reaction.
The observation time for each reaction tube is short, and the sample processing speed can be increased without sacrificing measurement accuracy.

In addition, since it is possible to measure multiple items on the reaction line,
A random access method is possible, no empty reaction tubes are produced, and there is no problem of reduced processing capacity even if items are selected for each sample.

However, the reaction line is naturally limited in its ability to process a large number of samples, and when processing a large number of samples, it is necessary to build in several sets of circumferential reaction line blocks, which requires a large amount of space. There is a drawback.

In the latter case, observation of reaction tubes, washing and drying of reaction tubes, or dispensing of reagents to specimens are performed in a chronological series, so cleaning is necessary due to processing capacity.

Usually, sufficient drying is not possible.

In the above-mentioned random access method, since various items are measured using one reaction tube, interference between reagents for each item is likely to occur, and therefore, sufficient washing and drying of the reaction tube is required.

[Object of the Invention] The present invention has been made in view of the above circumstances, and provides an automatic chemical analyzer that can be stored in a small space and can process samples at high speed using a random access method while maintaining high measurement accuracy. The aim is to do so.

[Summary of the Invention] The outline of the present invention for achieving the above object is to form a multi-channel reaction line in which reaction tubes in each channel are transferred simultaneously in parallel, and to form a reaction line consisting of a sample and a reagent in the reaction tubes. This is an automatic chemical analyzer that analyzes and measures samples by detecting the absorbance of a liquid. A reagent dispensing nozzle portion comprising a nozzle and capable of sucking a reagent from within the plurality of reagent cups and dispensing the sucked reagent into any reaction tube of the reaction line. This feature enables high-speed processing using a random access method.

[Embodiment 1 of the Invention] Examples of the present invention will be described below with reference to the drawings.

FIG. 1 is a plan view showing an automatic chemical analyzer according to an embodiment of the present invention. As shown in the figure, the apparatus of this embodiment includes a multi-channel reaction line 1 consisting of a row of reaction tube cassettes containing a plurality of reaction tubes, and a light flux is irradiated onto the reaction liquid in the reaction tubes to measure the absorbance. It comprises a photometry section 2, a washing/drying means 3 for washing and drying the reaction tube after photometry, and a dispensing means 4 for dispensing the sample and reagent into the reaction tube of the reaction line 1. .

Here, the reaction line 1 and photometry section 2 will be explained with reference to FIG. 2.

FIG. 2 is an explanatory diagram of the reaction line section and the photometry section.

In FIGS. 1 and 2, 5 is a constant temperature bath that is kept at a constant temperature, for example, 37° C., by appropriate known means. is forming.

Inside the thermostatic chamber 5 are reaction tube cassettes C-1 to G-4,0-5 to C-24,0 each housing a plurality of reaction tubes 6.
A reaction tube cassette row consisting of -25 to C-28 is accommodated, and the bottom of each of these reaction tube cassettes C-1 to C-28 is kept at a constant temperature by contacting the bottom of the thermostatic chamber 5. It looks like this.

Incidentally, each of the reaction tube cassettes C-1 to C-28 may be made of a material having good thermal conductivity, and the material is not limited to a metal material.

The upper part of the reaction tube cassette C-1, the reaction tube cassette C,
-4 and reaction tube cassette C-5, reaction tube cassette C
-15 and between the reaction tube cassette C-24 and reaction tube cassette C-25, there are blank spaces a, b, c, and d, respectively.
is formed. And blank area a1 reaction tube cassette-1 to C-4.

The first reaction line RL1 is connected to the blank section C1 and the reaction tube cassettes C-5 to C-14.
-15 to G-24, blank section d and reaction tube cassette C-2
5 to C-28 form a second reaction line RL2,
Each reaction tube cassette C-1 to G-28 has both reaction lines RL.
z, along RL2, and can be circumferentially shaped in one direction (clockwise in this embodiment) while moving toward each other at both ends.

In addition, the blank part a2 reaction tube cassette-1 to C-4,
Both reaction lines RL1. Washing/drying section A spanning RL2,
Blank space 9 reaction tube cassettes C-5 to G-14. Blank area C
The reaction tube cassettes C-15 to C-24 form a reaction section B spanning both reaction lines R and 1° RL2.

Each of the reaction tube cassettes belonging to the washing/drying section A1 and reaction section B can be moved independently, and the reaction tube cassettes C-1 to C-4, 0-25 to C- in the washing/drying section A can be moved independently.
28 is only in this washing/drying section A, reaction tube cassettes C-5 to G-14, C-15 to C-2 in reaction section B.
4 are the reaction lines R only in this reaction section B.
L1. It is possible to circumferentially straddle RL2 in one direction (clockwise).

A light source 7. is provided between one end of the reaction line RLI and the blank area C. A photometric section 2 consisting of lenses 8, 9 and a spectrometer 10 is provided, and a blank section C is provided from one end of the photometric section 2.
When the reaction tube cassettes C-1 to C-28 are sequentially transferred to the photometer 2, they cross the optical path of the photometry section 2, and photometry is performed.

Next, the configuration of the dispensing means 4 will be explained.

In FIG. 1, reference numeral 11 denotes a sample supply section that accommodates a sample cassette 12, and a plurality of sample cups 13 containing specimens are arranged within the sample cassette 12. Further, 14 is a reagent table section that can each store a plurality of types of reagents, and a plurality of reagent cups 15,
While arranging the plurality of reagent cups 15 in a circular shape,
The first and second sections are configured to rotate in the Z direction, respectively. Second
turntables 16a and 16b, and a distal end portion thereof at an array position of each of the plurality of reagent cups 15 in order to supply reagents into the plurality of reagent cups 15 from a reagent storage (not shown) disposed outside. A plurality of reagent supply tubes 17 are arranged.

Furthermore, 18 is a sample dispensing nozzle portion for aspirating the sample in the sample cassette 13 and dispensing the aspirated sample into the reaction tube of the reaction line 1; The first nozzle has eight nozzles corresponding to the reaction tubes, and sucks the reagent in the reagent cup 15 and dispenses the sucked reagent into the reaction tube of the reaction line 1. It is a second reagent dispensing nozzle section, and is the sample dispensing nozzle section 18 and IL2! Second
! The second reagent dispensing nozzle sections 19 and 20 are respectively connected to the first nozzle sections extending from the top of the reaction line 1 to the top of the reagent table section 14. Second. Third dispensing arm 21.22.2
It is configured to be movable on 3.

Here, the above 1. Second reagent dispensing nozzle part 19.20
Each nozzle constituting the turntable 16a is movable up and down independently.

16b rotates, the first. The reagent in the reagent cup 15 that has arrived at a position directly below the second reagent dispensing nozzle 19, 20 is sucked.

In this sense, the bamboo record No. 1 and No. 2 of the reagent cup 15 are
The positions directly below each of the reagent dispensing nozzle portions 19 and 20 are referred to as reagent suction positions.

Further, each of the plurality of reagent cups 15 and each of the plurality of reagent supply thin tubes 17 are matched in advance, and each of the plurality of reagent cups 15 is moved to a predetermined position by rotation of the turntables 16a and 1-6b. When the reagent reaches the tip of the reagent supply capillary 17, a predetermined reagent is supplied from a reagent storage (not shown) as necessary. In this sense, the position corresponding to the tip of the predetermined reagent supply capillary tube 17 of each of the plurality of shake cups 15 is referred to as a reagent supply position.

Note that 24a and 24b are the first and second reagent dispensing nozzles 19 and 24b for cleaning the inner and outer walls of each nozzle in the second reagent dispensing nozzle 19 and 20, respectively. This is a second nozzle cleaning tank.

Next, the operation of the embodiment device having the above configuration will be explained.

First, the movements of the reaction tube cassettes C-1 to C-28 will be explained based on the operation diagrams shown in FIGS. 3 to 7.

In the reaction section B of FIG. 3, first, the first reaction line R
The reaction tube cassette C-14 located at one end of Lz is placed in the blank space C of the second reaction line RL2, and the reaction tube cassette C-14 located at one end of the reaction section B of the second reaction line RL2 is Transfer the cassettes C-24 to the blank spaces of the first reaction line RLx. The state after this transition is shown in FIG.

At this time, the reaction tube 6 in the reaction tube cassette C-14 crosses the optical path of the photometry section 2 and is photometered.

Next, as shown in FIG. 4, in the reaction section B, all the reaction tube cassettes C-24 belonging to the first reaction line RLr are
, C~, 5~C-13 indicate all the reaction tube cassettes C-14~C belonging to the second reaction line RL2 in the direction of arrow x1.
-23 moves one pitch each in the direction of arrow Y1.

When such a two-step operation is repeated for all the reaction tube cassettes C-5 to C-24 in the reaction section B, all of these reaction tube cassettes C-5 to C-24 are connected to the optical path of the photometry section 2. Therefore, all the reaction tubes 6 will be photometered, and each reaction tube cassette C-5 to
The arrangement state of C-24 returns to the state shown in FIG. Then move to C- and move the 14 reaction tube cassettes to blank area C.

The arrangement of each reaction tube cassette C-5 to C-24 at this time is shown in FIG.

Next, the operation of exchanging reaction tube cassettes between the reaction section B and the washing/drying section will be explained.

From the arrangement shown in FIG. 5, the reaction tube cassette C-24 of reaction section B is moved to the blank section d of washing/drying section A, and the reaction tube cassette C-4 of washing/drying section A is moved to the blank section of reaction section B. At the same time, the reaction tube cassette C-28 is moved to the blank area a. This state is shown in FIG.

At this time, it is assumed that the sample has already been dispensed into the reaction tube cassette C-4.

All reaction tube cassettes C-1 from the arrangement shown in Figure 6.
When C-28 is advanced by one pitch, one cycle of operation is completed, and the arrangement state at this time is as shown in FIG. That is, when one cycle is completed, the reaction tube cassette C
-5 advances to the original reaction tube cassette C-6 position.

At this time, the reagent is dispensed into each reaction tube 6 at the reagent dispensing point in the reaction section B, as described above.

After the completion of the above-described one cycle, each reaction tube cassette in the reaction section B rotates only within this reaction section B, as described above, and crosses the optical path of the photometry section 2, so that photometry of each reaction tube 7 is performed.

At this time, each reaction tube cassette in the washing/drying section A is washed at its respective position within this washing/drying section A.

Drying and sample sampling are performed.

Therefore, in each cycle, one new reaction tube cassette into which a sample has been dispensed enters the reaction section B, while one reaction tube cassette in which the reaction has been completed is transferred to the washing/drying section.

Note that the cleaning, drying, and sampling in the cleaning/drying section A can be carried out over a sufficient period of time while each reaction tube cassette in the reaction section B is being measured.

Next, dispensing the sample and reagent into the reaction tube will be explained.

When a specific reaction tube cassette to which a sample is to be divided arrives at the reaction tube cassette C-3 position (sample dispensing position) in FIG. 1 sample is aspirated and sequentially dispensed into each reaction tube of the reaction tube cassette located at the sample dispensing position. Here, if the number of measurement items of the first sample is 8 or less, the sample dispensing nozzle section 18 aspirates the second sample from within the designated sample cup 13 and transfers it to the sample dispensing position. Dispense into the empty reaction tube of the reaction tube cassette located at . The reaction tube cassette into which the sample has been dispensed is then moved to the reaction tube cassette C-4 position in FIG.

On the other hand, the first reagent dispensing nozzle section 19 sucks a designated reagent from within a predetermined reagent cup 15 .

That is, the first nozzle of the eight nozzles of the first reagent dispensing nozzle 19 is set to the reagent suction position, and the first nozzle is set to the reagent suction position.
When the reagent cup 15 containing a predetermined reagent to be aspirated by the first nozzle reaches the reagent suction position by the rotation of the turntable 16a, the first nozzle descends and a predetermined reagent is drawn from inside the reagent cup 15. Aspirate the reagent. After suction, this first nozzle rises and returns to its home position, then the first reagent dispensing nozzle section 19 moves again, and the second nozzle of the melon is set at the reagent suction position. When the reagent cup 15 containing a predetermined reagent to be aspirated by the second nozzle reaches the reagent suction position by one movement of the first turntable 16a, the second nozzle descends and the reagent cup 15 reaches the reagent suction position.
Aspirate the specified reagent from inside 5. In this way, the first
A designated reagent is sucked into each of the eight nozzles of the reagent dispensing nozzle section 19. After finishing reagent aspiration,
This first reagent dispensing nozzle section 19 moves to the first reagent dispensing position (reaction tube cassette C-4 position) of the reaction line 1. When the reaction tube into which the first reagent is to be dispensed arrives at this first reagent dispensing position, the reagent is dispensed into the reaction tube by a predetermined nozzle of the first reagent dispensing nozzle section 19. be done.

On the other hand, the second reagent dispensing nozzle section 20 operates in the same manner as the first reagent dispensing nozzle section 19 described above, so that the designated 8 points from within the reagent cup 15 are moved to a predetermined position on the second turntable 16b. The second reagent of the type is aspirated into the corresponding eight nozzles, and the aspirated reagent is transferred to the corresponding eight reactions at the second reagent dispensing position (reaction tube cassette C-13 position). It is dispensed into a tube.

1st. When each of the second reagent dispensing nozzle parts 19 and 20 finishes reagent dispensing, it is moved to the first and second nozzle cleaning tanks 24a and 24b, respectively, and is moved into the nozzle for the next reagent dispensing. The exterior walls are cleaned.

In addition, such a first. Second reagent dispensing nozzle section 19.2
0 and 1st. The operation of the second turntables 16a, 16b is controlled by a computer (not shown) provided in the apparatus of this embodiment.

Therefore, the operator only has to input the sample to be measured and the measurement items of the sample in advance using an appropriate manual means such as a numeric keypad.

Also, 1st. The replenishment of the reagent cups 15 in the second turntable 168.16b takes place via the reagent supply capillaries 17 when the reagent cups are in the reagent supply position. Specifically, the first. Each nozzle of the second reagent dispensing nozzle section 19.20 is connected to the first nozzle. Second nozzle cleaning tank 24a.

24b, each reagent cup 15 on the first and second turntables 16a and 16b returns to the reagent supply position, and at this time, desirably replenishes m of the reagent consumed by dispensing. be done. This is conveniently designed to keep the reagent level at a constant level and eliminate residual reagent during nozzle cleaning, by immersing the nozzle tip a certain length below the liquid level when sucking in the reagent. It is.

Therefore, if a liquid level sensor is attached, for example, it is not necessary to replenish the amount of reagent consumed each time.

Note that in order to monitor the amount of reagent remaining in each reagent cup 15 (not shown), the first. Second turntable 16
It is desirable that a sensor be attached to each of a and 16b, and that reagents and chemicals are replenished from a reagent storage (not shown) in accordance with the output of the sensor. Examples of the sensor include an optical type (in this case, the reagent cup is made of a transparent material), a nitrogen gas capacity type, and an ultrasonic type, which can be easily realized using existing technology. I can do it.

In this way, in the apparatus of this embodiment, the reaction tube cassettes can be arranged with almost no gaps, and the reagent storage can be freely arranged inside and outside the apparatus, and reagents can be supplied from this reagent storage. By taking , the reagent table section 14
Since the device can be constructed in a small size, there is a high degree of freedom in device design, an excellent space factor, and the device can be easily made compact. In addition, since each reaction tube is photometered every cycle from the start of the reaction to the end, highly accurate measurements are possible, and since photometry is performed while the reaction tube cassette is moving, High-speed processing becomes possible. Furthermore, since the reagent is supplied from the reagent storage as much as is needed at the moment, the reagent cup 15 may be small, and as a result, the first. Although the second turntables 16a, 16b are compactly configured, they can accommodate a wide variety of reagents. In addition, the photometry in the reaction section and the cleaning and drying in the cleaning and drying section can be performed independently, and
Wash the reaction tube by doing it in parallel.

In addition, the reagent table section is composed of a rotatable turntable, and a wide variety of reagents can be dispensed from the plurality of reagent cups arranged on the turntable to the reagent dispensing nozzle section. By subjecting it to suction,
Specified reagents can be quickly aspirated by the reagent dispensing nozzle, and by configuring the reagent dispensing nozzle with multiple nozzles, multiple types of reagents can be quickly dispensed into designated reaction tubes. By cleaning the reagent dispensing nozzle section in the nozzle cleaning section after each dispensing operation, it is possible to prevent cumulative contamination caused by minute amounts of different reagents adhering to the nozzle. The device of this embodiment is most suitable for a random access method. In addition, even if the reagent is kept cold to prevent deterioration, the temperature will rise once due to room temperature in the reagent cup in the reagent table, so there is no need for a heater S for pre-heating. Since the reagent cup holds a reagent of almost constant width, there is no need for a so-called liquid level sensor to insert only the nozzle tip of the reagent dispensing nozzle section into the liquid surface, which is advantageous in terms of equipment cost. becomes.

Although one embodiment of the present invention has been described above, it goes without saying that the present invention is not limited to the above-mentioned embodiment, and can be modified as appropriate within the scope of the gist of the present invention. An example of this will be described below.

In the above embodiment, each reaction tube cassette C-5 to C-24 crosses the optical path of the photometer 2 once in one cycle. You can also try to improve your abilities.

For example, a specific reaction tube cassette C-5 shaded in FIG. 3 is advanced to the initial position of the reaction tube cassette C-16 as shown in FIG. 8, and this is defined as one cycle. In this process, the reaction tube cassette C-5 crosses the optical path of the photometer 7 and is photometered.

A new reaction tube cassette into which the sample was dispensed during the above-mentioned cycle is transferred from the washing/drying section to the reaction section 8, and a reaction tube cassette whose reaction has been completed is transferred from the reaction section B to the washing/drying section. .

In the next cycle, a specific reaction tube cassette is advanced to the initial position of reaction tube cassette C-7 as shown in FIG. 9, and this is defined as the next cycle.

Of course, in this process as well, the fm* reaction tube cassettes are exchanged between the washing/drying section A and the reaction section B as in the case of the first cycle.

Generally, it is possible to configure a specific reaction tube cassette to cross the optical path once in n cycles (n=1 to reaction tube response time), regardless of the number of photometry and reaction time.

On the contrary, it is possible to configure the light beam to cross the optical path of the photometry section multiple times in one cycle.

In addition, the number of reaction tube cassettes 1 the pitch period of the reaction tube cassette 1 the number and shape of reaction tubes to be stored in the reaction cassette, the setting position of the photometry section (blue), the number of reagent dispensing nozzles, the reagent dispensing nozzle section Number of nozzles.

Various design changes are possible with respect to the number of reagent cups in the reagent table section, the number of blank steps between the reagent dispensing position 1 reaction section and the washing/drying section, etc.

Although the embodiments have been described above only in the case of a reaction tank in which a multi-channel reaction line formed of reaction tube cassettes is formed, it is clear that the invention can also be implemented in reaction tanks with other multi-channel reaction lines.

[Effects of the Invention] As explained above, the present invention provides an automatic chemical analyzer that can be stored in a small space and can rapidly process samples using a random access method while maintaining high measurement accuracy. be able to.

[Brief explanation of drawings]

FIG. 1 is a plan view showing an automatic chemical analyzer as an embodiment of the present invention, FIG. 2 is an explanatory diagram of the reaction line and photometry section in the device shown in FIG. 1, and FIGS. 3 to 7 are diagrams showing the reaction FIG. 8 and FIG. 9 are explanatory diagrams showing other operations of the reaction line. DESCRIPTION OF SYMBOLS 1... Reaction line, 2... Photometry part, 6... Reaction tube, 14... Reagent table part, 15... Reagent cup,
19.20... Reagent dispensing nozzle section, C-1 to C-28... Reaction tube cassette, RLt...
First reaction line. RL'2...Second reaction line, A...Washing/drying section. B...Reaction part. C-14-Li9”

Claims (4)

[Claims] (1) A multi-channel reaction line is formed in which the reaction tubes of each channel are transferred simultaneously in parallel, and the absorbance of the reaction solution consisting of the sample and reagent in the reaction tube is detected to provide analysis and measurement of the sample. An automatic chemical analyzer, comprising: a reagent table portion in which a plurality of reagent cups each capable of storing different types of reagents are arranged; and a plurality of nozzles; An automatic chemical analysis apparatus characterized by comprising a reagent dispensing nozzle section capable of aspirating a reagent and dispensing the aspirated reagent into any reaction tube of the reaction line. (2) A multi-channel reaction line is formed from a reaction tube cassette row containing a plurality of reaction tubes, and the reaction line is
It has a first and second reaction line and is divided into a reaction section that performs reaction photometry of reaction tubes and a washing/drying section that performs washing and drying or sampling of reaction tubes, and belongs to the reaction section and washing/drying section. The automatic system according to claim 1, wherein the reaction tube cassettes are movable independently, and each of the reaction tube cassettes is configured to be able to transfer one reaction tube cassette to the other side from each of the two parts. Chemical analyzer. (3) The reagent table section includes a rotatable turntable, and when each reagent cup is at the reagent supply position, a predetermined reagent is supplied from the outside. The automatic chemical analyzer according to item 2. (4) Each nozzle of the reagent dispensing nozzle section is configured to be able to move up and down independently, and when a predetermined reagent cup in the reagent table section is at the reagent suction position, the nozzles in the reagent cup are sucked. An automatic chemical analyzer according to any one of claims 1 to 3, wherein the automatic chemical analyzer is