JPS60959A - Package - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a packaging body with excellent water vapor barrier properties and gas permeability.

Conventionally, press-through packs (hereinafter abbreviated as FTP) have been used to seal and package drugs such as capsules and other products in a moisture-proof manner.
Generally, a laminating agent coated with an adhesive such as polyvinyl chloride (PVC) resin was applied to the side having the storage chamber, that is, the package body.

However, since the PvC that forms the storage chamber has poor moisture resistance, there is a risk that it will deteriorate when highly hygroscopic drugs such as vitamins are packaged.

For this reason, a vinyl chloride sheet coated with polyvinylidene chloride, which has excellent moisture resistance, was developed. However, vinylidene chloride is very expensive, and 9. FTP packaging is much more expensive than vinyl chloride alone, and products such as synthetic penicillin, which generate carbon dioxide and other gases when they absorb moisture, In the packaging of chemicals, etc., which themselves have a gas-generating function, the barrier properties of vinylidene chloride are detrimental, causing problems such as bulging and tearing of the packaging.

To solve the above drawbacks, it is necessary to have excellent moisture resistance and gas permeability, and polyolefin resins such as high density polyethylene (HDPE) and polypropylene (PP), which have excellent moisture resistance, have been developed. . However, polyolefin resin differs from polystyrene (PS) and PVC, which have traditionally been used as thermoforming materials, in that it is a crystalline resin with high specific heat, low thermal conductivity, and poor work stability during thermoforming. In addition, molded products with poor elasticity and transparency are poorly evaluated.In addition, the heat trace caused by heating causes wavy wrinkles, followed by tension wrinkles due to shrinkage, and furthermore due to a decrease in melt tension. Produces sauce. Polyolefin sheets have weaker contraction than PS sheets, so they do not hold up well and tend to sag in wrinkles. Therefore, it is difficult to obtain a well-balanced molded product with less uneven thickness because it is formed into a wavy and sagging trench. In addition, molded products shaped in a mold using vacuum or compressed air go through post-processes such as cooling, mold release, and l-rimming. It takes time to process, and the molding cycle becomes long. As described above, there are many problems in molding polyolefin sheets, and it is often impossible to mold them with general molding machines, and the curling of the polyolefin resin is so severe that automatic stacking is impossible.

In view of the above-mentioned current state of FTP packaging materials, the inventors of the present invention have as follows:
We have conducted various studies with the aim of providing inexpensive FrP sheets and FTP packaging that have a high degree of moisture resistance and gas permeability, and are easily applicable to commercial FTP packaging machines. As a result, they came up with the following PTP packaging.

That is, the packaging body according to the present invention is made of polystyrene resin,
Contains a layer of polyethylene terephthalate resin or vinyl chloride resin, a layer of polypropylene or high-density polyethylene, and has a moisture permeability of 1.5 ff/rr.
?・It is an FTP package made of a laminated sheet with carbon dioxide permeability of 150 ccy-・24 hr or less at 24 hr or less (at 40° C. x 90% r<H).

Furthermore, in the above sheet, the laminated structure is more elastic than the sheet (C) - (CB) - (C) - (B) - (C) - (A) The package (C) is modified polyolefin. (adhesive resins such as) are preferred. Furthermore, 1) TP packaging body made of a sheet of Pukudiene-styrene copolymer (BS resin) is preferable. Hereinafter, polypropylene and high-density polyethylene will be collectively referred to as polyolefin resins. Although polyolefin resin sheets have excellent water vapor barrier properties and outstanding gas permeability, they have drawbacks such as moldability, rigidity, gloss, transparency, and curling. By combining it with resin and vinyl chloride resin, it was possible to obtain a sheet that was greatly improved in terms of moldability, rigidity, gloss, transparency, curl, etc. However, in this laminated sheet, the thickness ratio of each host resin is important and affects the moisture resistance and gas permeability of the sheet.
Gas permeability is 100 ccAt?・24hr (at 2
It is necessary to adjust the temperature to 5°C, 1 kg/shoulder differential pressure). Polystyrene type 4! , JJ resin, polyethylene terephthalate resin, polyvinyl chloride #layer (4)
and polyolefin resin layer [F]> thickness ratio (to)
is R=(A)/)=0.05 to 2.0, preferably 0.
In the range of 1 to 0.4, if a special molding machine was prepared for a single polyolefin resin sheet, it would be necessary to make a major improvement to the molding machine, but the sheet according to the present invention It was possible to obtain a molded article equivalent to a polyvinyl chloride resin molded article without modifying the resin molding machine.

Each component material and the method for manufacturing the package of the present invention will be described in detail below.

Examples of polystyrene resins include general polystyrene, impact-resistant polystyrene, styrene-maleic anhydride copolymer, butadiene-styrene copolymer, styrene-acrylonitrile copolymer, acrylonitrile-butadiene-
It is possible to use styrene copolymers. Also, although it is not a styrene resin, various polyacrylonis) IJ
resin can be used. Furthermore, depending on the purpose of use, the above resins can be used alone or as a mixture, which can be selected as appropriate.

In addition, in order to strengthen the adhesion with polyolefin resins or improve the performance of the above polystyrene resins, it is possible to add various additives such as those shown below to the extent that they do not impair the properties of the polystyrene resins. It is. For example, additives include the following: Polyethylene, polypropylene or their copolymers, ethylene-vinyl acetate coplanar polymers, ethylene-acrylic acid copolymers, unsaturated dicarboxylic acids, various modified polyolefins,
Rubber-like substances such as polyurethane resin, polybutadiene, polybutene, methyl methacrylate resin, butyl rubber, silicone rubber, acrylic rubber, polyether rubber, natural rubber, or various auxiliaries and stabilizers such as inorganic fillers, pigments, and UV inhibitors. It is also possible to add. As the polyethylene terephthalate resin, a thermoplastic copolyester in which a part of the glycol component is replaced with 1,4-cyclohexane dimetatool is mainly used.
It is not particularly specified, and unsubstituted polyester can also be used. Further, various polymers, additives, pigments, etc. can be added within the range not to impair the properties of the polyethylene terephthalate resin, or in the sense of imparting physical properties that the polyethylene terephthalate resin does not have.

The polyvinyl chloride resin includes one or more of vinyl chloride, chlorinated polyvinyl chloride, or copolymer resins mainly composed of vinyl chloride, such as vinyl acetate, vinylidene chloride, acrylic esters, and higher fatty acid vinyl esters. This refers to a resin in which auxiliaries, stabilizers, and lubricants are added to the mixed resin, and further inorganic fillers, pigments, etc. are added as necessary.

The polyolefin resin referred to in the present invention is not particularly limited, and is appropriately selected depending on the application molding method described in -7, but mainly polyethylene, polypropylene, and one or a mixture of two or more of ethylene-propylene copolymers are used. .

Further, various resins for modifying the polyolefin, various nucleating agents for increasing the degree of crystallinity, and various additives for improving the physical properties of the polyolefin can be used.

Although the present invention does not specify the adhesive for bonding layer A and layer B, various adhesives can be used to strengthen the interlayer adhesive force, and by providing an adhesive layer, Furthermore, the physical properties of the sheet can be improved.

Methods for producing the packaging of the present invention are not particularly specified, but a laminated sheet may be produced by a coextrusion method, an extrusion lamination method, a coextrusion lamination method, a dry lamination method, a vacuum forming method, a pressure forming method, etc. It can be molded by a molding method such as a molding method.

As described above, the packaging body according to the present invention has a high degree of moisture resistance and gas permeability, and is an inexpensive FTP with excellent mechanical suitability that can be easily applied to a general-purpose FTP packaging machine.
It can be widely used as a TP packaging sheet and an FTP packaging material, and as a packaging material for pharmaceutical products.

The present invention will be explained below with reference to Examples.

Example 1 Melts of the following three types of molding materials were fed into a coextrusion five-layer die to form a laminar flow overlapping in the order of A-C-B-C-A.

A: Impact-resistant polystyrene (KR-0 manufactured by Philips)
5) B: Polypropylene (Sumitomo Noprene FH1 manufactured by Sumitomo Chemical)
015) C: Ethylene-vinyl acetate copolymer (Evaflex P2505C manufactured by Mitsui Polychemical Co., Ltd.): 80 parts by weight modified polyolefin (Mersene H6410D manufactured by Toyo Soda Co., Ltd.)
): 20 parts by weight of a mixture. The thickness of each layer of the laminated sheet obtained by extrusion from the T-die is: A layer: 30μB layer: 170μC layer: 10μ
The total thickness was 250μ.

Example 2 A similar sheet was prepared in Example 1 except that the resin constituting layer A was replaced with a thermoplastic copolyester (PET-G manufactured by Eastman Kodak).

Example 3 The following two types of sheets were A-B- by dry lamination method.
A laminated sheet with A layer: 30μ and B layer: 170μ was created.

A: Hard vinyl chloride sheet (Sumito Bakelite Co., Ltd. Sumilite VSS1202) B-Polypropylene sheet (Sumitomo Chemical Co., Ltd. Sumitomo Blen FH1015) Example 4 The B layer constituent resin of Example 1 was made of high-density polyethylene (Showa Denko Co., Ltd. Showa Rex 55008) Instead, I created a similar sheet.

Example 5 A similar sheet was prepared by adding 0.5 part of a nucleating agent to the B-layer constituent resin of Example 1.

Example 6 Melts of the following three resins were fed into a coextrusion die, and A
A laminar flow layered in the order of -C-B-C-A-C was formed.

A: Impact-resistant polystyrene (Philips m-05
) B: Polypropylene (Sumitomo Noprene FH manufactured by Sumitomo Chemical Co., Ltd.
1015) C: Ethylene-vinyl acetate copolymer (Evaflex P2505C manufactured by Mitsui Polychemical Co., Ltd.): 80 parts by weight modified polyolefin (Mersene H6410 manufactured by Toyo Soda Co., Ltd.)
D): The thickness of each layer of the MM sheet obtained by extruding a mixture consisting of 20 parts by weight from a T-die is 30μ for the A layer, 170μ for the 8 layer, and 10μ for the 0 layer.
The total μ was 260 μ.

Example 7.8 The melts of the following three resins were fed into a coextrusion die, and A-
Laminar flow layered in the order of C-H, A layer 30μ, 8 layers 170μ
μ A: Impact-resistant polystyrene (KR-0 manufactured by Philips
5) B: Polypropylene (Sumitomo Chemical Co., Ltd. Sumitomo Noblen FH1
015) C: Ethylene vinyl acetate copolymer (Evaflex P2505C manufactured by Mitsui Polychemical Co., Ltd.): 80ffi modified polyolefin (Mersene H6410D manufactured by Toyo Soda Co., Ltd.)
): The obtained sheet was formed to have a layer thickness of 10 μm in the mixture C layer consisting of 20 parts by weight, and the obtained sheet was designated as Example 7, and a hard vinyl chloride sheet (VSS 1202 manufactured by Sumitomo Bakelite Co., Ltd.) was attached to the sheet of Example 7 by a dry lamination method. Example 8 was obtained by laminating 30 μm.

Example 9 A melt of the following three resins was fed into a coextrusion die, and A-
A laminar flow in the order of B-B'-B-A was formed.

A: Impact-resistant polystyrene (KR-0 manufactured by Philips)
5) B: High-density polyethylene (Showa Denko Showlex S
-5008') B': Polypropylene + 0.5 part of nucleating agent (Sumitomo Noprene FH1015 manufactured by Sumitomo Chemical) The thickness of each layer of the obtained laminated sheet is A layer = 30 μB layer:
35μB'layer; 100μ, total thickness was 230μ.

Example 10 A melt of the following three resins was fed into a coextrusion five-layer die,
A laminar flow in the order B-C-A-C-B was formed.

A: Impact-resistant polystyrene (KR-0 manufactured by Philips)
5) B: Polypropylene (Sumitomo Noblen PH1 manufactured by Sumitomo Chemical Co., Ltd.
015) C: Ethylene-vinyl acetate copolymer (Evaflex P2505G manufactured by Mitsui, 1ζ Rechemical Co., Ltd.): 8 parts and 3 parts modified polyolefin (Mersene H641 manufactured by Toyo-Sodatsu Co., Ltd.)
0D): Mixture consisting of 20 parts by weight. The thickness of each seedling of the obtained laminated sheet was A layer: 30 μB layer: 100 / (and 70 μC layer: l
The total amount of Oμ was 250μ.

Comparative Example 1 In order to compare with the example, a polypropylene annual leave sheet (Sumitomo Noprene FH1015 manufactured by Sumitomo Chemical Co., Ltd.) was extruded using a single-layer die. Thickness: 250μ.

Comparative Example 2 A hard vinyl chloride sheet (250μ) was prepared by the calendar method for comparison (VSS12 manufactured by Sumitomo Bakelite).
02).

Comparative Example 3 For comparison, a vinyl chloride sheet (230μ) coated with vinylidene chloride (20μ) was prepared (
Resident Bakelite VSL 4601).

Comparative Example 4 A transparent impact-resistant polystyrene sheet (250μ) was prepared for comparison (KR-05 manufactured by Philips).

Comparative Example 5 The following two types of sheets were D-E- by dry lamination method.
0 layer: 50μE layer created by laminating in the order of D:
It was 100μ, a total of 200μ.

D=Hard vinyl chloride sheet (VSS 120 manufactured by Juju Chemical Co., Ltd.)
2) E: The details of the rolled polyethylene test are shown below.

It was molded using a drum-type continuous vacuum forming machine for FTP molding, and its moldability was examined. Also, put a lid on the molded product,
Water vapor permeability was measured by the change in weight over time. Gas permeability was also checked by observing the bulge of the packaging material after a similar molded product was filled with synthetic penicillin and stored for a month.

In addition, the moisture permeability of the sheet state of Examples, 10 types and 5 types of comparative examples,
Gas permeability is JISZO208, ASTM D-
1434.

The experimental results are summarized in Table 1.

Claims (1)

[Claims] 1. Contains a layer made of polystyrene resin, polyethylene terephthalate resin, or vinyl chloride resin, and a layer (B) made of polypropylene or high-density polyethylene, and has a moisture permeability of 1.5? /rr?・FTP packaging body made of a laminated sheet with a carbon dioxide permeability of 150 cc/i・24 hr or more.