JPS6092764A - Surface treatment of polyurethane coating layer of medical instrument - Google Patents
Surface treatment of polyurethane coating layer of medical instrumentInfo
- Publication number
- JPS6092764A JPS6092764A JP58202257A JP20225783A JPS6092764A JP S6092764 A JPS6092764 A JP S6092764A JP 58202257 A JP58202257 A JP 58202257A JP 20225783 A JP20225783 A JP 20225783A JP S6092764 A JPS6092764 A JP S6092764A
- Authority
- JP
- Japan
- Prior art keywords
- coating layer
- polyurethane coating
- polyurethane
- solvent
- surface treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Materials For Medical Uses (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
従来、各種カニユーレ、人工心臓駆動用チューブ、各種
カテーテル等の医療器具には生体適合性のよいポリウレ
タン化合物がコーティングされている。このような医療
器具が皮膚の表面を貝通する部分で感染を防ぐために当
該部分の表面を粗面化して生体化する必要がある。また
、人工心臓や人工弁のような医療器具では、血液に接触
する面についても同様に粗面化し、この部分に内皮細胞
を着床させて生体化することによって血液に対する凝固
や血栓形成の問題を解決することが必要である。DETAILED DESCRIPTION OF THE INVENTION Conventionally, medical instruments such as various cannulas, artificial heart drive tubes, and various catheters have been coated with polyurethane compounds that are highly biocompatible. In order to prevent infection at the part where such a medical instrument passes through the skin surface, it is necessary to roughen the surface of the part and make it into a living body. In addition, in medical devices such as artificial hearts and artificial valves, the surfaces that come into contact with blood are similarly roughened, and endothelial cells are implanted in these areas to make them biogenic, thereby reducing the problem of blood coagulation and thrombus formation. It is necessary to solve the problem.
この発明は上記の事情に鑑みてなされたもので、医療器
具のポリウレタンコーティング層の表面を簡易に粗面化
することができる方法を提供することを目的とするもの
である。The present invention was made in view of the above circumstances, and an object of the present invention is to provide a method that can easily roughen the surface of a polyurethane coating layer of a medical device.
以下、その実施例について説明する。Examples thereof will be described below.
第１図において符号１は各種カニユーレ、人工心臓駆動
用チューブ、各種カテーテル等のようなチューブ（医療
器具）を示す−ものである。このチューブ１は例えばポ
リ塩化ビニル、ポリカーボネート、アクリル樹脂等の合
成樹脂で構成されている。このチューブ１には生体適合
性のよいポリウレタンコーティング層２を形成り−るた
めにこのチューブ１は例えばポリジメチルシロキサン−
ポリウレタン共重合体等のポリウレタン化合物の溶液中
にディッピング（侵積）される。この時、このポリウレ
タン化合物の種類に応じて１８℃ないし６５℃の空気中
で乾燥し、同時にこの乾燥雰囲気の相対湿度または溶媒
の相対飽和度を４０％ないし９５％のうちの必要な値に
調節すると、上記ポリウレタン化合物の溶液の溶剤が蒸
発することにより硬化前のポリウレタンコーティング層
２の表面温度が露点以下になり、第２図に示すように微
小な水滴や溶媒の小満３が上記硬化前のポリウレタンコ
ーティング層２の表面層に凝縮する。この状態でさらに
時間が経過づると、上記水滴や溶媒小滴３およびポリウ
レタンコーティング層２中の溶剤が蒸発しつくして、ポ
リウレタンコーティング層２は、その表面に上記水滴や
溶媒小滴３の跡を残した状態のまま硬化Ｊ”る。これに
よって、第３図に示すように、硬化後のポリウレタンコ
ーティング層２の表面には、その人きさが１μｍないし
１０μｍ程度の縮緬状の皺４が形成される。In FIG. 1, reference numeral 1 indicates tubes (medical instruments) such as various cannulas, artificial heart drive tubes, various catheters, and the like. The tube 1 is made of a synthetic resin such as polyvinyl chloride, polycarbonate, or acrylic resin. In order to form a biocompatible polyurethane coating layer 2 on the tube 1, the tube 1 is coated with polydimethylsiloxane, for example.
It is dipped into a solution of a polyurethane compound such as a polyurethane copolymer. At this time, it is dried in air at a temperature of 18°C to 65°C depending on the type of polyurethane compound, and at the same time the relative humidity of this drying atmosphere or the relative saturation of the solvent is adjusted to a necessary value between 40% and 95%. Then, as the solvent in the solution of the polyurethane compound evaporates, the surface temperature of the polyurethane coating layer 2 before curing becomes below the dew point, and as shown in FIG. It condenses on the surface layer of the polyurethane coating layer 2. As more time passes in this state, the water droplets and solvent droplets 3 and the solvent in the polyurethane coating layer 2 are completely evaporated, leaving traces of the water droplets and solvent droplets 3 on the surface of the polyurethane coating layer 2. The remaining state is cured. As a result, as shown in FIG. 3, crepe-like wrinkles 4 with a size of about 1 μm to 10 μm are formed on the surface of the cured polyurethane coating layer 2. be done.
以上説明したように、この発明によれば、たいへん簡単
に医療器具のポリウレタン」−ティング層の表面を粗面
化することができ、これにより、このポリウレタンコー
ティング層の表面を生体化することができる。従って、
各種カニユーレ、人工心臓駆動用チューブ、各種カテー
テル、人工心臓、人工弁等の医療器具に、この発明に係
るポリウレタンコーティング層の表面処理法を適用すれ
ば、医療器具の使用による感染や血液凝固、面枠形成を
防止するのに非常に有効である。As explained above, according to the present invention, the surface of the polyurethane coating layer of a medical device can be roughened very easily, and thereby the surface of the polyurethane coating layer can be biomorphized. . Therefore,
If the surface treatment method of the polyurethane coating layer according to the present invention is applied to medical devices such as various cannulae, artificial heart drive tubes, various catheters, artificial hearts, and artificial valves, infection, blood coagulation, and surface treatment due to the use of medical devices can be prevented. Very effective in preventing frame formation.
第１図ないし第３図はこの発明の一実施例を説明するた
めのもので、第１図はチューブ（医療器具）をポリウレ
タン化合物の溶液中にディッピングした直後の１！７ｉ
面斜視図、第２図は乾燥中のポリウレタンコーティング
層の表面層に水滴や溶媒小滴が凝縮したところの断面斜
視図、第３図はポリウレタンコーティング層の表面に縮
緬状の皺が形成されたところの断面斜視図である。
１・・・・・・チューブ（医療器具）、２・・・・・・
ポリウレタンコーティング層、３・・自・・水滴や溶媒
小滴、４・・・・・・縮緬状の皺。
出願人 泉工医科工業株式会社
第１図
第２図
第３図Figures 1 to 3 are for explaining one embodiment of the present invention.
Figure 2 is a cross-sectional perspective view of water droplets and solvent droplets condensing on the surface layer of the polyurethane coating layer during drying, and Figure 3 shows crepe-like wrinkles formed on the surface of the polyurethane coating layer. However, it is a cross-sectional perspective view. 1...Tube (medical instrument), 2...
Polyurethane coating layer, 3... Water droplets and solvent droplets, 4... Crepe-like wrinkles. Applicant: Senko Medical Industry Co., Ltd. Figure 1 Figure 2 Figure 3
Claims (2)
脂等の合成樹脂製の医療器具の表面を生体適合性のよい
ポリウレタン化合物によりコーティングする際において
、ポリウレタンコーティング層形成のディッピング後の
乾燥時に乾燥雰囲気中の水蒸気や不溶性溶媒を硬化前の
前記ポリウレタンコーティング層の表面に凝縮させ、つ
づいてこの水蒸気または溶媒を蒸発させることにより前
記ポリウレタンコーティング層の表面に縮緬状の皺を形
成することを特徴とする医療器具のポリウレタンコーテ
ィング層の表面処理法。(1) When coating the surface of a medical device made of synthetic resin such as polyvinyl chloride, polycarbonate, or acrylic resin with a biocompatible polyurethane compound, water vapor in the dry atmosphere is generated during drying after dipping to form a polyurethane coating layer. A medical device characterized in that crepe-like wrinkles are formed on the surface of the polyurethane coating layer by condensing water vapor or an insoluble solvent on the surface of the polyurethane coating layer before curing, and then evaporating the water vapor or solvent. Surface treatment method for polyurethane coating layer.
の温度をポリウレタン化合物の種類に応じて１５℃ない
し１５０℃の間で変化させるとともに相対湿度または溶
媒の相対飽和度を４０％ないし９５％との間で変化させ
、ポリウレタンコーティング層の表面に形成される縮緬
状の皺の大きさを１μｍないし５０μｍの範囲内で変化
させることを特徴とする特許請求の範囲第１項記載の医
療器具のポリウレタンコーティング層の表面処理法。(2) The temperature of the dipping and drying atmosphere after dipping is varied between 15°C and 150°C depending on the type of polyurethane compound, and the relative humidity or relative saturation of the solvent is varied between 40% and 95%. The surface of the polyurethane coating layer of the medical device according to claim 1, wherein the size of the crepe-like wrinkles formed on the surface of the polyurethane coating layer is varied within the range of 1 μm to 50 μm. Processing method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58202257A JPS6092764A (en) | 1983-10-28 | 1983-10-28 | Surface treatment of polyurethane coating layer of medical instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58202257A JPS6092764A (en) | 1983-10-28 | 1983-10-28 | Surface treatment of polyurethane coating layer of medical instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6092764A true JPS6092764A (en) | 1985-05-24 |
| JPH0364145B2 JPH0364145B2 (en) | 1991-10-04 |
Family
ID=16454545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58202257A Granted JPS6092764A (en) | 1983-10-28 | 1983-10-28 | Surface treatment of polyurethane coating layer of medical instrument |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6092764A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04221571A (en) * | 1990-03-26 | 1992-08-12 | Becton Dickinson & Co | Catheter tube with in vivo softening property controlled |
| WO2009119761A1 (en) | 2008-03-26 | 2009-10-01 | 株式会社カネカ | Antithrombotic surface |
-
1983
- 1983-10-28 JP JP58202257A patent/JPS6092764A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04221571A (en) * | 1990-03-26 | 1992-08-12 | Becton Dickinson & Co | Catheter tube with in vivo softening property controlled |
| WO2009119761A1 (en) | 2008-03-26 | 2009-10-01 | 株式会社カネカ | Antithrombotic surface |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0364145B2 (en) | 1991-10-04 |
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